Research Topics
| Takashi SatoSummaryAffiliation: Osaka University Country: Japan Publications
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Detail Information
Publications
Progressive hearing loss in mice carrying a mutation in the p75 geneTakashi Sato
Department of Otolaryngology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Brain Res 1091:224-34. 2006....
Visualization of endolymphatic hydrops after administration of a standard dose of an intravenous gadolinium-based contrast agentTohru Tanigawa
Department of Otolaryngology, Aichi Medical University, Japan
Acta Otolaryngol 131:596-601. 2011..The next step would be to consistently visualize ELH in the upper part of the cochlea...- Craniometaphyseal dysplasia unnoticed until 19 years of age: First diagnosed from facial nerve paralysisTohru Tanigawa
Department of Otolaryngology, Aichi Medical University, Nagakute, Aichi, Japan
Auris Nasus Larynx 38:406-10. 2011..High-dose corticosteroid could be effective in treating facial nerve paralysis, even when nerves have been directly constricted by a bony overgrowth... 
Uncovering genes required for neuronal morphology by morphology-based gene trap screening with a revertible retrovirus vectorYukiko Hashimoto
Department of Cell Biology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
FASEB J 26:4662-74. 2012..Because our novel morphology-based gene trap method is generally applicable, this method is promising for uncovering novel genes involved in the function of interest in any cell lines...- Ménière's disease is associated with single nucleotide polymorphisms in the human potassium channel genes, KCNE1 and KCNE3Katsumi Doi
Department of Otolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
ORL J Otorhinolaryngol Relat Spec 67:289-93. 2005..The result indicates that 112G/A SNP in the KCNE1 gene and 198T/C SNP in the KCNE3 gene could determine an increased susceptibility to develop MD... - 3D-FLAIR MRI findings in patients with low-tone sudden deafnessTohru Tanigawa
Department of Otolaryngology, Aichi Medical University, Aichi, Japan
Acta Otolaryngol 130:1324-8. 2010..Disordered blood flow in the inner ear is associated with an increased permeability of the blood-labyrinth barrier. Therefore, the disordered blood flow in the cochlea may be closely related to the pathophysiological mechanisms of LTSD... - Involvement of Ca2+-independent phospholipase A2 in the translocation of hypoxia-inducible factor-1alpha to the nucleus under hypoxic conditionsMayuko Osada-Oka
Department of Pathological Biochemistry, Kyoto Pharmaceutical University, Kyoto, Japan
Eur J Pharmacol 549:58-62. 2006..Thus, iPLA2, but not cPLA2alpha, may play an important role in regulating the transport of HIF-1alpha to the nucleus... - Changes in microstructure and gene expression of articular chondrocytes cultured in a tube under mechanical stressShuitsu Maeda
Department of Orthopaedic Surgery, Iwate Medical University, Hanamaki Onsen Hospital, Japan
Osteoarthritis Cartilage 13:154-61. 2005..Centrifugal pressure was applied to chondrocytes cultured in a tube for 28 days, and the effect of this stress was evaluated using a molecular biological method... - 14-3-3 proteins and protein phosphatases are not reduced in tau-deficient miceKatsunori Fujio
Laboratory of Molecular Traffic, Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, Japan
Neuroreport 18:1049-52. 2007..We propose that tau-deficient mice are an ideal system for confirming the function of tau-interacting proteins... - Polylactosamine on glycoproteins influences basal levels of lymphocyte and macrophage activationAkira Togayachi
Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Central 2 OSL, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
Proc Natl Acad Sci U S A 104:15829-34. 2007..These results indicate that polylactosamine on N-glycans is a putative immune regulatory factor presumably suppressing excessive responses during immune reactions... - Neuron-specific recombination by Cre recombinase inserted into the murine tau locusKazuhiro Muramatsu
Laboratory of Molecular Traffic, Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa, Maebashi, Gunma 371 8512, Japan
Biochem Biophys Res Commun 370:419-23. 2008..Thus, tau-Cre knockin mouse is a useful tool for studying the neuronal function of a gene in vivo... - Localization of cAMP-dependent protein kinase in the actin and microtubule cytoskeletons in mouse hippocampal neuronsTakashi Sato
