Toshikazu Nakamura

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2
    T Sumi
    Division of Biochemistry, Department of Oncology, Biomedical Research Center, Osaka University Medical School, Suita, Japan
    J Cell Biol 147:1519-32. 1999
  2. ncbi Hepatocyte growth factor prevents tissue fibrosis, remodeling, and dysfunction in cardiomyopathic hamster hearts
    Teruya Nakamura
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Am J Physiol Heart Circ Physiol 288:H2131-9. 2005
  3. ncbi Possible role of scavenger receptor SRCL in the clearance of amyloid-beta in Alzheimer's disease
    Kenji Nakamura
    Department of Biochemistry andMolecular Biology, Division of Molecular Regenerative Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Neurosci Res 84:874-90. 2006
  4. ncbi Molecular cloning of a mouse scavenger receptor with C-type lectin (SRCL)(1), a novel member of the scavenger receptor family
    K Nakamura
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka Graduate School of Medicine, Japan
    Biochim Biophys Acta 1522:53-8. 2001
  5. ncbi Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family
    K Nakamura
    Division of Biochemistry, Osaka University Graduate School of Medicine, Osaka, 565 0871, Japan
    Biochem Biophys Res Commun 280:1028-35. 2001
  6. ncbi Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein
    T Nakamura
    Division of Biochemistry, Department of Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, 565 0871, Osaka, Japan
    Biochim Biophys Acta 1518:63-72. 2001
  7. ncbi Angiogenesis inhibitors: from laboratory to clinical application
    Toshikazu Nakamura
    Division of Molecular Regenerative Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
    Biochem Biophys Res Commun 333:289-91. 2005
  8. ncbi Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF
    T Nakamura
    Division of Biochemistry, Department of Oncology, Biomedical Research Center B7, Osaka University Graduate School of Medicine, Suita, Japan
    J Clin Invest 106:1511-9. 2000
  9. ncbi Hepatocyte growth factor: renotropic role and potential therapeutics for renal diseases
    K Matsumoto
    Division of Biochemistry, Biomedical Research Center, Osaka University Graduate School of Medicine, Osaka, Japan
    Kidney Int 59:2023-38. 2001
  10. ncbi Amelioration of pulmonary emphysema by in vivo gene transfection with hepatocyte growth factor in rats
    Norihisa Shigemura
    Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Circulation 111:1407-14. 2005

Collaborators

Detail Information

Publications165 found, 100 shown here

  1. ncbi Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2
    T Sumi
    Division of Biochemistry, Department of Oncology, Biomedical Research Center, Osaka University Medical School, Suita, Japan
    J Cell Biol 147:1519-32. 1999
    ....
  2. ncbi Hepatocyte growth factor prevents tissue fibrosis, remodeling, and dysfunction in cardiomyopathic hamster hearts
    Teruya Nakamura
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Am J Physiol Heart Circ Physiol 288:H2131-9. 2005
    ....
  3. ncbi Possible role of scavenger receptor SRCL in the clearance of amyloid-beta in Alzheimer's disease
    Kenji Nakamura
    Department of Biochemistry andMolecular Biology, Division of Molecular Regenerative Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Neurosci Res 84:874-90. 2006
    ..These findings suggest that SRCL could be the receptor involved in the binding or clearing of Abeta by glial and vascular/perivascular cells in AD...
  4. ncbi Molecular cloning of a mouse scavenger receptor with C-type lectin (SRCL)(1), a novel member of the scavenger receptor family
    K Nakamura
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka Graduate School of Medicine, Japan
    Biochim Biophys Acta 1522:53-8. 2001
    ..Mouse SRCL mRNA was expressed in the macrophage cell line J774A.1 cells at a high level and in the embryo as early as E9...
  5. ncbi Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family
    K Nakamura
    Division of Biochemistry, Osaka University Graduate School of Medicine, Osaka, 565 0871, Japan
    Biochem Biophys Res Commun 280:1028-35. 2001
    ..These results indicate that hSRCL is a novel bacteria-binding receptor containing a C-type CRD and this receptor may play an important role in host defense...
  6. ncbi Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein
    T Nakamura
    Division of Biochemistry, Department of Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, 565 0871, Osaka, Japan
    Biochim Biophys Acta 1518:63-72. 2001
    ..Kringle-SAGE is expected to facilitate further elucidation of structure and functions of kringle proteins...
