Hiromi Rakugi

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Evaluation of the efficacy and tolerability of fixed-dose combination therapy of azilsartan and amlodipine besylate in Japanese patients with grade I to II essential hypertension
    Hiromi Rakugi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan Electronic address
    Clin Ther 36:711-21. 2014
  2. doi request reprint Effect of azilsartan versus candesartan on nocturnal blood pressure variation in Japanese patients with essential hypertension
    Hiromi Rakugi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Blood Press 22:22-8. 2013
  3. doi request reprint Evaluation of the efficacy and tolerability of combination therapy with candesartan cilexetil and amlodipine besilate compared with candesartan cilexetil monotherapy and amlodipine besilate monotherapy in Japanese patients with mild-to-moderate essential
    Hiromi Rakugi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka Suita, Osaka, Japan
    Clin Ther 34:838-48. 2012
  4. ncbi request reprint Anti-oxidative effect of Klotho on endothelial cells through cAMP activation
    Hiromi Rakugi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka B6, Suita, 565 0871, Japan
    Endocrine 31:82-7. 2007
  5. ncbi request reprint Earlier management of subjects who are prone to hypertension and diabetes mellitus
    Hiromi Rakugi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, B6, Suita 565 0871, Japan
    Curr Diab Rep 4:77-8. 2004
  6. doi request reprint Comparison of strict- and mild-blood pressure control in elderly hypertensive patients: a per-protocol analysis of JATOS
    Hiromi Rakugi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertens Res 33:1124-8. 2010
  7. ncbi request reprint The metabolic syndrome in the asian population
    Hiromi Rakugi
    Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Hypertens Rep 7:103-9. 2005
  8. ncbi request reprint Vascular signaling pathways in the metabolic syndrome
    Hiromi Rakugi
    Department of Geriatric Medicine B6, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Hypertens Rep 4:105-11. 2002
  9. doi request reprint Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling
    Shuko Takeda
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Hypertension 54:1345-52. 2009
  10. doi request reprint Combined use of vitamin D status and FGF23 for risk stratification of renal outcome
    Chikako Nakano
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Clin J Am Soc Nephrol 7:810-9. 2012

Collaborators

Detail Information

Publications139 found, 100 shown here

  1. ncbi request reprint Evaluation of the efficacy and tolerability of fixed-dose combination therapy of azilsartan and amlodipine besylate in Japanese patients with grade I to II essential hypertension
    Hiromi Rakugi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan Electronic address
    Clin Ther 36:711-21. 2014
    ..Guidelines for the management of hypertension recommend using drugs with different mechanisms of action in antihypertensive regimens that include simple single-pill fixed-dose combination (FDC) products...
  2. doi request reprint Effect of azilsartan versus candesartan on nocturnal blood pressure variation in Japanese patients with essential hypertension
    Hiromi Rakugi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Blood Press 22:22-8. 2013
    ..Abnormal variations in night-time hypertension such as "non-dipping" type (< 10% decrease in nocturnal systolic blood pressure [SBP] from daytime SBP) are a risk factor for cardiovascular events independent of 24-h BP...
  3. doi request reprint Evaluation of the efficacy and tolerability of combination therapy with candesartan cilexetil and amlodipine besilate compared with candesartan cilexetil monotherapy and amlodipine besilate monotherapy in Japanese patients with mild-to-moderate essential
    Hiromi Rakugi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka Suita, Osaka, Japan
    Clin Ther 34:838-48. 2012
    ....
  4. ncbi request reprint Anti-oxidative effect of Klotho on endothelial cells through cAMP activation
    Hiromi Rakugi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka B6, Suita, 565 0871, Japan
    Endocrine 31:82-7. 2007
    ..These findings provide new insights into the mechanisms of Klotho action and support the therapeutic potential of membrane-form Klotho to regulate endothelial function...
  5. ncbi request reprint Earlier management of subjects who are prone to hypertension and diabetes mellitus
    Hiromi Rakugi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, B6, Suita 565 0871, Japan
    Curr Diab Rep 4:77-8. 2004
  6. doi request reprint Comparison of strict- and mild-blood pressure control in elderly hypertensive patients: a per-protocol analysis of JATOS
    Hiromi Rakugi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertens Res 33:1124-8. 2010
    ....
  7. ncbi request reprint The metabolic syndrome in the asian population
    Hiromi Rakugi
    Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Hypertens Rep 7:103-9. 2005
    ..This variant susceptibility may be caused by gene-environmental interactions and low birth weight in Asian populations...
