Riko Nishimura

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi Regulation of endochondral ossification by transcription factors
    Riko Nishimura
    Osaka University Graduate School of Dentistry, Molecular and Cellular Biochemistry, Suita, Osaka, Japan
    Front Biosci (Landmark Ed) 17:2657-66. 2012
  2. pmc Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification
    Riko Nishimura
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Biol Chem 287:33179-90. 2012
  3. doi Regulation of bone and cartilage development by network between BMP signalling and transcription factors
    Riko Nishimura
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
    J Biochem 151:247-54. 2012
  4. ncbi The role of Smads in BMP signaling
    Riko Nishimura
    Department of Biochemistry, Osaka University Graduate School Faculty of Dentistry, 1 8, Yamadaoka, Suita, Osaka, 565 0871 Japan
    Front Biosci 8:s275-84. 2003
  5. doi Signal transduction and transcriptional regulation during mesenchymal cell differentiation
    Riko Nishimura
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Suita, Osaka, 565 0871, Japan
    J Bone Miner Metab 26:203-12. 2008
  6. ncbi Core-binding factor alpha 1 (Cbfa1) induces osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5
    R Nishimura
    Department of Biochemistry, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    Bone 31:303-12. 2002
  7. pmc Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription
    Katsuhiko Amano
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka 565 0871, Japan
    Mol Biol Cell 22:1300-11. 2011
  8. ncbi Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation
    Fumitaka Ichida
    Department of Biochemistry and Fixed Prothodontics, Graduate School of Dentistry, Osaka University, Suita, Osaka, 565 0871 Japan
    J Biol Chem 279:34015-22. 2004
  9. pmc A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes
    Kenji Hata
    Department of Biochemistry, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Cell Biol 25:1971-9. 2005
  10. doi The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9
    Yoko Takigawa
    Osaka University Graduate School of Dentistry, Molecular and Cellular Biochemistry, 1 8 Suita, Osaka 565 0871, Japan
    J Cell Sci 123:3780-8. 2010

Collaborators

Detail Information

Publications42

  1. ncbi Regulation of endochondral ossification by transcription factors
    Riko Nishimura
    Osaka University Graduate School of Dentistry, Molecular and Cellular Biochemistry, Suita, Osaka, Japan
    Front Biosci (Landmark Ed) 17:2657-66. 2012
    ..We would like to discuss how the transcription factors regulate endochondral ossification...
  2. pmc Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification
    Riko Nishimura
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Biol Chem 287:33179-90. 2012
    ....
  3. doi Regulation of bone and cartilage development by network between BMP signalling and transcription factors
    Riko Nishimura
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry
    J Biochem 151:247-54. 2012
    ..Thus, BMP harmoniously regulates bone and cartilage development by forming network with several transcription factors...
  4. ncbi The role of Smads in BMP signaling
    Riko Nishimura
    Department of Biochemistry, Osaka University Graduate School Faculty of Dentistry, 1 8, Yamadaoka, Suita, Osaka, 565 0871 Japan
    Front Biosci 8:s275-84. 2003
    ..Here we provide an overview of recent knowledge about the roles of Smad family in the regulation of BMP signaling...
  5. doi Signal transduction and transcriptional regulation during mesenchymal cell differentiation
    Riko Nishimura
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Suita, Osaka, 565 0871, Japan
    J Bone Miner Metab 26:203-12. 2008
  6. ncbi Core-binding factor alpha 1 (Cbfa1) induces osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5
    R Nishimura
    Department of Biochemistry, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    Bone 31:303-12. 2002
    ..On the other hand, Cbfa1 expression requires the activation of Smad1/Smad5 by BMP-2...
  7. pmc Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription
    Katsuhiko Amano
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka 565 0871, Japan
    Mol Biol Cell 22:1300-11. 2011
    ..Our results suggest that Arid5a may directly interact with Sox9 and thereby enhance its chondrocyte-specific action...