  7. ncbi Angiogenesis inhibitors: from laboratory to clinical application
    Toshikazu Nakamura
    Division of Molecular Regenerative Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
    Biochem Biophys Res Commun 333:289-91. 2005
  8. ncbi Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF
    T Nakamura
    Division of Biochemistry, Department of Oncology, Biomedical Research Center B7, Osaka University Graduate School of Medicine, Suita, Japan
    J Clin Invest 106:1511-9. 2000
    ..Supplements of HGF, an endogenous cardioprotective factor, may be found clinically suitable in treating subjects with myocardial infarction...
  9. ncbi Hepatocyte growth factor: renotropic role and potential therapeutics for renal diseases
    K Matsumoto
    Division of Biochemistry, Biomedical Research Center, Osaka University Graduate School of Medicine, Osaka, Japan
    Kidney Int 59:2023-38. 2001
    ..Thus, HGF supplementation may be one therapeutic strategy to treat subjects with renal diseases, as it enhances the intrinsic ability of the kidney to regenerate...
  10. ncbi Amelioration of pulmonary emphysema by in vivo gene transfection with hepatocyte growth factor in rats
    Norihisa Shigemura
    Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Circulation 111:1407-14. 2005
    ..In addition, induction of HGF expression by a gene-transfection method resulted in improved pulmonary function via inhibition of alveolar cell apoptosis, enhancement of alveolar regeneration, and promotion of angiogenesis...
  11. ncbi No influence of tumor growth by intramuscular injection of hepatocyte growth factor plasmid DNA: safety evaluation of therapeutic angiogenesis gene therapy in mice
    Atsushi Matsuki
    Division of Gene Therapy Science, Biomedical Research Center, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan
    Biochem Biophys Res Commun 315:59-65. 2004
    ..Although recombinant HGF stimulated the growth of A431 cells in vitro, temporally and locally HGF elevation in hindlimb had no effect on tumor growth in mice...
  12. ncbi Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma
    Yoshinori Suzuki
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Cancer 127:1948-57. 2010
    ..Thus, the simultaneous inhibition of the HGF-Met pathway and angiogenesis by NK4 for treatment of malignant pleural mesothelioma is significant, particularly to attenuate migration and invasive growth...
  13. ncbi Lack of association between the hepatocyte growth factor receptor, c-met, and the anti-apoptotic action of bag-1 in endothelial cells
    Hironori Nakagami
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Japan
    Hypertens Res 27:359-65. 2004
    ..Taken together, these results indicate that over-expression of bag-1 has an anti-apoptotic effect on endothelial cells independent of HGF signaling...
  14. ncbi Recombinant hepatocyte growth factor accelerates cutaneous wound healing in a diabetic mouse model
    Saho Yoshida
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Yamadaoka 2-2-B7, Suita 565-0871, Osaka, Japan
    Growth Factors 22:111-9. 2004
    ..We propose that supplement of HGF may be a potential therapeutic approach for treatment of cutaneous ulcer...
  15. ncbi Hepatocyte growth factor suppresses vascular medial hyperplasia and matrix accumulation in advanced pulmonary hypertension of rats
    Masamichi Ono
    Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Circulation 110:2896-902. 2004
    ..Pathophysiologically, proliferation of pulmonary artery smooth muscle cells triggers pulmonary arterial stenosis and/or regurgitation, especially in advanced PH...
  16. ncbi Inhibition of tubular cell proliferation by neutralizing endogenous HGF leads to renal hypoxia and bone marrow-derived cell engraftment in acute renal failure
    Hiroyuki Ohnishi
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Physiol Renal Physiol 294:F326-35. 2008
    ..Thus we conclude that HGF is a positive regulator for eliciting resident tubular cell proliferation, and SDF1 for BMDC engraftment during the repair process of ARF...
  17. ncbi Lung tissue engineering technique with adipose stromal cells improves surgical outcome for pulmonary emphysema
    Norihisa Shigemura
    Division of Cardiothoracic Surgery, Department of Surgery, Course of Advanced Medicine, Medical Center for Translational Research, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Respir Crit Care Med 174:1199-205. 2006
    ..This approach may provide a new strategy for lung tissue engineering to improve LVRS outcome...
  18. ncbi Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS
    Keiichi Kadoyama
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Neurosci Res 65:194-200. 2009
    ....
  19. ncbi Inhibition of colon cancer growth and metastasis by NK4 gene repetitive delivery in mice
    Jinhua Wen
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 358:117-23. 2007
    ..Inhibition of the HGF-Met receptor pathway and tumor angiogenesis by NK4 gene expression has potential therapeutic value toward inhibition of invasion, growth, and metastasis of colon cancer...
