N Ouchi

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 100:2473-6. 1999
  2. ncbi request reprint Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue
    Noriyuki Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circulation 107:671-4. 2003
  3. ncbi request reprint Obesity, adiponectin and vascular inflammatory disease
    Noriyuki Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Curr Opin Lipidol 14:561-6. 2003
  4. ncbi request reprint Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 103:1057-63. 2001
  5. ncbi request reprint Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 102:1296-301. 2000
  6. ncbi request reprint PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    N Maeda
    Department of Internal Medicine and Molecular Science (B5, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes 50:2094-9. 2001
  7. ncbi request reprint Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel
    K Kishida
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita 565 0871, Japan
    J Biol Chem 276:36251-60. 2001
  8. ncbi request reprint Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 20:1595-9. 2000
  9. ncbi request reprint Enhancement of the aquaporin adipose gene expression by a peroxisome proliferator-activated receptor gamma
    K Kishida
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita 565 0871, Japan
    J Biol Chem 276:48572-9. 2001
  10. ncbi request reprint An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls
    Y Okamoto
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Japan
    Horm Metab Res 32:47-50. 2000

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 100:2473-6. 1999
    ..The present study investigated whether adiponectin could modulate endothelial function and relate to coronary disease...
  2. ncbi request reprint Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue
    Noriyuki Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circulation 107:671-4. 2003
    ..The present study investigated the association between adiponectin and CRP in the blood stream and adipose tissue...
  3. ncbi request reprint Obesity, adiponectin and vascular inflammatory disease
    Noriyuki Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Curr Opin Lipidol 14:561-6. 2003
    ..Chronic inflammatory processes contribute to the development of atherosclerosis. In this review, the authors focus on the relationship between adiponectin, a recently discovered anti-atherogenic adipocytokine, and vascular inflammation...
  4. ncbi request reprint Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 103:1057-63. 2001
    ..The present study investigated the effects of adiponectin on lipid accumulation in human monocyte-derived macrophages...
  5. ncbi request reprint Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 102:1296-301. 2000
    ..However, the intracellular signal by which adiponectin suppressed adhesion molecule expression was not elucidated. The present study investigated the mechanism of modulation for endothelial function by adiponectin...
  6. ncbi request reprint PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    N Maeda
    Department of Internal Medicine and Molecular Science (B5, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes 50:2094-9. 2001
    ..TZDs might prevent atherosclerotic vascular disease in insulin-resistant patients by inducing the production of adiponectin through direct effect on its promoter and antagonizing the effect of TNF-alpha on the adiponectin promoter...
  7. ncbi request reprint Genomic structure and insulin-mediated repression of the aquaporin adipose (AQPap), adipose-specific glycerol channel
    K Kishida
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita 565 0871, Japan
    J Biol Chem 276:36251-60. 2001
    ..Sustained up-regulation of AQPap mRNA in adipose tissue in the insulin-resistant condition may disturb glucose homeostasis by increasing plasma glycerol...
  8. ncbi request reprint Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 20:1595-9. 2000
    ..These results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy...
  9. ncbi request reprint Enhancement of the aquaporin adipose gene expression by a peroxisome proliferator-activated receptor gamma
    K Kishida
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita 565 0871, Japan
    J Biol Chem 276:48572-9. 2001
    ..We conclude that AQPap is a novel adipose-specific target gene of PPARgamma through the binding of PPARgamma-retinoid X receptor complex to the PPRE region in its promoter...
  10. ncbi request reprint An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls
    Y Okamoto
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Japan
    Horm Metab Res 32:47-50. 2000
    ..These data suggest that adiponectin is a plasma protein produced by adipose tissue and accumulates in vascular walls when the endothelial barrier is injured...
  11. ncbi request reprint The expression of SPARC in adipose tissue and its increased plasma concentration in patients with coronary artery disease
    M Takahashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Obes Res 9:388-93. 2001
    ..In the current study, we have examined the expression of secreted protein, acidic and rich in cysteine (SPARC) in adipose tissue and its significance in obesity and coronary artery disease (CAD)...
  12. ncbi request reprint Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
    T Yokota
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Blood 96:1723-32. 2000
    ..Blood. 2000;96:1723-1732)..
  13. ncbi request reprint Localization of CD9, an enhancer protein for proheparin-binding epidermal growth factor-like growth factor, in human atherosclerotic plaques: possible involvement of juxtacrine growth mechanism on smooth muscle cell proliferation
    M Nishida
    Department of Internal Medicine and Molecular Science Graduate School of Medicine, Osaka University, Japan
    Arterioscler Thromb Vasc Biol 20:1236-43. 2000
    ..CD9, when coexpressed with proHB-EGF, enhances proHB-EGF activities for SMC growth in a so-called juxtacrine manner in vitro and may be involved in atherogenesis...