Laboratory of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
Neurosci Lett 325:83-6. 2002..This result indicates that PKA is anchored to the actin and MT cytoskeletons, and disruption of F-actin releases PKA to the cytoplasm, which then leads to an increase in the amount of PKA in MT domains in the neuron... - Circulating tumor cells detected by reverse transcription-polymerase chain reaction for carcinoembryonic antigen mRNA: distinguishing follicular thyroid carcinoma from adenomaTakashi Sato
Department of Breast and Endocrine Surgery, Aichi Medical University, Japan
Surgery 137:552-8. 2005..CONCLUSIONS: RT-PCR detection of tumor cells in preoperative blood often can distinguish malignant from benign follicular thyroid tumors... - Function of androgen receptor in gene regulationsShigeaki Kato
Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
J Steroid Biochem Mol Biol 89:627-33. 2004..When androgen was administered to the flies induced with the polyQ-expanded hAR, their optical nerves were devastated... - Toxic advanced glycation end products (TAGE) theory in Alzheimer's diseaseTakashi Sato
Department of Pathophysiological Science, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan
Am J Alzheimers Dis Other Demen 21:197-208. 2006..These results suggest that TAGE is involved in the pathogenesis of AD as well as other age-related diseases. In this review, the authors discuss the molecular mechanisms of AD, especially focusing on TAGE-RAGE system... - Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamstersShinsuke Suzuki
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan
Circ J 71:1970-6. 2007..1 cardiomyopathic hamsters... - Study of androgen action in bone by analysis of androgen-receptor deficient miceTakashi Sato
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
J Bone Miner Metab 20:326-30. 2002 - Androgen receptor functions from reverse genetic modelsTakahiro Matsumoto
Laboratory of Nuclear Signaling, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
J Steroid Biochem Mol Biol 85:95-9. 2003..Although no overt phenotype was detected in adult fly-eye neurons expressing mutant hAR, the ingestion of androgen caused marked neurodegeneration... - Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injuryTakashi Sato
Department of Internal Medicine and Clinical Immunology, Yokohama City University, and Rosai Hospital for Silicosis, Tochigi, Japan
Am J Respir Crit Care Med 174:906-14. 2006..Heme oxygenase-1 (HO-1), a rate-limiting enzyme in heme catabolism, has antioxidative, antiapoptotic, and antiinflammatory activities. We examined whether HO-1 might be involved in silicosis... - An HLA-A24-restricted cytotoxic T lymphocyte epitope of a tumor-associated protein, survivinYoshihiko Hirohashi
Department of Pathology, Sapporo Medical University School of Medicine, South-1 West-17, Chuo-ku Sapporo 060-8543, Japan
Clin Cancer Res 8:1731-9. 2002..These data suggest that survivin-2B80-88 may be a potent T-cell epitope eliciting CTL response against a splicing variant survivin-2B, which is specifically expressed in many kinds of cancer cells... - Study of androgen receptor functions by genetic modelsTakahiro Matsumoto
Institute of Molecular and Cellular Biosciences, University of Tokyo
J Biochem (Tokyo) 138:105-10. 2005..Here we review recent results of our studies into genetic models of the loss of AR function in mice and the gain of AR function in Drosophila... - Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalitiesChiho Sumi-Ichinose
Department of Pharmacology, School of Medicine, Fujita Health University, Tokoake, Aichi, Japan
J Neurochem 95:703-14. 2005..Biochemical and pathological changes in DPS-rescued mice were similar to those in human malignant hyperphenylalaninemia and DRD... - Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activitiesToshikazu Yada
Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
J Biol Chem 278:30235-47. 2003..Sequence analysis based on three-dimensional structure revealed the presence of not typical but significant beta 4-glycosyltransferase architecture... - Frequent detection of anti-recoverin cytotoxic T-lymphocyte precursors in peripheral blood of cancer patients by using an HLA-A24-recoverin tetramerShunshui Rong
Department of Pathology, Sapporo Medical University School of Medicine, Minami-1-jo, Nishi-17-chome, Chuo-ku, Sapporo 060-8556, Japan