  20. ncbi In vivo evidence of angiogenesis induced by transcription factor Ets-1: Ets-1 is located upstream of angiogenesis cascade
    Naotaka Hashiya
    Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circulation 109:3035-41. 2004
    ..Thus, we examined (1) the effects of overexpression of the ets-1 gene on angiogenesis in a rat hindlimb ischemia model, and (2) how ets-1 induced angiogenesis...
  21. ncbi Contact inhibition of hepatocyte growth regulated by functional association of the c-Met/hepatocyte growth factor receptor and LAR protein-tyrosine phosphatase
    Mitsuru Machide
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:8765-72. 2006
    ..Thus functional association of LAR and c-Met underlies the inhibition of c-Met-mediated mitogenic signaling through the dephosphorylation of c-Met, which specifically occurs under the confluent condition...
  22. ncbi Regulation of cell migration and cytokine production by HGF-like protein (HLP) / macrophage stimulating protein (MSP) in primary microglia
    Yoshinori Suzuki
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Biomed Res 29:77-84. 2008
    ..These findings provide the first evidence that HLP has the potential to modulate inflammatory actions of microglia, which proposes novel aspects for the process of degeneration and/or regeneration of the brain...
  23. ncbi Gene transfection of hepatocyte growth factor attenuates the progression of cardiac remodeling in the hypertrophied heart
    Keiji Iwata
    Division of Cardiovascular Surgery, Department of Surgery E1, School of Allied Health Science, Faculty of Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Thorac Cardiovasc Surg 130:719-25. 2005
    ..In this study, we investigated the effect of transfection of the hepatocyte growth factor gene in attenuation of cardiac remodeling in the hypertrophied heart...
  24. ncbi Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice
    Jinhua Wen
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Cancer Gene Ther 11:419-30. 2004
    ....
  25. ncbi Essential role of HGF (hepatocyte growth factor) in blood formation in Xenopus
    Nobutaka Koibuchi
    Division of Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Japan
    Blood 103:3320-5. 2004
    ..Overall, the present study demonstrated that HGF is necessary for primitive hematopoiesis by regulating the expression of SCL...
  26. ncbi Myocardial protective effect of human recombinant hepatocyte growth factor for prolonged heart graft preservation in rats
    Masahiro Ryugo
    Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Transplantation 78:1153-8. 2004
    ..Therefore, we assessed whether the administration of recombinant human HGF (rh-HGF) prevents apoptosis in the prolonged preserved myocardium, resulting in an improvement in the cardiac function of the graft...
  27. ncbi Gene transfer of hepatocyte growth factor with prostacyclin synthase in severe pulmonary hypertension of rats
    Masamichi Ono
    Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    Eur J Cardiothorac Surg 26:1092-7. 2004
    ..Thus, gene therapy with HGF and PGIS may be a promising strategy for severe pulmonary hypertension...
  28. ncbi HGF reduces advancing lung fibrosis in mice: a potential role for MMP-dependent myofibroblast apoptosis
    Shinya Mizuno
    Division of Molecular Regenerative Medicine, Department of Molecular Regenerative Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    FASEB J 19:580-2. 2005
    ....
  29. ncbi Angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association
    Katsuya Sakai
    Kringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University, 2 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 284:22491-9. 2009
    ..The identified mechanism for angiostatic action provides further proof of significance for NK4 in the treatment of cancer and potentially for vascular regulation as well...
  30. ncbi Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models
    Yuko Kishi
    Division of Molecular Regenerative Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Cancer Sci 100:1351-8. 2009
    ..NK4 gene therapy is thus a safe and promising strategy for the treatment of cancer patients, and further validation in clinical trials is needed...
  31. ncbi Hepatocyte growth factor prevents multiple organ injuries in endotoxemic mice through a heme oxygenase-1-dependent mechanism
    Miyuki Kamimoto
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, 2 2 B7 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 380:333-7. 2009
    ..This is the first report showing that "growth factor therapy" successfully inhibits both ARDS and ARF during endotoxemia, partially via HO-1-dependent suppression of hyper-cytokinemia...
  32. ncbi Bi-directional regulation of Ser-985 phosphorylation of c-met via protein kinase C and protein phosphatase 2A involves c-Met activation and cellular responsiveness to hepatocyte growth factor
    Atsuko Hashigasako
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    J Biol Chem 279:26445-52. 2004
    ....
