Hiroaki Ohigashi

Summary

Affiliation: Osaka Medical Center for Cancer and Cardiovascular Diseases
Country: Japan

Publications

  1. pmc Liver metastasis originating from colorectal cancer with macroscopic portal vein tumor thrombosis: a case report and review of the literature
    Yoshito Tomimaru
    Department of Surgery, Yao Municipal Hospital, Osaka, Japan
    J Med Case Reports 4:382. 2010
  2. ncbi request reprint A simple and safe anastomosis in pancreaticogastrostomy using mattress sutures
    Hiroaki Ohigashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Am J Surg 196:130-4. 2008
  3. ncbi request reprint Feasibility and efficacy of combination therapy with preoperative and postoperative chemoradiation, extended pancreatectomy, and postoperative liver perfusion chemotherapy for locally advanced cancers of the pancreatic head
    Hiroaki Ohigashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Ann Surg Oncol 12:629-36. 2005
  4. doi request reprint Feasibility and efficacy of combination therapy with preoperative full-dose gemcitabine, concurrent three-dimensional conformal radiation, surgery, and postoperative liver perfusion chemotherapy for T3-pancreatic cancer
    Hiroaki Ohigashi
    Departments of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashi nari ku, Osaka 537 8511, Japan
    Ann Surg 250:88-95. 2009
  5. ncbi request reprint Early ligation of the inferior pancreaticoduodenal artery to reduce blood loss during pancreaticoduodenectomy
    Hiroaki Ohigashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Hepatogastroenterology 51:4-5. 2004
  6. ncbi request reprint Intra-arterial infusion chemotherapy with angiotensin-II for locally advanced and nonresectable pancreatic adenocarcinoma: further evaluation and prognostic implications
    Hiroaki Ohigashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Surg Oncol 10:927-34. 2003
  7. doi request reprint Effects of neoadjuvant chemotherapy on primary tumor and lymph node metastasis in esophageal squamous cell carcinoma: additive association with prognosis
    Hirofumi Akita
    Department of Digestive Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Dis Esophagus 22:291-7. 2009
  8. doi request reprint Myelotoxicity of preoperative chemoradiotherapy is a significant determinant of poor prognosis in patients with T4 esophageal cancer
    Norikatsu Miyoshi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Surg Oncol 99:302-6. 2009
  9. doi request reprint Effects of intraperitoneal chemotherapy with mitomycin C on the prevention of peritoneal recurrence in colorectal cancer patients with positive peritoneal lavage cytology findings
    Shingo Noura
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Surg Oncol 18:396-404. 2011
  10. doi request reprint Preoperative chemoradiation reduces the risk of pancreatic fistula after distal pancreatectomy for pancreatic adenocarcinoma
    Hidenori Takahashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Surgery 150:547-56. 2011

Detail Information

Publications85

  1. pmc Liver metastasis originating from colorectal cancer with macroscopic portal vein tumor thrombosis: a case report and review of the literature
    Yoshito Tomimaru
    Department of Surgery, Yao Municipal Hospital, Osaka, Japan
    J Med Case Reports 4:382. 2010
    ..Macroscopic tumor thrombi occupying the main portal branch are rarely seen in patients with liver metastasis...
  2. ncbi request reprint A simple and safe anastomosis in pancreaticogastrostomy using mattress sutures
    Hiroaki Ohigashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Am J Surg 196:130-4. 2008
    ..Postoperative amylase levels in the drainage fluid decreased significantly and none of the 17 patients developed pancreatic fistula formation. The technique is simple and shortens the time required for anastomosis...
  3. ncbi request reprint Feasibility and efficacy of combination therapy with preoperative and postoperative chemoradiation, extended pancreatectomy, and postoperative liver perfusion chemotherapy for locally advanced cancers of the pancreatic head
    Hiroaki Ohigashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Ann Surg Oncol 12:629-36. 2005
    ..We performed a combination of chemoradiation and liver perfusion chemotherapy and extended pancreatectomy...
  4. doi request reprint Feasibility and efficacy of combination therapy with preoperative full-dose gemcitabine, concurrent three-dimensional conformal radiation, surgery, and postoperative liver perfusion chemotherapy for T3-pancreatic cancer
    Hiroaki Ohigashi
    Departments of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashi nari ku, Osaka 537 8511, Japan
    Ann Surg 250:88-95. 2009
    ....
