Y Nishizawa

Summary

Affiliation: Osaka City University
Country: Japan

Publications

  1. ncbi request reprint Clinical usefulness of measurements of urinary deoxypyridinoline (DPD) in patients with postmenopausal osteoporosis receiving intermittent cyclical etidronate: advantage of free form of DPD over total DPD in predicting treatment efficacy
    Kayoko Kitatani
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Bone Miner Metab 21:217-24. 2003
  2. pmc Serum C-reactive protein and thioredoxin levels in subjects with mildly reduced glomerular filtration rate
    Shoko Tsuchikura
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    BMC Nephrol 11:7. 2010
  3. ncbi request reprint Intima-media thickness of carotid artery predicts cardiovascular mortality in hemodialysis patients
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
    Am J Kidney Dis 41:S76-9. 2003
  4. ncbi request reprint Does paricalcitol reduce proteinuria in patients with chronic kidney disease?
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Nat Clin Pract Nephrol 2:352-3. 2006
  5. ncbi request reprint Endogenous secretory receptor for advanced glycation end-products and cardiovascular disease in end-stage renal disease
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Ren Nutr 18:76-82. 2008
  6. doi request reprint Reference intervals of serum tartrate-resistant acid phosphatase type 5b activity measured with a novel assay in Japanese subjects
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, 545 8585, Japan
    J Bone Miner Metab 26:265-70. 2008
  7. ncbi request reprint Paradox of risk factors for cardiovascular mortality in uremia: is a higher cholesterol level better for atherosclerosis in uremia?
    Y Nishizawa
    Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Am J Kidney Dis 38:S4-7. 2001
  8. ncbi request reprint Body composition and cardiovascular risk in hemodialysis patients
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Ren Nutr 16:241-4. 2006
  9. ncbi request reprint Guidelines for the use of biochemical markers of bone turnover in osteoporosis (2004)
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    J Bone Miner Metab 23:97-104. 2005
  10. ncbi request reprint Roles of metabolic and endocrinological alterations in atherosclerosis and cardiovascular disease in renal failure: another form of metabolic syndrome
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Medical School, Osaka, Japan
    Semin Nephrol 24:423-5. 2004

Collaborators

Detail Information

Publications184 found, 100 shown here

  1. ncbi request reprint Clinical usefulness of measurements of urinary deoxypyridinoline (DPD) in patients with postmenopausal osteoporosis receiving intermittent cyclical etidronate: advantage of free form of DPD over total DPD in predicting treatment efficacy
    Kayoko Kitatani
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Bone Miner Metab 21:217-24. 2003
    ..We conclude, therefore, that the measurement of free DPD by ELISA is more useful, especially when treatment efficacy of ICE is clinically predicted in individual patients with osteoporosis...
  2. pmc Serum C-reactive protein and thioredoxin levels in subjects with mildly reduced glomerular filtration rate
    Shoko Tsuchikura
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    BMC Nephrol 11:7. 2010
    ..We compared the levels of serum biomarkers for inflammation and oxidative stress between subjects with normal and mildly reduced glomerular filtration rate (GFR)...
  3. ncbi request reprint Intima-media thickness of carotid artery predicts cardiovascular mortality in hemodialysis patients
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
    Am J Kidney Dis 41:S76-9. 2003
    ..Previous studies showed that patients with ESRD had increased intima-media thickness of the carotid artery (CA-IMT). In the present study, we examined whether CA-IMT would predict cardiovascular mortality in patients with ESRD...
  4. ncbi request reprint Does paricalcitol reduce proteinuria in patients with chronic kidney disease?
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Nat Clin Pract Nephrol 2:352-3. 2006
  5. ncbi request reprint Endogenous secretory receptor for advanced glycation end-products and cardiovascular disease in end-stage renal disease
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Ren Nutr 18:76-82. 2008
    ..Thus, we postulate that plasma esRAGE is a potential protective factor and a novel biomarker against the occurrence of cardiovascular disease in ESRD...
  6. doi request reprint Reference intervals of serum tartrate-resistant acid phosphatase type 5b activity measured with a novel assay in Japanese subjects
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, 545 8585, Japan
    J Bone Miner Metab 26:265-70. 2008
    ..The reference intervals (logarithmic mean +/-1.96 SD) for men, premenopausal women, and postmenopausal women were 1.7-5.9 U/l, 1.2-4.4 U/l, and 2.5-7.6 U/l, respectively...
  7. ncbi request reprint Paradox of risk factors for cardiovascular mortality in uremia: is a higher cholesterol level better for atherosclerosis in uremia?
    Y Nishizawa
    Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Am J Kidney Dis 38:S4-7. 2001
    ..Further studies are needed to show the differential effects of a risk factor on event rate and fatality rate. Patients with ESRD would have a better chance of living longer by better management of the two categories of risk factors...
