Yukihiro Ohno


Affiliation: Osaka University of Pharmaceutical Sciences
Country: Japan


  1. Kinboshi M, Shimizu S, Mashimo T, Serikawa T, Ito H, Ikeda A, et al. Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats. Int J Mol Sci. 2019;20: pubmed publisher
    ..1 channels in astrocytes is involved in audiogenic epileptogenesis caused by Lgi1 mutation. In addition, VPA seemed to have a prophylactic effect on Lgi1-related seizures. ..
  2. Iha H, Kunisawa N, Shimizu S, Onishi M, Nomura Y, Matsubara N, et al. Mechanism Underlying Organophosphate Paraoxon-Induced Kinetic Tremor. Neurotox Res. 2019;35:575-583 pubmed publisher
    ..The present results suggest that OPs elicit kinetic tremor at least partly by activating IO neurons via nACh receptors. ..
  3. Ohno Y, Kinboshi M, Shimizu S. Inwardly Rectifying Potassium Channel Kir4.1 as a Novel Modulator of BDNF Expression in Astrocytes. Int J Mol Sci. 2018;19: pubmed publisher
    ..1 channels, with a focus on their regulation of spatial K⁺ buffering and BDNF expression in astrocytes, and discuss the role of the astrocytic Kir4.1-BDNF system in modulating CNS disorders. ..
  4. Ohno Y, Shimizu S, Tokudome K, Kunisawa N, Sasa M. New insight into the therapeutic role of the serotonergic system in Parkinson's disease. Prog Neurobiol. 2015;134:104-21 pubmed publisher
    ..All these findings emphasize the therapeutic roles of the serotonergic system in PD and stimulate new insight into novel treatments by modulating 5-HT1A and 5-HT2 receptors. ..
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    Ohno Y, Sofue N, Imaoku T, Morishita E, Kumafuji K, Sasa M, et al. Serotonergic modulation of absence-like seizures in groggy rats: a novel rat model of absence epilepsy. J Pharmacol Sci. 2010;114:99-105 pubmed
    ..The present results suggest that the serotonergic system negatively regulates the incidence of absence seizures by stimulation of 5-HT(1A) and 5-HT(2) receptors. ..
  6. Ohno Y, Shimizu S, Harada Y, Morishita M, Ishihara S, Kumafuji K, et al. Regional expression of Fos-like immunoreactivity following seizures in Noda epileptic rat (NER). Epilepsy Res. 2009;87:70-6 pubmed publisher
    ..g., pons-medulla oblongata). These results suggest that GTC seizures in NER are of forebrain origin and are evoked primarily by activation of the limbic and/or cortical seizure circuits. ..
  7. Ohno Y, Okano M, Imaki J, Tatara A, Okumura T, Shimizu S. Atypical antipsychotic properties of blonanserin, a novel dopamine D2 and 5-HT2A antagonist. Pharmacol Biochem Behav. 2010;96:175-80 pubmed publisher
    ..In addition, AD-6048 seems to contribute at least partly to the atypical properties of blonanserin. ..
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    Ohno Y. New insight into the therapeutic role of 5-HT1A receptors in central nervous system disorders. Cent Nerv Syst Agents Med Chem. 2010;10:148-57 pubmed
    ..g., inhibition of serotonin transporter, dopamine D(2) receptors and other 5-HT receptor subtypes). Such new 5-HT(1A) ligands may overcome clinical efficacy limitations and/or improve adverse reactions in current CNS therapies. ..
  9. Ohno Y, Shimizu S, Imaki J, Ishihara S, Sofue N, Sasa M, et al. Evaluation of the antibradykinetic actions of 5-HT1A agonists using the mouse pole test. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:1302-7 pubmed publisher
    ..p. for 3 days). These results suggest that 5-HT1A agonists improve extrapyramidal motor disorders associated with antipsychotic treatments by stimulating the postsynaptic 5-HT1A receptor. ..