  14. ncbi request reprint Aquaporin adipose, a putative glycerol channel in adipocytes
    K Kishida
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Japan
    J Biol Chem 275:20896-902. 2000
    ..Exposure of epinephrine translocated AQPap protein from perinuclear cytoplasm to the plasma membrane in 3T3-L1 adipocytes. These results strongly suggest that AQPap plays an important role in glycerol release from adipocytes...
  15. ncbi request reprint Novel LPL mutation (L303F) found in a patient associated with coronary artery disease and severe systemic atherosclerosis
    Y Saika
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan
    Eur J Clin Invest 33:216-22. 2003
    ..In this paper, we report a 55-year-old type I hyperlipidaemic patient with a novel missense mutation in the LPL gene...
  16. ncbi request reprint Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages
    Masahiro Kumada
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circulation 109:2046-9. 2004
    ..The present study was designed to elucidate the effects of adiponectin on matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in human monocyte-derived macrophages...
  17. ncbi request reprint Adiponectin down-regulates acyl-coenzyme A:cholesterol acyltransferase-1 in cultured human monocyte-derived macrophages
    Kohichiro Furukawa
    Department of Medical Biochemistry, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Biochem Biophys Res Commun 317:831-6. 2004
    ..These results demonstrate the inhibitory effect of adiponectin on ACAT-1 expression, suggesting that adiponectin may play an anti-atherogenic role by down-regulating the expression of ACAT-1 as well as SR-A in human macrophages...
  18. ncbi request reprint Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease
    Koji Ohashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    J Am Coll Cardiol 43:1195-200. 2004
    ..This study examined the association of mutations in adiponectin gene with the prevalence of coronary artery disease (CAD)...
  19. ncbi request reprint Hypoadiponectinemia is an independent risk factor for hypertension
    Yoshio Iwashima
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertension 43:1318-23. 2004
    ..01), and most of them had hypertension. In contrast, the G276T polymorphism was not associated with adiponectin concentration or hypertension. In conclusion, hypoadiponectinemia is a marker for predisposition to hypertension in men...
  20. ncbi request reprint Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street W611, Boston, Massachusetts 02118, USA
    J Biol Chem 279:28670-4. 2004
    ..Therefore, adiponectin may be useful in the treatment for obesity-related vascular deficiency diseases...
  21. pmc Adiponectin-mediated modulation of hypertrophic signals in the heart
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, Massachusetts 02118, USA
    Nat Med 10:1384-9. 2004
    ..Adiponectin may have utility for the treatment of hypertrophic cardiomyopathy associated with diabetes and other obesity-related diseases...
  22. ncbi request reprint Adiponectin replenishment ameliorates obesity-related hypertension
    Koji Ohashi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Hypertension 47:1108-16. 2006
    ....
  23. ncbi request reprint Adiponectin and cardiovascular inflammatory responses
    Yukihiro Takemura
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Curr Atheroscler Rep 9:238-43. 2007
    ..This review focuses on the anti-inflammatory properties of adiponectin in various experimental systems, especially with respect to cardiovascular diseases...
  24. ncbi request reprint Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    Cardiovasc Res 74:471-9. 2007
    ..This study investigated the expression and myocardial accumulation of adiponectin in a murine model of ischemia-reperfusion injury...
  25. ncbi request reprint Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms
    Masaki Nishimura
    Stroke and Neurovascular Regulation Laboratory, Boston University School of Medicine, Boston, MA, USA
    Circulation 117:216-23. 2008
    ..A low level of plasma adiponectin is associated with increased mortality after ischemic stroke; however, the causal role of adiponectin in ischemic stroke is unknown...
  26. doi request reprint A novel role for adiponectin in the regulation of inflammation
    Noriyuki Ouchi
    Arterioscler Thromb Vasc Biol 28:1219-21. 2008
  27. ncbi request reprint Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin
    Hideki Kobayashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circ Res 94:e27-31. 2004
    ..These data suggest that HMW adiponectin specifically confers the vascular-protective activities of this adipocytokine. The full text of this article is available online at http://circres.ahajournals.org...