  8. ncbi request reprint Body composition and cardiovascular risk in hemodialysis patients
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Ren Nutr 16:241-4. 2006
    ....
  9. ncbi request reprint Guidelines for the use of biochemical markers of bone turnover in osteoporosis (2004)
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    J Bone Miner Metab 23:97-104. 2005
  10. ncbi request reprint Roles of metabolic and endocrinological alterations in atherosclerosis and cardiovascular disease in renal failure: another form of metabolic syndrome
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Medical School, Osaka, Japan
    Semin Nephrol 24:423-5. 2004
    ..It is expected that treatment of these metabolic and endocrinologic alterations would improve the survival of patients with renal failure...
  11. doi request reprint Significant inverse relationship between serum undercarboxylated osteocalcin and glycemic control in maintenance hemodialysis patients
    S Okuno
    Kidney Center, Shirasagi Hospital, Osaka, Japan
    Osteoporos Int 24:605-12. 2013
    ....
  12. ncbi request reprint Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes
    M Emoto
    Second Department of Internal Medicine, Institute of Geriatrics and Medical Science, Osaka City University Medical School, Japan
    Diabetes Care 24:533-8. 2001
    ..To assess the impacts of insulin resistance and renal function on plasma total homocysteine (tHcy) levels in patients with type 2 diabetes with a wide range of nephropathy...
  13. ncbi request reprint Impaired secretion of parathyroid hormone is coherent to diabetic hemodialyzed patients
    M Inaba
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
    Am J Kidney Dis 38:S139-42. 2001
    ....
  14. doi request reprint Reduction of whole PTH/intact PTH ratio as a predictor of bone metabolism in cinacalcet treatment of hemodialysis patients with secondary hyperparathyroidism
    M Kurajoh
    Department of Metabolism, Endocrinology and Molecular Medicine, Internal Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Osteoporos Int 22:923-30. 2011
    ..Changes in W-PTH/I-PTH ratio significantly correlated and predicted changes in bone marker...
  15. ncbi request reprint Atherogenic lipoprotein changes in diabetic nephropathy
    T Shoji
    Second Department of Internal Medicine, Osaka City University Medical School, 1 4 3 Asahi machi, Osaka 545 8585, Abeno Ku, Japan
    Atherosclerosis 156:425-33. 2001
    ..These lipoprotein alterations may contribute to an increased cardiovascular risk in diabetic nephropathy, especially in diabetic renal failure...
  16. ncbi request reprint Renal insufficiency accelerates atherosclerosis in patients with type 2 diabetes mellitus
    E Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Am J Kidney Dis 38:S186-90. 2001
    ....
  17. ncbi request reprint Impaired endothelium-dependent vascular responses of retinal and intrarenal arteries in patients with type 2 diabetes
    T Kawagishi
    Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Arterioscler Thromb Vasc Biol 19:2509-16. 1999
    ....
  18. ncbi request reprint Arterial wall stiffness is associated with peripheral circulation in patients with type 2 diabetes
    Akane Kizu
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Atherosclerosis 170:87-91. 2003
    ..Thus, arterial wall stiffness of femoral artery appears to be a major determinant of peripheral circulation in patients with type 2 diabetes...
  19. doi request reprint Serum adiponectin and bone mineral density in male hemodialysis patients
    S Okuno
    Kidney Center, Shirasagi Hospital, 7 11 23, Kumata, Higashisumiyoshi ku, Osaka, 546 0002, Japan
    Osteoporos Int 23:2027-35. 2012
    ..There was a significant positive correlation between serum adiponectin and serum NTX. Thus, adiponectin may play a role in mineral and bone disorder in chronic kidney disease stage 5 dialysis (CKD 5D) patients...
  20. ncbi request reprint Glycemic control is a predictor of survival for diabetic patients on hemodialysis
    T Morioka
    Department of Internal Medicine, Osaka City University Graduate Medical School, Osaka, Japan
    Diabetes Care 24:909-13. 2001
    ..133 per 1.0% increment of HbA1c, 95% CI 1.028-1.249, P = 0.012), as were Cre and CTR. CONCLUSIONS: Good glycemic control (HbA1c <7.5%) predicts better survival of diabetic ESRD patients starting hemodialysis treatment...
  21. ncbi request reprint Diabetes mellitus increases the severity of anemia in non-dialyzed patients with renal failure
    E Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School, Japan
    J Nephrol 11:83-6. 1998
    ..494, p < 0.001). DM appeared to be a risk factor for the severity of anemia in patients with renal failure who were not receiving dialysis...
