H Saito

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice
    Kazutake Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 104:16702-7. 2007
  2. ncbi Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule
    Kazutake Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka, Suita, Osaka, Japan
    Mol Cancer Res 1:155-63. 2002
  3. ncbi Distinct functions of the two protein tyrosine phosphatase domains of LAR (leukocyte common antigen-related) on tyrosine dephosphorylation of insulin receptor
    K Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Endocrinol 15:271-80. 2001
  4. ncbi Detection of CD45iota mRNA in murine Th1 but not Th2 clones
    K Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan
    Immunobiology 201:506-14. 2000
  5. ncbi Expression and sub-cellular localization of human ABH family molecules
    Kazutake Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    J Cell Mol Med 11:1105-16. 2007
  6. ncbi Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling
    M Narazaki
    Department of Medicine III, Osaka University Medical School, 2 2, Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 95:13130-4. 1998
  7. ncbi Effective cancer targeting using an anti-tumor tissue vascular endothelium-specific monoclonal antibody (TES-23)
    Y Wakai
    Department of Biopharmaceutics, School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Jpn J Cancer Res 91:1319-25. 2000
  8. ncbi IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-gamma
    H Saito
    Department of Molecular Medicine, Osaka University Medical School, and Osaka University, Suita City, Osaka, Japan
    J Immunol 164:5833-43. 2000
  9. ncbi Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice
    T Naka
    Department of Medicine III, Osaka University Medical School, 2 2, Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 95:15577-82. 1998
  10. ncbi Impaired beta-cell function in the presence of reduced insulin sensitivity determines glucose tolerance status in acromegalic patients
    S Kasayama
    Department of Medicine III, Osaka University Medical School, Osaka, Japan
    Clin Endocrinol (Oxf) 52:549-55. 2000

Collaborators

Detail Information

Publications71

  1. ncbi Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice
    Kazutake Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 104:16702-7. 2007
    ..These results indicate that CGRP signaling through CLR/RAMP1 receptors plays a crucial role in the regulation of both blood pressure by vascular relaxation and proinflammatory cytokine production from dendritic cells...
  2. ncbi Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule
    Kazutake Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka, Suita, Osaka, Japan
    Mol Cancer Res 1:155-63. 2002
    ..Our results indicate that Lck and Fyn would be substrates of LAR in immature thymocytes and that each LAR PTPase domain plays distinct functional roles in phosphorylation and dephosphorylation...
  3. ncbi Distinct functions of the two protein tyrosine phosphatase domains of LAR (leukocyte common antigen-related) on tyrosine dephosphorylation of insulin receptor
    K Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Endocrinol 15:271-80. 2001
    ..These results indicate that each domain of LAR plays distinct functional roles through phosphorylation and dephosphorylation in vivo...
  4. ncbi Detection of CD45iota mRNA in murine Th1 but not Th2 clones
    K Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan
    Immunobiology 201:506-14. 2000
    ..These results suggested that CD45t might be an important isoform of CD45 for differentiation signaling of Th cells, and might be used as a marker to distinguish between Th1 and Th2 cells...
  5. ncbi Expression and sub-cellular localization of human ABH family molecules
    Kazutake Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    J Cell Mol Med 11:1105-16. 2007
    ..In some HeLa cells transfected with EmGFP-hABH5, dot-like fluorescence was also detected in the cytoplasm. These observations provide important information for the future annotation of the hABH family of molecules...
  6. ncbi Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling
    M Narazaki
    Department of Medicine III, Osaka University Medical School, 2 2, Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 95:13130-4. 1998
    ..Based on these findings, we concluded that three distinct domains of SSI-1 (the pre-SH2 domain, the SH2 domain, and the SC-motif) cooperate in the suppression of interleukin 6 signaling...
  7. ncbi Effective cancer targeting using an anti-tumor tissue vascular endothelium-specific monoclonal antibody (TES-23)
    Y Wakai
    Department of Biopharmaceutics, School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Jpn J Cancer Res 91:1319-25. 2000
    ..Mice treated with the immunoconjugate showed improved survival with no side effects. This result indicates that common antigens may be found in different kinds of tumor endothelial cells, and that TES-23 might recognize these antigens...