  28. ncbi request reprint Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor-alpha, and insulin sensitivity
    Aafje Sierksma
    Department of Nutritional Physiology, Netherlands Organization for Applied Scientific Research Nutrition and Food Research, Zeist, The Netherlands
    Diabetes Care 27:184-9. 2004
    ..Moderate alcohol consumption may increase adiponectin, which in turn causes a decrease of tumor necrosis factor (TNF)-alpha. A decreased TNF-alpha level may consequently increase insulin sensitivity...
  29. ncbi request reprint Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease
    Carmine Zoccali
    National Research Council Center of Clinical Physiology, Reggio Calabria, Italy
    J Am Soc Nephrol 13:134-41. 2002
    ..Furthermore, ADPN is related to several metabolic risk factors in a manner consistent with the hypothesis that this protein acts as a protective factor for the cardiovascular system...
  30. ncbi request reprint Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
    Norikazu Maeda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Nat Med 8:731-7. 2002
    ..Our results indicate that adiponectin/ACRP30 deficiency and high TNF-alpha levels in KO mice reduced muscle FATP-1 mRNA and IRS-1-mediated insulin signaling, resulting in severe diet-induced insulin resistance...
  31. ncbi request reprint Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell
    Yukio Arita
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka and First Institute of New Drug Research, Otsuka Pharmaceutical Co, Ltd, Tokushima, Japan
    Circulation 105:2893-8. 2002
    ..Adiponectin also reduced PDGF-AA-stimulated or HB-EGF-stimulated ERK phosphorylation in a dose-dependent manner without affecting autophosphorylation of PDGF alpha-receptor or EGF receptor...
  32. ncbi request reprint Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome
    Hidehiko Kondo
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, B5 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes 51:2325-8. 2002
    ..Our findings suggest that I164T mutation is associated with low plasma adiponectin concentration and type 2 diabetes...
  33. ncbi request reprint Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis
    Morihiro Matsuda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 277:37487-91. 2002
    ..The current study suggests an adipo-vascular axis, a direct link between fat and artery. A therapeutic strategy to increase plasma adiponectin should be useful in preventing vascular restenosis after angioplasty...
  34. ncbi request reprint Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice
    Yoshihisa Okamoto
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circulation 106:2767-70. 2002
    ..The current study investigated whether the increased plasma adiponectin could actually reduce atherosclerosis in vivo...
  35. ncbi request reprint Disturbed secretion of mutant adiponectin associated with the metabolic syndrome
    Ken Kishida
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, B5, Osaka University, 2 2, Yamadaoka, Suita, 565 0871, Osaka, Japan
    Biochem Biophys Res Commun 306:286-92. 2003
    ..Our results suggest that I164T mutation is associated with hypoadiponectinemia through disturbed secretion into plasma, which may contribute to the development of the metabolic syndrome...
  36. ncbi request reprint Association of hypoadiponectinemia with coronary artery disease in men
    Masahiro Kumada
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Arterioscler Thromb Vasc Biol 23:85-9. 2003
    ..This study was designed to determine whether a decreased plasma adiponectin level (hypoadiponectinemia) can be independently associated with the prevalence of coronary artery disease (CAD)...
  37. ncbi request reprint Adiponectin in essential hypertension
    Francesca Mallamaci
    CNR, Center of Clinical Physiology, Reggio Calabria, Italy
    J Nephrol 15:507-11. 2002
    ..High levels in essential hypertensives may be the expression of a counter-regulatory response aimed at mitigating endothelial damage and cardiovascular risk associated with high arterial pressure...
  38. ncbi request reprint Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:1304-9. 2004
    ..These data indicate that adiponectin can function to stimulate the new blood vessel growth by promoting cross-talk between AMP-activated protein kinase and Akt signaling within endothelial cells...
  39. ncbi request reprint Association of hypoadiponectinemia with impaired vasoreactivity
    Noriyuki Ouchi
    Department of Internal Medicine, Graduate School of Medicine, Osaka University, 2 2, Yamada oka, Suita, 565 0671 Osaka, Japan
    Hypertension 42:231-4. 2003
    ..Our observations suggest that hypoadiponectinemia is associated with impaired endothelium-dependent vasorelaxation and that the measurement of plasma adiponectin level might be helpful as a marker of endothelial dysfunction...
  40. pmc Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart
    Yuichi Oshima
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University Medical School, 700 Albany St, W611, Boston, MA 02118, USA
    Circulation 117:3099-108. 2008
    ..To identify factors with novel therapeutic applications in cardiac diseases, we focused on the identification of factors secreted from Akt1-activated cells that have cardioprotective effects through autocrine/paracrine mechanisms...