  22. ncbi request reprint Paraarticular trabecular bone loss at the ultradistal radius and increased arterial stiffening in postmenopausal patients with rheumatoid arthritis
    Kazumasa Tanaka
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, and Senboku Second Hospital, Asahi machi, Osaka, Japan
    J Rheumatol 33:652-8. 2006
    ..Our aim was to examine whether arterial stiffening, another aspect of atherosclerosis, is also increased in patients with RA, and to determine if it is an important risk factor...
  23. ncbi request reprint Plasma leptin level and its relationship with body composition in hemodialysis patients
    Y Nishizawa
    Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Am J Kidney Dis 31:655-61. 1998
    ....
  24. ncbi request reprint Activation of human neutrophil by cytokine-activated endothelial cells
    T Takahashi
    Second Department of Physiology, Department of Clinical Hematology, Osaka City University Medical School, Osaka, Japan
    Circ Res 88:422-9. 2001
    ..We show here for the first time, to our knowledge, that the collaboration between GM-CSF and PAF synthesized by activated ECs markedly potentiated neutrophil activation...
  25. ncbi request reprint Increasing body fat mass in the first year of hemodialysis
    E Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan Shirasagi Hospital Kidney Center, Osaka, Japan
    J Am Soc Nephrol 12:1921-6. 2001
    ..More general, dual x-ray absorptiometry assessment of body fat mass was found to be useful for evaluating the nutritional status of hemodialysis patients...
  26. ncbi request reprint Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure
    E Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Kidney Int 55:1019-27. 1999
    ..In patients with chronic renal failure (CRF), abnormalities in vitamin D metabolism are known to be present, and several factors could contribute to the abnormalities...
  27. ncbi request reprint Role of fibroblast growth factor-23 in peripheral vascular calcification in non-diabetic and diabetic hemodialysis patients
    M Inaba
    Department of Endocrinology, Metabolism, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    Osteoporos Int 17:1506-13. 2006
    ....
  28. doi request reprint Association of increased active PTH(1-84) fraction with decreased GFR and serum Ca in predialysis CRF patients: modulation by serum 25-OH-D
    M Kurajoh
    Department of Metabolism, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, 545 8585, Japan
    Osteoporos Int 19:709-16. 2008
    ..As the serum calcium and glomerular filtration rate decreased, the proportion of active PTH(1-84) molecules in PTH immunoreactivity increased in serum from predialysis uremic patients, particularly those with vitamin D insufficiency...
  29. doi request reprint Glycemic control and survival of diabetic hemodialysis patients--importance of lower hemoglobin A1C levels
    E Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Diabetes Res Clin Pract 83:320-6. 2009
    ..The significance of hemoglobin A1C (HbA1C) on the survival of diabetic hemodialysis patients still remains controversial. We investigated the impact of HbA1C on the survival...
  30. ncbi request reprint Poor muscle quality rather than reduced lean body mass is responsible for the lower serum creatinine level in hemodialysis patients with diabetes mellitus
    M Inaba
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Clin Nephrol 74:266-72. 2010
    ..The factors associated with this finding have not been determined...
  31. ncbi request reprint Diabetes mellitus, aortic stiffness, and cardiovascular mortality in end-stage renal disease
    T Shoji
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Am Soc Nephrol 12:2117-24. 2001
    ..These results demonstrate that the increased aortic stiffness of the ESRD patients with diabetes mellitus contributed to the higher all-cause and cardiovascular mortality rates...
  32. ncbi request reprint Mechanism of atherosclerotic calcification
    A Shioi
    Department of Cardiovascular Medicine, Osaka City University Medical School, Japan
    Z Kardiol 89:75-9. 2000
    ..Therefore, the phenotypic changes of VSMCs in atherosclerotic plaque may contribute to the development of atherosclerotic calcification...
  33. ncbi request reprint Serum BAP as the clinically useful marker for predicting BMD reduction in diabetic hemodialysis patients with low PTH
    Misako Ueda
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City, University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Life Sci 77:1130-9. 2005
    ..In conclusion, serum BAP is a clinically useful bone formation marker to predict the BMD reduction in DM HD patients with low level of PTH...
  34. ncbi request reprint Changes in body fat mass in male hemodialysis patients: a comparison between diabetics and nondiabetics
    S Okuno
    Kidney Center, Shirasagi Hospital, Osaka, Japan
    Am J Kidney Dis 38:S208-11. 2001
    ..Dual x-ray absorptiometry assessment of fat mass changes is suggested as a useful method to examine clinically the nutritional status of hemodialysis patients...
  35. ncbi request reprint Serum N-terminal midfragment vs. intact osteocalcin immunoradiometric assay as markers for bone turnover and bone loss in hemodialysis patients
    K Nagasue
    Shirasagi Hospital, 7 11 23, Kumata, Higashisumiyoshi ku, Osaka, Japan
    Biomed Pharmacother 57:98-104. 2003
    ..It may, therefore, prove more reliable than iOC assay for evaluating bone turnover, and thus for reflecting bone loss, in HD patients...