  8. ncbi IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-gamma
    H Saito
    Department of Molecular Medicine, Osaka University Medical School, and Osaka University, Suita City, Osaka, Japan
    J Immunol 164:5833-43. 2000
    ..These results demonstrated that IRF-1, which is induced by activation of Stat1, mediated transcriptional activation of the SSI-1 gene by IFN-gamma via VIRE...
  9. ncbi Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice
    T Naka
    Department of Medicine III, Osaka University Medical School, 2 2, Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 95:15577-82. 1998
    ..These findings suggest that SSI-1 prevents apoptosis by inhibiting the expression of Bax...
  10. ncbi Impaired beta-cell function in the presence of reduced insulin sensitivity determines glucose tolerance status in acromegalic patients
    S Kasayama
    Department of Medicine III, Osaka University Medical School, Osaka, Japan
    Clin Endocrinol (Oxf) 52:549-55. 2000
    ..In order to elucidate this issue, we investigated insulin sensitivity and beta-cell function in acromegalic patients...
  11. ncbi Progesterone, but not medroxyprogesterone, inhibits vascular cell adhesion molecule-1 expression in human vascular endothelial cells
    M Otsuki
    Department of Molecular Medicine, Osaka University Graduate School Medicine, Suita-city, Osaka, Japan
    Arterioscler Thromb Vasc Biol 21:243-8. 2001
    ..The contrasting effects of progesterone and MPA seem clinically important, inasmuch as MPA is a widely used progestin in the regimen of hormone replacement therapy...
  12. ncbi Characterization of premature atherosclerosis of carotid arteries in acromegalic patients
    M Otsuki
    Department of Molecular Medicine, Osaka University Medical School (C-4, Osaka, Japan
    Clin Endocrinol (Oxf) 54:791-6. 2001
    ..Increased concentration of IGF-I might be involved in the lack of susceptibility to atherosclerosis in some acromegalic patients...
  13. ncbi PPARalpha and GR differentially down-regulate the expression of nuclear factor-kappaB-responsive genes in vascular endothelial cells
    X Xu
    Department of Molecular Medicine, Osaka University Graduate School of Medicine (C-4, Suita, Osaka 565-0871, Japan
    Endocrinology 142:3332-9. 2001
    ..These results strongly suggest the existence of a target gene-specific mechanism for the nuclear receptor-mediated down-regulation of nuclear factor-kappaB activity...
  14. ncbi OmpC and OmpF are required for growth under hyperosmotic stress above pH 8 in Escherichia coli
    M Kaeriyama
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Lett Appl Microbiol 42:195-201. 2006
    ..To investigate the requirement of outer membrane porins for osmotic adaptation at alkaline pH in Escherichia coli...
  15. ncbi Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3
    S Minamoto
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Biochem Biophys Res Commun 237:79-83. 1997
    ..We also demonstrated the structure of human SSI-1...
  16. ncbi Specific binding of TES-23 antibody to tumour vascular endothelium in mice, rats and human cancer tissue: a novel drug carrier for cancer targeting therapy
    S Tsunoda
    Department of Biopharmaceutics, School of Pharmaceutical Sciences, Osaka University, Suita, Japan
    Br J Cancer 81:1155-61. 1999
    ..Thus, from a clinical view, TES-23 would be a novel drug carrier because of its high specificity to tumour vascular endothelium and its application to many types of cancer...
  17. ncbi PGC7/Stella protects against DNA demethylation in early embryogenesis
    Toshinobu Nakamura
    Department of Pathology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka 565 0871, Japan
    Nat Cell Biol 9:64-71. 2007
    ..These results demonstrate that PGC7/Stella is indispensable for the maintenance of methylation involved in epigenetic reprogramming after fertilization...
  18. ncbi Adenosine deamination increases the survival under acidic conditions in Escherichia coli
    Y Sun
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    J Appl Microbiol 112:775-81. 2012
    ..The aim of this study was to examine whether nucleosides have a role in the survival under acidic conditions in Escherichia coli...
  19. ncbi Carbon dioxide increases acid resistance in Escherichia coli
    L Sun
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Lett Appl Microbiol 40:397-400. 2005
    ..SIGNIFICANCE AND IMPACT OF THE STUDY: This study provides useful information for research into bacterial pathogenesis, fermentation and food preservation...