  33. ncbi Angiogenic property of hepatocyte growth factor is dependent on upregulation of essential transcription factor for angiogenesis, ets-1
    Naruya Tomita
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Circulation 107:1411-7. 2003
    ..Upregulation of angiogenesis-related genes was largely dependent on the induction of ets, especially ets-1. These data provide new information about the mechanisms of angiogenesis...
  34. ncbi [Myocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplasty]
    Shigeru Miyagawa
    Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Yamada-oka 2-2, Suita, Osaka 565-0871
    J Cardiol 41:36-8. 2003
    ..The combined effects might have lead to the improved cardiac performance. Thus, combined therapy may be a promising strategy for the treatment of heart failure caused by myocardial infarction...
  35. ncbi Antinecrotic and antiapoptotic effects of hepatocyte growth factor on cholestatic hepatitis in a mouse model of bile-obstructive diseases
    Zhaodong Li
    Division of Molecular Regenerative Medicine, Dept of Biochemistry and Molecular Biology, Osaka Univ Graduate School of Medicine, Yamadaoka 2 2 B7, Suita, Osaka, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G639-46. 2007
    ....
  36. ncbi Therapeutic angiogenesis induced by injecting hepatocyte growth factor in ischemic canine hearts
    Takahiro Yamaguchi
    First Department of Surgery, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan
    Surg Today 35:855-60. 2005
    ..CONCLUSION: The intramural injection of recombinant human HGF resulted in therapeutic angiogenesis with an intrinsic contractile state, and it may have greater advantages than TMLR for the treatment of chronic ischemic heart disease...
  37. ncbi Hepatocyte growth factor gene therapy for hypertension
    Kazuo Komamura
    Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center, Suita, Japan
    Methods Mol Biol 423:393-404. 2008
    ..We outline the technique of intramuscular electroporation of HGF gene as a remedy for hypertension...
  38. ncbi Hepatocyte growth factor overexpression in the nervous system enhances learning and memory performance in mice
    Takashi Kato
    Kringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University, Osaka, Japan
    J Neurosci Res 90:1743-55. 2012
    ..These results demonstrate that modulation of learning and memory performance is an important physiological function of HGF that contributes to normal CNS plasticity, and we propose HGF as a novel regulator of higher brain functions...
  39. ncbi Identification of mannose receptor as receptor for hepatocyte growth factor β-chain: novel ligand-receptor pathway for enhancing macrophage phagocytosis
    Hiroyuki Ohnishi
    Kringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    J Biol Chem 287:13371-81. 2012
    ..Thus, the HGF-β·MR complex may provide a new pathway for the enhancement of cell clearance systems, which is associated with resolution of inflammation...
  40. ncbi Induction of compensatory lung growth in pulmonary emphysema improves surgical outcomes in rats
    Norihisa Shigemura
    Department of Surgery, Division of Molecular Regenerative Medicine, Osaka University Graduate School of Medicine, E1, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Am J Respir Crit Care Med 171:1237-45. 2005
    ....
  41. ncbi Hepatocyte growth factor stimulates proliferation of respiratory epithelial cells during postpneumonectomy compensatory lung growth in mice
    Yasushi Sakamaki
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Respir Cell Mol Biol 26:525-33. 2002
    ..These results strongly suggest that HGF has a role as a pulmotrophic factor in postpneumonectomy compensatory lung regeneration...
  42. ncbi Reciprocal regulation of IL-6 and IL-10 balance by HGF via recruitment of heme oxygenase-1 in macrophages for attenuation of liver injury in a mouse model of endotoxemia
    Miyuki Kamimoto
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka, 565 0871, Japan
    Int J Mol Med 24:161-70. 2009
    ..Based on the current data, we conclude that up-regulation of HO-1 plays an important role in HGF-mediated hepatoprotection during endotoxemia, by favoring production of IL-10 over IL-6...
  43. ncbi [Molecular basis for HGF-mediated regression of renal fibrosis]
    Shinya Mizuno
    Division of Molecular Regenerative Medicine, Department of Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine
    Nippon Rinsho 64:312-21. 2006
  44. ncbi Hepatocyte growth factor (HGF) attenuates gliosis and motoneuronal degeneration in the brainstem motor nuclei of a transgenic mouse model of ALS
    Keiichi Kadoyama
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurosci Res 59:446-56. 2007
    ..These findings suggest that, in addition to direct neurotrophic activity on motoneurons, HGF-suppression of gliosis may retard disease progression, making HGF a potential therapeutic agent for the treatment of ALS patients...
