Shigenori Nonaka

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc Notch signaling regulates left-right asymmetry determination by inducing Nodal expression
    Luke T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genes Dev 17:1207-12. 2003
  2. ncbi request reprint Determination of left-right patterning of the mouse embryo by artificial nodal flow
    Shigenori Nonaka
    Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 418:96-9. 2002
  3. pmc Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2
    Satoko Yoshiba
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, 565 0871 Osaka, Japan
    Science 338:226-31. 2012
  4. pmc De novo formation of left-right asymmetry by posterior tilt of nodal cilia
    Shigenori Nonaka
    Graduate School of Frontier Biosciences, Osaka University, Japan
    PLoS Biol 3:e268. 2005
  5. doi request reprint Planar polarization of node cells determines the rotational axis of node cilia
    Masakazu Hashimoto
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University and CREST, Japan Science and Technology Corporation JST, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 12:170-6. 2010
  6. ncbi request reprint The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia
    Daisuke Watanabe
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Development 130:1725-34. 2003
  7. ncbi request reprint Cilia: tuning in to the cell's antenna
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California San Francisco, 600 16th St, San Francisco, California 94143, USA
    Curr Biol 16:R604-14. 2006

Collaborators

Detail Information

Publications7

  1. pmc Notch signaling regulates left-right asymmetry determination by inducing Nodal expression
    Luke T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genes Dev 17:1207-12. 2003
    ..Our results demonstrate that Dll1-mediated Notch signaling is essential for generation of left-right asymmetry, and that the Notch pathway acts upstream of Nodal expression during left-right asymmetry determination in mice...
  2. ncbi request reprint Determination of left-right patterning of the mouse embryo by artificial nodal flow
    Shigenori Nonaka
    Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 418:96-9. 2002
    ..The artificial flow was also able to direct the situs of mutant mouse embryos with immotile cilia. These results provide the first direct evidence for the role of mechanical fluid flow in L-R patterning...
  3. pmc Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2
    Satoko Yoshiba
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, 565 0871 Osaka, Japan
    Science 338:226-31. 2012
    ..Our results thus suggest that nodal flow is sensed in a manner dependent on Pkd2 by the cilia of crown cells located at the edge of the node...
  4. pmc De novo formation of left-right asymmetry by posterior tilt of nodal cilia
    Shigenori Nonaka
    Graduate School of Frontier Biosciences, Osaka University, Japan
    PLoS Biol 3:e268. 2005
    ....
  5. doi request reprint Planar polarization of node cells determines the rotational axis of node cilia
    Masakazu Hashimoto
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University and CREST, Japan Science and Technology Corporation JST, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 12:170-6. 2010
    ..These results suggest that posterior positioning of the basal body, which provides the posterior tilt to node cilia, is determined by planar polarization mediated by noncanonical Wnt signalling...
  6. ncbi request reprint The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia
    Daisuke Watanabe
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Development 130:1725-34. 2003
    ..These results suggest that the Inv protein contributes to left-right determination as a component of monocilia in the node and is essential for the generation of normal nodal flow...
  7. ncbi request reprint Cilia: tuning in to the cell's antenna
    Wallace F Marshall
    Department of Biochemistry and Biophysics, University of California San Francisco, 600 16th St, San Francisco, California 94143, USA
    Curr Biol 16:R604-14. 2006
    ..While these diseases highlight the pivotal roles of cilia in physiology and development, the mechanistic link between cilia, physiology, and disease remains unclear...