Shigehiro Osada

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Organization of gene structure and expression of nuclear factor 1 family in rat
    Shigehiro Osada
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    DNA Seq 16:151-5. 2005
  2. pmc Chromatin assembly factor Asf1p-dependent occupancy of the SAS histone acetyltransferase complex at the silent mating-type locus HMLalpha
    Shigehiro Osada
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University 1 6 Yamada Oka, Suita, Osaka 565 0871, Japan
    Nucleic Acids Res 33:2742-50. 2005
  3. ncbi request reprint Some organotin compounds enhance histone acetyltransferase activity
    Shigehiro Osada
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Toxicol Lett 155:329-35. 2005
  4. doi request reprint A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion
    Tomoaki Hishida
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Aichi, Japan
    FEBS J 275:5576-88. 2008
  5. doi request reprint Inositol phosphate kinase Vip1p interacts with histone chaperone Asf1p in Saccharomyces cerevisiae
    Shigehiro Osada
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi, 467 8603, Japan
    Mol Biol Rep 39:4989-96. 2012
  6. ncbi request reprint TC10-like/TC10betaLong regulates adipogenesis by controlling mitotic clonal expansion
    Atsuko Kawaji
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Aichi 467 8603, Japan
    Biol Pharm Bull 33:404-9. 2010
  7. ncbi request reprint Gelsolin, an actin regulatory protein, is required for differentiation of mouse 3T3-L1 cells into adipocytes
    Atsuko Kawaji
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    Biol Pharm Bull 33:773-9. 2010
  8. ncbi request reprint FAD24, a regulator of adipogenesis, is required for the regulation of DNA replication in cell proliferation
    Yoshikazu Johmura
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi, Japan
    Biol Pharm Bull 31:1092-5. 2008
  9. doi request reprint Interleukin enhancer-binding factor 3 functions as a liver receptor homologue-1 co-activator in synergy with the nuclear receptor co-activators PRMT1 and PGC-1α
    Masae Ohno
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Nagoya, Aichi 467 8603, Japan
    Biochem J 437:531-40. 2011
  10. ncbi request reprint Repression of the promoter activity mediated by liver receptor homolog-1 through interaction with ku proteins
    Masae Ohno
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    Biol Pharm Bull 33:784-91. 2010

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Organization of gene structure and expression of nuclear factor 1 family in rat
    Shigehiro Osada
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    DNA Seq 16:151-5. 2005
    ....
  2. pmc Chromatin assembly factor Asf1p-dependent occupancy of the SAS histone acetyltransferase complex at the silent mating-type locus HMLalpha
    Shigehiro Osada
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University 1 6 Yamada Oka, Suita, Osaka 565 0871, Japan
    Nucleic Acids Res 33:2742-50. 2005
    ..These data suggest that the HAT activity and ASF1-dependent localization of the SAS complex are required for SIR1-dependent HMLalpha silencing...
  3. ncbi request reprint Some organotin compounds enhance histone acetyltransferase activity
    Shigehiro Osada
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Toxicol Lett 155:329-35. 2005
    ....
  4. doi request reprint A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion
    Tomoaki Hishida
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Aichi, Japan
    FEBS J 275:5576-88. 2008
    ..Taken together, these results show that fad49, a novel gene, plays a crucial role in the immediate early stage of adipogenesis...
  5. doi request reprint Inositol phosphate kinase Vip1p interacts with histone chaperone Asf1p in Saccharomyces cerevisiae
    Shigehiro Osada
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi, 467 8603, Japan
    Mol Biol Rep 39:4989-96. 2012
    ..It is thought that 6-AU decreases nucleotide levels and reduces transcription elongation. These observations suggest that the association of Asf1p and Vip1p may be implicated in transcription elongation...
  6. ncbi request reprint TC10-like/TC10betaLong regulates adipogenesis by controlling mitotic clonal expansion
    Atsuko Kawaji
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Aichi 467 8603, Japan
    Biol Pharm Bull 33:404-9. 2010
    ..The results strongly suggest that TCL/TC10betaL regulates adipocyte differentiation by controlling MCE and this regulatory effect is closely linked to C/EBPbeta and C/EBPdelta expression...
  7. ncbi request reprint Gelsolin, an actin regulatory protein, is required for differentiation of mouse 3T3-L1 cells into adipocytes
    Atsuko Kawaji
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    Biol Pharm Bull 33:773-9. 2010
    ..Gelsolin plays a crucial role in the differentiation of 3T3-L1 cells into adipocytes...
  8. ncbi request reprint FAD24, a regulator of adipogenesis, is required for the regulation of DNA replication in cell proliferation
    Yoshikazu Johmura
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi, Japan
    Biol Pharm Bull 31:1092-5. 2008
    ..fad24 plays positive roles in the proliferation of pre-confluent cells as well as adipogenesis...