  5. ncbi request reprint Early ligation of the inferior pancreaticoduodenal artery to reduce blood loss during pancreaticoduodenectomy
    Hiroaki Ohigashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Hepatogastroenterology 51:4-5. 2004
    ..This approach was feasible in reducing blood loss presumably related to blood congestion...
  6. ncbi request reprint Intra-arterial infusion chemotherapy with angiotensin-II for locally advanced and nonresectable pancreatic adenocarcinoma: further evaluation and prognostic implications
    Hiroaki Ohigashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Surg Oncol 10:927-34. 2003
    ..In our preliminary report, this treatment resulted in a median of 14 months of survival without objective adverse effects. This study was designed to clarify the prognostic factor in this chemotherapy by using a larger number of cases...
  7. doi request reprint Effects of neoadjuvant chemotherapy on primary tumor and lymph node metastasis in esophageal squamous cell carcinoma: additive association with prognosis
    Hirofumi Akita
    Department of Digestive Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Dis Esophagus 22:291-7. 2009
    ..0255) in addition to the number of histological lymph node metastases (HR 2.551, P = 0.0328). The response to NACT in LNM and PT correlates closely with postoperative survival. A good response in both enhances the postoperative prognosis...
  8. doi request reprint Myelotoxicity of preoperative chemoradiotherapy is a significant determinant of poor prognosis in patients with T4 esophageal cancer
    Norikatsu Miyoshi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Surg Oncol 99:302-6. 2009
    ..This study retrospectively analyzed the prognostic factors in patients with curatively resected cancer after chemoradiotherapy...
  9. doi request reprint Effects of intraperitoneal chemotherapy with mitomycin C on the prevention of peritoneal recurrence in colorectal cancer patients with positive peritoneal lavage cytology findings
    Shingo Noura
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Surg Oncol 18:396-404. 2011
    ..The aim of this study was to investigate the effects of intraperitoneal chemotherapy (IPC) with mitomycin C (MMC) on preventing peritoneal recurrence in CRC patients with positive peritoneal lavage cytology findings...
  10. doi request reprint Preoperative chemoradiation reduces the risk of pancreatic fistula after distal pancreatectomy for pancreatic adenocarcinoma
    Hidenori Takahashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Surgery 150:547-56. 2011
    ..In this context, the impact of preoperative chemoradiation therapy (CRT) on PF formation after distal pancreatectomy is of interest...
  11. doi request reprint Perineural invasion and lymph node involvement as indicators of surgical outcome and pattern of recurrence in the setting of preoperative gemcitabine-based chemoradiation therapy for resectable pancreatic cancer
    Hidenori Takahashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Surg 255:95-102. 2012
    ..To analyze the histopathological indicators significantly associated with surgical outcome and the pattern of recurrence in the setting of preoperative gemcitabine-based chemoradiation therapy (CRT) and subsequent pancreatectomy...
  12. doi request reprint Feasibility of a lateral region sentinel node biopsy of lower rectal cancer guided by indocyanine green using a near-infrared camera system
    Shingo Noura
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka, Japan
    Ann Surg Oncol 17:144-51. 2010
    ..The aim of this study was to investigate the feasibility of lateral region SN biopsy by means of indocyanine green (ICG) visualized with a near-infrared camera system (Photodynamic Eye, PDE)...
  13. doi request reprint CEA-antigen and SCC-antigen mRNA expression in peripheral blood predict hematogenous recurrence after resection in patients with esophageal cancer
    Koji Tanaka
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Surg Oncol 17:2779-86. 2010
    ..The aim of this study was to prospectively examine the correlation between CTC and outcome in a large number of patients who underwent esophagectomy...
  14. doi request reprint Laparoscopic detection of sentinel node in gastric cancer surgery by indocyanine green fluorescence imaging
    Isao Miyashiro
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka, 537 8511, Japan
    Surg Endosc 25:1672-6. 2011
    ..However, the ICG fluorescence imaging system cannot be used in laparoscopic surgery because of technological difficulties...
  15. doi request reprint Staging laparoscopy using ALA-mediated photodynamic diagnosis improves the detection of peritoneal metastases in advanced gastric cancer
    Kentaro Kishi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Surg Oncol 106:294-8. 2012
    ..This study evaluated the usefulness of photodynamic diagnosis (PDD) using oral 5-aminolevulinic acid (ALA) for the detection of peritoneal metastases in advanced gastric cancer...