  8. ncbi Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation
    Fumitaka Ichida
    Department of Biochemistry and Fixed Prothodontics, Graduate School of Dentistry, Osaka University, Suita, Osaka, 565 0871 Japan
    J Biol Chem 279:34015-22. 2004
    ..These data indicate that Msx2 promotes osteoblast differentiation independently of Runx2 and negatively regulates adipocyte differentiation through inhibition of PPARgamma and the C/EBP family...
  9. pmc A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes
    Kenji Hata
    Department of Biochemistry, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Cell Biol 25:1971-9. 2005
    ..Thus, identification of a novel role of the C/EBPbeta isoform provides insight into the molecular basis of the regulation of osteoblast and adipocyte commitment...
  10. doi The transcription factor Znf219 regulates chondrocyte differentiation by assembling a transcription factory with Sox9
    Yoko Takigawa
    Osaka University Graduate School of Dentistry, Molecular and Cellular Biochemistry, 1 8 Suita, Osaka 565 0871, Japan
    J Cell Sci 123:3780-8. 2010
    ..Our results suggest that Znf219 plays an important role in the regulation of chondrocyte differentiation as a transcriptional partner of Sox9...
  11. pmc BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation
    Takuma Matsubara
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
    J Biol Chem 283:29119-25. 2008
    ..These findings suggest that Osterix is regulated via both Runx2-dependent and -independent mechanisms, and that Osterix controls osteoblast differentiation, at least in part, by regulating the expression of genes not controlled by Runx2...
  12. pmc Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function
    Atsuko Shimoyama
    The Department of Molecular and Cellular Biochemistry, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Biol Cell 18:2411-8. 2007
    ..Collectively, these results suggest that Ihh regulates osteoblast differentiation of mesenchymal cells through up-regulation of the expression and function of Runx2 by Gli2...
  13. pmc Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis
    Kenji Hata
    Department of Biochemistry, Osaka University Graduate School Faculty of Dentistry, Japan
    Mol Biol Cell 14:545-55. 2003
    ..Thus, BMP2 controls adipocytic differentiation by using two distinct signaling pathways that play differential roles in this process in C3H10T1/2 cells...
  14. pmc MSX2 stimulates chondrocyte maturation by controlling Ihh expression
    Katsuhiko Amano
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Suita 565 0871, Japan
    J Biol Chem 283:29513-21. 2008
    ..Collectively, our results indicated that Msx2 promotes the maturation of chondrocytes, at least in part, through up-regulating Ihh expression...
  15. pmc Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein
    Katsuhiko Amano
    Department of Molecular and Cellular Biology, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
    Mol Biol Cell 20:4541-51. 2009
    ..Our results provide novel evidence that Sox9 family members mediate endochondral ossification by up-regulating PTHrP expression in association with Ihh/Gli2 signaling...
  16. doi Retinoic acid regulates commitment of undifferentiated mesenchymal stem cells into osteoblasts and adipocytes
    Kunihiro Hisada
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Bone Miner Metab 31:53-63. 2013
    ..In conclusion, our data suggest that RA regulates commitment of MSCs into osteoblasts and adipocytes by controlling transcriptional regulators...
  17. pmc Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice
    Kenji Hata
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Clin Invest 118:3098-108. 2008
    ..These data suggest that p54nrb plays an important role in the regulation of Sox9 function and the formation of paraspeckle bodies during chondrogenesis...
  18. pmc Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation
    Fumiyo Ikeda
    Department of Biochemistry, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Invest 114:475-84. 2004
    ..Collectively, these results indicate that c-Jun signaling in cooperation with NFAT is crucial for RANKL-regulated osteoclast differentiation...
  19. ncbi Activation of NFAT signal in vivo leads to osteopenia associated with increased osteoclastogenesis and bone-resorbing activity
    Fumiyo Ikeda
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka 565 0871, Japan
    J Immunol 177:2384-90. 2006
    ..Collectively, our data indicate that NFAT controls bone resorption in vivo by stimulating the differentiation and functioning of osteoclasts but not their survival...
  20. ncbi [Relationship between bone metabolism and adipogenesis]
    Riko Nishimura
    Osaka University Graduate School of Dentistry, Department of Molecular and Cellular Biochemistry
    Clin Calcium 17:233-40. 2007
    ..Recently, experimental findings indicated the involvement of adipokines including leptin and adiponectin in bone metabolisms. Thus, adipocytes appear to play a role in regulation of bone metabolisms...