  8. ncbi request reprint Vascular signaling pathways in the metabolic syndrome
    Hiromi Rakugi
    Department of Geriatric Medicine B6, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Hypertens Rep 4:105-11. 2002
    ..Finally, novel substances such as the adipokines, factors produced from fat cells, reveal new risk factors in the metabolic syndrome and offer further evidence for a link between insulin resistance and accelerated atherosclerosis...
  9. doi request reprint Angiotensin receptor blocker prevented beta-amyloid-induced cognitive impairment associated with recovery of neurovascular coupling
    Shuko Takeda
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Hypertension 54:1345-52. 2009
    ..These findings suggest the possibility that amelioration of cerebrovascular dysfunction with an angiotensin receptor blocker could be a novel therapeutic strategy for the early stage of Alzheimer disease...
  10. doi request reprint Combined use of vitamin D status and FGF23 for risk stratification of renal outcome
    Chikako Nakano
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Clin J Am Soc Nephrol 7:810-9. 2012
    ..However, studies with simultaneous measurement of mineral bone disorder (MBD)-related factors were scarce. This study aimed to identify factors predicting renal outcome independent of other factors...
  11. doi request reprint The impact of diabetes mellitus on vitamin D metabolism in predialysis patients
    Hirotaka Tanaka
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2 2 Yamadaoka, Suita, Osaka, Japan
    Bone 45:949-55. 2009
    ..Poorer vitamin D status and higher CaP product might be partly responsible for functional and structural changes of vasculature, respectively, in DM...
  12. doi request reprint The impact of visit-to-visit variability in blood pressure on renal function
    Tatsuo Kawai
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Hypertens Res 35:239-43. 2012
    ..This parameter could provide additional information about renal arteriosclerotic change independent of estimated glomerular filtration rate and albuminuria, and should be considered a therapeutic target for renal protection...
  13. doi request reprint Variation in OSBPL10 is associated with dyslipidemia
    Hiroshi Koriyama
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
    Hypertens Res 33:511-4. 2010
    ..003), with an odds ratio of 0.35 (95% confidence interval=0.17-0.76). Overall, the rs2290532 (D254N) polymorphism in OSBPL10 may predispose individuals with this SNP to hyper-LDL cholesterolemia...
  14. ncbi request reprint Renin-angiotensin inhibition reverses advanced cardiac remodeling in aging spontaneously hypertensive rats
    Norihisa Ito
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Hypertens 20:792-9. 2007
    ....
  15. doi request reprint The combination of chronic kidney disease and increased arterial stiffness is a predictor for stroke and cardiovascular disease in hypertensive patients
    Mitsuru Ohishi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    Hypertens Res 34:1209-15. 2011
    ..0332) by Cox's proportional hazard model. These data suggest that increased aortic stiffness and CKD may be predictors for stroke and cardiovascular events in hypertensive patients...
  16. ncbi request reprint Tissue inhibitor of metalloproteinase-3 deficiency inhibits blood pressure elevation and myocardial microvascular remodeling induced by chronic administration of Nomega-nitro-L-arginine methyl ester in mice
    Masayoshi Higuchi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 30:563-71. 2007
    ..Our findings suggest that Timp-3 may be a novel therapeutic target for the treatment of hypertension and consequent organ damage...
  17. ncbi request reprint Rationale, study design and implementation of the COLM study: the combination of OLMesartan and calcium channel blocker or diuretic in high-risk elderly hypertensive patients
    Toshio Ogihara
    Osaka University Graduate School of Medicine, Osaka, Japan
    Hypertens Res 32:163-7. 2009
    ..Safety and tolerability will also be investigated. A total of more than 4000 patients were recruited and will be followed up for at least 3 years...
  18. doi request reprint The counterregulating role of ACE2 and ACE2-mediated angiotensin 1-7 signaling against angiotensin II stimulation in vascular cells
    Norihiro Hayashi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 33:1182-5. 2010
    ..Endogenous ACE2 in vascular cells may contribute to counteracting the Ang II-mediated cellular response partly by upregulating the Ang 1-7 signaling through Mas...
  19. doi request reprint Intact fibroblast growth factor 23 levels predict incident cardiovascular event before but not after the start of dialysis
    Chikako Nakano
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Bone 50:1266-74. 2012
    ..However, the independent associations of these factors with cardiovascular disease (CVD), the leading cause of death among CKD patients, remain unclear. Our purpose was to identify which of these factors predict incident CVD in CKD...