  16. ncbi request reprint Advantage of pancreaticogastrostomy in detecting recurrent intraductal papillary mucinous carcinoma in the remnant pancreas: a case of successful re-resection after pancreaticoduodenectomy
    Yoshito Tomimaru
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Japan
    J Surg Oncol 93:511-5. 2006
    ..Based on this experience, we decided to recommend PG for all patients deemed to be at high risk for the recurrence of cancer in the pancreatic remnants following PD for IPMC of the pancreatic head...
  17. doi request reprint Comparison between radical esophagectomy and definitive chemoradiotherapy in patients with clinical T1bN0M0 esophageal cancer
    Masaaki Motoori
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Surg Oncol 19:2135-41. 2012
    ..However, to our knowledge, no comparative studies of esophagectomy and CRT have been reported in clinical T1bN0M0 esophageal cancer...
  18. ncbi request reprint Association of the primary tumor location with the site of tumor recurrence after curative resection of thoracic esophageal carcinoma
    Yuichiro Doki
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka, 537 8511, Japan
    World J Surg 29:700-7. 2005
    ..Regional radiotherapy might be expected to have an adjuvant effect on Ut/Mt tumors and systemic chemotherapy on Lt tumors...
  19. doi request reprint Serum REG4 level is a predictive biomarker for the response to preoperative chemoradiotherapy in patients with pancreatic cancer
    Hidetoshi Eguchi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
    Pancreas 38:791-8. 2009
    ..The aim of this study was to prospectively evaluate the predictive value of REG4, a new member of the regenerating (REG) islet-derived family of proteins...
  20. doi request reprint Is routine measurement of amylase concentration in drainage fluid necessary after total gastrectomy for gastric cancer?
    Yoshito Tomimaru
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Surg Oncol 104:274-7. 2011
    ..However, PF incidence has decreased and PF formation can be judged by changes in drainage fluid properties. The aim of study is to compare the significance of drainage fluid inspection for PF formation with D-AMY measurement...
  21. ncbi request reprint Possible indication for surgical treatment of squamous cell carcinomas of the esophagus that involve the stomach
    Yuichiro Doki
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Surgery 133:479-85. 2003
    ..The caudal spread of esophageal squamous cell carcinoma (ESCC) frequently involves the stomach. An extended surgical treatment may provide a tumor-free margin; however, its clinical benefit has not been elucidated...
  22. doi request reprint Serum CA19-9 alterations during preoperative gemcitabine-based chemoradiation therapy for resectable invasive ductal carcinoma of the pancreas as an indicator for therapeutic selection and survival
    Hidenori Takahashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka City, Japan
    Ann Surg 251:461-9. 2010
    ..To evaluate serum CA19-9 alterations during preoperative gemcitabine-based chemoradiation therapy (CRT) for resectable pancreatic cancer (PC) in the earlier identification of patients who are likely to benefit from subsequent resection...
  23. doi request reprint Second primary cancer in patients with colorectal cancer after a curative resection
    Shingo Noura
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan noura si mc pref osaka jp
    Dig Surg 26:400-5. 2009
    ..Colorectal cancer (CRC) patients have an increased risk of developing other malignancies. Understanding the characteristics of the second primary cancer is important to establish an effective surveillance program...
  24. doi request reprint In situ telomerase activity in pancreatic juice may discriminate pancreatic cancer from other pancreatic diseases
    Hiroyuki Uehara
    Departments of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Pancreas 36:236-40. 2008
    ..In the present study using an in situ TRAP assay, we investigated the specificity of telomerase activity in pancreatic juice for pancreatic cancer...
  25. ncbi request reprint Role of intraoperative cytology combined with histology in detecting continuous and skip type intraductal cancer existence for intraductal papillary mucinous carcinoma of the pancreas
    Hidetoshi Eguchi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Cancer 107:2567-75. 2006
    ..Recent reports suggest a higher frequency of cancer recurrence in the remnant pancreas after surgical resection of IPMN. It is therefore important to precisely detect intraductal cancer extension and skip lesions when resecting IPMN...
  26. doi request reprint Case of isolated lateral lymph node recurrence occurring after TME for T1 lower rectal cancer treated with lateral lymph node dissection: report of a case
    Toshinori Sueda
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka, 537 8511, Japan
    Surg Today 43:809-13. 2013
    ..Patients with isolated LLN recurrence treated with surgery might have good long-term prognoses. Therefore, for such patients, surgical resection should be considered as a curative treatment only...