  21. ncbi Cbp recruitment of Csk into lipid rafts is critical to c-Src kinase activity and bone resorption in osteoclasts
    Takuma Matsubara
    Department molecular and cellular biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Bone Miner Res 25:1068-76. 2010
    ..These findings contribute to an understanding of the unique regulatory system for c-Src in osteoclasts...
  22. ncbi Critical role of cortactin in actin ring formation and osteoclastic bone resorption
    Takuma Matsubara
    Department of Molecular and Cellular Biochemistry, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, 565 0871, Japan
    J Bone Miner Metab 24:368-72. 2006
    ..Collectively, our data indicate that cortactin controls osteoclastic bone resorption by regulating actin organization...
  23. doi [Modulation of transcriptional regulation during bone and cartilage development and their disease]
    Riko Nishimura
    Osaka University Graduate School of Dentistry, Department of Molecular and Cellular Biochemistry, Japan
    Clin Calcium 23:1585-93. 2013
    ..In addition, we discuss possible application of these information in regeneration of bone and cartilage. ..
  24. doi Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes
    Kenji Hata
    1 Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan 2
    Nat Commun 4:2850. 2013
    ..Our findings establish an epigenomic mechanism of skeletal development, whereby Arid5b promotes chondrogenesis by facilitating Phf2-mediated histone demethylation of Sox9-regulated chondrogenic gene promoters. ..
  25. ncbi JNK/c-Jun signaling mediates an anti-apoptotic effect of RANKL in osteoclasts
    Fumiyo Ikeda
    Department of Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Bone Miner Res 23:907-14. 2008
    ..It has been shown that ERK is critical for regulation of osteoclast survival. However, an involvement of other RANKL signaling pathways such as JNK signaling in survival of osteoclasts has not been fully understood yet...
  26. pmc CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation
    Ken Shirakawa
    Department of Biochemistry, the Cancer Institute of the Japanese Foundation for Cancer Research JFCR, 3 10 6, Ariake, Koto ku, Tokyo 135 8550, Japan
    Mol Cell Biol 26:6105-16. 2006
    ..Thus, endogenous CHOP may have dual roles in regulating osteoblast differentiation and bone formation...
  27. ncbi A synthetic peptide fragment of human MEPE stimulates new bone formation in vitro and in vivo
    Tetsuyuki Hayashibara
    Department of Biochemistry, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan
    J Bone Miner Res 19:455-62. 2004
    ..We found that a synthetic peptide fragment of MEPE containing the RGD and SGDG sequence stimulated new bone formation in vitro and in vivo...
  28. doi [Bone and calcium update; bone research update. Regulatory mechanisms in osteoblast differentiation]
    Riko Nishimura
    Department molecular and cellular biochemistry, Osaka University Graduate School of Dentistry, Japan
    Clin Calcium 21:103-12. 2011
    ..Thus, these milestone studies have dramatically progressed in our understanding of the cellular and molecular mechanisms of osteoblast differentiation for 20 years...
  29. doi [Bone and Stem Cells. Regulation of chondrocyte differentiation from mesenchymal stem cells]
    Riko Nishimura
    Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Japan
    Clin Calcium 24:509-16. 2014
    ....
  30. ncbi [Roles of PPAR family in bone metabolisms]
    Riko Nishimura
    Department of Biochemistry, Osaka University Graduate School of Dentistry
    Nihon Rinsho 63:591-6. 2005
    ..Here, we summarized the functional roles of PPAR family in bone remodeling and regulation of bone microenvironments. We also discuss the potential mechanisms that regulate expression and function of PPAR family during bone metabolisms...
  31. doi Carbonic anhydrase II regulates differentiation of ameloblasts via intracellular pH-dependent JNK signaling pathway
    Xiaogu Wang
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    J Cell Physiol 225:709-19. 2010
    ..Regulation of intracellular pH, followed by activation of the JNK signaling pathway, may be responsible for the effects of CAII on ameloblasts...
