H Sasaki

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc The role of nitric oxide in cholinergic neurotransmission in rat trachea
    K Sekizawa
    Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan
    Br J Pharmacol 110:816-20. 1993
  2. ncbi request reprint A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    H Sasaki
    Laboratory of Developmental Biology, Osaka University, Suita, Japan
    Development 124:1313-22. 1997
  3. ncbi request reprint Hedgehog signaling enhances core-binding factor a1 and receptor activator of nuclear factor-kappaB ligand (RANKL) gene expression in chondrocytes
    M Takamoto
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Endocrinol 177:413-21. 2003
  4. ncbi request reprint Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
    H Sasaki
    Laboratory of Developmental Biology, Institute for Molecular and Cellular Biology, Osaka University, Suita, Osaka 565 0871, Japan
    Development 126:3915-24. 1999
  5. ncbi request reprint Identification of essential sequence motifs in the node/notochord enhancer of Foxa2 (Hnf3beta) gene that are conserved across vertebrate species
    Y Nishizaki
    Laboratory of Developmental Biology, Institute for Molecular and Cellular Biology, Osaka University, 1 3 Yamada oka, Suita, 565 0871, Osaka, Japan
    Mech Dev 102:57-66. 2001
  6. pmc Enzymatic properties of de novo-type mouse DNA (cytosine-5) methyltransferases
    A Aoki
    Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    Nucleic Acids Res 29:3506-12. 2001
  7. ncbi request reprint HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma
    S Bao
    Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 59:2023-8. 1999
  8. ncbi request reprint Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
    Q Ding
    Program in Developmental Biology and Division of Endocrinology, Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Development 125:2533-43. 1998
  9. ncbi request reprint A methylation imprint mark in the mouse imprinted gene Grf1/Cdc25Mm locus shares a common feature with the U2afbp-rs gene: an association with a short tandem repeat and a hypermethylated region
    H Shibata
    Genome Science Laboratory, RIKEN Tsukuba Life Science Center, Ibaraki, Japan
    Genomics 49:30-7. 1998
  10. ncbi request reprint Bisulfite sequencing and dinucleotide content analysis of 15 imprinted mouse differentially methylated regions (DMRs): paternally methylated DMRs contain less CpGs than maternally methylated DMRs
    H Kobayashi
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima, Japan
    Cytogenet Genome Res 113:130-7. 2006

Collaborators

Detail Information

Publications63

  1. pmc The role of nitric oxide in cholinergic neurotransmission in rat trachea
    K Sekizawa
    Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan
    Br J Pharmacol 110:816-20. 1993
    ..7. These results suggest that an endogenous NO-like factor may mediate prejunctional inhibition of cholinergic contraction through a cyclic GMP-dependent mechanism in rat trachea...
  2. ncbi request reprint A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    H Sasaki
    Laboratory of Developmental Biology, Osaka University, Suita, Japan
    Development 124:1313-22. 1997
    ..These results also support the idea that Gli/Ci are evolutionary conserved transcription factors in the Hedgehog signalling pathway...
  3. ncbi request reprint Hedgehog signaling enhances core-binding factor a1 and receptor activator of nuclear factor-kappaB ligand (RANKL) gene expression in chondrocytes
    M Takamoto
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Endocrinol 177:413-21. 2003
    ..We conclude that hedgehog signaling activates Cbfa1 gene expression through its promoter in chondrocytes, and also activates and interacts with RANKL to maintain cartilage development...
  4. ncbi request reprint Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
    H Sasaki
    Laboratory of Developmental Biology, Institute for Molecular and Cellular Biology, Osaka University, Suita, Osaka 565 0871, Japan
    Development 126:3915-24. 1999
    ....
  5. ncbi request reprint Identification of essential sequence motifs in the node/notochord enhancer of Foxa2 (Hnf3beta) gene that are conserved across vertebrate species
    Y Nishizaki
    Laboratory of Developmental Biology, Institute for Molecular and Cellular Biology, Osaka University, 1 3 Yamada oka, Suita, 565 0871, Osaka, Japan
    Mech Dev 102:57-66. 2001
    ..These motifs do not correspond to the consensus binding sequences of transcription factors known to be involved in node/notochord development...
