Miki Shinohara

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc Multiple pathways suppress non-allelic homologous recombination during meiosis in Saccharomyces cerevisiae
    Miki Shinohara
    Division of Integrated Protein Functions, Institute for Protein Research, Osaka University, Suita, Osaka, Japan
    PLoS ONE 8:e63144. 2013
  2. doi request reprint Mps3 SUN domain is important for chromosome motion and juxtaposition of homologous chromosomes during meiosis
    Hanumanthu B D Prasada Rao
    Institute for Protein Research, Graduate School of Science, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Genes Cells 16:1081-96. 2011
  3. pmc In vivo assembly and disassembly of Rad51 and Rad52 complexes during double-strand break repair
    Toshiko Miyazaki
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan
    EMBO J 23:939-49. 2004
  4. doi request reprint Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosis
    Miki Shinohara
    Institute for Protein Research, Osaka University, Suita 565 0871, Japan
    Nat Genet 40:299-309. 2008
  5. pmc Csm4-dependent telomere movement on nuclear envelope promotes meiotic recombination
    Hiromichi Kosaka
    Institute for Protein Research, Graduate School of Science, Osaka University, Suita, Osaka, Japan
    PLoS Genet 4:e1000196. 2008
  6. ncbi request reprint A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1
    Atsuko Hayase
    Institute for Protein Research, Graduate School of Science, Osaka University, Suita, Osaka 565 0871, Japan
    Cell 119:927-40. 2004
  7. doi request reprint Cyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection
    Kenichiro Matsuzaki
    Department of Integrated Protein Functions, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    Genes Cells 17:473-93. 2012
  8. doi request reprint Cyclin-dependent kinase promotes formation of the synaptonemal complex in yeast meiosis
    Zhihui Zhu
    Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    Genes Cells 15:1036-50. 2010
  9. pmc Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase
    Hiroyuki Sasanuma
    Institute for Protein Research, Graduate School of Science, Osaka University, Suita, Osaka, Japan
    Genetics 194:859-72. 2013
  10. pmc The mitotic DNA damage checkpoint proteins Rad17 and Rad24 are required for repair of double-strand breaks during meiosis in yeast
    Miki Shinohara
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Japan
    Genetics 164:855-65. 2003

Collaborators

  • Neil Hunter
  • Hiroyuki Oshiumi
  • Atsushi Nakagawa
  • Masahiro Terasawa
  • Akira Shinohara
  • Kenichiro Matsuzaki
  • Hiroyuki Sasanuma
  • Toshiko Miyazaki
  • Mohammad Bani Ismail
  • Hanumanthu B D Prasada Rao
  • Kentaro Yamashita
  • Zhihui Zhu
  • Hiromichi Kosaka
  • Atsuko Hayase
  • Mariko Tsukamoto
  • Mamoru Suzuki
  • Jessica P Lao
  • Eiki Yamashita
  • Yuko Furihata
  • Eri Sanda
  • Maki S Tawaramoto
  • Harumi Hosaka
  • Mika Higashide
  • Daichi Iwasaki
  • Saori Mori
  • James E Haber
  • Debra A Bressan
  • Misato Takagi

