Masayasu Okochi

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Secretion of the Notch-1 Abeta-like peptide during Notch signaling
    Masayasu Okochi
    Department of Post Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    J Biol Chem 281:7890-8. 2006
  2. pmc The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system
    Kanta Yanagida
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    EMBO Mol Med 1:223-35. 2009
  3. doi request reprint γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43
    Masayasu Okochi
    Neuropsychiatry and Neurochemistry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Cell Rep 3:42-51. 2013
  4. doi request reprint Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients
    Masayasu Okochi
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurodegener Dis 7:42-5. 2010
  5. doi request reprint Association study of KIBRA gene with memory performance in a Japanese population
    Yuka Yasuda
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    World J Biol Psychiatry 11:852-7. 2010
  6. doi request reprint The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 116:126-32. 2010
  7. doi request reprint The AKT1 gene is associated with attention and brain morphology in schizophrenia
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    World J Biol Psychiatry 14:100-13. 2013
  8. doi request reprint The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel
    Kohji Mori
    Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Psychogeriatrics 10:117-23. 2010
  9. doi request reprint Processes of beta-amyloid and intracellular cytoplasmic domain generation by presenilin/gamma-secretase
    Shinji Tagami
    Department of Post Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurodegener Dis 5:160-2. 2008
  10. pmc Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1
    Masayasu Okochi
    Department of Post Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, 565 0871 Osaka, Japan
    EMBO J 21:5408-16. 2002

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Secretion of the Notch-1 Abeta-like peptide during Notch signaling
    Masayasu Okochi
    Department of Post Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    J Biol Chem 281:7890-8. 2006
    ..We anticipate that this study will open the door to searches for markers of RIP signaling and surrogate markers for Abeta42 production...
  2. pmc The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system
    Kanta Yanagida
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    EMBO Mol Med 1:223-35. 2009
    ..Based on these results, we propose the relative level of APL1beta28 in the CSF as a candidate surrogate marker for the relative level of Abeta42 production in the brain...
  3. doi request reprint γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43
    Masayasu Okochi
    Neuropsychiatry and Neurochemistry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Cell Rep 3:42-51. 2013
    ..Therefore, we suggest a concept to describe the Aβ42(43) production process and propose how GSMs act, and we suggest that a loss of PS/γ-secretase function to cleave Aβ42(43) may initiate AD and might represent a therapeutic target...
  4. doi request reprint Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients
    Masayasu Okochi
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurodegener Dis 7:42-5. 2010
    ..g. Abeta) in the brain, or (c) develop biomarkers for predicting the accumulation of Abeta/tau in the brain. Our recent discovery of APL1beta28, a possible biomarker of AD, may help in the development of early detection methods for AD...
  5. doi request reprint Association study of KIBRA gene with memory performance in a Japanese population
    Yuka Yasuda
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    World J Biol Psychiatry 11:852-7. 2010
    ..KIBRA is highly expressed in the brain and kidneys, and is reported to be involved in synaptic plasticity. Therefore, we first tried to replicate the association between the SNP and memory performance in a Japanese subjects...
  6. doi request reprint The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 116:126-32. 2010
    ..003). We conclude that the genetic variants in the CHI3L1 gene have ethnic heterogeneity and confer a susceptibility to schizophrenia in Asian populations...
  7. doi request reprint The AKT1 gene is associated with attention and brain morphology in schizophrenia
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    World J Biol Psychiatry 14:100-13. 2013
    ..A meta-analysis of the associations between genetic variants in the AKT1 gene and schizophrenia found that a single nucleotide polymorphism (SNP5; rs2494732) was associated with schizophrenia in Asian populations...
  8. doi request reprint The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel
    Kohji Mori
    Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Psychogeriatrics 10:117-23. 2010
    ..Thus, one might evaluate compounds by analyzing the generation ratio of the βAPP intracellular domain (AICD) species (ε-cleavage-derived), instead of that of Aβ42...
  9. doi request reprint Processes of beta-amyloid and intracellular cytoplasmic domain generation by presenilin/gamma-secretase
    Shinji Tagami
    Department of Post Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurodegener Dis 5:160-2. 2008
    ..Gamma-/S4 and epsilon-cleavages have diversity, and produce a number of Abeta/Nbeta and AICD species. S3 cleavage diversity has been recently identified. It is significant that each cleavage occurs with strict precision, not randomly...
  10. pmc Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1
    Masayasu Okochi
    Department of Post Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, 565 0871 Osaka, Japan
    EMBO J 21:5408-16. 2002
    ..Considering these similarities between intramembranous processing of Notch and betaAPP, we conclude that these proteins are cleaved by a common mechanism utilizing the same protease, i.e. PS/gamma-secretase...
  11. doi request reprint The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Suite, Osaka, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:1459-64. 2010
    ..018). In contrast, there was no genotype effect for any index in the healthy control subjects (P > 0.05). Our data suggest that rs1344706 may be related to memory dysfunction in schizophrenia. © 2010 Wiley-Liss, Inc...
  12. doi request reprint Involvement of endoplasmic reticulum stress in tauopathy
    Yukako Sakagami
    Department of Psychiatry, Osaka University Graduate School of Medicine, D3 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 430:500-4. 2013
    ..This mechanism may provide clue to treatment for tauopathy...
  13. pmc Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1
    Shinji Tagami
    Department of Post Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, D3, Yamada oka 2 2, Suita, Osaka 565 0871, Japan
    Mol Cell Biol 28:165-76. 2008
    ....