  6. pmc Enzymatic properties of de novo-type mouse DNA (cytosine-5) methyltransferases
    A Aoki
    Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    Nucleic Acids Res 29:3506-12. 2001
    ..On the other hand, Dnmt3b1 methylated CpG > CpT >/= CpA. Immuno-purified Dnmt3a, Myc-tagged and overexpressed in HEK 293T cells, methylated CpG >> CpA > CpT. Neither Dnmt3a nor Dnmt3b1 methylated the first cytosine of CpC...
  7. ncbi request reprint HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma
    S Bao
    Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 59:2023-8. 1999
    ....
  8. ncbi request reprint Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
    Q Ding
    Program in Developmental Biology and Division of Endocrinology, Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Development 125:2533-43. 1998
    ..Our results imply that Gli2 is required to mediate high level but not low level Shh activity and show that the development of motor neurons can occur in the absence of floor plate induction...
  9. ncbi request reprint A methylation imprint mark in the mouse imprinted gene Grf1/Cdc25Mm locus shares a common feature with the U2afbp-rs gene: an association with a short tandem repeat and a hypermethylated region
    H Shibata
    Genome Science Laboratory, RIKEN Tsukuba Life Science Center, Ibaraki, Japan
    Genomics 49:30-7. 1998
    ..These common features in methylation imprint regions may be a clue to identifying regions carrying primary information for the imprinting regulation...
  10. ncbi request reprint Bisulfite sequencing and dinucleotide content analysis of 15 imprinted mouse differentially methylated regions (DMRs): paternally methylated DMRs contain less CpGs than maternally methylated DMRs
    H Kobayashi
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima, Japan
    Cytogenet Genome Res 113:130-7. 2006
    ..Our findings provide a basis for the further characterization of DMRs...
  11. ncbi request reprint Enhancer-dependent, locus-wide regulation of the imprinted mouse insulin-like growth factor II gene
    N Hatano
    Division of Disease Genes, Institute of Genetic Information, Kyushu University, Fukuoka 812 8582, Japan
    J Biochem 123:984-91. 1998
    ..Our findings suggest that enhancer-dependent, locus-wide mechanisms play a major role in the coordinate regulation of the multiple IGF-II promoters...
  12. ncbi request reprint Impaired behavioral suppression by light in metabotropic glutamate receptor subtype 6-deficient mice
    M Takao
    Department of Physiology and Biosignalling, Graduate School of Medicine, Institute for Protein Research, Osaka University, Suita, 565 0871, Osaka, Japan
    Neuroscience 97:779-87. 2000
    ..This study clearly demonstrates that the dysfunction of the ON visual pathway in metabotropic glutamate receptor subtype 6-deficient mice impairs their behavioral responsiveness to light and yet preserves their circadian system...
  13. ncbi request reprint HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo
    A Perea-Gomez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, BP163, CU de Strasbourg, France
    Development 126:4499-511. 1999
    ..Moreover, HNF3beta (-)(/)(-);Lim1(-)(/)(-) mutant embryos also exhibit defects in mesoderm patterning that are likely due to lack of specification of anterior primitive streak cells...
  14. ncbi request reprint Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration
    N Jones
    Division of Cancer Biology Research, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario M4N 3M5
    J Biol Chem 274:30896-905. 1999
    ..Taken together, these results demonstrate that Angiopoietin-1-induced signaling from the Tek receptor is mediated by a multifunctional docking site that is responsible for activation of both cell migration and cell survival pathways...
  15. ncbi request reprint Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1
    Q Ding
    Program in Developmental Biology The Hospital for Sick Children Department of Molecular and Medical Genetics University of Toronto 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Curr Biol 9:1119-22. 1999
    ..Our findings indicate that mSu(fu) can function as a negative regulator of Shh signaling and suggest that this effect is mediated by interaction with Gli transcription factors...
  16. ncbi request reprint Basal cell carcinomas in mice overexpressing Gli2 in skin
    M Grachtchouk
    University of Michigan Comprehensive Cancer Center and Department of Dermatology, Ann Arbor, Michigan, USA
    Nat Genet 24:216-7. 2000
  17. ncbi request reprint Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and huma
    H Yatsuki
    Department of Biochemistry, Saga Medical School, Saga, Japan
    DNA Res 7:195-206. 2000
    ..Further characterization of this locus based on the sequence comparison between mouse and human will contribute valuable information towards resolving the mechanism of the occurrence of BWS and the associated childhood tumor...