  20. ncbi request reprint Renal protective effect in hypertensive patients: the high doses of angiotensin II receptor blocker (HARB) study
    Mitsuru Ohishi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 30:1187-92. 2007
    ..0011) prior to changeover were independently correlated with reduction in UPE. Our results suggest that the maximum dose of valsartan is more effective than the maximum dose of candesartan for reducing BP and proteinuria...
  21. doi request reprint Strong suppression of the renin-angiotensin system has a renal-protective effect in hypertensive patients: high-dose ARB with ACE inhibitor (Hawaii) study
    Mitsuru Ohishi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 33:1150-4. 2010
    ....
  22. ncbi request reprint Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model
    Nobuyasu Shindo
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    J Hepatol 52:903-12. 2010
    ..The lack of a spontaneous animal model of NASH, however, has hampered basic research in this field...
  23. pmc Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes
    Shuko Takeda
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 107:7036-41. 2010
    ..Cerebrovascular changes and alteration in brain insulin signaling might play a pivotal role in this relationship. These findings could provide insights into this intensely debated association...
  24. doi request reprint -374 T/A polymorphism in RAGE gene is associated with onset of diabetes mellitus, atherosclerosis, and renal dysfunction in patients with hypertension
    Tatsuo Kawai
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Exp Hypertens 35:236-41. 2013
    ..These significant correlations were only seen in male subjects. Carriers of the A allele of -374 T/A RAGE show an independent risk of atherosclerosis and reduced renal function in male hypertensive patients with DM...
  25. doi request reprint A nonerythropoietic derivative of erythropoietin inhibits tubulointerstitial fibrosis in remnant kidney
    Ryoichi Imamura
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 16:852-62. 2012
    ..Recently, we reported that carbamylated erythropoietin (CEPO) protected kidneys from ischemia-reperfusion injury as well as EPO...
  26. doi request reprint Influence of renin angiotensin system gene polymorphisms on visit-to-visit blood pressure variability in hypertensive patients
    Tatsuo Kawai
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Hypertens 25:1249-55. 2012
    ..In this study, we aimed to reveal the relationship between visit-to-visit BP variability and RAS gene polymorphisms...
  27. doi request reprint Hepatocyte growth factor inhibits lipopolysaccharide-induced oxidative stress via epithelial growth factor receptor degradation
    Kazutaka Shimizu
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Japan
    Arterioscler Thromb Vasc Biol 32:2687-93. 2012
    ..Here, we examined whether HGF can protect against systemic inflammatory response syndrome induced by LPS and investigated the mechanism...
  28. doi request reprint Hepatocyte growth factor reduces cardiac fibrosis by inhibiting endothelial-mesenchymal transition
    Keita Okayama
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertension 59:958-65. 2012
    ..We conclude that HGF reduced cardiac fibrosis by inhibiting endothelial-mesenchymal transition and the transformation of fibroblasts into myofibroblasts...
  29. doi request reprint Telmisartan exerts renoprotective actions via peroxisome proliferator-activated receptor-γ/hepatocyte growth factor pathway independent of angiotensin II type 1 receptor blockade
    Hiroshi Kusunoki
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
    Hypertension 59:308-16. 2012
    ..Further development of the next generation of Ang II type 1 receptor blockers with added organ protective actions, such as PPARγ activation, might provide new beneficial drugs to treat renal and cardiovascular diseases...
  30. doi request reprint Safety and efficacy of administering the maximal dose of candesartan in renal transplant recipients
    Masayoshi Okumi
    Department of Urology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 15:907-15. 2011
    ..We evaluate the efficacy and safety of the maximal dose of candesartan administered to renal transplant patients...
  31. doi request reprint Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice
    Atsushi Shiota
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita City, Japan
    Hypertens Res 33:298-307. 2010
    ..The renal-protective effect of ACE2 might involve more than just suppressing angiotensin II-mediated AT1 receptor signaling...
  32. doi request reprint Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension
    Hironori Nakagami
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Hypertens Res 30:1239-46. 2007
    ..Our results suggest that the polymorphism of myospryn is associated with left ventricular hypertrophy, and an association between a Z-disc protein and cardiac adaptation in response to pressure overload...
  33. doi request reprint Target blood pressure for treatment of isolated systolic hypertension in the elderly: valsartan in elderly isolated systolic hypertension study
    Toshio Ogihara
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Hypertension 56:196-202. 2010
    ....
  34. ncbi request reprint Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease
    Koji Ohashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    J Am Coll Cardiol 43:1195-200. 2004
    ..This study examined the association of mutations in adiponectin gene with the prevalence of coronary artery disease (CAD)...
