C Shukunami

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Molecular cloning of tenomodulin, a novel chondromodulin-I related gene
    C Shukunami
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, 606 8507, Japan
    Biochem Biophys Res Commun 280:1323-7. 2001
  2. ncbi request reprint Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro
    C Shukunami
    Department of Molecular Interaction and Tissue Engineering, Kyoto University, Japan
    Biochem Biophys Res Commun 249:885-90. 1998
  3. ncbi request reprint Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells
    Y Hiraki
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Eur J Biochem 260:869-78. 1999
  4. ncbi request reprint Spatiotemporal pattern of the mouse chondromodulin-I gene expression and its regulatory role in vascular invasion into cartilage during endochondral bone formation
    C Shukunami
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Int J Dev Biol 43:39-49. 1999
  5. ncbi request reprint Molecular cloning of mouse and bovine chondromodulin-II cDNAs and the growth-promoting actions of bovine recombinant protein
    C Shukunami
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, 606 8507, Japan
    J Biochem 125:436-42. 1999
  6. ncbi request reprint Role of cartilage-derived anti-angiogenic factor, chondromodulin-I, during endochondral bone formation
    C Shukunami
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Osteoarthritis Cartilage 9:S91-101. 2001
  7. ncbi request reprint Generation of multiple transcripts from the chicken chondromodulin-I gene and their expression during embryonic development
    C Shukunami
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    FEBS Lett 456:165-70. 1999
  8. ncbi request reprint Chondromodulin-I as a novel cartilage-specific growth-modulating factor
    Y Hiraki
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Pediatr Nephrol 14:602-5. 2000
  9. ncbi request reprint Differentiation of chondrogenic precursor cells during the regeneration of articular cartilage
    Y Hiraki
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Osteoarthritis Cartilage 9:S102-8. 2001
  10. ncbi request reprint Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5
    H Akiyama
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Sakyo, Japan
    Biochem Biophys Res Commun 235:142-7. 1997

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Molecular cloning of tenomodulin, a novel chondromodulin-I related gene
    C Shukunami
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, 606 8507, Japan
    Biochem Biophys Res Commun 280:1323-7. 2001
    ....
  2. ncbi request reprint Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro
    C Shukunami
    Department of Molecular Interaction and Tissue Engineering, Kyoto University, Japan
    Biochem Biophys Res Commun 249:885-90. 1998
    ..These results indicated that the expression ChM-I was placed under the dynamic control of local growth and differentiation factors...
  3. ncbi request reprint Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells
    Y Hiraki
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Eur J Biochem 260:869-78. 1999
    ..In contrast, it inhibited the tube morphogenesis of cultured vascular endothelial cells in vitro and angiogenesis in chick chorioallantoic membrane in vivo...
  4. ncbi request reprint Spatiotemporal pattern of the mouse chondromodulin-I gene expression and its regulatory role in vascular invasion into cartilage during endochondral bone formation
    C Shukunami
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Int J Dev Biol 43:39-49. 1999
    ....
  5. ncbi request reprint Molecular cloning of mouse and bovine chondromodulin-II cDNAs and the growth-promoting actions of bovine recombinant protein
    C Shukunami
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, 606 8507, Japan
    J Biochem 125:436-42. 1999
    ..We then expressed recombinant bovine ChM-II protein which was purified to homogeneity. The recombinant protein stimulated the growth of rabbit growth plate chondrocytes, mouse MC3T3-E1 cells and rat UMR-106 osteoblastic cells in vitro...
  6. ncbi request reprint Role of cartilage-derived anti-angiogenic factor, chondromodulin-I, during endochondral bone formation
    C Shukunami
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Osteoarthritis Cartilage 9:S91-101. 2001
    ..Taking advantage of ectopic bone formation and xenograft tumour model by human chondrosarcoma cell line OUMS-27, we examined how ChM-I is involved in switching of angiogenesis in cartilage...
  7. ncbi request reprint Generation of multiple transcripts from the chicken chondromodulin-I gene and their expression during embryonic development
    C Shukunami
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    FEBS Lett 456:165-70. 1999
    ..The expression pattern of the gene suggests a role for ChM-I in the morphogenesis during embryonic development...
