Affiliation: Osaka University
- A multicenter prospective randomized controlled trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure. Mild Hypothermia Study Group in JapanT Shiozaki
Department of Traumatology, Osaka University Medical School, Kinki University School of Medicine, Japan
J Neurosurg 94:50-4. 2001..A prospective randomized controlled trial was conducted to determine whether mild hypothermia is essential in the treatment of severely head injured patients with low intracranial pressure (ICP)...
- Delayed hemispheric neuronal loss in severely head-injured patientsT Shiozaki
Department of Traumatology, Osaka University Medical School, Japan
J Neurotrauma 18:665-74. 2001..It is concluded that focal primary injury to underlying brain, if severe enough, can result in delayed hemispheric atrophy...
- Efficacy of moderate hypothermia in patients with severe head injury and intracranial hypertension refractory to mild hypothermiaTadahiko Shiozaki
Department of Traumatology, Osaka University Graduate School of Medicine, Suita Shi, Osaka, Japan
J Neurosurg 99:47-51. 2003..This study was performed to determine whether moderate hypothermia (31 degrees C) improves clinical outcome in severely head injured patients whose intracranial hypertension cannot be controlled using mild hypothermia (34 degrees C)...
- Hypertension and head injuryTadahiko Shiozaki
Department of Traumatology, Osaka University Graduate School of Medicine, 2 2, Suita Shi, Yamada oka, Osaka, 565 0871, Japan
Curr Hypertens Rep 7:450-3. 2005....
- Cerebrospinal fluid concentrations of anti-inflammatory mediators in early-phase severe traumatic brain injuryTadahiko Shiozaki
Department of Traumatology, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
Shock 23:406-10. 2005..We conclude that anti-inflammatory mediators in CSF may be useful indicators of the severity of brain damage in terms of ICP as well as overall prognosis of patients with severe TBI...
- Enhanced expression of heat shock proteins in activated polymorphonuclear leukocytes in patients with sepsisN Hashiguchi
Department of Traumatology, Osaka University Medical School, Suita Shi, Osaka, Japan
J Trauma 51:1104-9. 2001..The objective of this study was to investigate the HSP expression in polymorphonuclear leukocytes (PMNLs) from severe septic patients and the relation between the expression of HSPs and PMNL function...
- Enhanced expression of heat shock proteins in leukocytes from trauma patientsN Hashiguchi
Department of Traumatology, Osaka University Medical School, 2-15 Yamadaoka, Suita-shi, Osaka 565-0871, Japan. hashi!hp-emerg.med.osaka-u.ac.jp
J Trauma 50:102-7. 2001..CONCLUSION: Severe trauma causes demonstrated enhanced expression of HSPs in PMNLs during the acute phase. This enhanced expression of HSPs may regulate PMNL functions...
- Mismatch recovery of regional cerebral blood flow and brain temperature during reperfusion after prolonged brain ischemia in gerbilsGoro Tajima
Departments of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
J Trauma 62:36-43; discussion 43. 2007..Recovery of cerebral reperfusion after stroke or cardiac arrest can take a long time. We aimed to identify differences in the postischemic recovery of physiologic parameters between short and prolonged brain ischemia...
- Changes in cerebral blood flow from the acute to the chronic phase of severe head injuryYoshiaki Inoue
Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2 15 Yamadaoka, Suita, Osaka 565 0871, Japan
J Neurotrauma 22:1411-8. 2005..05). We conclude that patients whose CBF returns to normal at 2-3 weeks following severe traumatic brain injury after being abnormally low in the acute phase of injury can be expected to achieve a good neurological outcome...
- Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injuryToshiaki Hayakata
Department of Traumatology and Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan
Shock 22:102-7. 2004..057). CSF concentrations of S100B and cytokines peak within 24 h after severe TBI and decrease gradually thereafter. CSF S100B and IL-1beta may be useful as predictors of outcome in cases of severe TBI...
- Mild hypothermia reduces expression of heat shock protein 60 in leukocytes from severely head-injured patientsNaoyuki Hashiguchi
Department of Traumatology and Critical Care Medicine, Tottori Prefectural General Hospital, Japan
J Trauma 55:1054-60. 2003..Thus, we conducted a study to clarify the impact of mild hypothermia on the expression of HSPs in polymorphonuclear leukocytes (PMNLs) in severely head-injured patients...
- Acute cerebral blood flow variations after human cardiac arrest assessed by stable xenon enhanced computed tomographyYoshiaki Inoue
Department of Traumatology and Acute Critical Medicine of Osaka University Graduate School of Medicine, Osaka, Japan
Curr Neurovasc Res 4:49-54. 2007..Furthermore, patients with abnormally low CBF that returns to supernormal within the first 48 hours following CPA can be expected to recover well neurologically...
- Profile of gene expression in the subventricular zone after traumatic brain injuryKazuhisa Yoshiya
Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
J Neurotrauma 20:1147-62. 2003..In the future, this may enable regeneration of the damaged central nervous system...