  27. pmc Visceral fat changes after distal gastrectomy according to type of reconstruction procedure for gastric cancer
    Koji Tanaka
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    World J Surg Oncol 11:146. 2013
    ..The aim of this study was to analyze the impact of the reconstruction procedure (Roux-en-Y reconstruction (RY) and Billroth I reconstruction (BI)) on changes in visceral fat, as determined using computed tomography...
  28. ncbi request reprint Prognostic significance of the size of cancer nests in metastatic lymph nodes in human esophageal cancers
    Takamichi Komori
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Surg Oncol 82:19-27. 2003
    ..The number and location of lymph node metastases have been evaluated and graded, but the clinical significance of their size has not been well investigated...
  29. ncbi request reprint Clinical significance of the second cycle response to cisplatin-based chemotherapy as preoperative treatment for esophageal squamous cell carcinoma
    Hirofumi Akita
    Department of Digestive Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    J Surg Oncol 93:401-9. 2006
    ..Repeating two cycles of cisplatin-based chemotherapy is standard protocol for preoperative treatment for advanced esophageal squamous cell carcinoma (ESCC). However, the second cycle of chemotherapy is often less effective than the first...
  30. ncbi request reprint Concurrent chemoradiotherapy for advanced pancreatic cancer: 1,000 mg/m2 gemcitabine can be administered using limited-field radiotherapy
    Hideya Yamazaki
    Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka, Japan
    Strahlenther Onkol 183:301-6. 2007
    ..To examine the feasibility of concurrent use of full-dose gemcitabine (GEM) and radiotherapy for advanced pancreatic cancer...
  31. ncbi request reprint Intraductal papillary-mucinous carcinoma of the pancreas with tumor thrombus in the portal vein: a report of two cases
    Yoshito Tomimaru
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Hepatogastroenterology 54:1585-8. 2007
    ..In addition, a higher possibility for subsequent liver metastasis should be anticipated after the tumor forms a thrombus in the portal vein...
  32. doi request reprint Metastatic tumor doubling time is an independent predictor of intrapulmonary recurrence after pulmonary resection of solitary pulmonary metastasis from colorectal cancer
    Yoshito Tomimaru
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Dig Surg 25:220-5. 2008
    ..However, there have so far been no reports describing prognostic factors related to the tumor doubling time (TDT) of pulmonary metastasis...
  33. ncbi request reprint Liver perfusion chemotherapy for selected patients at a high-risk of liver metastasis after resection of duodenal and ampullary cancers
    Takehiro Noda
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Surg 246:799-805. 2007
    ..To evaluate the prognostic benefit of postoperative liver perfusion chemotherapy (LPC) in patients who undergo curative resection of duodenal and ampullary cancers...
  34. doi request reprint Doubling time of carcinoembryonic antigen is a significant prognostic factor after the surgical resection of locally recurrent rectal cancer
    Koji Tanaka
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Dig Surg 25:319-24. 2008
    ..A curative resection for local recurrence is the option of improvement in prognosis. However, a curative resection is sometimes too invasive and should be considered in selected patients...
  35. doi request reprint Detection of sentinel node in gastric cancer surgery by indocyanine green fluorescence imaging: comparison with infrared imaging
    Isao Miyashiro
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Ann Surg Oncol 15:1640-3. 2008
    ..This was a clinical exploration/feasibility study of a novel detection system for SN biopsy using indocyanine green (ICG) fluorescence imaging in gastric cancer surgery...
  36. doi request reprint Presence of minute cancer cell dissemination in peritoneal lavage fluid detected by reverse transcription PCR is an independent prognostic factor in patients with resectable pancreatic cancer
    Hidetoshi Eguchi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Surgery 146:888-95. 2009
    ....
  37. ncbi request reprint [Preoperative chemoradiation for pancreatic cancer]
    Osamu Ishikawa
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases
    Nihon Rinsho 64:254-7. 2006
  38. ncbi request reprint When is curative gastrectomy justified for gastric cancer with positive peritoneal lavage cytology but negative macroscopic peritoneal implant?
    Isao Miyashiro
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    World J Surg 29:1131-4. 2005
    ....