  18. ncbi request reprint Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells
    N Saeki
    Department of Biochemistry, Faculty of Medicine, University of the Ryukyus, Uehara 207, Nishihara, Okinawa 903 0215, Japan
    Mamm Genome 11:718-24. 2000
    ..These data suggest that the loss of the expression of the human homolog is required for the carcinogenesis of gastric tissue and that the gene has an activity adverse to malignant transformation of cells...
  19. ncbi request reprint Effect of oxygen on induction of the cystine transporter by bacterial lipopolysaccharide in mouse peritoneal macrophages
    H Sato
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575 Japan
    J Biol Chem 276:10407-12. 2001
    ..These results suggest the importance of system x(c)(-) in antioxidant defense in macrophages exposed to LPS and oxidative stress...
  20. ncbi request reprint Allele-specific detection of nascent transcripts by fluorescence in situ hybridization reveals temporal and culture-induced changes in Igf2 imprinting during pre-implantation mouse development
    M Ohno
    Division of Disease Genes, Institute of Genetic Information, Kyushu University, Maidashi, Fukuoka 812 8582, Japan
    Genes Cells 6:249-59. 2001
    ..There is conflicting evidence, however, for the monoallelic transcription of some imprinted genes, such as Igf2, in pre-implantation embryos...
  21. ncbi request reprint The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm
    S J Kinder
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 128:3623-34. 2001
    ..The gastrula organizer is therefore composed of a constantly changing population of cells that are allocated to different parts of the axial mesoderm...
  22. ncbi request reprint Distribution pattern of HNF-3beta proteins in developing embryos of two mammalian species, the house shrew and the mouse
    K Yasui
    Department of Oral Anatomy, Kagoshima University Dental School, Sakuragaoka, Japan
    Dev Growth Differ 39:667-76. 1997
    ..The present immunohistochemical study elucidated that the distribution of HNF-3beta is conserved initially but soon manifests species specificities in development even between mammalian species...
  23. ncbi request reprint Structure and expression of the mouse L23mrp gene downstream of the imprinted H19 gene: biallelic expression and lack of interaction with the H19 enhancers
    M Zubair
    Institute of Genetic Information, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 82, Japan
    Genomics 45:290-6. 1997
    ..These findings indicate that L23mrp is functionally insulated from the Ins-2/Igf-2/H19 domain in terms of both imprinting and enhancer action...
  24. ncbi request reprint Developmental defects of the ventromedial hypothalamic nucleus and pituitary gonadotroph in the Ftz-F1 disrupted mice
    K Shinoda
    Department of Anatomy II, Kinki University School of Medicine, Osakasayama
    Dev Dyn 204:22-9. 1995
    ..The present results clearly showed that the hypothalamic and pituitary Ad4BPs are essential to normal development of the functional VMH and gonadotroph through some mechanism distinct from that in the peripheral steroidogenic tissues...
  25. ncbi request reprint HNF-3 beta as a regulator of floor plate development
    H Sasaki
    Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175
    Cell 76:103-15. 1994
    ..Ectopic dorsal neuronal differentiation and abnormal dorsal axonal projections are also seen. These results suggest that HNF-3 beta is an important regulator of floor plate development in vivo...
  26. ncbi request reprint Fine structure of the human ceruloplasmin gene
    M Daimon
    Third Department of Internal Medicine, Yamagata University, School of Medicine, Japan
    Biochem Biophys Res Commun 208:1028-35. 1995
    ..Putative lariat sequences were identified between -17 and -42 nucleotides from the 3' splice junction for all 18 introns...
  27. pmc Specific DNA binding of the two chicken Deformed family homeodomain proteins, Chox-1.4 and Chox-a
    H Sasaki
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neurosciences, Japan
    Nucleic Acids Res 18:1739-47. 1990
    ..A clustered binding site was identified in the 5'-upstream of the Chox-a gene, suggesting that this clustered binding site works as a cis-regulatory element for auto- and/or cross-regulation of Chox-a gene expression...