  20. ncbi Insulin sensitivity independently influences brachial-ankle pulse-wave velocity in non-diabetic subjects
    S Kasayama
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, and Department of Internal Medicine, Kinki Central Hospital, Hyogo, Japan
    Diabet Med 22:1701-6. 2005
    ..We also examined the effects of oral glucose tolerance test (OGTT) 2-h glucose and plasma high-sensitivity C-reactive protein (CRP) on PWV, as these two parameters are associated with atherosclerosis...
  21. ncbi Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid
    F Sakurai
    Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan
    Gene Ther 8:677-86. 2001
    ..These results indicate that the interaction with erythrocytes depends on the properties of the cationic lipid vectors and this is an important factor for intravenous gene delivery using cationic lipid vectors...
  22. ncbi Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia
    Y Yamakawa
    Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Clin Pharmacol Ther 90:157-63. 2011
    ..075) and the SLCO1A2 -361GG genotype (P = 0.005). These findings suggest that imatinib is transported into cells by OATP1A2, and that SLCO1A2 polymorphisms significantly affect imatinib pharmacokinetics...
  23. ncbi Genetic analysis of protein C deficiency in nineteen Japanese families: five recurrent defects can explain half of the deficiencies
    T Miyata
    Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Thromb Res 92:181-7. 1998
    ..For the identification of the genetic defect in Japanese patients with protein C deficiency, screening of these recurrent defects by using restriction enzyme cleavage is a rational method...
  24. ncbi Risk factors for asymptomatic atherosclerosis in Japanese type 2 diabetic patients without diabetic microvascular complications
    K Goya
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Metabolism 52:1302-6. 2003
    ..Conventional risk factors and diabetes treatment are independently associated with atherosclerosis of the carotid arteries in these patients...
  25. ncbi DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes
    Satomi Kuramochi-Miyagawa
    Department of Pathology, Medical School, Graduate School of Frontier Biosciences, Research Institute for Microbial Diseases, Osaka University, Yamada oka 2 2 Suita, Osaka 565 0871, Japan
    Genes Dev 22:908-17. 2008
    ..Our data strongly suggest that MILI and MIWI2 play essential roles in establishing de novo DNA methylation of retrotransposons in fetal male germ cells...
  26. ncbi Mouse germ cell-less as an essential component for nuclear integrity
    Tohru Kimura
    Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, Suita Shi, Osaka 565 0871, Japan
    Mol Cell Biol 23:1304-15. 2003
    ....
  27. ncbi Effects of the acyl chain composition of phosphatidylcholines on the stability of freeze-dried small liposomes in the presence of maltose
    H Komatsu
    Division of Drugs, National Institute of Health Sciences, Osaka, 540 0005, Japan
    Chem Phys Lipids 113:29-39. 2001
    ..These interactions were significant in the saturated or mixed chain liposomes but were markedly reduced in the DOPC liposomes...
  28. ncbi Ameliorative effect of S-allylcysteine, a major thioallyl constituent in aged garlic extract, on learning deficits in senescence-accelerated mice
    N Nishiyama
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    J Nutr 131:1093S-5S. 2001
    ..These studies suggest that diet supplementation with SAC may reduce age-related learning disabilities and cognitive disorders in senescence-accelerated mice...
  29. ncbi Autocrine stimulatory mechanism by transforming growth factor beta in human hepatocellular carcinoma
    K Matsuzaki
    Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan
    Cancer Res 60:1394-402. 2000
    ..Our observations suggest that this constant suppression of the p15INK4B gene could be involved in the malignant progression of HCC...
  30. ncbi Mineralocorticoid receptor-mediated enhancement of neuronal excitability and synaptic plasticity in the dentate gyrus in vivo is dependent on the beta-adrenergic activity
    M Smriga
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    J Neurosci Res 51:593-601. 1998
    ....
  31. ncbi Randomised, phase III trial of epoetin-β to treat chemotherapy-induced anaemia according to the EU regulation
    Y Fujisaka
    Respiratory Medicine, Osaka Medical College Hospital, Osaka, Japan
    Br J Cancer 105:1267-72. 2011
    ....
  32. ncbi Expression of sodium/proton antiporter NhaA at various pH values in Escherichia coli
    T Shijuku
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 33, Yayoi cho, Inage Ku, Chiba 263 8522, Japan
    Biochim Biophys Acta 1506:212-7. 2001
    ..These results suggested that nhaA is induced only when a low level of internal sodium ions is not kept by NhaB and ChaA. Strains used in the previous study may have low active ChaA...
