Toru Nakano


Affiliation: Osaka University
Country: Japan


  1. Nagamori I, Kobayashi H, Nishimura T, Yamagishi R, Katahira J, Kuramochi Miyagawa S, et al. Relationship between PIWIL4-Mediated H3K4me2 Demethylation and piRNA-Dependent DNA Methylation. Cell Rep. 2018;25:350-356 pubmed publisher
    ..In addition, PIWIL4, which binds the H3K4 demethylases KDM1A and KDM5B, is required for removing H3K4me2 marks. These data show that PIWIL4 plays important roles in histone modification and piRNA-dependent DNA methylation. ..
  2. Nakatani T, Yamagata K, Kimura T, Oda M, Nakashima H, Hori M, et al. Stella preserves maternal chromosome integrity by inhibiting 5hmC-induced γH2AX accumulation. EMBO Rep. 2015;16:582-9 pubmed publisher
    ..Thus, Stella protects maternal chromosomes from aberrant epigenetic modifications to ensure early embryogenesis. ..
  3. Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Nakano T. Inhibition of maintenance DNA methylation by Stella. Biochem Biophys Res Commun. 2014;453:455-60 pubmed publisher
    ..Considering that impaired DNA methylation profiles are associated with various developmental or disease phenomena, Stella may be a powerful tool with which to study the biological effects of global DNA hypomethylation. ..
  4. Itou D, Shiromoto Y, Yukiho S, Ishii C, Nishimura T, Ogonuki N, et al. Induction of DNA methylation by artificial piRNA production in male germ cells. Curr Biol. 2015;25:901-6 pubmed publisher
    ..This study not only provides novel insights into the molecular mechanisms of piRNA production, but also presents an innovative strategy for inducing epigenetic modification in germ cells. ..
  5. Kuramochi Miyagawa S, Nakano T. Reply to Shoji and Katsuma. Curr Biol. 2015;25:R710 pubmed publisher
  6. Nagamori I, Kobayashi H, Shiromoto Y, Nishimura T, Kuramochi Miyagawa S, Kono T, et al. Comprehensive DNA Methylation Analysis of Retrotransposons in Male Germ Cells. Cell Rep. 2015;12:1541-7 pubmed publisher
    ..These observations raise the possibility of piRNA-dependent DNA methylation without Miwi2. Therefore, it appears that the molecular mechanisms of the gene silencing of retrotransposons are more complicated than previously thought. ..
  7. Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Okumura M, et al. Global DNA hypomethylation coupled to cellular transformation and metastatic ability. FEBS Lett. 2015;589:4053-60 pubmed publisher
    ..These results provide new insights into the function of global DNA hypomethylation in carcinogenesis. ..
  8. request reprint
    Nakamura T, Arai Y, Umehara H, Masuhara M, Kimura T, Taniguchi H, et al. PGC7/Stella protects against DNA demethylation in early embryogenesis. Nat Cell Biol. 2007;9:64-71 pubmed
    ..These results demonstrate that PGC7/Stella is indispensable for the maintenance of methylation involved in epigenetic reprogramming after fertilization. ..
  9. Arakawa T, Nakatani T, Oda M, Kimura Y, Sekita Y, Kimura T, et al. Stella controls chromocenter formation through regulation of Daxx expression in 2-cell embryos. Biochem Biophys Res Commun. 2015;466:60-5 pubmed publisher
    ..These abnormalities were restored by the enforced expression of Daxx in Stella-null embryos. Thus, Stella controls the expression of Daxx and ensures chromatin reorganization in early embryos. ..

More Information


  1. Kojima Kita K, Kuramochi Miyagawa S, Nagamori I, Ogonuki N, Ogura A, Hasuwa H, et al. MIWI2 as an Effector of DNA Methylation and Gene Silencing in Embryonic Male Germ Cells. Cell Rep. 2016;16:2819-2828 pubmed publisher
    ..In addition, ZF-MIWI2 was associated with the proteins involved in DNA methylation. These data indicate that MIWI2 functions as an effector of de novo DNA methylation of the retrotransposon. ..