  45. ncbi Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 276:34089-97. 2001
    ..These results suggest that galectin-12, an adipose-expressed galectin-like molecule, may participate in the apoptosis of adipocytes...
  46. ncbi Different activity regulation and subcellular localization of LIMK1 and LIMK2 during cell cycle transition
    Tomoyuki Sumi
    Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, 2 2 B7 Yamadaoka, Suita, Osaka 565 0871, Japan
    Exp Cell Res 312:1021-30. 2006
    ....
  47. ncbi Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis
    Wook-Hwan Kim
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Yamada-oka 2-2-B7, Suita, Osaka 565-0871, Japan
    Am J Pathol 166:1017-28. 2005
    ..Growth inhibition and enhanced apoptosis in portal myofibroblasts by HGF are newly identified mechanisms aiding resolution from liver fibrosis/cirrhosis by HGF...
  48. ncbi In vivo gene transfection with hepatocyte growth factor via the pulmonary artery induces angiogenesis in the rat lung
    Masamichi Ono
    Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Circulation 106:I264-9. 2002
    ..These results suggest therapeutic angiogenesis induced by HGF gene expression in the lung may be found suitable in treating subjects with decreased pulmonary vasculature or increased pulmonary vascular resistance...
  49. ncbi Hepatocyte growth factor prevents endothelial cell death through inhibition of bax translocation from cytosol to mitochondrial membrane
    Hironori Nakagami
    Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes 51:2604-11. 2002
    ..HGF may be an important factor in the maintenance of endothelial function...
  50. ncbi A newly identified AMSH-family protein is specifically expressed in haploid stages of testicular germ cells
    Keiko Kitajima
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Biochem Biophys Res Commun 309:135-42. 2003
    ..We suggested that AMSH-FPbeta had a functional role in the spermiogenesis...
  51. ncbi Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction
    Munehisa Shimamura
    Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Osaka, Japan
    Hypertension 47:742-51. 2006
    ..Our results also provide evidence for the feasibility of gene therapy in the chronic stage of cerebral infarction...
  52. ncbi Preservations of nephrin and synaptopodin by recombinant hepatocyte growth factor in podocytes for the attenuations of foot process injury and albuminuria in nephritic mice
    Takashi Kato
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Nephrology (Carlton) 16:310-8. 2011
    ..In the present study, we examined whether and how nephrin expression is sustained by podocytes during the HGF-mediated attenuation of albuminuria...
  53. ncbi Visceral fat is a major contributor for multiple risk factor clustering in Japanese men with impaired glucose tolerance
    H Nagaretani
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes Care 24:2127-33. 2001
    ..CONCLUSIONS: Visceral fat accumulation is a major contributor for multiple risk factor clustering in Japanese men with IGT and NGT...
  54. ncbi Genomic structure and mutations in adipose-specific gene, adiponectin
    M Takahashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int J Obes Relat Metab Disord 24:861-8. 2000
    ..Adiponectin is a collagen-like plasma protein specifically synthesized in adipose tissue. Plasma adiponectin concentrations are decreased in obesity whereas it is adipose-specific...
  55. ncbi Treatment of dilated cardiomyopathy with electroporation of hepatocyte growth factor gene into skeletal muscle
    Kazuo Komamura
    Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Hypertension 44:365-71. 2004
    ..Systemic delivery of gene products with in vivo electroporation into skeletal muscle seemed to be an alternative means of direct gene delivery...
  56. ncbi Identification and characterization of novel variants of the tryptophan 2,3-dioxygenase gene: differential regulation in the mouse nervous system during development
    Masaaki Kanai
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Neurosci Res 64:111-7. 2009
    ..Our findings indicate that tdo and its novel variants may play an important role in not only the liver but also in local areas in developing and adult brain...
  57. ncbi HGF as a renotrophic and anti-fibrotic regulator in chronic renal disease
    Shinya Mizuno
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Front Biosci 13:7072-86. 2008
    ..Since insufficient production of HGF is causative for renal fibrosis, supplementation with HGF represents a new approach to inhibit or improve chronic renal failure...
  58. ncbi Counteractive effects of HGF on PDGF-induced mesangial cell proliferation in a rat model of glomerulonephritis
    Kazuhiko Bessho
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Physiol Renal Physiol 284:F1171-80. 2003
    ..These results indicate that HGF counteracts PDGF-induced mesangial cell proliferation and functions as a negative regulator of activated mesangial cell proliferation...
