Takashi Sato

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Progressive hearing loss in mice carrying a mutation in the p75 gene
    Takashi Sato
    Department of Otolaryngology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Brain Res 1091:224-34. 2006
  2. doi request reprint Visualization of endolymphatic hydrops after administration of a standard dose of an intravenous gadolinium-based contrast agent
    Tohru Tanigawa
    Department of Otolaryngology, Aichi Medical University, Japan
    Acta Otolaryngol 131:596-601. 2011
  3. doi request reprint Craniometaphyseal dysplasia unnoticed until 19 years of age: First diagnosed from facial nerve paralysis
    Tohru Tanigawa
    Department of Otolaryngology, Aichi Medical University, Nagakute, Aichi, Japan
    Auris Nasus Larynx 38:406-10. 2011
  4. pmc Uncovering genes required for neuronal morphology by morphology-based gene trap screening with a revertible retrovirus vector
    Yukiko Hashimoto
    Department of Cell Biology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    FASEB J 26:4662-74. 2012
  5. doi request reprint 3D-FLAIR MRI findings in patients with low-tone sudden deafness
    Tohru Tanigawa
    Department of Otolaryngology, Aichi Medical University, Aichi, Japan
    Acta Otolaryngol 130:1324-8. 2010
  6. ncbi request reprint Ménière's disease is associated with single nucleotide polymorphisms in the human potassium channel genes, KCNE1 and KCNE3
    Katsumi Doi
    Department of Otolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    ORL J Otorhinolaryngol Relat Spec 67:289-93. 2005
  7. ncbi request reprint Involvement of Ca2+-independent phospholipase A2 in the translocation of hypoxia-inducible factor-1alpha to the nucleus under hypoxic conditions
    Mayuko Osada-Oka
    Department of Pathological Biochemistry, Kyoto Pharmaceutical University, Kyoto, Japan
    Eur J Pharmacol 549:58-62. 2006
  8. ncbi request reprint 14-3-3 proteins and protein phosphatases are not reduced in tau-deficient mice
    Katsunori Fujio
    Laboratory of Molecular Traffic, Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, Japan
    Neuroreport 18:1049-52. 2007
  9. pmc Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences and 21st Century Center of Excellence Program, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Clin Invest 117:1514-26. 2007
  10. ncbi request reprint Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters
    Shinsuke Suzuki
    Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Circ J 71:1970-6. 2007

Collaborators

  • Tohru Tanigawa
  • Arata Horii
  • Toshihide Yamashita
  • Yoshiaki Saito
  • Naoyuki Takahashi
  • Koichi Sato
  • Akiko Maeda
  • Seiji Kikuchi
  • Hiroshi Kawaguchi
  • Masataka Sata
  • Takashi Kudo
  • Toshiki Sudo
  • Susumu Imaoka
  • Masashi Akaike
  • Masayoshi Takeuchi
  • Hiroshi Nakanishi
  • Kazuhiro Nakamura
  • Shigeaki Kato
  • Takahiro Matsumoto
  • Akihiro Harada
  • Hirotaka Kawano
  • Yukiko Hashimoto
  • Kazuhiro Muramatsu
  • Ken ichi Aihara
  • Hiromi Ii
  • Satoshi Akiba
  • Mayuko Osada-Oka
  • Akira Togayachi
  • Takashi Nakamura
  • Reiko Harada
  • Yuko Nakamichi
  • Takefumi Uemura
  • Junko Miyamoto
  • Katsunori Fujio
  • Hiroko Shiina
  • Yasumasa Ikeda
  • Hisashi Narimatsu
  • Yoko Yamamoto
  • Takashi Yamada
  • Kimihiro Yoshimura
  • Ken ichi Takeyama
  • Masataka Kunii
  • Yoshihiko Hirohashi
  • Keisuke Yamamoto
  • Jun Hirabayashi
  • Shinsuke Suzuki
  • Hiroaki Tateno
  • Yoshiyuki Kobayashi
  • Atsushi Kuno
  • Ichiro Takada
  • Hiroyuki Azuma
  • Shoko Okitsu-Negishi
  • Toshio Matsumoto
  • Toshihiko Yanase
  • Reiko Sato-Harada
  • Shusuke Yagi
  • Hajime Nawata
  • Shuitsu Maeda
  • Tomoyuki Watanabe
  • Nobuhisa Iriuchijima
  • Toru Fukuda
  • Katsumi Doi
  • Chiho Sumi-Ichinose
  • Keisuke Sekine
  • WuQiang Fan
  • Daniel Metzger
  • Pierre Chambon
  • Ju Qiang Wang
  • Toko Jotsuka
  • Toshikazu Yada
  • Shunshui Rong
  • Hideyuki Ikeda
  • Noriyuki Sato
  • Yasumasa Ishida
  • Shin ichiro Yoshimura
  • Minami Yamada
  • Kae Tsutsumi
  • Takako Ikeda
  • Naoya Hontani
  • Akihiro Morikawa
  • Koichi Okamoto
  • Issei Toshida
  • Shinji Hatakeyama
  • Mayuko Oka
  • Tomoko Ohkusa
  • Yoshiyuki R Osamura
  • Masao Kobayashi
  • Masanori Sato
  • Takeo Minematsu
  • Yuko Kozono

Detail Information

Publications47

  1. ncbi request reprint Progressive hearing loss in mice carrying a mutation in the p75 gene
    Takashi Sato
    Department of Otolaryngology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Brain Res 1091:224-34. 2006
    ....