  39. ncbi request reprint Long-term follow-up of glucose tolerance function after pancreaticoduodenectomy: comparison between pancreaticogastrostomy and pancreaticojejunostomy
    Osamu Ishikawa
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Surgery 136:617-23. 2004
    ....
  40. ncbi request reprint Practical usefulness of bipolar scissors in hepatectomy
    Terumasa Yamada
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Hepatogastroenterology 49:597-600. 2002
    ..Since 1998, bipolar scissors have been introduced toward hepatectomy as a new, simple and easy device to use...
  41. doi request reprint Brain metastasis from colorectal cancer: prognostic factors and survival
    Shingo Noura
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Surg Oncol 106:144-8. 2012
    ..Unfortunately, the median survival for patients with brain metastasis (BM) from CRC is short. In this study, we retrospectively investigated the BM from CRC and examined the prognostic factors...
  42. doi request reprint Subtotal gastrectomy for gastric tube cancer after esophagectomy: a safe procedure preserving the proximal part of gastric tube based on intraoperative ICG blood flow evaluation
    Takuro Saito
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Surg Oncol 106:107-10. 2012
    ..In summary, subtotal gastrectomy as a treatment for GTC is potentially safe, curative, and beneficial for the patient's quality of life...
  43. doi request reprint Usefulness of the CLIP scoring system for prediction of postoperative prognosis of patients with large hepatocellular carcinoma
    Takehiro Noda
    Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Hepatobiliary Pancreat Surg 16:538-45. 2009
    ..The aim of this study was to identify the staging system with the best prognostic value for such patients...
  44. ncbi request reprint Plasma D-dimer levels show correlation with number of lymph node metastases in patients with esophageal cancer
    Yoshito Tomimaru
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Am Coll Surg 202:139-45. 2006
    ..We investigated the clinical importance of measuring plasma levels of D-dimer (DD), which is a marker of the hypercoagulable stage, in preoperative patients with esophageal cancer...
  45. ncbi request reprint Ghrelin reduction after esophageal substitution and its correlation to postoperative body weight loss in esophageal cancer patients
    Yuichiro Doki
    Department of Digestive Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Surgery 139:797-805. 2006
    ..The functional and anatomical alteration of the stomach by this surgery should affect ghrelin secretion, a novel gastric hormone that upregulates body weight through appetite control and metabolic reaction...
  46. ncbi request reprint Surgical significance of superficial cancer spread in early gallbladder cancer
    Hidetoshi Eguchi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Jpn J Clin Oncol 35:134-8. 2005
    ....
  47. ncbi request reprint Fibrosis in non-cancerous tissue is the unique prognostic factor for primary hepatocellular carcinoma without hepatitis B or C viral infection
    Yoshito Tomimaru
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    World J Surg 30:1729-35. 2006
    ....
  48. doi request reprint Preoperative gemcitabine-based chemoradiation therapy for resectable and borderline resectable pancreatic cancer
    Hidenori Takahashi
    Departments of Surgery Diagnostic Radiology Cancer Survey Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Surg 258:1040-50. 2013
    ....
  49. ncbi request reprint Total removal of the posterior mediastinal gastric conduit due to gastric cancer after esophagectomy
    Hirofumi Akita
    Department of Digestive Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Surg Oncol 85:204-8. 2004
    ..This is one of the reasons for the retro-sternal or subcutaneous route being preferred for gastric conduit replacement in esophageal cancer operation...
  50. ncbi request reprint [A case of rectal cancer with long-term disease-free survival following resection of the right iliac artery due to isolated para-aortic lymph node recurrence]
    Toshinori Sueda
    Dept of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Gan To Kagaku Ryoho 39:2258-60. 2012
    ..As of 10 years after the second operation, the patient is alive and recurrence free. Isolated aortic lymph node recurrence may be cured by resection; hence, surgical resection should be considered if possible...
  51. pmc Risk of recurrence in a long-term follow-up after surgery in 417 patients with hepatitis B- or hepatitis C-related hepatocellular carcinoma
    Yo Sasaki
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Ann Surg 244:771-80. 2006
    ..The aim of this study is to clarify the difference of risk of recurrence after hepatic resection between patients with hepatitis B- and hepatitis C-related hepatocellular carcinoma (HCC)...
  52. ncbi request reprint Adult capillary hemangioma of the liver: report of a case
    Takehiro Noda
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka, 537 8511, Japan
    Surg Today 35:796-9. 2005
    ..Thus, we must be aware of the possibility of capillary hemangioma when finding an atypical liver tumor inconsistent with HCC or cavernous hemangioma...