  35. ncbi request reprint A common polymorphism of uncoupling protein 2 gene is associated with hypertension
    Quihe Ji
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Hypertens 22:97-102. 2004
    ..To clarify the contribution of this polymorphism to obesity and related conditions, we studied the association of the -866 G/A polymorphism of the UCP2 gene with obesity, hypertension and type 2 diabetes mellitus...
  36. ncbi request reprint Insulin-mediated regulation of the endothelial renin-angiotensin system and vascular cell growth
    Kei Kamide
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    J Hypertens 22:121-7. 2004
    ..We previously reported that the vascular RAS activity is activated in vascular smooth muscle cells (SMC) by insulin stimulation. However, the effect of insulin on the RAS in endothelial cells (EC) is not fully understood...
  37. ncbi request reprint Association between hepatocyte growth factor gene polymorphism and essential hypertension
    Masaharu Motone
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 27:247-51. 2004
    ..In conclusion, our data suggested that C/A polymorphism in intron 13 of the HGF gene is associated with susceptibility to essential hypertension in lean or female subjects...
  38. pmc Decrease in blood pressure and regression of cardiovascular complications by angiotensin II vaccine in mice
    Futoshi Nakagami
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 8:e60493. 2013
    ..Taken together, these data indicate that vaccines targeting Ang II might be effective to decrease high BP and prevent cardiovascular complications without severe side effects...
  39. ncbi request reprint Adiponectin single nucleotide polymorphism is a genetic risk factor for stroke through high pulse wave pressure: a cohort study
    Tatsuo Kawai
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan
    J Atheroscler Thromb 20:152-60. 2013
    ....
  40. doi request reprint Serum uric acid is an independent risk factor for cardiovascular disease and mortality in hypertensive patients
    Tatsuo Kawai
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 35:1087-92. 2012
    ..19; P=0.0083), but not stroke (P=0.4268). The significant correlations were particularly marked in women. Serum UA levels may be an independent risk factor for stroke and CVD in patients with essential hypertension, particularly women...
  41. ncbi request reprint Renal-protective effect of T-and L-type calcium channel blockers in hypertensive patients: an Amlodipine-to-Benidipine Changeover (ABC) study
    Mitsuru Ohishi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 30:797-806. 2007
    ..0284) were correlated with reduction of urinary proteins during changeover. Taken together, our results suggest that benidipine may have greater efficacy than amlodipine in reducing blood pressure and proteinuria...
  42. doi request reprint Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension
    Ryosuke Oguro
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Geriatr Gerontol Int 10:311-8. 2010
    ..Here, we studied whether klotho single nucleotide polymorphisms (SNP) were associated with carotid atherosclerosis...
  43. ncbi request reprint Cigarette smoking and progression of IgA nephropathy
    Ryohei Yamamoto
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Am J Kidney Dis 56:313-24. 2010
    ..However, little information is available about an effect of cigarette smoking on progression of primary kidney diseases, including immunoglobulin A (IgA) nephropathy...
  44. ncbi request reprint Hypoadiponectinemia is an independent risk factor for hypertension
    Yoshio Iwashima
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertension 43:1318-23. 2004
    ..01), and most of them had hypertension. In contrast, the G276T polymorphism was not associated with adiponectin concentration or hypertension. In conclusion, hypoadiponectinemia is a marker for predisposition to hypertension in men...
  45. ncbi request reprint Relationship of bradykinin B2 receptor gene polymorphism with essential hypertension and left ventricular hypertrophy
    Yuxiao Fu
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
    Hypertens Res 27:933-8. 2004
    ....
  46. ncbi request reprint Carotid plaque score and intima media thickness as predictors of stroke and mortality in hypertensive patients
    Tatsuo Kawai
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 36:902-9. 2013
    ..We also showed that marginal thickening of the intima media (as measured by mean IMT) may be a predictor of stroke...
  47. ncbi request reprint Telmisartan modulates mitochondrial function in vascular smooth muscle cells
    Kiyo Takeuchi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertens Res 36:433-9. 2013
    ....
  48. doi request reprint Serum hepcidin-25 levels predict the progression of renal anemia in patients with non-dialysis chronic kidney disease
    Kakuya Niihata
    Department of Kidney Disease and Hypertension, Osaka General Medical Center, Osaka, Japan
    Nephrol Dial Transplant 27:4378-85; discussion 4384-5. 2012
    ..This longitudinal study aimed at ascertaining the association between hepcidin-25 levels and the progression of renal anemia...