  9. doi request reprint Interleukin enhancer-binding factor 3 functions as a liver receptor homologue-1 co-activator in synergy with the nuclear receptor co-activators PRMT1 and PGC-1α
    Masae Ohno
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Nagoya, Aichi 467 8603, Japan
    Biochem J 437:531-40. 2011
    ..Taken together, our results suggest that ILF3 functions as a novel LRH-1 co-activator by acting synergistically with PRMT1 and PGC-1α, thereby promoting LRH-1-dependent gene expression...
  10. ncbi request reprint Repression of the promoter activity mediated by liver receptor homolog-1 through interaction with ku proteins
    Masae Ohno
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    Biol Pharm Bull 33:784-91. 2010
    ..Ku proteins may function as corepressors for various nuclear receptors including LRH-1...
  11. ncbi request reprint FAD24 acts in concert with histone acetyltransferase HBO1 to promote adipogenesis by controlling DNA replication
    Yoshikazu Johmura
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    J Biol Chem 283:2265-74. 2008
    ..Thus, FAD24 controls DNA replication by recruiting HBO1 to origins of DNA replication and is required for MCE during adipocyte differentiation...
  12. doi request reprint Crucial roles of D-type cyclins in the early stage of adipocyte differentiation
    Tomoaki Hishida
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    Biochem Biophys Res Commun 370:289-94. 2008
    ..Each of the D-type cyclins seems to play a crucial role in adipocyte differentiation by regulating MCE...
  13. doi request reprint The role of C/EBPdelta in the early stages of adipogenesis
    Tomoaki Hishida
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    Biochimie 91:654-7. 2009
    ..Taken together, these findings show that C/EBPdelta is involved in MCE and gene expression in the early stages of adipocyte differentiation...
  14. ncbi request reprint Fad24 causes hyperplasia in adipose tissue and improves glucose metabolism
    Yoshikazu Johmura
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Aichi 467 8603, Japan
    Biol Pharm Bull 32:1656-64. 2009
    ..Moreover, the increase in the number of smaller adipocytes caused by the overexpression of fad24 appears to enhance glucose metabolic activity, perhaps by increasing the serum adiponectin level...
  15. doi request reprint FAD24, a regulator of adipogenesis and DNA replication, inhibits H-RAS-mediated transformation by repressing NF-kappaB activity
    Yoshikazu Johmura
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    Biochem Biophys Res Commun 369:464-70. 2008
    ..The over-expression of fad24 repressed NF-kappaB-mediated promoter activity and gene expression. Taken together, these results reveal a novel role for fad24 in the repression of NF-kappaB activity and H-ras-mediated transformation...
  16. pmc FAD104, a regulatory factor of adipogenesis, acts as a novel regulator of calvarial bone formation
    Keishi Kishimoto
    From the Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    J Biol Chem 288:31772-83. 2013
    ..These findings will aid a comprehensive description of the mechanism that controls normal and premature calvarial ossification. ..
  17. pmc Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis
    Kumiko Ohta
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem J 402:559-66. 2007
    ..Further, exogenous MOZ induced GSTP expression in rat hepatoma H4IIE cells. These results suggest that during early hepatocarcinogenesis, aberrantly expressed MOZ may induce GSTP expression through the Nrf2-mediated pathway...
  18. ncbi request reprint Interactions of thyroid hormone receptor with Ku proteins and interleukin enhancer binding factor 3 modulate the promoter activity of thyroid-stimulating hormone alpha
    Masae Ohno
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Nagoya, Aichi, Japan
    Biol Pharm Bull 35:380-4. 2012
    ..Taken together, our results suggest that Ku proteins and ILF3 function as co-regulators for TR-mediated TSHα expression...
  19. ncbi request reprint Factor for adipocyte differentiation 158 gene disruption prevents the body weight gain and insulin resistance induced by a high-fat diet
    Takahiro Hayashi
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi, Japan
    Biol Pharm Bull 34:1257-63. 2011
    ..These results indicate that fad158 is a key factor in the development of obesity and insulin resistance caused by a high-fat diet...
  20. ncbi request reprint Histone modification enzymes induced during chemical hepatocarcinogenesis
    Shigehiro Osada
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    Yakugaku Zasshi 127:469-79. 2007
    ..Here I review the characterization and functions of these factors and discuss the mechanisms of tumor marker gene expression during chemical hepatocarcinogenesis...