  53. ncbi request reprint Long-term complete response of unresectable liver metastases from colorectal cancer
    Tsukasa Tanida
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Hepatogastroenterology 57:764-7. 2010
    ..It is speculated that a small size and a low level carcinoembryonic antigen may predict a good response to chemotherapy for unresectable liver metastases from colorectal cancer...
  54. ncbi request reprint [Pre- and post-operative chemoradiation therapies for pancreatic cancers]
    Osamu Ishikawa
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases
    Nihon Geka Gakkai Zasshi 107:182-6. 2006
    ..is influenced not only by local control but also by distant (the liver is the most common) metastases, we should develop other strategies that can prevent liver metastases, in addition to the combination of chemoradiation with sur-..
  55. pmc Postoperative cytology for drained fluid from the pancreatic bed after "curative" resection of pancreatic cancers: does it predict both the patient's prognosis and the site of cancer recurrence?
    Osamu Ishikawa
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3 Nakamichi, 1 chome, Higashinari ku, Osaka 537 8511, Japan
    Ann Surg 238:103-10. 2003
    ..To evaluate the postoperative cytology of drained fluid from the pancreatic bed as a predictive indicator of local recurrence after curative (R0) resection of pancreatic cancer...
  56. doi request reprint Is preservation of the remnant stomach safe during distal pancreatectomy in patients who have undergone distal gastrectomy?
    Hidenori Takahashi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    World J Surg 37:430-6. 2013
    ....
  57. doi request reprint Impact of perioperative administration of synbiotics in patients with esophageal cancer undergoing esophagectomy: a prospective randomized controlled trial
    Koji Tanaka
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Surgery 152:832-42. 2012
    ..The clinical value of synbiotics in patients undergoing esophagectomy remains unclear. This study investigated the effects of synbiotics on intestinal microflora and surgical outcomes in a clinical setting...
  58. ncbi request reprint Reduced tumor vessel density and high expression of glucose transporter 1 suggest tumor hypoxia of squamous cell carcinoma of the esophagus surviving after radiotherapy
    Yuichiro Doki
    Department of Digestive Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka City, Japan
    Surgery 137:536-44. 2005
    ..This alteration of tumor behavior may result from tumor hypoxia induced by radiotherapy...
  59. doi request reprint Surgical usefulness of indocyanine green as an alternative to India ink for endoscopic marking
    Norikatsu Miyoshi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3, Nakamichi, Higashinari, Osaka, 537 8511, Japan
    Surg Endosc 23:347-51. 2009
    ..India ink has been commonly used for preoperative colonic tattooing, but various complications have been reported. This study aimed to evaluate the usefulness of indocyanine green (ICG) marking as a replacement for India ink...
  60. ncbi request reprint Radical resection for pancreatic cancer
    Osamu Ishikawa
    Department of Surgery, Internal Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3 Nakamichi, 1 chome, Higashinari ku, Osaka, 537, Japan
    Acta Gastroenterol Belg 65:166-70. 2002
    ..In the future, we need to detect patients with a high risk of pancreatic cancer and develop a less-painful method to collect the pancreatic juice...
  61. ncbi request reprint A subsegmental pancreatectomy performed for carcinoma in situ limited to the proximal half of the pancreatic head with the aid of intraoperative 4-segment cytology for pancreatic juice--a case report
    Norikatsu Miyoshi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Surgery 138:947-50. 2005
  62. doi request reprint Real-time intraoperative assessment of residual liver functional reserve using pulse dye densitometry
    Hirofumi Akita
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka Suita, Osaka, 565 0871, Japan
    World J Surg 32:2668-74. 2008
    ..The aim of this study was to assess the utility of ICG-R15 measured by pulse dye densitometry to predict residual liver function prior to hepatectomy...
  63. doi request reprint A novel image-guided surgery of hepatocellular carcinoma by indocyanine green fluorescence imaging navigation
    Kunihito Gotoh
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Nakamichi, Higashinari ku, Osaka, Japan
    J Surg Oncol 100:75-9. 2009
    ..The clear delineation between tumor and normal tissue is ideal for real-time surgical navigation imaging. We present a novel indocyanine green (ICG) fluorescence imaging technique to visualize hepatocellular carcinoma (HCC)...