  2. doi request reprint Visualization of endolymphatic hydrops after administration of a standard dose of an intravenous gadolinium-based contrast agent
    Tohru Tanigawa
    Department of Otolaryngology, Aichi Medical University, Japan
    Acta Otolaryngol 131:596-601. 2011
    ..The next step would be to consistently visualize ELH in the upper part of the cochlea...
  3. doi request reprint Craniometaphyseal dysplasia unnoticed until 19 years of age: First diagnosed from facial nerve paralysis
    Tohru Tanigawa
    Department of Otolaryngology, Aichi Medical University, Nagakute, Aichi, Japan
    Auris Nasus Larynx 38:406-10. 2011
    ..High-dose corticosteroid could be effective in treating facial nerve paralysis, even when nerves have been directly constricted by a bony overgrowth...
  4. pmc Uncovering genes required for neuronal morphology by morphology-based gene trap screening with a revertible retrovirus vector
    Yukiko Hashimoto
    Department of Cell Biology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    FASEB J 26:4662-74. 2012
    ..Because our novel morphology-based gene trap method is generally applicable, this method is promising for uncovering novel genes involved in the function of interest in any cell lines...
  5. doi request reprint 3D-FLAIR MRI findings in patients with low-tone sudden deafness
    Tohru Tanigawa
    Department of Otolaryngology, Aichi Medical University, Aichi, Japan
    Acta Otolaryngol 130:1324-8. 2010
    ..Disordered blood flow in the inner ear is associated with an increased permeability of the blood-labyrinth barrier. Therefore, the disordered blood flow in the cochlea may be closely related to the pathophysiological mechanisms of LTSD...
  6. ncbi request reprint Ménière's disease is associated with single nucleotide polymorphisms in the human potassium channel genes, KCNE1 and KCNE3
    Katsumi Doi
    Department of Otolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    ORL J Otorhinolaryngol Relat Spec 67:289-93. 2005
    ..The result indicates that 112G/A SNP in the KCNE1 gene and 198T/C SNP in the KCNE3 gene could determine an increased susceptibility to develop MD...
  7. ncbi request reprint Involvement of Ca2+-independent phospholipase A2 in the translocation of hypoxia-inducible factor-1alpha to the nucleus under hypoxic conditions
    Mayuko Osada-Oka
    Department of Pathological Biochemistry, Kyoto Pharmaceutical University, Kyoto, Japan
    Eur J Pharmacol 549:58-62. 2006
    ..Thus, iPLA2, but not cPLA2alpha, may play an important role in regulating the transport of HIF-1alpha to the nucleus...
  8. ncbi request reprint 14-3-3 proteins and protein phosphatases are not reduced in tau-deficient mice
    Katsunori Fujio
    Laboratory of Molecular Traffic, Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, Japan
    Neuroreport 18:1049-52. 2007
    ..We propose that tau-deficient mice are an ideal system for confirming the function of tau-interacting proteins...
  9. pmc Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice
    Ken ichi Aihara
    Department of Medicine and Bioregulatory Sciences and 21st Century Center of Excellence Program, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
    J Clin Invest 117:1514-26. 2007
    ....
  10. ncbi request reprint Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters
    Shinsuke Suzuki
    Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Circ J 71:1970-6. 2007
    ..1 cardiomyopathic hamsters...