  49. doi request reprint Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3
    Kazunori Inoue
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Japan
    Lab Invest 92:1686-97. 2012
    ..This recruitment promoted the dephosphorylation of pSmad3 and attenuated the pSmad3-dependent production of TGF-β1. Our findings provide a novel approach to inhibit the TGF-β pathway in fibrotic diseases...
  50. pmc Loss of ACE2 exaggerates high-calorie diet-induced insulin resistance by reduction of GLUT4 in mice
    Masao Takeda
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Diabetes 62:223-33. 2013
    ..In conclusion, ACE2 protects against high-calorie diet-induced insulin resistance in mice. This mechanism may involve the transcriptional regulation of GLUT4 via an A1-7-dependent pathway...
  51. doi request reprint Gene polymorphisms contributing to hypertension in immunoglobulin A nephropathy
    Maki Shinzawa
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Clin Exp Nephrol 16:250-8. 2012
    ..Identification of the genetic factor contributing to hypertension in patients with chronic kidney disease may potentially refine a therapeutic strategy...
  52. doi request reprint Relationship between renal hemodynamic status and aging in patients without diabetes evaluated by renal Doppler ultrasonography
    Tatsuo Kawai
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka B6, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 16:786-91. 2012
    ..In this study, we investigated whether RI could be used to evaluate the pathogenesis of renal damage or the mechanisms of reduction of renal function by aging...
  53. doi request reprint Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy
    Hiroki Omori
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 16:549-56. 2012
    ..While some reports suggest a relationship between hyperuricemia and chronic kidney disease (CKD), the renoprotective mechanism of an XO inhibitor in CKD remains unknown. Recent reports have focused on XO as a source of oxidative stress...
  54. doi request reprint Combination therapy for hypertension in the elderly: a sub-analysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial
    Toshio Ogihara
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 35:441-8. 2012
    ..Further studies will be necessary to evaluate the usefulness of benidipine combined with a β-blocker in terms of the incidence of stroke and new-onset diabetes in older patients...
  55. doi request reprint Klotho protein diminishes endothelial apoptosis and senescence via a mitogen-activated kinase pathway
    Yoshihiro Maekawa
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Geriatr Gerontol Int 11:510-6. 2011
    ..Here, we designed an in vitro study to test whether inhibitors of extracellular signal-regulated kinase and mitogen-activated kinase kinase could affect Klotho regulation of apoptosis and cellular senescence...
  56. ncbi request reprint Fluvastatin improves osteoporosis in fructose-fed insulin resistant model rats through blockade of the classical mevalonate pathway and antioxidant action
    Rie Hanayama
    Division of Clinical Gene Therapy, Osaka University, Graduate School of Medicine, Osaka 565 0871, Japan
    Int J Mol Med 23:581-8. 2009
    ....
  57. doi request reprint A polymorphism regulates CYP4A11 transcriptional activity and is associated with hypertension in a Japanese population
    Ken Sugimoto
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertension 52:1142-8. 2008
    ..We have identified a functional variant (-845A/G) of CYP4A11 that is significantly associated with hypertension and that appears to be a novel candidate for a predisposing factor for hypertension...
  58. doi request reprint Guideline-practice gap in the management of predialysis chronic kidney disease mineral bone disorder in Japan
    Takayuki Hamano
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Ther Apher Dial 15:2-8. 2011
    ..Given these results, nephrologists should consider prescribing active vitamin D, especially for females and patients with diabetes, massive proteinuria, or secondary hyperparathyroidism...
  59. pmc Fetuin-mineral complex reflects extraosseous calcification stress in CKD
    Takayuki Hamano
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Am Soc Nephrol 21:1998-2007. 2010
    ..These data suggest that a quantitative measure of FMC, not supernatant or serum fetuin-A as measured in previous studies, reflects extraosseous calcification stress...
  60. ncbi request reprint Role of endothelin-1 induced by insulin in the regulation of vascular cell growth
    Michiko Nagai
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Hypertens 16:223-8. 2003
    ..In summary, a severely hyperinsulinemic state may regulate VSMC and EC proliferation via activation of vasoactive substances such as ET-1 and nitric oxide induced by insulin...
  61. ncbi request reprint Genetic influences of beta-adrenoceptor polymorphisms on arterial functional changes and cardiac remodeling in hypertensive patients
    Ming Yuan
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 29:875-81. 2006
    ..05). These data suggested that two polymorphisms of different beta-adrenoreceptor subtypes are the genetic influences on the development of arterial stiffness and left ventricular hypertrophy in essential hypertension...