  33. ncbi Blue-light hazard from CO2 arc welding of mild steel
    T Okuno
    Hazard Evaluation and Epidemiology Research Group, National Institute of Occupational Safety and Health, Japan, Nagao 6 21 1, Tama ku, Kawasaki 214 8585, Japan
    Ann Occup Hyg 54:293-8. 2010
    ..The objective was to quantify the blue-light hazard from CO(2) arc welding of mild steel...
  34. ncbi Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse
    Yoshitaka Fujihara
    Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    J Cell Sci 123:1531-6. 2010
    ..It was demonstrated that SPESP1 is necessary to produce the fully 'fusion competent' sperm...
  35. ncbi Lats2 is an essential mitotic regulator required for the coordination of cell division
    Norikazu Yabuta
    Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita City, Osaka 565 0871, Japan
    J Biol Chem 282:19259-71. 2007
    ..These results suggest that Lats2 plays an essential mitotic role in coordinating accurate cytokinesis completion, governing the stabilization of other mitotic regulators...
  36. ncbi Transforming growth factor-beta(2) polymorphisms are associated with childhood atopic asthma
    K Hatsushika
    Department of Immunology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
    Clin Exp Allergy 37:1165-74. 2007
    ..Recent studies suggest that TGF-beta(2) is a predominant isoform expressed in severe asthma and it is also associated with airway remodelling...
  37. ncbi Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells
    Takashi Akazawa
    Department of Immunology, Osaka Medical Center for Cancer, Nakamichi 1 3 2, Higashinari ku, Osaka 537 8511, Japan
    Proc Natl Acad Sci U S A 104:252-7. 2007
    ..Thus, TICAM-1 in mDCs critically facilitated mDC-NK contact and activation of antitumor NK, resulting in the regression of low MHC-expressing tumors...
  38. ncbi PGAP1 knock-out mice show otocephaly and male infertility
    Yasutaka Ueda
    Department of Immunoregulation, Osaka University, Osaka, Japan
    J Biol Chem 282:30373-80. 2007
    ..Therefore, an extra acyl chain in GPI anchors caused severe deleterious effects to development and sperm function...
  39. ncbi Fertilization: a sperm's journey to and interaction with the oocyte
    Masahito Ikawa
    Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita, Osaka, 565 0871, Japan
    J Clin Invest 120:984-94. 2010
    ..This Review focuses on the advantages of studying fertilization using gene-manipulated animals and highlights an emerging molecular mechanism of mammalian fertilization...
  40. ncbi Sperm-egg interaction and gene manipulated animals
    Naokazu Inoue
    Genome Information Research Center, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    Soc Reprod Fertil Suppl 65:363-71. 2007
    ..Here we describe various gene manipulated animals that are useful to elucidate the mechanism of fertilisation...
  41. ncbi Cd52, known as a major maturation-associated sperm membrane antigen secreted from the epididymis, is not required for fertilization in the mouse
    Ryo Yamaguchi
    Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Genes Cells 13:851-61. 2008
    ..As a consequence, there was no difference in the litter size from the wild-type and Cd52-null males. Our results therefore indicate CD52 is not required for fertilization in the mouse either in vivo or in vitro...
  42. ncbi Placenta-specific gene activation and inactivation using integrase-defective lentiviral vectors with the Cre/LoxP system
    Yuka Morioka
    Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Genesis 47:793-8. 2009
    ..Since IDLV vectors can efficiently transduce a variety of cell types similarly to wild-type vectors, our IDLV-Cre strategy is potentially useful for a wide range of applications...
  43. ncbi Targeted gene modification in mouse ES cells using integrase-defective lentiviral vectors
    Yuka Okada
    Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Genesis 47:217-23. 2009
    ..Because lentiviral vectors can efficiently transduce a variety of stem cell types, our strategy has potential relevance for secure gene-manipulation in therapeutic applications...
  44. ncbi Putative sperm fusion protein IZUMO and the role of N-glycosylation
    Naokazu Inoue
    Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 377:910-4. 2008
    ..These data suggest that glycosylation is not essential for the function of IZUMO, but has a role in protecting it from fragmentation in cauda epididymis...