  59. ncbi Therapeutic angiogenesis in the ischemic canine heart induced by myocardial injection of naked complementary DNA plasmid encoding hepatocyte growth factor
    Toshihiro Funatsu
    Division of Cardiovascular Surgery, Department of Surgery E1, Osaka University Graduate School of Medicine, Osaka, Japan
    J Thorac Cardiovasc Surg 124:1099-105. 2002
    ..0005 by analysis of variance). CONCLUSIONS: These results support the efficacy of the direct injection of plasmid complementary DNA encoding human hepatocyte growth factor to induce therapeutic angiogenesis in the ischemic myocardium...
  60. ncbi Hepatocyte growth factor (HGF) promotes oligodendrocyte progenitor cell proliferation and inhibits its differentiation during postnatal development in the rat
    Wakana Ohya
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, B 7, Osaka 565 0871, Japan
    Brain Res 1147:51-65. 2007
    ..Our findings suggest that c-Met signaling, together with HGF regulation, plays an important role in developmental oligodendrogenesis...
  61. ncbi Multiple biological responses are induced by glycosylation-deficient hepatocyte growth factor
    Kazuhiro Fukuta
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, 2-2-B7 Yamadaoka, Suita, Osaka 565-0871, Japan
    Biochem J 388:555-62. 2005
    ..Hence, non-glycosylated HGF is promising as an alternative for glycosylated HGF in clinical applications...
  62. ncbi Possible effects of hepatocyte growth factor for the prevention of peritoneal fibrosis
    Koki Matsuo
    Department of Hematology, Kinki University School of Medicine, Osaka, Japan
    Nephron Exp Nephrol 99:e87-94. 2005
    ..Furthermore, the production of TGF-beta1 was also significantly decreased. CONCLUSION: These results suggested that exogenous HGF could possibly prevent peritoneal fibrosis...
  63. ncbi Hepatocyte growth factor: a regenerative drug for acute hepatitis and liver cirrhosis
    Shinya Mizuno
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan
    Regen Med 2:161-70. 2007
    ....
  64. ncbi Localization and functional role of hepatocyte growth factor (HGF) and its receptor c-met in the rat developing cerebral cortex
    Woong Sun
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, B 7, Osaka 565 0871, Japan
    Brain Res Mol Brain Res 103:36-48. 2002
    ..These lines of evidence suggest that HGF is involved in the development and maintenance of cortical neurons during differentiation, motogenesis, neuritogenesis and neuronal survival...
  65. ncbi Prevention of neutrophil extravasation by hepatocyte growth factor leads to attenuations of tubular apoptosis and renal dysfunction in mouse ischemic kidneys
    Shinya Mizuno
    Division of Molecular Regenerative Medicine, Department of Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, 2-2-B7 Yamadaoka, Suita 565-0871, Japan
    Am J Pathol 166:1895-905. 2005
    ..Our study provides a rationale for why HGF supplementation elicits therapeutic effects in ischemic kidneys...
  66. ncbi Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice
    Masaaki Kanai
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Mol Brain 2:8. 2009
    ..These findings demonstrate a direct molecular link between Trp metabolism and neurogenesis and anxiety-related behavior under physiological conditions...
  67. ncbi Molecular cloning, expression and partial characterization of Xksy, Xenopus member of the Sky family of receptor tyrosine kinases
    Yuko Akasaka Kishi
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Japan
    Gene 288:29-40. 2002
    ..And doxycycline pre-treatment eliminated these activities. These findings suggest that Xksy may play an important role in growth, differentiation and the accurate migration of cells during embryogenesis and early neural development...
  68. ncbi Improvement of survival of skin flaps by combined gene transfer of hepatocyte growth factor and prostacyclin synthase
    Aya Nakagawa
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
    J Gene Med 9:1087-94. 2007
    ....
  69. ncbi Relationship of regional adiposity to serum leptin level in nonobese Japanese type 2 diabetic male patients
    T Okumura
    Division of Diabetes, Kansai-Denryoku Hospital, Osaka, Japan
    Diabetes Metab 29:15-8. 2003
    ..CONCLUSIONS: These results indicate that serum leptin levels are reflective of subcutaneous fat area in nonobese Japanese type 2 diabetic male patients...
  70. ncbi 3-D Finite element analysis of all-ceramic posterior crowns
    A Imanishi
    Division of Oromaxillofacial Regeneration, Course for Integrated Oral Sciences and Stomatology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan
    J Oral Rehabil 30:818-22. 2003
    ....