  64. ncbi request reprint Surgery for hepatocellular carcinoma with tumor thrombus extending into the right atrium: report of a successful resection without the use of cardiopulmonary bypass
    Mamoru Uemura
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Hepatogastroenterology 51:1259-62. 2004
    ..Surgery without the use of cardiopulmonary bypass is safe and can be minimally invasive when it is performed with a reliable diagnosis and technique...
  65. doi request reprint Real-time and the in vivo detection of minute cancer invasion to the portal-superior mesenteric vein using contact endoscopy during a pancreatic cancer resection
    Hidetoshi Eguchi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537 8511, Japan
    Am J Surg 198:e66-71. 2009
    ..Thus, contact endoscopy is considered a promising modality for making a real-time diagnosis on the precise location of minute cancer, without requiring any tissue sampling...
  66. ncbi request reprint Successful preoperative treatment for hepatocellular carcinoma with tumor thrombus in the major portal branch by three-dimensional conformal radiation therapy--two case reports
    Hiroshi Wada
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Disease, Higashinari, Osaka, Japan
    Hepatogastroenterology 52:343-7. 2005
    ..No serious complications occurred, and there have been no recurrences for more than one year after surgery in both cases. 3D-CRT targeting the PVTT may be promising as a preoperative adjuvant therapy for HCC with PVTT...
  67. ncbi request reprint Patients with pancreatic intraductal papillary mucinous neoplasms are at high risk of colorectal cancer development
    Hidetoshi Eguchi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Surgery 139:749-54. 2006
    ....
  68. doi request reprint Surgical resection for hepatocellular carcinoma with metastasis to the gallbladder: report of a case
    Ryu Kanzaki
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka, Japan
    Surg Today 41:285-91. 2011
    ..The patient is currently doing well 2 years after surgery, without any signs of recurrence. This case demonstrated that good clinical outcome could be achieved by performing surgery in HCC patients with metastasis to the gallbladder...
  69. ncbi request reprint The significance of surgical resection for pulmonary metastasis from hepatocellular carcinoma
    Yoshito Tomimaru
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Am J Surg 192:46-51. 2006
    ..Until now there have been few reports about surgical resection for pulmonary metastasis from HCC. The aim of the present study was to evaluate the significance of surgical resection for pulmonary metastasis from HCC...
  70. doi request reprint Significance of the resection of ovarian metastasis from colorectal cancers
    Ayako Fujiwara
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Surg Oncol 102:582-7. 2010
    ..We assessed the clinicopathological characteristics of CRC patients with ovarian metastasis and the significance of the resection of ovarian metastases...
  71. doi request reprint Accumulation of excess visceral fat is a risk factor for pancreatic fistula formation after total gastrectomy
    Koji Tanaka
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
    Ann Surg Oncol 16:1520-5. 2009
    ..The degree of abdominal fat increases the technical difficulty of abdominal surgery. This study examined the effect of visceral fat on total gastrectomy and risk factors associated with the formation of pancreatic fistula...
  72. ncbi request reprint Frequent brain metastasis after chemotherapy and surgery for advanced esophageal cancers
    Ryohei Kawabata
    Department of Digestive Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka City, Japan
    Hepatogastroenterology 54:1043-8. 2007
    ..Brain metastasis, rarely observed as a tumor recurrence after curative surgery for thoracic esophageal cancers (TEC), has been increasingly observed with improvement of the clinical outcome of TEC...
  73. ncbi request reprint Attachment of human colon cancer cells to vascular endothelium is enhanced by N-acetylglucosaminyltransferase V
    Kohei Murata
    Department of Surgery, Osaka Medical Center for Cancer and CVD, Nakamichi, Higashinari, Japan
    Oncology 66:492-501. 2004
    ..Inhibition of GnT-V activity may prevent metastasis in colon cancer patients with high sialyl Lewis x expression...
  74. ncbi request reprint Unusual atrophic change after repeated arterial therapy for hepatocellular carcinoma: report of a case
    Takamichi Komori
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higasinari ku, Osaka 537 8511, Japan
    Surg Today 34:76-9. 2004
    ..A thorough understanding of this phenomenon and the development of methods to clinically apply it in the treatment of cancer patients may thus lead to an increase in the percentage of resectable cases of advanced HCC...