  8. ncbi request reprint Chondromodulin-I as a novel cartilage-specific growth-modulating factor
    Y Hiraki
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Pediatr Nephrol 14:602-5. 2000
    ....
  9. ncbi request reprint Differentiation of chondrogenic precursor cells during the regeneration of articular cartilage
    Y Hiraki
    Department of Molecular Interaction and Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Osteoarthritis Cartilage 9:S102-8. 2001
    ....
  10. ncbi request reprint Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5
    H Akiyama
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Sakyo, Japan
    Biochem Biophys Res Commun 235:142-7. 1997
    ..Our data suggest that hh signalling molecules may be involved in chondrogenesis and cartilage differentiation in ATDC5 cells...
  11. ncbi request reprint Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis
    S W Sachdev
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, D 85764, Neuherberg, Germany
    Mech Dev 105:157-62. 2001
    ..At later developmental stages, chm1 expression was detected in areas surrounding the otic vesicles, in the developing craniofacial cartilage elements, and in the chondrogenic region of the pectoral fins...
  12. ncbi request reprint Expression and localization of angiogenic inhibitory factor, chondromodulin-I, in adult rat eye
    H Funaki
    Department of Structural Pathology, Institute of Nephrology, Niigata University, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Invest Ophthalmol Vis Sci 42:1193-200. 2001
    ..To determine the role in the eye of chondromodulin (ChM)-I, which has been identified in cartilage as an angiogenic inhibitor, the expression and localization and a possible function of ChM-I were investigated...
  13. ncbi request reprint A novel growth-promoting factor derived from fetal bovine cartilage, chondromodulin II. Purification and amino acid sequence
    Y Hiraki
    Department of Biochemistry and Calcified Tissue Metabolism, Osaka University Faculty of Dentistry, Osaka 565, Japan
    J Biol Chem 271:22657-62. 1996
    ..These findings suggest that the growth and differentiation of chondrocytes are regulated by multiple components in the cartilage matrix...
  14. pmc Cartilage-specific matrix protein chondromodulin-I is associated with chondroid formation in salivary pleomorphic adenomas: immunohistochemical analysis
    K Kusafuka
    Department of Pathology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, Japan
    Am J Pathol 158:1465-72. 2001
    ..In conclusion, pleomorphic adenoma expressed ChM-I, which is involved in hypovascularity and chondroid formation in this type of tumor...
  15. ncbi request reprint Genomic organization of the human chondromodulin-1 gene containing a promoter region that confers the expression of reporter gene in chondrogenic ATDC5 cells
    I Yanagihara
    Department of Environmental Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Japan
    J Bone Miner Res 15:421-9. 2000
    ..These results suggest that the element -446/+87 confers the cartilage-specific expression of this gene by some factor(s) other than Sox9, Og12, and Cart-1...
  16. ncbi request reprint Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo
    T Hayami
    Department of Orthopaedic Surgery, Niigata University School of Medicine, Japan
    FEBS Lett 458:436-40. 1999
    ..Moreover, ChM-I also inhibited the growth of HT-29 colon adenocarcinoma in vivo, implying its therapeutic potential for solid tumors...
  17. ncbi request reprint Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans
    H Satoh
    Discovery Research Laboratories 1, Sumitomo Pharmaceuticals Research Center, Osaka 544, Japan
    J Biol Chem 273:12307-15. 1998
    ....
  18. ncbi request reprint A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells
    A Shimizu
    Department of Biotechnology, Faculty of Engineering, Kyoto Sangyo University, Kamigamo Motoyama, Kita ku, Kyoto 603 8555, Japan
    J Biol Chem 276:11031-40. 2001
    ..These results suggest that the acid box plays an important role in the regulation of FGFR3 to mediate biological activities in response to FGFs...
  19. ncbi request reprint Minute pleomorphic adenoma of the submandibular gland in patients with oral malignancy: a report of two cases with histological and immunohistochemical examination
    K Kusafuka
    Histopathology 51:258-61. 2007