  36. ncbi request reprint Femoral artery wall thickness and stiffness in evaluation of peripheral vascular disease in type 2 diabetes mellitus
    H Taniwaki
    Second Department of Internal Medicine, Osaka City University Medical School, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
    Atherosclerosis 158:207-14. 2001
    ..These data suggest that stiffening of arterial wall has a significant impact on PVD manifestations, particularly on the leg symptoms, in patients with type 2 diabetes...
  37. ncbi request reprint Mönckeberg's medial sclerosis and inorganic phosphate in uremia
    A Shioi
    Department of Cardiovascular Medicine, Institute of Geriatrics and Medical Science, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Kidney Dis 38:S47-9. 2001
    ..As a possible etiologic factor inducing these two responses, hyperphosphatemia among various metabolic disturbances recognized in uremia may play an important role in the development of MMS in uremia...
  38. ncbi request reprint Effect of aminohydroxypropylidene diphosphonate on the bone metabolism of patients with parathyroid adenoma
    E Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School, Japan
    Horm Metab Res 25:493-7. 1993
    ..Elevation of PTH and 1,25(OH)2D after APD-induced decrease in serum calcium level may explain the partial and limited effect of APD on lowering serum calcium in patients with parathyroid adenoma...
  39. ncbi request reprint Effect of cinacalcet on bone mineral density of the radius in hemodialysis patients with secondary hyperparathyroidism
    E Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, Japan
    Clin Nephrol 76:259-65. 2011
    ..Cortical bone, rather than cancellous bone, was particularly affected by cinacalcet treatment...
  40. ncbi request reprint The clinical significance of serum osteocalcin and N-terminal propeptide of type I collagen in predialysis patients with chronic renal failure
    Takao Tsuchida
    Department of Endocrinology, Metabolism, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Osteoporos Int 16:172-9. 2005
    ..OC and PINP are suggested to be possible parameters for the clinical evaluation of the effect of bone metabolism on BMD...
  41. ncbi request reprint Clinical usefulness of the serum N-terminal propeptide of type I collagen as a marker of bone formation in hemodialysis patients
    Misako Ueda
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Kidney Dis 40:802-9. 2002
    ..The present study was performed to investigate the clinical usefulness of serum PINP as a bone-formation marker in hemodialysis (HD) patients...
  42. ncbi request reprint Increased incidence of vertebral fracture in older female hemodialyzed patients with type 2 diabetes mellitus
    M Inaba
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, 545 8585, Osaka, Japan
    Calcif Tissue Int 76:256-60. 2005
    ....
  43. ncbi request reprint Significant association between the presence of peripheral vascular calcification and lower serum magnesium in hemodialysis patients
    E Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Clin Nephrol 68:222-7. 2007
    ..The aim of the present study was to examine the association between serum magnesium levels and vascular calcification in hemodialysis patients...
  44. ncbi request reprint Influence of nutritional status on serum large N-truncated PTH, but not PTH(1-84) in hemodialysis patients
    Kaori Shidara
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Biomed Pharmacother 61:142-7. 2007
    ..We investigated whether PTH(7-84) and larger N-truncated PTH or PTH(1-84) might be affected by nutritional status in HD patients...
  45. ncbi request reprint Short-term aerobic exercise improves arterial stiffness in type 2 diabetes
    Hisayo Yokoyama
    Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Diabetes Res Clin Pract 65:85-93. 2004
    ..To investigate whether: (1) aerobic exercise decreases arterial stiffness and (2) reduction in arterial stiffness is associated with improvement in insulin resistance in type 2 diabetes...
  46. ncbi request reprint Clinical evaluation of the Elecsys beta-CrossLaps serum assay, a new assay for degradation products of type I collagen C-tlopeptides
    R Okabe
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
    Clin Chem 47:1410-4. 2001
    ..9% +/- 3.9% and 16.9% +/- 4.6%, respectively). CONCLUSIONS: The Elecsys beta-CrossLaps serum assay provides a potentially useful tool for assessing bone resorption state, including its response to estrogen replacement therapy...
  47. ncbi request reprint Different risk factors for peripheral vascular calcification between diabetic and non-diabetic haemodialysis patients--importance of glycaemic control
    E Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Diabetologia 45:1446-8. 2002
    ..We compared factors affecting peripheral vascular calcification between haemodialysis patients with and without diabetes...