  28. ncbi request reprint The chromosomal mapping of four genes encoding winged helix proteins expressed early in mouse development
    P A Labosky
    Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, Tennessee, 37232 2175, USA
    Genomics 34:241-5. 1996
    ..Since Mf3 is located in a region of Chromosome 9 containing many well-characterized mouse mutations such as short ear (se), ashen (ash), and dilute (d), we have analyzed deletion mutants to determine the location of Mf3 more precisely...
  29. ncbi request reprint Expression of Id2 mRNA in neuroblastoma and normal ganglion
    Y Sato
    Department of Surgery II, Nagoya City University Medical School, Japan
    Eur J Surg Oncol 29:284-7. 2003
    ..It has been suggested that Id2 may be involved in the disturbed regulation of cell cycle by interfering with retinoblastoma protein...
  30. ncbi request reprint Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene
    M Masu
    Institute for Immunology, Kyoto University Faculty of Medicine, Japan
    Cell 80:757-65. 1995
    ..The results demonstrate that mGluR6 is essential in synaptic transmission to the ON bipolar cell and that the OFF response provides an important means for transmitting visual information...
  31. ncbi request reprint Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo
    E Marti
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 121:2537-47. 1995
    ..Thus, either long-range signaling is mediated indirectly by the activation of other signals, or alternatively the low levels of diffusing peptide are undetectable using available techniques...
  32. ncbi request reprint Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis
    S Filosa
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Université Louis Pasteur Collège de France, Illkirch, CU de Strasbourg
    Development 124:2843-54. 1997
    ..Our results also suggest that interaction between gsc and HNF-3beta regulates other signalling molecules required for proper development of the foregut, branchial arches and heart...
  33. ncbi request reprint Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family
    K Toda
    Department of Medical Chemistry, Kochi Medical School, Japan
    Eur J Biochem 231:292-9. 1995
    ..These results indicate the intrinsic importance of NF-IL6 in the transcriptional regulation of CYP19 expression...
  34. ncbi request reprint Effects of hypoxia/reoxygenation on angiogenic factors and their tyrosine kinase receptors in the rat myocardium
    P S Ray
    Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030-1110, USA
    Antioxid Redox Signal 3:89-102. 2001
    ..Such relationships may potentially be utilized in formulating strategies for sequential gene therapy to achieve clinically relevant myocardial angiogenesis...
  35. pmc Loss of hippocampal CA3 pyramidal neurons in mice lacking STAM1
    M Yamada
    Department of Microbiology and Immunology, Sendai 980 8575, Japan
    Mol Cell Biol 21:3807-19. 2001
    ..These data suggest that STAM1 is dispensable for cytokine-mediated signaling in lymphocytes but may be involved in the survival of hippocampal CA3 pyramidal neurons...
  36. ncbi request reprint Sequence polymorphisms, allelic expression status and chromosome locations of the chicken IGF2 and MPR1 genes
    T Yokomine
    Division of Human Genetics, National Institute of Genetics, Graduate University for Advanced Studies, 1-111 Yata, Mishima 411-8540, Japan
    Cytogenet Cell Genet 93:109-13. 2001
    ..IGF2 and MPR1 were mapped on chicken chromosomes 5 and 3, respectively, by fluorescence in situ hybridization, demonstrating conserved linkage homology between mammals and birds...
  37. ncbi request reprint Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor
    S Kobayashi
    Department of Biochemistry, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Miyagi, Japan
    J Biol Chem 275:10723-6. 2000
    ..These results strongly suggest that the receptor is encoded by the exostoses-like gene and mediates a growth signal of Reg protein for beta-cell regeneration...
  38. ncbi request reprint Genomic organization of the human amyloid beta-protein precursor gene
    S Yoshikai
    Research Laboratory for Genetic Information, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Gene 87:257-63. 1990
    ..Northern blotting showed that the transcription of the BPP gene was apparently induced by 12-O-tetradecanoylphorbol-13-acetate (phorbol derivative) in HeLa cells...
  39. ncbi request reprint Insulin inhibits glucagon-induced glycogenolysis in perivenous hepatocytes specifically
    Y Ikezawa
    Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    J Lab Clin Med 138:387-92. 2001
    ..The specific effect of insulin on PVHs might depend on the differences in intracellular characteristics between PPHs and PVHs rather than hormone binding...