  11. pmc The pituitary function of androgen receptor constitutes a glucocorticoid production circuit
    Junko Miyamoto
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell Biol 27:4807-14. 2007
    ..Thus, this study suggests that the activated AR supports the negative feedback regulation of glucocorticoid production via up-regulation of GR expression in the pituitary gland...
  12. ncbi request reprint Successful treatment with liposteroid followed by reduced intensity stem cell transplantation in an infant with perforin deficiency presenting with hemophagocytic lymphohistiocytosis
    Yoshiyuki Kobayashi
    Department of Pediatrics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Pediatr Hematol Oncol 29:178-82. 2007
    ..These observations suggest that this treatment strategy might thus be recommended in infants with FHL to reduce treatment-related complications, especially in patients with relatively mild clinical courses...
  13. pmc Detection of norovirus antigens from recombinant virus-like particles and stool samples by a commercial norovirus enzyme-linked immunosorbent assay kit
    Shoko Okitsu-Negishi
    Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 0033, Japan
    J Clin Microbiol 44:3784-6. 2006
    ..9%. Our results clearly indicated that the kit allows the detection of the most prevalent genotype, GII/4. In order to increase the sensitivity of the kit, the reactivity with norovirus of GII/3 and GII/6 genotypes needs to be improved...
  14. ncbi request reprint The Rab8 GTPase regulates apical protein localization in intestinal cells
    Takashi Sato
    Laboratory of Molecular Traffic, Department of Molecular and Cellullar Biology, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371 8512, Japan
    Nature 448:366-9. 2007
    ..Our results demonstrate that Rab8 is necessary for the proper localization of apical proteins and the absorption and digestion of various nutrients in the small intestine...
  15. ncbi request reprint A novel strategy for mammalian cell surface glycome profiling using lectin microarray
    Hiroaki Tateno
    Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Central 2, 1 1 1 Umezono, Ibaraki 305 8568, Japan
    Glycobiology 17:1138-46. 2007
    ..These results demonstrate that the technique provides a novel strategy for profiling global changes of the mammalian cell surface glycome...
  16. doi request reprint Neuron-specific and inducible recombination by Cre recombinase in the mouse
    Yukiko Hashimoto
    Department of Molecular and Cellular Biology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Neuroreport 19:621-4. 2008
    ..Thus, tau (CrePR) knockin line is a useful tool for studying neuronal gene functions...
  17. doi request reprint Neuron-specific recombination by Cre recombinase inserted into the murine tau locus
    Kazuhiro Muramatsu
    Laboratory of Molecular Traffic, Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa, Maebashi, Gunma 371 8512, Japan
    Biochem Biophys Res Commun 370:419-23. 2008
    ..Thus, tau-Cre knockin mouse is a useful tool for studying the neuronal function of a gene in vivo...
  18. ncbi request reprint Group IVA phospholipase A2-associated production of MMP-9 in macrophages and formation of atherosclerotic lesions
    Hiromi Ii
    Department of Pathological Biochemistry, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Biol Pharm Bull 31:363-8. 2008
    ..The protection against the lesions in IVA-PLA2-deficient mice may be ascribable, in part, to the impaired production of MMP-9 and/or the maintained levels of HDL-C...
  19. doi request reprint Group IVA phospholipase A2 is associated with the storage of lipids in adipose tissue and liver
    Hiromi Ii
    Department of Pathological Biochemistry, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Prostaglandins Other Lipid Mediat 86:12-7. 2008
    ..Our findings suggest that group IVA PLA(2) is involved in the storage of lipids in the adipose tissue and liver and in determining circulating PGE(2) levels...
  20. ncbi request reprint VEGF-enhanced proliferation under hypoxia by an autocrine mechanism in human vascular smooth muscle cells
    Mayuko Osada-Oka
    Department of Pathological Biochemistry, Kyoto Pharmaceutical University, Kyoto, Japan
    J Atheroscler Thromb 15:26-33. 2008
    ....
  21. ncbi request reprint Altered expression of connexin43 contributes to the arrhythmogenic substrate during the development of heart failure in cardiomyopathic hamster
    Takashi Sato
    Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1 1 1, Minami Kogushi, Ube, Yamaguchi 755 8505, Japan
    Am J Physiol Heart Circ Physiol 294:H1164-73. 2008
    ....