  62. doi request reprint Inhibition of Lp(a)-induced functional impairment of endothelial cells and endothelial progenitor cells by hepatocyte growth factor
    Masaaki Iwabayashi
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 423:79-84. 2012
    ..Since risk factors for atherosclerosis accelerate endothelial senescence and impair angiogenesis, we examined the role of Lp(a) in dysfunction and senescence of endothelial progenitor cells (EPC) and endothelial cells...
  63. doi request reprint Autophagy guards against cisplatin-induced acute kidney injury
    Atsushi Takahashi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Am J Pathol 180:517-25. 2012
    ..Enhancing autophagy may provide a novel therapeutic option to minimize AKI...
  64. doi request reprint Role of serotonin in angiogenesis: induction of angiogenesis by sarpogrelate via endothelial 5-HT1B/Akt/eNOS pathway in diabetic mice
    Masaaki Iwabayashi
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Atherosclerosis 220:337-42. 2012
    ..Enhancement of vasodilation and angiogenesis by sarpogrelate might provide a unique treatment for PAD and DM patients...
  65. doi request reprint Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of the N-type calcium channel
    Hideo Shimizu
    Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Hypertens Res 35:77-81. 2012
    ..These pleiotropic effects of antihypertensive drugs such as cilnidipine and carvedilol might provide additional benefits in the treatment of hypertensive postmenopausal women...
  66. doi request reprint β-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease: a cohort study with hypertensive patients
    Yoshihiro Iwamoto
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Hypertens Res 34:573-7. 2011
    ..0209). These three SNPs, especially the Trp64Arg SNP of β(3)ADR, might be risk factors for CVD in hypertensive patients...
  67. doi request reprint Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese
    Izumi Shimaoka
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertens Res 33:214-8. 2010
    ..One SNP, rs1121980, and a haplotype of three SNPs in FTO that contains this SNP, might be important in the progression of insulin resistance in Japanese subjects...
  68. doi request reprint Estrogen attenuates vascular remodeling in Lp(a) transgenic mice
    Futoshi Nakagami
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Japan
    Atherosclerosis 211:41-7. 2010
    ..Thus, it is mandatory to develop novel therapy to prevent atherosclerosis in high Lp(a) concentration. Here, we focused on the effect of estrogen on Lp(a) level and Lp(a)-induced vascular remodeling...
  69. doi request reprint Macrophage inflammatory protein-1beta induced cell adhesion with increased intracellular reactive oxygen species
    Yuji Tatara
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Japan
    J Mol Cell Cardiol 47:104-11. 2009
    ..In conclusion, MIP-1beta directly induced cell adhesion to endothelial cells through oxidative stress via PI3k-Rac1 cascades. Serum MIP-1beta level might be a useful predictor for cerebro-cardiovascular events in hypertensive patients...
  70. ncbi request reprint Plasma asymmetric dimethylarginine and coronary and peripheral endothelial dysfunction in hypertensive patients
    Shin Takiuchi
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    Am J Hypertens 17:802-8. 2004
    ..We hypothesized that changes in serum asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, and concomitant insulin resistance may be underlying factors connecting the two pathologic alterations...
  71. ncbi request reprint G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women
    Akiko Matsuo
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    J Hypertens 22:2123-7. 2004
    ..We examined the genetic involvement of the TSC gene in essential hypertension in Japanese...
  72. doi request reprint Microarray analysis of tonsils of IgA nephropathy patients
    Hirotsugu Iwatani
    Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan
    Adv Otorhinolaryngol 72:75-8. 2011
    ..The downregulated genes include the polymeric Ig receptor (pIgR) which was reportedly involved in single nucleotide polymorphism (SNP) of Japanese IgAN patients...
  73. doi request reprint ANG II inhibits insulin-mediated production of PI 3,4,5-trisphosphates via a Ca2+-dependent but PKC-independent pathway in the cardiomyocytes
    Masashi Ikushima
    Department of Pharmacology, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Physiol Heart Circ Physiol 299:H680-9. 2010
    ..Therefore, it is suggested that ANG II antagonizes insulin-mediated production of PI(3,4,5)P(3) via a Ca(2+)-dependent but PKC-independent pathway in cardiac myocytes...
  74. doi request reprint Akt activation prevents Apop-1-induced death of cells
    Xin Sun
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 377:1097-101. 2008
    ..Furthermore, our data indicate that the inhibition of Apop-1-induced death by IGF-1 is mediated by the activation of the PI3K/Akt signaling pathway...