Cancer Immunol Immunother 51:282-90. 2002..Thus, we hypothesize that anti-recoverin CTLp may exist in some cancer patients, and that anti-recoverin CTL may be readily induced... - Reduced expression of kinase-associated phosphatase in cortical dendrites of MAP2-deficient miceNobuhisa Iriuchijima
Laboratory of Molecular Traffic, Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371 8512, Japan
Biochem Biophys Res Commun 338:1216-21. 2005..We also propose MAP2-deficient mice as an ideal system for identifying protein phosphatases essential for dendritic functions... - Detection of norovirus antigens from recombinant virus-like particles and stool samples by a commercial norovirus enzyme-linked immunosorbent assay kitShoko Okitsu-Negishi
Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 0033, Japan
J Clin Microbiol 44:3784-6. 2006..9%. Our results clearly indicated that the kit allows the detection of the most prevalent genotype, GII/4. In order to increase the sensitivity of the kit, the reactivity with norovirus of GII/3 and GII/6 genotypes needs to be improved... - Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAcTakashi Sato
Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory Central 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
J Biol Chem 278:47534-44. 2003..These results suggest that beta 4GalNAc-T3 could transfer GalNAc residues, producing N,N'-diacetylgalactosediamine structures at least in N-glycans and probably in both N- and O-glycans... - Suppressive function of androgen receptor in bone resorptionHirotaka Kawano
Institute of Molecular and Cellular Biosciences and Department of Orthopedic Surgery, Faculty of Medicine, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
Proc Natl Acad Sci U S A 100:9416-21. 2003..Our results indicate that AR function is indispensable for male-type bone formation and remodeling... - Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient miceKen ichi Aihara
Department of Medicine and Bioregulatory Sciences and 21st Century Center of Excellence Program, The University of Tokushima Graduate School of Health Biosciences, Tokushima, Japan
J Clin Invest 117:1514-26. 2007.... - Late onset of obesity in male androgen receptor-deficient (AR KO) miceTakashi Sato
Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Japan
Biochem Biophys Res Commun 300:167-71. 2003..However, no significant alteration in serum lipid parameters and food intake was observed. Thus, the present results suggest that AR may serve as a negative regulator of adipose development in adult males... - Group IVA phospholipase A2 is associated with the storage of lipids in adipose tissue and liverHiromi Ii
Department of Pathological Biochemistry, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
Prostaglandins Other Lipid Mediat 86:12-7. 2008..Our findings suggest that group IVA PLA(2) is involved in the storage of lipids in the adipose tissue and liver and in determining circulating PGE(2) levels... - Group IVA phospholipase A2-associated production of MMP-9 in macrophages and formation of atherosclerotic lesionsHiromi Ii
Department of Pathological Biochemistry, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
Biol Pharm Bull 31:363-8. 2008..The protection against the lesions in IVA-PLA2-deficient mice may be ascribable, in part, to the impaired production of MMP-9 and/or the maintained levels of HDL-C... - Chondromodulin I is a bone remodeling factorYuko Nakamichi
The Institute of Molecular and Cellular Biosciences The Department of Orthopedic Surgery, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
Mol Cell Biol 23:636-44. 2003..However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I(-/-) mice. Thus, the present study established that ChM-I is a bone remodeling factor... - Premature ovarian failure in androgen receptor-deficient miceHiroko Shiina
Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
Proc Natl Acad Sci U S A 103:224-9. 2006..Our findings suggest that AR function is required for normal female reproduction, particularly folliculogenesis, and that AR is a potential therapeutic target in POF syndrome... - A novel strategy for mammalian cell surface glycome profiling using lectin microarrayHiroaki Tateno
Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Central 2, 1 1 1 Umezono, Ibaraki 305 8568, Japan