  21. ncbi request reprint Toxicity of nickel compounds mediated by HTZ1, histone variant H2A.Z, in Saccharomyces cerevisiae
    Shigehiro Osada
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Aichi, Japan
    Biol Pharm Bull 31:2007-11. 2008
    ..Taken together, these results reveal that the incorporation into chromatin, but not acetylation, of Htz1p is important to the toxicity of nickel compounds...
  22. doi request reprint Wnt4 and Wnt5a promote adipocyte differentiation
    Makoto Nishizuka
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Nagoya, Aichi 467 8603, Japan
    FEBS Lett 582:3201-5. 2008
    ..Furthermore, the inhibition of Wnt4 or Wnt5a expression prevented the accumulation of triacylglycerol and decreased the expression of adipogenesis-related genes. Wnt4 and Wnt5a have crucial roles in adipogenesis as positive regulators...
  23. doi request reprint Targeted disruption of fad24, a regulator of adipogenesis, causes pre-implantation embryonic lethality due to the growth defect at the blastocyst stage
    Natsuki Ochiai
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    Biochem Biophys Res Commun 438:301-5. 2013
    ..These results strongly suggested that fad24 is essential for pre-implantation in embryonic development, particularly for the progression to the blastocyst stage. ..
  24. ncbi request reprint Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration
    Makoto Nishizuka
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    Exp Cell Res 315:809-19. 2009
    ..These results indicate that fad104 is essential for the survival of newborns just after birth and important for cell proliferation, adhesion, spreading and migration...
  25. doi request reprint Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression
    Masae Ohno
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi 467 8603, Japan
    Biochem Biophys Res Commun 390:738-42. 2009
    ..Furthermore, we demonstrated that ectopic expression of the Ku proteins decreased the promoter activity and expression of BSEP gene mediated by FXR. These results suggest that the Ku proteins function as corepressors for FXR...
  26. doi request reprint Elevated expression of coactivator-associated arginine methyltransferase 1 is associated with early hepatocarcinogenesis
    Shigehiro Osada
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi 467 8603, Japan
    Oncol Rep 30:1669-74. 2013
    ..Knockdown of Carm1 by shRNA in H4IIE cells inhibited cell proliferation. These findings suggest that aberrantly expressed CARM1 in tumor marker-positive cells promotes tumorigenesis in the early stages of hepatocarcinogenesis. ..
  27. ncbi request reprint peg10, an imprinted gene, plays a crucial role in adipocyte differentiation
    Tomoaki Hishida
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    FEBS Lett 581:4272-8. 2007
    ..These findings strongly indicate that peg10 plays a crucial role at the immediate early stage of adipocyte differentiation...
  28. doi request reprint Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors via a peroxisome proliferator responsive element
    Keisuke Tachibana
    Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biochem 154:265-73. 2013
    ..These results indicate that human, but not rat, MBL2 expression is regulated by PPARs via a PPRE...
  29. ncbi request reprint Functional analysis of zinc finger proteins that bind to the silencer element in the glutathione transferase P gene
    Atsuhiro Tanabe
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Yamada oka, Suita, Japan
    Biol Pharm Bull 25:970-4. 2002
    ..Moreover, transfection analyses revealed that BTEB2, EZF, and TIEGI repressed the GST-P promoter activity. Therefore, these three factors might contribute to the repression of the GST-P gene expression in normal rat liver...
  30. ncbi request reprint Altered gene expression of transcriptional regulatory factors in tumor marker-positive cells during chemically induced hepatocarcinogenesis
    Shigehiro Osada
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Toxicol Lett 167:106-13. 2006
    ..DNA microarray analysis using RNA prepared from tumor marker-positive foci and control tissues provided a candidate gene link to the early stage of carcinogenesis and hepatotoxicity...
  31. ncbi request reprint [Functional link between histone acetyltransferase and chromatin assembling factor in gene silencing]
    Shigehiro Osada
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Seikagaku 75:297-301. 2003
  32. ncbi request reprint Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex
    Ann Sutton
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794 5215, USA
    J Biol Chem 278:16887-92. 2003
    ....
  33. ncbi request reprint Nuclear factor 1 family members interact with hepatocyte nuclear factor 1alpha to synergistically activate L-type pyruvate kinase gene transcription
    Shin ichi Satoh
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    J Biol Chem 280:39827-34. 2005
    ..Thus, we conclude that cooperative interaction between NF1 family members and HNF1alpha plays an important role in hepatic L-PK transcription...
  34. ncbi request reprint Characterization of the yeast trimeric-SAS acetyltransferase complex
    Wei Jong Shia
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    J Biol Chem 280:11987-94. 2005
    ..This specific lysine preference corresponds to the role of SAS complex in antagonizing the spreading of Sir proteins at silent loci in S. cerevisiae...
  35. ncbi request reprint Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors
    Hiroko Usami
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 280:25267-76. 2005
    ....