  75. doi request reprint C-reactive protein, left ventricular mass index, and risk of cardiovascular disease in essential hypertension
    Yoshio Iwashima
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 30:1177-85. 2007
    ..37, 95% CI: 1.02-1.85, p=0.025). Our findings demonstrate that the CRP level is independently associated with LVMI, and suggest that measurement of CRP may provide clinically important prognostic information to supplement LVH...
  76. doi request reprint Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B
    Ada Congrains
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Japan
    Atherosclerosis 220:449-55. 2012
    ..It is still not clear which of or how these transcripts are involved in the pathogenesis of atherosclerosis...
  77. doi request reprint Effects of nicorandil on the reduction of BNP levels in patients with chronic kidney disease
    Tomonori Kimura
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2 2 Yamada oka, Suita, Osaka 585 0871, Japan
    Clin Exp Nephrol 15:854-60. 2011
    ..We examined whether nicorandil, a hybrid nitrate and adenosine triphosphate-sensitive potassium channel opener, could improve a biomarker and physiological markers of cardiovascular events...
  78. pmc Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance
    Mitsuru Shinohara
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 285:22091-102. 2010
    ..These results have important implications for the development of disease-modifying therapy for Alzheimer disease as well as understanding of Abeta metabolism...
  79. doi request reprint Fas promoter region gene polymorphism is associated with an increased risk for myocardial infarction
    Hiroko Hanasaki
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertens Res 32:261-4. 2009
    ..We conclude that the Fas promoter gene, SNP (-670G/A), may be a risk factor of MI occurrence...
  80. ncbi request reprint Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II
    Koichi Yamamoto
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertension 47:718-26. 2006
    ..Disruption of this regulatory function may accelerate cardiac hypertrophy and shorten the transition period from compensated hypertrophy to cardiac failure...
  81. doi request reprint Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation
    Yoshihiro Maekawa
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Endocrine 35:341-6. 2009
    ..These results suggest that Klotho suppresses TNF-alpha-induced expression of adhesion molecules and NF-kappaB activation. Klotho may have a role in the modulation of endothelial inflammation...
  82. ncbi request reprint Comparison of arterial functional evaluations as a predictor of cardiovascular events in hypertensive patients: the Non-Invasive Atherosclerotic Evaluation in Hypertension (NOAH) study
    Minako Terai
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 31:1135-45. 2008
    ..In conclusion, increased aortic stiffness evaluated by PWV is more prognostic of cardiovascular events in hypertensive patients than several non-invasive atherosclerotic evaluations...
  83. pmc A superagonistic monoclonal antibody for CD28 ameliorates crescentic glomerulonephritis in wistar-kyoto rats
    Yoshitsugu Takabatake
    Department of Geriatric Medicine and Nephrology B6, Osaka University Graduate School of Medicine, Suita, Japan
    Mol Med 17:686-96. 2011
    ..In conclusion, we demonstrated that treatment with JJ316 has a dramatic therapeutic effect on an experimental crescentic glomerulonephritis, possibly due to expansion and activation of Treg cells...
  84. ncbi request reprint Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells
    Masashi Ikushima
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Biochem Biophys Res Commun 339:827-32. 2006
    ..The expression of p53 and p21 was lower in Klotho-treated cells. Our study suggests that Klotho acts as a humoral factor to reduce H(2)O(2)-induced apoptosis and cellular senescence in vascular cells...
  85. doi request reprint Usefulness of bone resorption markers in hemodialysis patients
    Takayuki Hamano
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Bone 45:S19-25. 2009
    ..Taken together, both markers give us additional information that cannot be obtained just by using PTH, provided that we know the characteristics of these markers...
  86. ncbi request reprint beta2- and beta3-Adrenoceptor polymorphisms relate to subsequent weight gain and blood pressure elevation in obese normotensive individuals
    Hideki Kawaguchi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 29:951-9. 2006
    ..beta2- and beta3-adrenoceptor polymorphisms could predict the future BP elevation and further weight gain-induced BP elevation in originally obese subjects...
  87. doi request reprint Elevation of plasma beta-amyloid level by glucose loading in Alzheimer mouse models
    Shuko Takeda
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Yamadaoka, Suita, Japan
    Biochem Biophys Res Commun 385:193-7. 2009
    ..These findings might provide a novel diagnostic tool for AD using the elevation of plasma Abeta level after glucose loading...
  88. pmc Potential role of CYLD (Cylindromatosis) as a deubiquitinating enzyme in vascular cells
    Yoichi Takami
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Pathol 172:818-29. 2008
    ..In conclusion, these data demonstrate that the deubiquitinating enzyme CYLD may inhibit inflammation and proliferation in vascular cells and may represent a novel target for the treatment or prevention of atherosclerosis...