  71. ncbi Molecular cloning and characterization of a human homologue of TBPIP, a BRCA1 locus-related gene
    H Ijichi
    First Department of Anatomy, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka, Japan
    Gene 248:99-107. 2000
    ....
  72. ncbi Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells
    H Nakagami
    Department of Geriatric Medicine, Division of Gene Therapy Science, Osaka University, Osaka, Japan
    Hypertension 37:581-6. 2001
    ..These findings provide new perspectives in the role of HGF in cardiovascular disease...
  73. ncbi PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    N Maeda
    Department of Internal Medicine and Molecular Science (B5, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes 50:2094-9. 2001
    ..TZDs might prevent atherosclerotic vascular disease in insulin-resistant patients by inducing the production of adiponectin through direct effect on its promoter and antagonizing the effect of TNF-alpha on the adiponectin promoter...
  74. ncbi Molecular cloning and characterization of a newly identified member of the cadherin family, PB-cadherin
    K Sugimoto
    Division of Biochemistry, Osaka University Medical School, Japan
    J Biol Chem 271:11548-56. 1996
    ..PB-cadherin may play an important role in morphogenesis and tissue formation in neural and non-neural cells for the development and maintenance of the brain and neuroendocrine organs by regulating cell-cell adhesion...
  75. ncbi Visceral fat accumulation contributes to insulin resistance, small-sized low-density lipoprotein, and progression of coronary artery disease in middle-aged non-obese Japanese men
    H Kobayashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Jpn Circ J 65:193-9. 2001
    ..In conclusion, visceral fat accumulation may contribute to the development of CAD through the progression of insulin resistance and the increase of apo B-containing lipoproteins and small-sized LDLs in middle-aged non-obese Japanese men...
  76. ncbi A potential cardioprotective role of hepatocyte growth factor in myocardial infarction in rats
    H Ueda
    Division of Biochemistry, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
    Cardiovasc Res 51:41-50. 2001
    ..Our working hypothesis is that HGF may afford myocardial protection from myocardial infarction...
  77. ncbi The expression of SPARC in adipose tissue and its increased plasma concentration in patients with coronary artery disease
    M Takahashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Obes Res 9:388-93. 2001
    ..In the current study, we have examined the expression of secreted protein, acidic and rich in cysteine (SPARC) in adipose tissue and its significance in obesity and coronary artery disease (CAD)...
  78. ncbi Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model: molecular mechanisms of delayed angiogenesis in diabetes
    Y Taniyama
    Department of Geriatric Medicine, Division of Gene Therapy Science, Biomedical Research Center, Osaka University Medical School, Suita, Japan
    Circulation 104:2344-50. 2001
    ..The delay of angiogenesis in diabetes might be due to downregulation of MMP-1 and ets-1 through a decrease in HGF by high D-glucose...
  79. ncbi DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95
    K Satoh
    Department of Oncogene Research, Institute for Microbial Diseases, Osaka University, Suita, Japan
    Genes Cells 2:415-24. 1997
    ....
  80. ncbi Myocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplasty
    Shigeru Miyagawa
    Division of Cardiovascular Surgery, Department of Surgery E1, School of Allied Health Science, Faculty of Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Circulation 105:2556-61. 2002
    ..The combined effects might have lead to the improved cardiac performance. Thus, combined therapy may be a promising strategy for the treatment of heart failure caused by myocardial infarction...
  81. ncbi Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS
    Woong Sun
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, B-7, Osaka 565-0871, Japan
    J Neurosci 22:6537-48. 2002
    ....
  82. ncbi Functional involvement of Xenopus LIM kinases in progression of oocyte maturation
    T Takahashi
    Division of Biochemistry, Department of Oncology, Biomedical Research Center B7, Osaka University Medical School, Suita, Osaka, 565 0871, Japan
    Dev Biol 229:554-67. 2001
    ..Based on these findings, we propose that XLIMK is a putative regulator of cytoskeletal rearrangements during oocyte maturation, and the interaction between XLIMK activity and microtubule dynamics seems highly likely...
  83. ncbi Inhibition of neointima by angiotensin-converting enzyme inhibitor in porcine coronary artery balloon-injury model
    K Matsumoto
    Department of Geriatric Medicine, Osaka University Medical School, Osaka, Japan
    Hypertension 37:270-4. 2001
    ..Downregulation of the local vascular HGF system may play an important role in the pathogenesis of cardiovascular disease...