  45. ncbi Mechanisms of sperm-egg interactions emerging from gene-manipulated animals
    Masahito Ikawa
    Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Int J Dev Biol 52:657-64. 2008
    ..In this review, information about sperm-egg interactions obtained from genetically manipulated animals is mainly revisited in order to propose a new vision...
  46. ncbi The testes-specific bZip type transcription factor Tisp40 plays a role in ER stress responses and chromatin packaging during spermiogenesis
    Ippei Nagamori
    Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita City, Osaka 565 0871, Japan
    Genes Cells 11:1161-71. 2006
    ..Taken together, we conclude that Tisp40 plays an important role in the unfolded protein response of the testis and in regulating the maturation of sperm head nuclei...
  47. ncbi Mili, a mammalian member of piwi family gene, is essential for spermatogenesis
    Satomi Kuramochi-Miyagawa
    Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    Development 131:839-49. 2004
    ..These data indicate that MILI is essential for the differentiation of spermatocytes...
  48. ncbi Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm
    Naokazu Inoue
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
    Mol Cell Biol 23:2614-22. 2003
    ..It was assumed that this increase caused the heightened fertilizing ability found in CD46(-/-) sperm. These data suggest that CD46 may have some role in regulating sperm acrosome reaction...
  49. ncbi The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs
    Naokazu Inoue
    Genome Information Research Center, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    Nature 434:234-8. 2005
    ..Human sperm also contain Izumo and addition of the antibody against human Izumo left the sperm unable to fuse with zona-free hamster eggs...
  50. ncbi RECS1 deficiency in mice induces susceptibility to cystic medial degeneration
    Hanjun Zhao
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Genes Genet Syst 81:41-50. 2006
    ..Taken together, we conclude that RECS1 is an endosomal/lysosomal membrane protein which plays protective roles in vascular remodeling...
  51. ncbi Comparison of gene expression in male and female mouse blastocysts revealed imprinting of the X-linked gene, Rhox5/Pem, at preimplantation stages
    Shin Kobayashi
    Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Biol 16:166-72. 2006
    ..Moreover, Rhox5/Pem was expressed predominantly from the paternally inherited X chromosome, indicating sex differences in early epigenetic gene regulation...
  52. ncbi Pluripotency of a single spermatogonial stem cell in mice
    Mito Kanatsu-Shinohara
    Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Biol Reprod 78:681-7. 2008
    ..Thus, our study provides evidence that a single spermatogonial stem cell can acquire pluripotentiality but that conversion into a pluripotent cell type is accompanied by loss of spermatogenic potential...
  53. ncbi Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2
    Shinichi Uchida
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Mol Cell Biol 25:7357-63. 2005
    ..Thus, UT-A2 is important for maintaining a high concentration of urea in the inner medulla when urea supply to the kidney is limited...
  54. ncbi FISH analysis of 142 EGFP transgene integration sites into the mouse genome
    Tomoko Nakanishi
    Genome Information Research Center, Osaka University, Yamadaoka 3-1, Suita Osaka, 565-0871, Japan
    Genomics 80:564-74. 2002
    ..This is the first report to analyze the transgene integration sites by producing more than 100 transgenic mouse lines...
  55. ncbi Mouse sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg
    Daichi Baba
    Institute of Applied Biochemistry, University of Tsukuba, Tsukuba Science City, Ibaraki 305 8572, Japan
    J Biol Chem 277:30310-4. 2002
    ....
  56. ncbi Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress
    Osamu Hori
    Department of Neuroanatomy, Kanazawa University, Graduate School of Medical Science, 13 1 Takara machi, Kanazawa City, Ishikawa 920 8640, Japan
    Mol Cell Biol 26:4257-67. 2006
    ....
  57. ncbi Sperm from the calmegin-deficient mouse have normal abilities for binding and fusion to the egg plasma membrane
    Kazuo Yamagata
    Genome Information Research Center, Osaka University, Yamadaoka 3 1, Suita, Osaka, 565 0871 Japan
    Dev Biol 250:348-57. 2002
    ..Because fertilin beta is absent from calmegin-deficient mice, these results also suggest that the role of fertilin beta in sperm-EPM interaction needs to be reevaluated...
  58. ncbi A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA
    Gustavo Tiscornia
    Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:1844-8. 2003
    ..We believe that this approach of generating "knockdown" mice will aid in functional genomics...