  32. ncbi Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARgamma pathway
    Masanobu Kawai
    Department of Pediatrics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Mol Endocrinol 38:19-34. 2007
    ..Thus, the GH-Stat5A/B signaling pathway stimulates adipogenesis through two distinct steps. In addition, cDNA microarray data provide us the further insights underlying the adipogenic effect of GH...
  33. ncbi C-SRC tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis
    Akira Myoui
    Osaka University, Graduate School of Medicine, Department of Orthopaedics, Suita, Osaka 565 0871, Japan
    Cancer Res 63:5028-33. 2003
    ....
  34. ncbi Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription
    Nandini Ghosh-Choudhury
    Department of Pathology, University of Texas Health Sciences Center, San Antonio, Texas 78229, USA
    J Biol Chem 277:33361-8. 2002
    ....
  35. ncbi [Role of Wnt in bone formation]
    Riko Nishimura
    Osaka University Graduate School of Dentistry, Department molecular and cellular biochemistry
    Clin Calcium 16:817-22. 2006
    ..In addition, Wnt signaling interacts with BMP signaling, thereby modulating its osteogenic action. Thus, the network systems of Wnt signaling temporally and spatially controls osteogenic action of Wnt family members...
  36. ncbi [Role of Gli family members in Indian hedgehog-induced osteoblast differentiation]
    Masahiro Wada
    Department of Biochem, Osaka University Graduate School of Dentistry
    Nihon Rinsho 65:75-80. 2007
  37. ncbi Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation
    Shuji Muramatsu
    Laboratory for Drug Discovery, Research Center, Asahi Kasei Pharma Corp, 2 1 Samejima, Fuji, Shizuoka 416 8501, Japan
    J Biol Chem 282:32158-67. 2007
    ..We showed that activation of TRPV4 increased the steady-state levels of SOX9 mRNA and protein and SOX6 mRNA. Taken together, our results suggest that TRPV4 regulates the SOX9 pathway and contributes to the process of chondrogenesis...
  38. ncbi Insulin-like growth factor-1 rescues the mutated FGF receptor 3 (G380R) expressing ATDC5 cells from apoptosis through phosphatidylinositol 3-kinase and MAPK
    Mio Koike
    Department of Pediatrics, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Bone Miner Res 18:2043-51. 2003
    ..Our findings that IGF-1 prevented the apoptosis through PI3K and MAPK pathways may explain how GH treatment improves the disturbed bone growth in ACH...
  39. pmc Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation
    Ming Zhao
    Department of Medicine, Division of Endocrinology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Cell Biol 157:1049-60. 2002
    ..These studies show the effects of alterations in BMP receptor function targeted to the osteoblast lineage and demonstrate a necessary role of BMP receptor signaling in postnatal bone growth and bone formation in vivo...
  40. ncbi PTHrP rescues ATDC5 cells from apoptosis induced by FGF receptor 3 mutation
    Yoshitaka Yamanaka
    Department of Pediatrics, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Bone Miner Res 18:1395-403. 2003
    ..ACH chondrocytes exhibited marked apoptotic with downregulation of PTHrP expression. Rescue of these cells by PTHrP replacement implies a potential therapy for this disorder...
  41. ncbi RANK ligand signaling modulates the matrix metalloproteinase-9 gene expression during osteoclast differentiation
    Kumaran Sundaram
    Charles P Darby Children s Research Institute, 173 Ashley Avenue, Charleston, SC 29425, USA
    Exp Cell Res 313:168-78. 2007
    ..Taken together, our results suggest that RANKL signals through TRAF6 and that NFATc1 is a downstream effector of RANKL signaling to modulate MMP-9 gene expression during osteoclast differentiation...
  42. ncbi Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1
    Daisuke Harada
    Department of Pediatrics, Okayama University, Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Bone 41:273-81. 2007
    ..DN-PLCgamma reduced the apoptosis of ATDC5 cells expressing TDII-FGFR3, but over-expression of both DN-PLCgamma and STAT1-C induced apoptosis. Therefore, we conclude that a PLCgamma-STAT1 pathway mediates apoptotic signaling by FGFR3...