  22. pmc Polylactosamine on glycoproteins influences basal levels of lymphocyte and macrophage activation
    Akira Togayachi
    Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Central 2 OSL, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Proc Natl Acad Sci U S A 104:15829-34. 2007
    ..These results indicate that polylactosamine on N-glycans is a putative immune regulatory factor presumably suppressing excessive responses during immune reactions...
  23. ncbi request reprint Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1
    Keisuke Yamamoto
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Dev Cell 13:365-76. 2007
    ..These results demonstrate that ATF6alpha functions as a critical regulator of ER quality control proteins in mammalian cells, in marked contrast to worm and fly cells in which IRE1 is responsible...
  24. ncbi request reprint Toxic advanced glycation end products (TAGE) theory in Alzheimer's disease
    Takashi Sato
    Department of Pathophysiological Science, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan
    Am J Alzheimers Dis Other Demen 21:197-208. 2006
    ..These results suggest that TAGE is involved in the pathogenesis of AD as well as other age-related diseases. In this review, the authors discuss the molecular mechanisms of AD, especially focusing on TAGE-RAGE system...
  25. ncbi request reprint Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury
    Takashi Sato
    Department of Internal Medicine and Clinical Immunology, Yokohama City University, and Rosai Hospital for Silicosis, Tochigi, Japan
    Am J Respir Crit Care Med 174:906-14. 2006
    ..Heme oxygenase-1 (HO-1), a rate-limiting enzyme in heme catabolism, has antioxidative, antiapoptotic, and antiinflammatory activities. We examined whether HO-1 might be involved in silicosis...
  26. ncbi request reprint Study of androgen receptor functions by genetic models
    Takahiro Matsumoto
    Institute of Molecular and Cellular Biosciences, University of Tokyo
    J Biochem 138:105-10. 2005
    ..Here we review recent results of our studies into genetic models of the loss of AR function in mice and the gain of AR function in Drosophila...
  27. ncbi request reprint Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc
    Takashi Sato
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory Central 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    J Biol Chem 278:47534-44. 2003
    ..These results suggest that beta 4GalNAc-T3 could transfer GalNAc residues, producing N,N'-diacetylgalactosediamine structures at least in N-glycans and probably in both N- and O-glycans...
  28. ncbi request reprint Androgen receptor functions from reverse genetic models
    Takahiro Matsumoto
    Laboratory of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Steroid Biochem Mol Biol 85:95-9. 2003
    ..Although no overt phenotype was detected in adult fly-eye neurons expressing mutant hAR, the ingestion of androgen caused marked neurodegeneration...
  29. pmc Suppressive function of androgen receptor in bone resorption
    Hirotaka Kawano
    Institute of Molecular and Cellular Biosciences and Department of Orthopedic Surgery, Faculty of Medicine, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 100:9416-21. 2003
    ..Our results indicate that AR function is indispensable for male-type bone formation and remodeling...
  30. ncbi request reprint Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities
    Toshikazu Yada
    Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
    J Biol Chem 278:30235-47. 2003
    ..Sequence analysis based on three-dimensional structure revealed the presence of not typical but significant beta 4-glycosyltransferase architecture...
  31. pmc Chondromodulin I is a bone remodeling factor
    Yuko Nakamichi
    The Institute of Molecular and Cellular Biosciences The Department of Orthopedic Surgery, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Mol Cell Biol 23:636-44. 2003
    ..However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I(-/-) mice. Thus, the present study established that ChM-I is a bone remodeling factor...
  32. ncbi request reprint Late onset of obesity in male androgen receptor-deficient (AR KO) mice
    Takashi Sato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Japan
    Biochem Biophys Res Commun 300:167-71. 2003
    ..However, no significant alteration in serum lipid parameters and food intake was observed. Thus, the present results suggest that AR may serve as a negative regulator of adipose development in adult males...
  33. ncbi request reprint Study of androgen action in bone by analysis of androgen-receptor deficient mice
    Takashi Sato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    J Bone Miner Metab 20:326-30. 2002
  34. ncbi request reprint Frequent detection of anti-recoverin cytotoxic T-lymphocyte precursors in peripheral blood of cancer patients by using an HLA-A24-recoverin tetramer
    Shunshui Rong
    Department of Pathology, Sapporo Medical University School of Medicine, Minami 1 jo, Nishi 17 chome, Chuo Ku, Sapporo 060 8556, Japan
    Cancer Immunol Immunother 51:282-90. 2002
    ..Thus, we hypothesize that anti-recoverin CTLp may exist in some cancer patients, and that anti-recoverin CTL may be readily induced...