Detail Information

Publications15

  1. pmc Multiple pathways suppress non-allelic homologous recombination during meiosis in Saccharomyces cerevisiae
    Miki Shinohara
    Division of Integrated Protein Functions, Institute for Protein Research, Osaka University, Suita, Osaka, Japan
    PLoS ONE 8:e63144. 2013
    ..Our results provide evidence for two types of ectopic recombination: one that occurs in wild-type cells and a second that occurs predominantly when the checkpoint pathway is inactivated...
  2. doi request reprint Mps3 SUN domain is important for chromosome motion and juxtaposition of homologous chromosomes during meiosis
    Hanumanthu B D Prasada Rao
    Institute for Protein Research, Graduate School of Science, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Genes Cells 16:1081-96. 2011
    ..These findings suggest that in meiosis, the Mps3 SUN domain is important for modulating chromosome motion events that act in meiotic chromosome juxtaposition and by extension, promoting proper morphogenesis of the synaptonemal complex...
  3. pmc In vivo assembly and disassembly of Rad51 and Rad52 complexes during double-strand break repair
    Toshiko Miyazaki
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan
    EMBO J 23:939-49. 2004
    ..Additional biochemical studies suggest the presence of an ssDNA complex containing both Rad51 and Rad52...
  4. doi request reprint Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosis
    Miki Shinohara
    Institute for Protein Research, Osaka University, Suita 565 0871, Japan
    Nat Genet 40:299-309. 2008
    ..In contrast, crossover assurance requires all ZMM proteins and full-length synaptonemal complexes...
  5. pmc Csm4-dependent telomere movement on nuclear envelope promotes meiotic recombination
    Hiromichi Kosaka
    Institute for Protein Research, Graduate School of Science, Osaka University, Suita, Osaka, Japan
    PLoS Genet 4:e1000196. 2008
    ..We propose that chromosome movement and associated telomere dynamics at the nuclear envelope promotes the completion of key biochemical steps during meiotic recombination...
  6. ncbi request reprint A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1
    Atsuko Hayase
    Institute for Protein Research, Graduate School of Science, Osaka University, Suita, Osaka 565 0871, Japan
    Cell 119:927-40. 2004
    ....
  7. doi request reprint Cyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection
    Kenichiro Matsuzaki
    Department of Integrated Protein Functions, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    Genes Cells 17:473-93. 2012
    ..CDK-dependent modification of the NHEJ pathway might make DSB ends compatible for NHEJ and thus prevent competition between HR and NHEJ in hierarchy on the choice of DSB repair pathways...
  8. doi request reprint Cyclin-dependent kinase promotes formation of the synaptonemal complex in yeast meiosis
    Zhihui Zhu
    Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    Genes Cells 15:1036-50. 2010
    ..Compromised CDK activity in meiotic prophase leads to defective SC formation without affecting DSB formation. These results suggest that CDK-dependent phosphorylation regulates meiotic chromosome morphogenesis...
  9. pmc Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase
    Hiroyuki Sasanuma
    Institute for Protein Research, Graduate School of Science, Osaka University, Suita, Osaka, Japan
    Genetics 194:859-72. 2013
    ..Our results suggest that a precise level of Srs2, in the form of the Srs2 translocase, is required to appropriately regulate the Rad51 nucleoprotein filament dynamics during meiosis. ..
  10. pmc The mitotic DNA damage checkpoint proteins Rad17 and Rad24 are required for repair of double-strand breaks during meiosis in yeast
    Miki Shinohara
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Japan
    Genetics 164:855-65. 2003
    ..Unexpectedly, the entry into meiosis I (metaphase I) is delayed in the checkpoint single mutants compared to wild type. The control of the cell cycle in response to meiotic DSBs is also discussed...
  11. pmc Rad6-Bre1-mediated histone H2B ubiquitylation modulates the formation of double-strand breaks during meiosis
    Kentaro Yamashita
    Department of Biology, Graduate School of Science, and Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 101:11380-5. 2004
    ..Histone tail modifications might play a role in DSB formation during meiosis...
  12. pmc Forkhead-associated domain of yeast Xrs2, a homolog of human Nbs1, promotes nonhomologous end joining through interaction with a ligase IV partner protein, Lif1
    Kenichiro Matsuzaki
    Institute for Protein Research, Graduate School of Science, Osaka University, Suita, Osaka 565 0871, Japan
    Genetics 179:213-25. 2008
    ..The interaction between Xrs2 and Lif1 through the FHA domain is conserved in humans; the FHA domain Nbs1 interacts with Xrcc4, a Lif1 homolog of human...
  13. doi request reprint A new protein complex promoting the assembly of Rad51 filaments
    Hiroyuki Sasanuma
    Institute for Protein Research, Graduate School of Science, Osaka University, Suita 565 0871, Japan
    Nat Commun 4:1676. 2013
    ..Together, these results reveal a novel molecular mechanism for this class of Rad51-mediators, which includes the human Rad51 paralogues...
  14. pmc The N-terminal DNA-binding domain of Rad52 promotes RAD51-independent recombination in Saccharomyces cerevisiae
    Mariko Tsukamoto
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043, Japan
    Genetics 165:1703-15. 2003
    ..These findings indicate that Rad52 itself, and more precisely its N-terminal DNA-binding domain, promote an essential reaction in recombination in the absence of RAD51...
  15. pmc Dot1-dependent histone H3K79 methylation promotes the formation of meiotic double-strand breaks in the absence of histone H3K4 methylation in budding yeast
    Mohammad Bani Ismail
    Institute for Protein Research, Graduate School of Science, Osaka University, Suita, Osaka, Japan
    PLoS ONE 9:e96648. 2014
    ..This suggests that high levels of DSBs mediated by histone H3K4 methylation promote SC elongation. ..