  41. pmc Adiponectin promotes endothelial progenitor cell number and function
    Rei Shibata
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    FEBS Lett 582:1607-12. 2008
    ..These data suggest that hypoadiponectinemia may contribute to the depression of EPC levels that are observed in patients with obesity-related cardiovascular disorders...
  42. pmc Cyclooxygenase-2 induction by adiponectin is regulated by a sphingosine kinase-1 dependent mechanism in cardiac myocytes
    Yasumasa Ikeda
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    FEBS Lett 582:1147-50. 2008
    ..These findings suggest that APN is a physiological regulator of COX-2 signaling in the heart and that this regulation occurs in part via a SphK-1-S1P receptor dependent mechanism in cardiac myocytes...
  43. doi request reprint Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardial infarction
    Rei Shibata
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Cardiol 101:1712-5. 2008
    ....
  44. pmc Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice
    Yasuhiro Izumiya
    Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Cell Metab 7:159-72. 2008
    ..Our findings indicate that an increase in fast/glycolytic muscle mass can result in the regression of obesity and metabolic improvement through its ability to alter fatty acid oxidation in remote tissues...
  45. ncbi request reprint Targeting adiponectin for cardioprotection
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    Expert Opin Ther Targets 10:573-81. 2006
    ..Thus, adiponectin could emerge as a potential cardioprotective agent for the treatment of several pathological heart conditions...
  46. ncbi request reprint Clinical significance of high-molecular weight form of adiponectin in male patients with coronary artery disease
    Noriyuki Komura
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Circ J 72:23-8. 2008
    ..Here, the relevance of high molecular weight (HMW) adiponectin with risk factors for atherosclerosis is investigated..
  47. pmc Adiponectin protects against the development of systolic dysfunction following myocardial infarction
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA
    J Mol Cell Cardiol 42:1065-74. 2007
    ....
  48. ncbi request reprint Association of hypoadiponectinemia with smoking habit in men
    Yoshio Iwashima
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Japan
    Hypertension 45:1094-100. 2005
    ..Smoking habit is associated with adiponectin concentration in men, and its suppressive effect is mediated in part through direct inhibition of smoking on adiponectin expression in adipocytes...
  49. ncbi request reprint Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism
    Yulin Liao
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Cardiovasc Res 67:705-13. 2005
    ..However, it is not clear whether adiponectin plays an important role in CHF. We hypothesize that deficiency of adiponectin might result in deterioration of heart failure...
  50. pmc Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis
    Eric Ackah
    Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 0812, USA
    J Clin Invest 115:2119-27. 2005
    ..Thus, the Akt1 isoform exerts an essential role in blood flow control, cellular migration, and NO synthesis during postnatal angiogenesis...
  51. ncbi request reprint PKCalpha activates eNOS and increases arterial blood flow in vivo
    Chohreh Partovian
    Angiogenesis Research Center, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Circ Res 97:482-7. 2005
    ..In conclusion, these data demonstrate for the first time that PKCalpha stimulates NO production in endothelial cells and plays a role in regulation of blood flow in vivo...
  52. pmc Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms
    Rei Shibata
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Nat Med 11:1096-103. 2005
    ..These data suggest that adiponectin protects the heart from ischemia-reperfusion injury through both AMPK- and COX-2-dependent mechanisms...
  53. pmc Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction
    Gennaro Galasso
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Circ Res 98:254-61. 2006
    ..These data suggest that EPC dysfunction is a mechanism by which elevated levels of ROS can contribute to vascular disease...
  54. pmc Cardioprotection by adiponectin
    Noriyuki Ouchi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Trends Cardiovasc Med 16:141-6. 2006
    ..This review focuses on the role of adiponectin in the regulation of myocardial remodeling and acute cardiac injury...
  55. pmc Adiponectin actions in the cardiovascular system
    Teresa A Hopkins
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Cardiovasc Res 74:11-8. 2007
    ..This review will discuss the epidemiological and experimental studies that have elucidated the role of adiponectin in a variety of cardiovascular diseases...
  56. pmc Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies
    Yukihiro Takemura
    Molecular Cardiology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Clin Invest 117:375-86. 2007
    ..We propose that adiponectin protects the organism from systemic inflammation by promoting the clearance of early apoptotic cells by macrophages through a receptor-dependent pathway involving calreticulin...
  57. ncbi request reprint Circulating adiponectin levels in patients with atrial fibrillation
    Masayuki Shimano
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Circ J 72:1120-4. 2008
    ....