  48. ncbi request reprint Inverse relationship between circulating oxidized low density lipoprotein (oxLDL) and anti-oxLDL antibody levels in healthy subjects
    T Shoji
    Second Department of Internal Medicine, Osaka City University Medical School, 1 4 3, Asahi machi, Abeno Ku, Osaka, Japan
    Atherosclerosis 148:171-7. 2000
    ..Although these results suggest that oxLDL Ab may play a role in maintaining the low level of plasma oxLDL, its role in atherogenesis awaits further studies...
  49. ncbi request reprint Correlation between peritoneal mesothelial cell cytology and peritoneal histopathology with respect to prognosis in patients on continuous ambulatory peritoneal dialysis
    T Izumotani
    Kidney Center, Shirasagi Hospital, Osaka, Japan
    Nephron 89:43-9. 2001
    ....
  50. ncbi request reprint Association of muscle glycogen synthase polymorphism with insulin resistance in type 2 diabetic patients
    Koka Motoyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
    Metabolism 52:895-9. 2003
    ..In conclusion, the M416V polymorphism of GYS1 gene is not associated with insulin resistance in type 2 diabetes...
  51. ncbi request reprint Arterial wall thickness is associated with insulin resistance in type 2 diabetic patients
    Shigehiko Fujiwara
    Metabolism, Endocrinology and Molecular Medicine, Department of Internal Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 10:246-52. 2003
    ..0001, respectively). In conclusion, insulin resistance is associated with both CA-IMT and FA-IMT in type 2 diabetic patients, suggesting that it is an independent risk factor for the development of atherosclerosis in type 2 diabetes...
  52. ncbi request reprint [Guideline for adequate use of metabolic bone markers in osteoporosis]
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
    Nihon Rinsho 62:325-32. 2004
  53. ncbi request reprint Inflammation and bone resorption as independent factors of accelerated arterial wall thickening in patients with rheumatoid arthritis
    Mayumi Nagata-Sakurai
    Osaka City University Graduate School of Medicine, Osaka, Japan
    Arthritis Rheum 48:3061-7. 2003
    ..The present longitudinal study was performed to determine whether the change in arterial thickness was accelerated in RA patients and to determine which factor was important in the progression of arterial wall changes...
  54. ncbi request reprint [Effects of vitamin D on the cardiovascular system]
    Tetsuo Shoji
    Osaka City University Graduate School of Medicine, Depanartment of Metabolism, Endocrinology and Molecular Medicine
    Clin Calcium 16:1107-14. 2006
    ..Experimentally, active vitamin D inhibits atherogenic cellular behaviors and activation of the renin-angiotensin system. Thus, active vitamin D is a regulator of cardiovascular and kidney functions...
  55. ncbi request reprint Association between plasma angiopoietin-like protein 3 and arterial wall thickness in healthy subjects
    Sawako Hatsuda
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Vasc Res 44:61-6. 2007
    ..We evaluated the possible association between plasma ANGPTL3 level and carotid artery intima-media thickness (CA-IMT) and femoral artery intima-media thickness (FA-IMT) in healthy human subjects...
  56. ncbi request reprint Significance of intima-media thickness in femoral artery in the determination of calcaneus osteo-sono index but not of lumbar spine bone mass in healthy Japanese people
    Shinsuke Yamada
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, 545 8585, Osaka, Japan
    Osteoporos Int 16:64-70. 2005
    ....
  57. doi request reprint Association of glycated albumin, but not glycated hemoglobin, with calcaneus quantitative ultrasound in male hemodialysis patients with type 2 diabetes mellitus
    Shinsuke Yamada
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
    Metabolism 59:390-4. 2010
    ..Furthermore, it is suggested that poor glycemic control might be a significant factor toward decreasing calcaneus SI in T2DM HD patients...
  58. ncbi request reprint Effects of lipid-lowering drugs on intermediate-density lipoprotein in uremic patients
    Y Nishizawa
    Osaka City University Medical School, Japan
    Kidney Int Suppl 71:S134-6. 1999
    ..There are a limited number of studies reporting pharmacological approaches to IDL reduction in a uremic population...
  59. ncbi request reprint Rare somatic inactivation of the multiple endocrine neoplasia type 1 gene in secondary hyperparathyroidism of uremia
    H Tahara
    Department of Internal Medicine, Osaka City University Graduate School of Medicine, Japan
    J Clin Endocrinol Metab 85:4113-7. 2000
    ..These observations indicate that somatic inactivation of the MEN1 gene contributes to the pathogenesis of uremia-associated parathyroid tumors, but its role in this disease appears to be very limited...
  60. ncbi request reprint Bone resorption associated with uncoupling of osteoclastic and osteoblastic activities in adult T cell leukemia with hypercalcemia: case report
    M Hino
    Department of Clinical Hematology, Osaka City University Medical School, Osaka, Japan
    Ann Hematol 80:426-9. 2001
    ..The ATL cells produced not only PTHrP but also IL-1alpha and IL-1beta. These results suggest that PTHrP may act as a humoral factor and IL-1 may act as a local factor in bone metabolism of ATL patients...