  59. ncbi Restoration of spermatogenesis by lentiviral gene transfer: offspring from infertile mice
    Masahito Ikawa
    Laboratory of Genetics, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:7524-9. 2002
    ..We propose that lentiviral vectors can be used for gene therapy of male infertility without the risk of germ-line transmission...
  60. ncbi Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method
    Naoko Shiomi
    Research Center for Radiation Safety, National Institute of Radiological Sciences, Inage Ku, Chiba 263 8555, Japan
    Mol Cell Biol 24:3712-9. 2004
    ..The XpgD811stop homozygous mice, however, exhibited a slightly milder CS phenotype than did the Xpg null mutant mice, indicating that the XpgD811stop protein still retains some Xpg function that affects the severity of the CS phenotype...
  61. ncbi Selective passage through the uterotubal junction of sperm from a mixed population produced by chimeras of calmegin-knockout and wild-type male mice
    Tomoko Nakanishi
    Genome Information Research Center, Osaka University, Osaka 565 0871, Japan
    Biol Reprod 71:959-65. 2004
    ..These findings indicate that the presence of wild-type sperm cannot compensate for the inability of calmegin-knockout sperm to enter the oviduct and that successful ascent into the oviduct depends on the capabilities of individual sperm...
  62. ncbi The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons
    Tetsuji Mori
    Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960 1295 Japan
    Eur J Neurosci 19:3129-41. 2004
    ..Neurotransmitter phenotypes other than cholinergic in the basal forebrain appeared intact. From these results, we suggested that L3/Lhx8 has a pivotal and specific role in the development and/or maintenance of BFCNs...
  63. ncbi Aberrant distribution of ADAM3 in sperm from both angiotensin-converting enzyme (Ace)- and calmegin (Clgn)-deficient mice
    Ryo Yamaguchi
    Genome Information Research Center, Pharmaceutical Sciences, Research Institute for Microbial Diseases, Osaka University, Osaka, 565 0871, Japan
    Biol Reprod 75:760-6. 2006
    ..This diminished amount of ADAM3 in the Triton X-114 detergent-enriched phase may explain the inability of Clgn-/- and Ace-/- sperm to bind to the zona pellucida...
  64. ncbi Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells
    Mito Kanatsu-Shinohara
    Department of Molecular Genetics, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan tshinoha2virus kyoto u ac jp
    Proc Natl Acad Sci U S A 103:8018-23. 2006
    ..These results demonstrate the feasibility of altering genes in tissue-specific stem cells in a manner similar to embryonic stem cells and have important implications for gene therapy and animal transgenesis...
  65. ncbi [How far was fertilization elucidated?]
    Naokazu Inoue
    Tanpakushitsu Kakusan Koso 50:1405-12. 2005
  66. ncbi Distinct roles of IkappaB proteins in regulating constitutive NF-kappaB activity
    Vinay Tergaonkar
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Nat Cell Biol 7:921-3. 2005
    ..We also show that in the absence of IkappaBalpha, IkappaBbeta and IkappaBepsilon proteins, cytoplasmic retention of NF-kappaB by other cellular proteins renders the pathway unresponsive to activation...
  67. ncbi Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation
    Mariko Hara-Chikuma
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 280:15493-6. 2005
    ..Increasing AQP7 expression/function in adipocytes may reduce adipocyte volume and fat mass in obesity...
  68. ncbi Innate versus learned odour processing in the mouse olfactory bulb
    Ko Kobayakawa
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113 0032, Japan
    Nature 450:503-8. 2007
    ..These results indicate that, in mice, aversive information is received in the olfactory bulb by separate sets of glomeruli, those dedicated for innate and those for learned responses...
  69. ncbi Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis
    Noriko Takegahara
    Department of Molecular Immunology and CREST Program of JST, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 8:615-22. 2006
    ..These findings reveal an unexpected role for plexin-A1 and present a novel signalling mechanism for exerting the pleiotropic functions of semaphorins...
  70. ncbi Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway
    Reiko Hanada
    Molecular Genetics, Institute of Life Science, Kurume University, Kurume, Fukuoka 839 0861, Japan
    Nat Med 10:1067-73. 2004
    ..These characteristic functions of NMU may provide new insight for understanding the pathophysiological basis of obesity...
  71. ncbi Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos
    Alexander Pfeifer
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:2140-5. 2002
    ..Ability to transfer foreign genes into human ES cells has potential relevance for the development of gene and cell-based therapies...