  75. ncbi request reprint Invasive ductal adenocarcinoma of the remnant pancreatic body 9 years after resection of an intraductal papillary-mucinous carcinoma of the pancreatic head: a case report and comparison of DNA sequence in K-ras gene mutation
    Takamichi Komori
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Jpn J Clin Oncol 32:146-51. 2002
    ..The following two suggestions are made: (1) the cell-origin might have differed between the two types of cancer (IDC and IPMC); and (2) no precursor lesion toward IDC or IPMC was identified in their surrounding duct epithelium...
  76. ncbi request reprint Evaluation of the lateral sentinel node by indocyanine green for rectal cancer based on micrometastasis determined by reverse transcriptase-polymerase chain reaction
    Shingo Noura
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Oncol Rep 20:745-50. 2008
    ..The sensitivity of identifying lateral LN metastasis was improved by the use of a genetic diagnosis. However, the detection rate was still low, therefore we need to develop a new method for detecting SNs...
  77. doi request reprint CD74 is a novel prognostic factor for patients with pancreatic cancer receiving multimodal therapy
    Shigenori Nagata
    Departments of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Surg Oncol 16:2531-8. 2009
    ..To further develop effective treatment for PDAC, establishment of prognostic indicators for patients receiving multimodal therapy is essential...
  78. ncbi request reprint Expression of smooth muscle calponin in tumor vessels of human hepatocellular carcinoma and its possible association with prognosis
    Yo Sasaki
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka City, Japan
    Cancer 94:1777-86. 2002
    ..The authors investigated the differentiation state of SMCs in tumor vessels by immunohistochemical examination of calponin in patients with HCC, and whether it is associated with the patients' prognosis...
  79. ncbi request reprint Prognostic significance of beta-catenin nuclear expression in hepatocellular carcinoma
    Tsutomu Fujito
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Hepatogastroenterology 51:921-4. 2004
    ..There have been a few clinical reports about beta-catenin nuclear expression for hepatocellular carcinoma patients. However, the clinical significance of the nuclear expression has not been fully elucidated and remains to be controversial...
  80. ncbi request reprint Talaporfin-mediated photodynamic therapy for peritoneal metastasis of gastric cancer in an in vivo mouse model: drug distribution and efficacy studies
    Kentaro Kishi
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinariku, Osaka, Osaka 537 8511, Japan
    Int J Oncol 36:313-20. 2010
    ..Talaporfin-mediated PDT may be an effective treatment modality for patients with advanced gastric adenocarcinoma and metastatic peritoneal nodules...
  81. ncbi request reprint Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma
    Shinji Yamamoto
    Department of Surgery and Clinical Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Cancer Res 10:2846-50. 2004
    ..In addition, activated extracellular signal-regulated kinase 1 and 2 (ERK1/2) and the proliferation activity of tumor cells detected by Ki-67 immunohistochemistry were examined...
  82. ncbi request reprint Fucosylated haptoglobin is a novel marker for pancreatic cancer: a detailed analysis of the oligosaccharide structure and a possible mechanism for fucosylation
    Noriko Okuyama
    Department of Biochemistry, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Cancer 118:2803-8. 2006
    ..One is that pancreatic cancer cells, themselves, produce fucosylated haptoglobin; the other is that pancreatic cancer produces a factor, which induces the production of fucosylated haptoglobin in the liver...
  83. ncbi request reprint Main pancreatic duct dilatation: a sign of high risk for pancreatic cancer
    Sachiko Tanaka
    Department of Cancer Survey and Laboratory of Ultrasonics, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Jpn J Clin Oncol 32:407-11. 2002
    ..The purpose of this study was to evaluate the main pancreatic duct dilatation as a sign of high risk for pancreatic cancer...
  84. ncbi request reprint [The diagnosis of pancreatic endocrine tumors]
    Takehiro Noda
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases
    Nihon Rinsho 62:907-13. 2004
    ..Nevertheless, these examinations occasionally failed to precisely locate the tumors especially when they are very small and/or multiple. For such cases, both portal venous sampling and arterial provocation test are helpful...
  85. ncbi request reprint Postoperative ghrelin levels and delayed recovery from body weight loss after distal or total gastrectomy
    Ko Takachi
    Department of Digestive Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Surg Res 130:1-7. 2006
    ..Body weight loss is a common but one of the most serious sequelae after gastrectomy. Ghrelin, a novel gastric hormone that up-regulates body weight through appetite control and metabolic reaction, seems to be affected by gastric surgery...