More Information


  1. Tatara A, Shimizu S, Masui A, Tamura M, Minamimoto S, Mizuguchi Y, et al. Atypical antipsychotic properties of AD-6048, a primary metabolite of blonanserin. Pharmacol Biochem Behav. 2015;138:14-9 pubmed publisher
    ..These results indicate that AD-6048 acts as an atypical antipsychotic, which seems to at least partly contribute to the atypicality of blonanserin. ..
  2. Shimizu S, Mizuguchi Y, Sobue A, Fujiwara M, Morimoto T, Ohno Y. Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in mice. J Pharmacol Sci. 2015;127:439-45 pubmed publisher
    ..In addition, second generation antipsychotics, which can stimulate 5-HT1A receptors or antagonize 5-HT2 and 5-HT6 receptors, seem to be favorable as an adjunctive therapy for BPSD. ..
  3. Kunisawa N, Shimizu S, Kato M, Iha H, Iwai C, Hashimura M, et al. Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents. J Pharmacol Sci. 2018;137:162-169 pubmed publisher
  4. Ohno Y, Shimizu S, Imaki J, Ishihara S, Sofue N, Sasa M, et al. Anticataleptic 8-OH-DPAT preferentially counteracts with haloperidol-induced Fos expression in the dorsolateral striatum and the core region of the nucleus accumbens. Neuropharmacology. 2008;55:717-23 pubmed publisher
  5. Kunisawa N, Iha H, Shimizu S, Tokudome K, Mukai T, Kinboshi M, et al. Nicotine evokes kinetic tremor by activating the inferior olive via α7 nicotinic acetylcholine receptors. Behav Brain Res. 2016;314:173-80 pubmed publisher
    ..The present results suggest that nicotine elicits kinetic tremor in rodents by activating the IO neurons via α7 nACh receptors. ..
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    Ohno Y, Shimizu S, Imaki J. Effects of tandospirone, a 5-HT1A agonistic anxiolytic agent, on haloperidol-induced catalepsy and forebrain Fos expression in mice. J Pharmacol Sci. 2009;109:593-9 pubmed
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    Shimizu S, Mizuguchi Y, Ohno Y. Improving the treatment of schizophrenia: role of 5-HT receptors in modulating cognitive and extrapyramidal motor functions. CNS Neurol Disord Drug Targets. 2013;12:861-9 pubmed
  8. Ohno Y, Okumura T, Terada R, Ishihara S, Serikawa T, Sasa M. Kindling-associated SV2A expression in hilar GABAergic interneurons of the mouse dentate gyrus. Neurosci Lett. 2012;510:93-8 pubmed publisher
    ..The present study suggests that SV2A specifically regulates hilar GABAergic neurotransmission in the kindled hippocampus probably as a compensatory or prophylactic mechanism against kindling epileptogenesis. ..
  9. Ohno Y, Ishihara S, Mashimo T, Sofue N, Shimizu S, Imaoku T, et al. Scn1a missense mutation causes limbic hyperexcitability and vulnerability to experimental febrile seizures. Neurobiol Dis. 2011;41:261-9 pubmed publisher
  10. Shimizu S, Sogabe S, Yanagisako R, Inada A, Yamanaka M, Iha H, et al. Glycine-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway. Int J Mol Sci. 2017;18: pubmed publisher
  11. Ohno Y, Imaki J, Mae Y, Takahashi T, Tatara A. Serotonergic modulation of extrapyramidal motor disorders in mice and rats: role of striatal 5-HT3 and 5-HT6 receptors. Neuropharmacology. 2011;60:201-8 pubmed publisher
    ..These results suggest that serotonergic stimulation augments extrapyramidal motor disorders by activating the striatal 5-HT(3) and 5-HT(6) receptors and the antagonism of these receptors effectively alleviates antipsychotic-induced EPS. ..
  12. Ohno Y, Sofue N, Ishihara S, Mashimo T, Sasa M, Serikawa T. Scn1a missense mutation impairs GABAA receptor-mediated synaptic transmission in the rat hippocampus. Biochem Biophys Res Commun. 2010;400:117-22 pubmed publisher
  13. Ohno Y, Okano M, Masui A, Imaki J, Egawa M, Yoshihara C, et al. Region-specific elevation of D? receptor-mediated neurotransmission in the nucleus accumbens of SHR, a rat model of attention deficit/hyperactivity disorder. Neuropharmacology. 2012;63:547-54 pubmed publisher
    ..The present study suggests that D? receptor-mediated neurotransmission in the AcC is region-specifically elevated in SHR, which could be responsible for behavioral hyperactivity. ..
  14. Kunisawa N, Iha H, Nomura Y, Onishi M, Matsubara N, Shimizu S, et al. Serotonergic modulation of nicotine-induced kinetic tremor in mice. J Pharmacol Sci. 2017;134:131-138 pubmed publisher
    ..In addition, 5-HT2 receptors have an inhibitory modulatory role in induction of nicotine tremor. ..
  15. Ohno Y, Ishihara S, Terada R, Serikawa T, Sasa M. Antiepileptogenic and anticonvulsive actions of levetiracetam in a pentylenetetrazole kindling model. Epilepsy Res. 2010;89:360-4 pubmed publisher
    ..The present study shows that LEV contrasts VPA by preventing the development of PTZ kindling and inhibiting seizures selectively in kindled animals...