  35. ncbi request reprint An HLA-A24-restricted cytotoxic T lymphocyte epitope of a tumor-associated protein, survivin
    Yoshihiko Hirohashi
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo ku Sapporo 060 8543, Japan
    Clin Cancer Res 8:1731-9. 2002
    ..These data suggest that survivin-2B80-88 may be a potent T-cell epitope eliciting CTL response against a splicing variant survivin-2B, which is specifically expressed in many kinds of cancer cells...
  36. pmc Brain masculinization requires androgen receptor function
    Takashi Sato
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 101:1673-8. 2004
    ..Our results suggested that perinatal brain masculinization requires AR function and that expression of male-typical behaviors in adults is mediated by both AR-dependent and -independent androgen signaling...
  37. ncbi request reprint Persistent evidence of circulating tumor cells detected by means of RT-PCR for CEA mRNA predicts early relapse: a prospective study in node-negative breast cancer
    Toko Jotsuka
    Department of Surgery, Aichi Medical University, Nagakute 21, Aichi 480 1195, Japan
    Surgery 135:419-26. 2004
    ....
  38. pmc Premature ovarian failure in androgen receptor-deficient mice
    Hiroko Shiina
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 103:224-9. 2006
    ..Our findings suggest that AR function is required for normal female reproduction, particularly folliculogenesis, and that AR is a potential therapeutic target in POF syndrome...
  39. ncbi request reprint Reduced expression of kinase-associated phosphatase in cortical dendrites of MAP2-deficient mice
    Nobuhisa Iriuchijima
    Laboratory of Molecular Traffic, Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371 8512, Japan
    Biochem Biophys Res Commun 338:1216-21. 2005
    ..We also propose MAP2-deficient mice as an ideal system for identifying protein phosphatases essential for dendritic functions...
  40. ncbi request reprint Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities
    Chiho Sumi-Ichinose
    Department of Pharmacology, School of Medicine, Fujita Health University, Tokoake, Aichi, Japan
    J Neurochem 95:703-14. 2005
    ..Biochemical and pathological changes in DPS-rescued mice were similar to those in human malignant hyperphenylalaninemia and DRD...
  41. ncbi request reprint Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis
    Yasumasa Ikeda
    Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    J Biol Chem 280:29661-6. 2005
    ..These results suggest that, in male mice, the androgen-AR system participates in normal cardiac growth and modulates cardiac adaptive hypertrophy and fibrosis during the process of cardiac remodeling under hypertrophic stress...
  42. ncbi request reprint Circulating tumor cells detected by reverse transcription-polymerase chain reaction for carcinoembryonic antigen mRNA: distinguishing follicular thyroid carcinoma from adenoma
    Takashi Sato
    Department of Breast and Endocrine Surgery, Aichi Medical University, Japan
    Surgery 137:552-8. 2005
    ....
  43. ncbi request reprint Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretion
    WuQiang Fan
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582 Japan
    Diabetes 54:1000-8. 2005
    ..The results revealed that AR plays important roles in male metabolism by affecting the energy balance, and it is negative to both adiposity and insulin sensitivity...
  44. ncbi request reprint Changes in microstructure and gene expression of articular chondrocytes cultured in a tube under mechanical stress
    Shuitsu Maeda
    Department of Orthopaedic Surgery, Iwate Medical University, Hanamaki Onsen Hospital, Japan
    Osteoarthritis Cartilage 13:154-61. 2005
    ..Centrifugal pressure was applied to chondrocytes cultured in a tube for 28 days, and the effect of this stress was evaluated using a molecular biological method...
  45. ncbi request reprint TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor
    Ju Qiang Wang
    Laboratory of Signal Transduction and Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371 8512, Japan
    J Biol Chem 279:45626-33. 2004
    ....
  46. ncbi request reprint Function of androgen receptor in gene regulations
    Shigeaki Kato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Steroid Biochem Mol Biol 89:627-33. 2004
    ..When androgen was administered to the flies induced with the polyQ-expanded hAR, their optical nerves were devastated...
  47. ncbi request reprint Localization of cAMP-dependent protein kinase in the actin and microtubule cytoskeletons in mouse hippocampal neurons
    Takashi Sato
    Laboratory of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Neurosci Lett 325:83-6. 2002
    ..This result indicates that PKA is anchored to the actin and MT cytoskeletons, and disruption of F-actin releases PKA to the cytoplasm, which then leads to an increase in the amount of PKA in MT domains in the neuron...