  14. ncbi request reprint Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct
    Akio Fukumori
    Division of Psychiatry and Behavioral Proteomics, Department of Post Genomics and Diseases, Osaka University Graduate School of Medicine, Osaka, Japan
    Biochemistry 45:4907-14. 2006
    ..These results suggest that the precision of cleavage by the PS/gamma-secretase complex may be physiologically regulated by the subcellular location and conditions...
  15. doi request reprint Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor
    Naohiro Itoh
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Neurodegener Dis 6:230-9. 2009
    ..Therefore, the data demonstrate that Dx-E represents a novel Abeta-reducing process which could have fewer side effects than secretase inhibitors...
  16. doi request reprint Apolipoprotein E and central nervous system disorders: reviews of clinical findings
    Masatoshi Takeda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Psychiatry Clin Neurosci 64:592-607. 2010
    ..The pathogenic role of ApoE-4 is still to be clarified; however, diverse evidence suggests that ApoE may play pleiotropic functions in dementia and central nervous system disorders...
  17. ncbi request reprint The unfolded protein response is involved in the pathology of Alzheimer's disease
    Takashi Kudo
    Department of Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Ann N Y Acad Sci 977:349-55. 2002
    ..Experimental manipulation of IRE1, PERK, or eIF2alpha phosphorylation or GRP78 expression might allow the development of therapeutic strategies for FAD...
  18. ncbi request reprint [Surrogate marker for ABeta42]
    Masayasu Okochi
    Psychiatry Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 30:169-72. 2010
    ..g., Abeta in the brain, or develop biomarkers for predicting Abeta/tau accumulation in the brain. Our recent discovery of APL1beta28, a possible biomarker of AD, may contribute to early detection of AD...
  19. ncbi request reprint [Amyloid-beta 42 generating process may have a biological role in regulation of Notch signaling intensity]
    Shinji Tagami
    Laboratory Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, D3, 2 2 Yamadaoka, Suita 565 0871, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 28:177-83. 2008
    ....
  20. doi request reprint Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death
    Kiyoko Kato
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Psychogeriatrics 11:90-7. 2011
    ..In the present study, we report on the possible role of PKC in cell survival during conditions of stress through phosphorylation of the X-linked inhibitor of apoptosis protein (XIAP)...
  21. ncbi request reprint Biological markers as outcome measures for Alzheimer's disease interventions--real problems and future possibilities
    Masatoshi Takeda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Japan
    Int Psychogeriatr 19:391-400. 2007
    ..In this study we examine whether the mechanism of secretase activity will offer a new surrogate marker of AD...
  22. ncbi request reprint Altered localization of amyloid precursor protein under endoplasmic reticulum stress
    Takashi Kudo
    Division of Psychiatry, Course of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Biochem Biophys Res Commun 344:525-30. 2006
    ..These findings suggest that induction of BiP/GRP78 during ER stress may be one of the regulatory mechanisms of Abeta generation...
  23. pmc Laughter and humor as complementary and alternative medicines for dementia patients
    Masatoshi Takeda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan
    BMC Complement Altern Med 10:28. 2010
    ..The number of dementia patients has increased worldwide, with an estimated 13.7 million dementia patients in the Asia Pacific region alone. This number is expected to increase to 64.6 million by the year 2050...
  24. doi request reprint Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress
    Teruhiko Mitsuda
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 415:519-25. 2011
    ..This study is the first report identifying the transcription factor regulating Sig-1Rs expression...
  25. doi request reprint KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort
    Noriyuki Hayashi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Japan
    Dement Geriatr Cogn Disord 30:302-8. 2010
    ..Importantly, the association between KIBRA and episodic memory in AD has never been addressed. In this study, we investigated whether the KIBRA rs17070145 SNP influences AD episodic memory and the disease in a Japanese cohort...
  26. doi request reprint Relative ratio and level of amyloid-β 42 surrogate in cerebrospinal fluid of familial Alzheimer disease patients with presenilin 1 mutations
    Shinji Tagami
    Neuropsychiatry and Neurochemistry, Division of Internal Medicine, Department of Integrated Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Neurodegener Dis 13:166-70. 2014
    ....
  27. doi request reprint Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier
    Takashi Morihara
    Department of Psychiatry, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 111:2638-43. 2014
    ..This unique combination of distinct mouse strains and model mice with transcriptomics is expected to be useful for the study of genetic mechanisms of other complex diseases. ..
  28. ncbi request reprint Development of new screening system for Alzheimer disease, in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils
    Naoyuki Sato
    Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurobiol Dis 22:487-95. 2006
    ..Here, we proposed that Abeta42 was more resistant to dissociation from fibrils to monomers and/or LMW soluble oligomers than Abeta40, and this system might be useful to identify dissociation of soluble Abeta from fibrils...
  29. pmc Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation
    Kiyoko Okamoto
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    J Virol 82:8349-61. 2008
    ..These results suggest that intramembrane processing of HCV core protein by SPP is required for the localization of the HCV core protein in the DRM and for viral propagation...
  30. doi request reprint Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia
    Hidetoshi Takahashi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Neurosci Res 62:187-94. 2008
    ..This did not correlate with any clinical variable in each group. Our results indicate that PPI and habituation of ASR are impaired in Asian patients with schizophrenia...
  31. ncbi request reprint FAD-linked presenilin-1 mutants impede translation regulation under ER stress
    Yuka Yasuda
    Division of Psychiatry and Behavioral Proteomics, Department of Post Genomics and Diseases, Course of Advanced Medicine, Graduate School of Medicine, Osaka University, 2 2, Yamadaoka, Siuta, Osaka, Japan
    Biochem Biophys Res Commun 296:313-8. 2002
    ....
  32. doi request reprint Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 109:80-5. 2009
    ..However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population...