Glycobiology 17:1138-46. 2007..These results demonstrate that the technique provides a novel strategy for profiling global changes of the mammalian cell surface glycome... - Successful treatment with liposteroid followed by reduced intensity stem cell transplantation in an infant with perforin deficiency presenting with hemophagocytic lymphohistiocytosisYoshiyuki Kobayashi
Department of Pediatrics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
J Pediatr Hematol Oncol 29:178-82. 2007..These observations suggest that this treatment strategy might thus be recommended in infants with FHL to reduce treatment-related complications, especially in patients with relatively mild clinical courses... - The pituitary function of androgen receptor constitutes a glucocorticoid production circuitJunko Miyamoto
Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
Mol Cell Biol 27:4807-14. 2007..Thus, this study suggests that the activated AR supports the negative feedback regulation of glucocorticoid production via up-regulation of GR expression in the pituitary gland... - The Rab8 GTPase regulates apical protein localization in intestinal cellsTakashi Sato
Laboratory of Molecular Traffic, Department of Molecular and Cellullar Biology, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371 8512, Japan
Nature 448:366-9. 2007..Our results demonstrate that Rab8 is necessary for the proper localization of apical proteins and the absorption and digestion of various nutrients in the small intestine... - Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretionWuQiang Fan
Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582 Japan
Diabetes 54:1000-8. 2005..The results revealed that AR plays important roles in male metabolism by affecting the energy balance, and it is negative to both adiposity and insulin sensitivity... - Persistent evidence of circulating tumor cells detected by means of RT-PCR for CEA mRNA predicts early relapse: a prospective study in node-negative breast cancerToko Jotsuka
Department of Surgery, Aichi Medical University, Nagakute 21, Aichi 480-1195, Japan
Surgery 135:419-26. 2004..CONCLUSIONS: Molecular detection of CEA mRNA in both pre- and postoperative blood samples is an independent, negative prognostic factor in patients with node-negative breast cancer undergoing curative surgery... - TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptorJu Qiang Wang
Laboratory of Signal Transduction and Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371 8512, Japan
J Biol Chem 279:45626-33. 2004.... - Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1Keisuke Yamamoto
Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
Dev Cell 13:365-76. 2007..These results demonstrate that ATF6alpha functions as a critical regulator of ER quality control proteins in mammalian cells, in marked contrast to worm and fly cells in which IRE1 is responsible... - Neuron-specific and inducible recombination by Cre recombinase in the mouseYukiko Hashimoto
Department of Molecular and Cellular Biology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
Neuroreport 19:621-4. 2008..Thus, tau (CrePR) knockin line is a useful tool for studying neuronal gene functions... - Altered expression of connexin43 contributes to the arrhythmogenic substrate during the development of heart failure in cardiomyopathic hamsterTakashi Sato
Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, 1 1 1, Minami Kogushi, Ube, Yamaguchi 755 8505, Japan
Am J Physiol Heart Circ Physiol 294:H1164-73. 2008.... - VEGF-enhanced proliferation under hypoxia by an autocrine mechanism in human vascular smooth muscle cellsMayuko Osada-Oka
Department of Pathological Biochemistry, Kyoto Pharmaceutical University, Kyoto, Japan
J Atheroscler Thromb 15:26-33. 2008.... - Brain masculinization requires androgen receptor functionTakashi Sato
Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
Proc Natl Acad Sci U S A 101:1673-8. 2004..Our results suggested that perinatal brain masculinization requires AR function and that expression of male-typical behaviors in adults is mediated by both AR-dependent and -independent androgen signaling... - Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosisYasumasa Ikeda
Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
J Biol Chem 280:29661-6. 2005..These results suggest that, in male mice, the androgen-AR system participates in normal cardiac growth and modulates cardiac adaptive hypertrophy and fibrosis during the process of cardiac remodeling under hypertrophic stress...