  61. ncbi request reprint Fibrillar collagen specifically regulates human vascular smooth muscle cell genes involved in cellular responses and the pericellular matrix environment
    T Ichii
    Department of Biochemistry, Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Circ Res 88:460-7. 2001
    ..Thus, polymerized type I collagen dynamically regulates gene expression, pericellular accumulation of extracellular matrix molecules, and the response to a given matrix molecule...
  62. ncbi request reprint Atherogenic lipoproteins in end-stage renal disease
    T Shoji
    Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Am J Kidney Dis 38:S30-3. 2001
    ..The effect of lipid-lowering therapy on cardiovascular mortality in ESRD, however, awaits the results of ongoing prospective trials...
  63. ncbi request reprint The K469E polymorphism of the intercellular adhesion molecule-1 gene is associated with plasma fibrinogen level in type 2 diabetes
    Hisayo Yokoyama
    Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Metabolism 54:381-6. 2005
    ....
  64. ncbi request reprint [Biochemical markers for bone metabolism--overview]
    Kiyoshi Nakatsuka
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
    Nihon Rinsho 60:220-7. 2002
  65. ncbi request reprint [Diabetes mellitus and osteoporosis]
    Yasuro Kumeda
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
    Nihon Rinsho 60:393-403. 2002
  66. ncbi request reprint [Outline of Guidelines 2004 for bone marker in osteoporosis]
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
    Nihon Rinsho 65:37-41. 2007
  67. doi request reprint Association of reduction in bone mineral density with mortality in male hemodialysis patients
    Kaori Kohno
    Department of Metabolism, Osaka City University Graduate School of Medicine, Osaka, Japan
    Calcif Tissue Int 84:180-5. 2009
    ..970, 95% CI 0.945-0.996). Our results suggest that BMD reduction at the UR might be a clinically relevant marker that predicts an increased risk of mortality in male hemodialysis patients...
  68. pmc Hepatocyte growth factor levels in bone marrow plasma of patients with leukaemia and its gene expression in leukaemic blast cells
    M Hino
    Second Department of Internal Medicine, Osaka City University Medical School, Japan
    Br J Cancer 73:119-23. 1996
    ..69 +/- 0.14 ng ml-1) remained low within the value for normal subjects. These results suggest that some populations of myeloid lineage cells have the ability to produce HGF...
  69. doi request reprint Serum levels of TRAP5b, a new bone resorption marker unaffected by renal dysfunction, as a useful marker of cortical bone loss in hemodialysis patients
    Kaori Shidara
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    Calcif Tissue Int 82:278-87. 2008
    ..9%, respectively, for serum TRAP5b. Measurement of serum TRAP5b, as well as intact OC, may be a clinically relevant assay for estimation of bone metabolic status in HD patients, although serum intact OC accumulates in uremic serum...
  70. ncbi request reprint [Biochemical markers of bone turnover: Serum P1NP]
    Yasuo Imanishi
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
    Nihon Rinsho 65:231-5. 2007
  71. ncbi request reprint [Vitamin D and survival of hemodialysis patients]
    Tetsuo Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
    Clin Calcium 14:64-8. 2004
    ..Although these observations need further confirmation by randomized controlled studies, appropriate use of active forms of vitamin D may improve the outcomes of patients with chronic kidney disease...
  72. ncbi request reprint Increased thickness of the arterial intima-media detected by ultrasonography in patients with rheumatoid arthritis
    Yasuro Kumeda
    Division of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Arthritis Rheum 46:1489-97. 2002
    ....
  73. ncbi request reprint Associations between physical activity, peripheral atherosclerosis and bone status in healthy Japanese women
    Shinsuke Yamada
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Atherosclerosis 188:196-202. 2006
    ....
  74. ncbi request reprint Presence of abdominal aortic calcification is significantly associated with all-cause and cardiovascular mortality in maintenance hemodialysis patients
    Senji Okuno
    Kidney Center, Shirasagi Hospital, Osaka, Japan
    Am J Kidney Dis 49:417-25. 2007
    ....
  75. ncbi request reprint Effect of diabetes on uremic dyslipidemia
    Eiji Kimoto
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 9:305-13. 2002
    ..These results indicate that increased IDL in ESRD is further deteriorated in the presence of diabetes, and that the adverse effect is accounted for at least partly by hypertriglyceridemia associated with chronic hyperglycemia...
  76. ncbi request reprint Factors affecting progression of renal failure in patients with type 2 diabetes
    Hideki Ueda
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
    Diabetes Care 26:1530-4. 2003
    ..Hyperglycemia and hypertension are known to be risk factors for the development of proteinuria in patients with diabetes. Little is known, however, about predictors of progression of renal failure in diabetic patients...