  40. ncbi request reprint Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene
    H Sasaki
    Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK
    Genes Dev 6:1843-56. 1992
    ..The differential activity of the parental Igf2 alleles could be achieved through epigenetic modifications situated outside the promoters or by subtle and yet unidentified modifications at the promoters...
  41. pmc Increased susceptibility to airway responses in CD40-deficient mice
    H Takahashi
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    Clin Exp Immunol 133:22-9. 2003
    ..These results suggest that CD40 may play a protective role in developing asthma in the phase after establishing specific memory T cells through the regulation of the balance between Th1 and Th2 cells presumably via induction of IL-12...
  42. ncbi request reprint Biallelic expression of Z-linked genes in male chickens
    A Kuroiwa
    Laboratory of Animal Cytogenetics, Center for Advanced Science and Technology, Hokkaido University, Sapporo, Japan
    Cytogenet Genome Res 99:310-4. 2002
    ..Comparison between expression levels in males and females by real-time quantitative PCR suggested that expression was compensated for the CHD-Z gene but not for the B4GALT1 gene...
  43. ncbi request reprint Role of de novo DNA methyltransferases in initiation of genomic imprinting and X-chromosome inactivation
    M Kaneda
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems ROIS, Mishima 411 8540, Japan
    Cold Spring Harb Symp Quant Biol 69:125-9. 2004
  44. ncbi request reprint Tsix-deficient X chromosome does not undergo inactivation in the embryonic lineage in males: implications for Tsix-independent silencing of Xist
    T Ohhata
    PRESTO, Japan Science and Technology Agency, Saitama, Japan
    Cytogenet Genome Res 113:345-9. 2006
    ..XDeltaTsix does not seem to undergo inactivation in the embryonic lineage in males, suggesting the presence of a Tsix-independent silencing mechanism for Xist in the embryonic lineage...
  45. ncbi request reprint GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling
    N Saeki
    Center for Medical Genomics, Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Oncogene 26:6488-98. 2007
    ..The present data suggest that TGF-beta, LMO1, possibly RUNX3, and GSDM form a regulatory pathway for directing the pit cells to apoptosis...
  46. ncbi request reprint Localization of mouse imprinted gene U2af1-rs1 to A3.2-4 band of chromosome 11 by FISH
    M Tada
    Division of Biological Science, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan
    Mamm Genome 5:655. 1994
  47. ncbi request reprint Early effects of hypoxia/reoxygenation on VEGF, ang-1, ang-2 and their receptors in the rat myocardium: implications for myocardial angiogenesis
    P S Ray
    Department of Surgery, University of Connecticut Health Center, Farmington, USA
    Mol Cell Biochem 213:145-53. 2000
    ..The stimulation of myocardial angiogenesis by H/R may constitute a potential basis for a possible more long-lived adaptive response to stress afforded by preconditioning stimuli...
  48. ncbi request reprint Differential chromatin packaging of genomic imprinted regions between expressed and non-expressed alleles
    T Watanabe
    First Department of Biochemistry, Niigata University School of Medicine, Asahimachi 1 757, Niigata 951 8122, Japan
    Hum Mol Genet 9:3029-35. 2000
    ..These results suggest that chromatin of imprinted domains in different compaction levels is affected by distinct blueprints in homologous chromosomes that are heritable through the germ line...
  49. ncbi request reprint Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer
    T Kishi
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 232:5-9. 1997
    ..We report here the structure of human GRB-7 cDNA, and we report that the amounts of mRNA for c-ERBB-2, CAB1, and GRB-7 were elevated in concordance with the amplification...
  50. ncbi request reprint Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp1)
    M Daimon
    The Third Department of Internal Medicine, Yamagata University School of Medicine, Japan
    Biochem Biophys Res Commun 230:100-4. 1997
    ..Northern blot analysis showed two HTP1 transcripts of about 2.8 and 5.5 kb, which were expressed concomitantly in various human tissues such as heart, brain, placenta, liver and pancreas...