  89. doi request reprint Angiotensin-converting enzyme single nucleotide polymorphism is a genetic risk factor for cardiovascular disease: a cohort study of hypertensive patients
    Nozomi Kato
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 34:728-34. 2011
    ..Thus, the DD genotype of ACE may be a genetic risk factor for cerebro-cardiovascular disease, especially cardiovascular events, in hypertensive patients in Japan...
  90. ncbi request reprint Evaluation of morning blood pressure elevation and autonomic nervous activity in hypertensive patients using wavelet transform of heart rate variability
    Takashi Takagi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 29:977-87. 2006
    ..Our results suggest that activation of HF before waking and LF/HF during waking might play an important role in the development of morning blood pressure elevation...
  91. ncbi request reprint Klotho protein promotes adipocyte differentiation
    Yukana Chihara
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2, Yamada oka, Number B6, Suita, Osaka 565 0871, Japan
    Endocrinology 147:3835-42. 2006
    ....
  92. doi request reprint Hepatocyte growth factor attenuates transforming growth factor-β-angiotensin II crosstalk through inhibition of the PTEN/Akt pathway
    Kazuma Iekushi
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
    Hypertension 58:190-6. 2011
    ..Moreover, these renal protective effects were abrogated by a neutralizing antibody against HGF. Thus, the present study demonstrated that HGF counteracts the vicious cycle of Ang II-TGF-β1-AT(1)R, mediating the inhibition of PTEN...
  93. ncbi request reprint Adiponectin and inflammatory markers in peripheral arterial occlusive disease
    Yoshio Iwashima
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Japan
    Atherosclerosis 188:384-90. 2006
    ..Adiponectin concentration could be a marker of the existence of atherosclerosis, and measurement of its concentration may be helpful in assessment of the progress of atherosclerosis...
  94. ncbi request reprint Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients
    Norio Komai
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Am J Hypertens 15:499-506. 2002
    ..005). These results suggest that in evaluation of serum HGF concentration, the forearm vasodilator response to reactive hyperemia and PWV might be useful for managing hypertension in patients who are receiving antihypertensive therapy...
  95. doi request reprint Relationship between the achieved blood pressure and the incidence of cardiovascular events in Japanese hypertensive patients with complications: a sub-analysis of the CASE-J trial
    Toshio Ogihara
    Osaka General Medical Center, Sumiyoshi ku, Osaka, Japan
    Hypertens Res 32:248-54. 2009
    ..Further investigation in a large-scale clinical trial is needed to determine the optimal target BP for LVH patients...
  96. doi request reprint Additive interaction of metabolic syndrome and chronic kidney disease on cardiac hypertrophy, and risk of cardiovascular disease in hypertension
    Yoshio Iwashima
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Osaka, Japan
    Am J Hypertens 23:290-8. 2010
    ..We examined the association between MetS, CKD, and left ventricular hypertrophy (LVH), and prospectively investigated the predictive value of the combination of MetS and CKD for cardiovascular disease (CVD) in essential hypertension...
  97. ncbi request reprint The renin-angiotensin and adrenergic nervous system in cardiac hypertrophy in fructose-fed rats
    Kei Kamide
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Am J Hypertens 15:66-71. 2002
    ....
  98. ncbi request reprint Association of hypoadiponectinemia with impaired vasoreactivity
    Noriyuki Ouchi
    Department of Internal Medicine, Graduate School of Medicine, Osaka University, 2 2, Yamada oka, Suita, 565 0671 Osaka, Japan
    Hypertension 42:231-4. 2003
    ..Our observations suggest that hypoadiponectinemia is associated with impaired endothelium-dependent vasorelaxation and that the measurement of plasma adiponectin level might be helpful as a marker of endothelial dysfunction...
  99. ncbi request reprint [Intervention trials for elderly hypertension in Western countries]
    Hiromi Rakugi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine
    Nihon Rinsho 63:1071-7. 2005
    ..Usefulness of inhibitors of the rennin-angiotensin system has been also reported in LIFE substudy and ANBP2. It is still required to perform large scale trials in the elderly hypertension to answer these undissolved problems...
  100. ncbi request reprint [VALISH]
    Hiromi Rakugi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine
    Nihon Rinsho 64:454-8. 2006
  101. ncbi request reprint [Renin-angiotensin system]
    Hiromi Rakugi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine
    Nihon Rinsho 64:21-6. 2006