  77. doi request reprint Fetuin-A and atherosclerotic calcified plaque in patients with type 2 diabetes mellitus
    Masanori Emoto
    The Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Metabolism 59:873-8. 2010
    ..753; 95% confidence interval, 0.608-0.933; P = .010). These results suggest that fetuin-A may inhibit the calcification of atherosclerotic plaques independently of the dialyzed condition...
  78. ncbi request reprint Increased insulin-insensitive glucose transport in polymorphonuclear leukocytes from non-insulin-dependent diabetic patients
    Y Okuno
    Second Department of Internal Medicine, Osaka City University Medical School, Japan
    Horm Metab Res 23:387-91. 1991
    ..Long-term, not short-term, derangement of glucose metabolism seems to be associated with increased glucose transport rate found in those patients...
  79. ncbi request reprint Effect of insulin resistance on serum paraoxonase activity in a nondiabetic population
    A Yamada
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Metabolism 50:805-11. 2001
    ..These results suggest that insulin resistance or hyperinsulinemia is a factor contributing to the intragenotype variability of paraoxonase activity in a population without overt hyperglycemia...
  80. ncbi request reprint In vivo and in vitro effects of glucocorticoids on glucose transport in human polymorphonuclear leukocytes
    Y Okuno
    Second Department of Internal Medicine, Osaka City University Medical School, Japan
    Horm Metab Res 25:165-9. 1993
    ....
  81. ncbi request reprint Modulation by cAMP of 1alpha,25-dihydroxyvitamin D3 sensitivity of murine erythroleukemia cells
    M Waki
    Division of Metabolism, Department of Biochemistry, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan
    Arch Biochem Biophys 391:265-70. 2001
    ....
  82. ncbi request reprint Impact of glycemic control on survival of diabetic patients on chronic regular hemodialysis: a 7-year observational study
    Takeshi Oomichi
    Division of Metabolism, Endocrinology, and Molecular Medicine, Department of Internal Medicine, Osaka City University Graduate Medical School, 1 4 3, Asahi machi, Osaka, Japan 545 8585
    Diabetes Care 29:1496-500. 2006
    ..To investigate the impact of glycemic control during regular hemodialysis on the survival of diabetic patients with chronic kidney disease (CKD) in a longitudinal observational study...
  83. ncbi request reprint Quantitative insulin sensitivity check index and the reciprocal index of homeostasis model assessment in normal range weight and moderately obese type 2 diabetic patients
    Hisayo Yokoyama
    Osaka City University Graduate School of Medicine, Metabolism, Endocrinology and Molecular Medicine, Osaka, Japan
    Diabetes Care 26:2426-32. 2003
    ....
  84. doi request reprint Association of glycated albumin, but not glycated hemoglobin, with peripheral vascular calcification in hemodialysis patients with type 2 diabetes
    Shinsuke Yamada
    Department of Metabolism, Endocrinology and Molecular Medicine, Internal Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Life Sci 83:516-9. 2008
    ..This study was to establish the significance of glycated albumin (GA) as a useful marker of peripheral vascular calcification in diabetic HD patients, in comparison with HbA(1C)...
  85. ncbi request reprint Aortic calcification in haemodialysis patients with diabetes mellitus
    Hiromichi Taniwaki
    Inoue Hospital, Department of Nephrology, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Nephrol Dial Transplant 20:2472-8. 2005
    ..This study examined the risk factors of aortic calcification in a large number of haemodialysis patients, and compared risk factors between diabetic and non-diabetic patients...
  86. ncbi request reprint [Osteoporosis: the Japanese clinical statistical data]
    Kiyoshi Nakatsuka
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine
    Nihon Rinsho 60:417-24. 2002
  87. doi request reprint [Chronic kidney disease (CKD) and bone. Pleiotropic actions of vitamin D and survival advantage]
    Tetsuo Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University, Graduate School of Medicine
    Clin Calcium 19:514-21. 2009
    ..Furthermore, the use of active vitamin D is associated with decreased proteinuria and a lower risk for developing end-stage renal disease. Further evidence is needed to establish these pleiotropic actions of vitamin D...
  88. doi request reprint Preferential reduction of bone mineral density at the femur reflects impairment of physical activity in patients with low-activity rheumatoid arthritis
    Shigeru Sugiguchi
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Mod Rheumatol 20:69-73. 2010
    ..This suggests that muscle tonus has more effect than weight-bearing activity on BMD in patients with RA. BMD of the femoral neck is a useful index for general evaluation of RA patients...