  51. ncbi request reprint Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT
    K Sanpei
    Department of Neurology, Niigata University, Japan
    Nat Genet 14:277-84. 1996
    ..DIRECT is a robust strategy for identification of pathologically expanded trinucleotide repeats and will dramatically accelerate the search for causative genes of neuropsychiatric diseases caused by trinucleotide repeat expansions...
  52. ncbi request reprint Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS-M
    C Plass
    Roswell Park Cancer Institute, Department of Molecular and Cellular Biology, Buffalo, New York 14263 0001, USA
    Nat Genet 14:106-9. 1996
    ..Our results indicate that imprinting may have a role in regulating mitogenic signal transduction pathways during growth and development...
  53. ncbi request reprint Mxi1 mutations in human neurofibrosarcomas
    X J Li
    First Department of Pathology, Hamamatsu University School of Medicine
    Jpn J Cancer Res 90:740-6. 1999
    ..Our data demonstrate that mutations occur in the Mxi1 gene in neurofibrosarcoma. Missense mutations in the functional domain of Mxi1 in these cases may be involved in the pathogenesis of neurofibrosarcoma...
  54. ncbi request reprint Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryos
    H Sasaki
    Wellcome CRC Institute of Cancer and Developmental Biology, University of Cambridge, UK
    Development 121:4195-202. 1995
    ..Differential methylation in the more upstream region, which is established in the gametes, is a likely candidate for the gametic signal and may directly control H19 activity...
  55. ncbi request reprint Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions
    M Matsuya
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060, Japan
    J Biol Chem 273:1003-14. 1998
    ..These results indicate that Hic-5 is a paxillin-related component of focal adhesions and binds to CAKbeta, implying possible involvement of Hic-5 in the downstream signaling of CAKbeta...
  56. ncbi request reprint Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo
    H Sasaki
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232
    Development 118:47-59. 1993
    ..A model is proposed linking FD gene expression with gastrulation events in the mouse...
  57. ncbi request reprint Transglutaminase type 1 and its cross-linking activity are concentrated at adherens junctions in simple epithelial cells
    T Hiiragi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 274:34148-54. 1999
    ....
  58. pmc Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis
    A Kubo
    Tsukita Cell Axis Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Shimogyo ku, Kyoto 600 8813, Japan
    J Cell Biol 147:969-80. 1999
    ..These findings suggested that centriolar satellites and fibrous granules are identical novel nonmembranous organelles containing PCM-1, which may play some important role(s) in centriolar replication...
  59. ncbi request reprint Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3
    R J Fiddes
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    J Biol Chem 273:7717-24. 1998
    ..These studies therefore identify Grb7 as an in vivo target of erbB3 and erbB4 and provide an underlying mechanism for the ability of erbB3 to recruit Grb7 and not Grb2, a property unique among erbB receptors...
  60. ncbi request reprint IL-10, but not IL-4, suppresses infection-stimulated bone resorption in vivo
    H Sasaki
    Department of Cytokine Biology, The Forsyth Institute, Boston, MA 02115, USA
    J Immunol 165:3626-30. 2000
    ..We conclude that IL-10, but not IL-4, is an important endogenous suppressor of infection-stimulated bone resorption in vivo, likely acting via inhibition of IL-1alpha expression...
  61. ncbi request reprint Structure and site-directed mutagenesis of a flavoprotein from Escherichia coli that reduces nitrocompounds: alteration of pyridine nucleotide binding by a single amino acid substitution
    T Kobori
    Departments of Applied Biological Chemistry and Biotechnology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Biol Chem 276:2816-23. 2001
    ..The R203A mutant results in a 33-fold increase in the K(m) value for NADPH indicating that the side chain of Arg(203) plays a key role in binding NADPH possibly to interact with the 2'-phosphate group...
  62. pmc Complex phenotype of mice lacking occludin, a component of tight junction strands
    M Saitou
    Department of Cell Biology, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto 606 8501, Japan
    Mol Biol Cell 11:4131-42. 2000
    ..These phenotypes suggested that the functions of TJs as well as occludin are more complex than previously supposed...
  63. ncbi request reprint Isolation of a candidate gene, CAB1, for cholesterol transport to mitochondria from the c-ERBB-2 amplicon by a modified cDNA selection method
    N Akiyama
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 57:3548-53. 1997
    ..It was established that multiple overexpressed genes are frequently present in a single amplicon...