  89. ncbi request reprint [Correlation of serum Bio-intact PTH (1-84) and parathyroid gland size in hemodialysed patients]
    Masaaki Inaba
    Department of Metabolism, Endocrinilogy and Molecular Medicine, Osaka City University Graduate School of Medicine
    Clin Calcium 15:64-6; discussion 66-7. 2005
    ..Therefore, we investigated whether serum Bio-PTH, in comparison with serum I-PTH, may provide a relevant assay to estimate parathyroid function as evidence by its correlation with parathyroid gland size on ultrasound examination...
  90. doi request reprint Poor glycemic control is a significant predictor of cardiovascular events in chronic hemodialysis patients with diabetes
    Yoshihiro Tsujimoto
    Inoue Hospital, Osaka, Japan
    Ther Apher Dial 13:358-65. 2009
    ..0046, respectively). In diabetic hemodialysis patients, poor glycemic control is a significant, independent predictor of the emergence of CVD, indicating the importance of careful management of glycemic control in hemodialysis patients...
  91. doi request reprint Cerebral microbleeds in predialysis patients with chronic kidney disease
    Hideaki Shima
    Department of Endocrinology, Metabolism and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Nephrol Dial Transplant 25:1554-9. 2010
    ..Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease. The relationship between CKD and CMBs, which has not been clarified to date, is examined...
  92. ncbi request reprint Arterial stiffness in predialysis patients with uremia
    Kayo Shinohara
    Department of Metabolism, Osaka City University Graduate School of Medicine, Osaka, Japan
    Kidney Int 65:936-43. 2004
    ..We compared aortic PWV of uremic patients before starting hemodialysis treatment with that of patients on maintenance hemodialysis...
  93. ncbi request reprint Central pulse wave velocity is responsible for increased brachial-ankle pulse wave velocity in subclinical hypothyroidism
    Toshiki Nagasaki
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Osaka, Japan
    Clin Endocrinol (Oxf) 66:304-8. 2007
    ..The current study was performed to assess which arterial segment is responsible for enhanced baPWV in subclinical hypothyroidism...
  94. doi request reprint Influence of atherosclerosis on the relationship between anaemia and mortality risk in haemodialysis patients
    Kiyoshi Maekawa
    Kidney Center, Shirasagi Hospital, Osaka, Japan
    Nephrol Dial Transplant 23:2329-36. 2008
    ..Since CKD is a high-risk population for cardiovascular disease (CVD), we tested a hypothesis that the presence of atherosclerosis affects the relationship between anaemia and mortality risk...
  95. ncbi request reprint Hyperphosphatemia and vascular calcification in end-stage renal disease
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Ren Nutr 15:178-82. 2005
    ....
  96. doi request reprint Significant correlation of glycated albumin, but not glycated haemoglobin, with arterial stiffening in haemodialysis patients with type 2 diabetes
    Yasuro Kumeda
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Clin Endocrinol (Oxf) 69:556-61. 2008
    ..As poor glycaemic control is considered an independent risk factor for atherosclerosis in diabetes, the relationship between GA, HbA1c and arterial stiffening was examined in HD patients with type 2 diabetes...
  97. doi request reprint Utility of serum tartrate-resistant acid phosphatase (TRACP5b) as a bone resorption marker in patients with chronic kidney disease: independence from renal dysfunction
    Shinsuke Yamada
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Clin Endocrinol (Oxf) 69:189-96. 2008
    ..The aim of the study was to establish the usefulness of a new assay for TRACP5b in assessing bone turnover in these patients...
  98. ncbi request reprint Factors associated with silent cerebral microbleeds in hemodialysis patients
    T Naganuma
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Clin Nephrol 75:346-55. 2011
    ..The present study investigated the clinical factors associated with the presence of CMBs in hemodialysis (HD) patients...
  99. ncbi request reprint Increased stiffness in common carotid artery in hyperthyroid Graves' disease patients
    M Inaba
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Biomed Pharmacother 56:241-6. 2002
    ..In summary, the significant increase in stiffness beta in the hyperthyroid state may reflect the harmful effect of hyperthyroidism on the arterial wall, which may in turn result from increased stroke volume...
  100. ncbi request reprint Platelet activation is associated with hypoadiponectinemia and carotid atherosclerosis
    Takuhito Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Atherosclerosis 188:190-5. 2006
    ..423), serum adiponectin levels (r = -0.289) and age (r = -0.184) were the three independent determinants. Thus, our data unveil novel link between hypoadiponectinemia and platelet activation...
  101. ncbi request reprint Annual fat mass change is a significant predictor of mortality in female hemodialysis patients
    Yoko Fujino
    Shirasagi Hospital Kidney Center, Osaka, Japan
    Biomed Pharmacother 60:253-7. 2006
    ..However, the influence of fat mass change over time on mortality in dialysis patients has not been determined...