  84. ncbi HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model
    M Nakabayashi
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetologia 46:115-23. 2003
    ..01). CONCLUSIONS/INTERPRETATION: Overall, HGF/NK4 inhibited angiogenesis induced by VEGF through inhibition of phosphorylation of ERK and ets-1 expression in in vitro cultured endothelial cells and in vivo rabbit model...
  85. ncbi Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models: preclinical study for treatment of peripheral arterial disease
    Y Taniyama
    Department of Geriatric Medicine, Biomedical Research Center, Osaka University Medical School, Japan
    Gene Ther 8:181-9. 2001
    ..01). Overall, intramuscular injection of naked human HGF plasmid induced therapeutic angiogenesis in rat and rabbit ischemic hindlimb models, as potential therapy for peripheral arterial disease...
  86. ncbi Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions
    Kunio Matsumoto
    Division of Molecular Regenerative Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Cancer 119:477-83. 2006
    ..In normal tissues, the HGF-Met axis plays diverse roles in organogenesis and in wound healing. The simile that "cancer is a never-healing wound" appears to be pertinent here...
  87. ncbi Hepatocyte growth factor plays roles in the induction and autocrine maintenance of bone marrow stromal cell IL-11, SDF-1 alpha, and stem cell factor
    Yoshiko Matsuda-Hashii
    Department of Developmental Medicine, Osaka University, Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Exp Hematol 32:955-61. 2004
    ..We also showed that stromal cells themselves express HGF receptor c-MET. It was therefore postulated that HGF exerts its effect on hematopoiesis and maintenance of the hematopoietic microenvironment in a paracrine and autocrine manner...
  88. ncbi The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine
    Toshikazu Nakamura
    Kringle Pharma Joint Research Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University, Osaka, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 86:588-610. 2010
    ..Molecular analysis of the HGF-c-Met system could provide bridges between basic biology and clinical medicine...
  89. ncbi NK4 (HGF-antagonist/angiogenesis inhibitor) in cancer biology and therapeutics
    Kunio Matsumoto
    Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
    Cancer Sci 94:321-7. 2003
    ..Targeting tumor invasion-metastasis and angiogenesis with NK4 seems to have considerable therapeutic potential for cancer patients...
  90. ncbi Impairment of collateral formation in lipoprotein(a) transgenic mice: therapeutic angiogenesis induced by human hepatocyte growth factor gene
    Ryuichi Morishita
    Division of Gene Therapy Science, Osaka University Medical School, Osaka, Japan
    Circulation 105:1491-6. 2002
    ..In addition, we examined the feasibility of gene therapy by using an angiogenic growth factor, hepatocyte growth factor (HGF), to treat PAD in the presence of high Lp(a)...
  91. ncbi Translucency of glass-fibre-reinforced composite materials
    T Nakamura
    Division of Oromaxillofacial Regeneration, Course for Integrated Oral Sciences and Stomatology, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Oral Rehabil 31:817-21. 2004
    ....
  92. ncbi X-ray polarization spectroscopy to study anisotropic velocity distribution of hot electrons produced by an ultra-high-intensity laser
    Y Inubushi
    Institute of Laser Engineering, Osaka University, Suita, Osaka, Japan
    Phys Rev E Stat Nonlin Soft Matter Phys 81:036410. 2010
    ..A full-angular spread in the overdense region of 22.4 degrees -2.4+5.4 was obtained from the measured polarization degree...
  93. ncbi Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson's disease
    H Koike
    Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
    Gene Ther 13:1639-44. 2006
    ..Overall, the present study demonstrated that overexpression of HGF prevented neuronal death in a PD rat model, providing a potential novel therapy for PD...
  94. ncbi Prototype of simulation of orthognathic surgery using a virtual reality haptic device
    T Sohmura
    Course for Integrated Oral Science and Stomatology, Division of Oralmaxillofacial Regeneration, Graduate School of Dentistry, Osaka University, Suita, Osaka 565 0871, Japan
    Int J Oral Maxillofac Surg 33:740-50. 2004
    ..Because of its versatility and functions, the present device was found to be useful for simulating various procedures for orthognathic surgery and thereby three-dimensionally determine surgical movements...
  95. ncbi Angiogenic and antifibrotic actions of hepatocyte growth factor improve cardiac dysfunction in porcine ischemic cardiomyopathy
    J Azuma
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Gene Ther 13:1206-13. 2006
    ..These favorable outcomes suggest potential utility to treat patients with ischemic heart disease using HGF gene transfer. Currently, a phase I study using human HGF plasmid DNA is ongoing to test the validity of this concept...
  96. ncbi Inhibition of experimental choroidal neovascularization by overexpression of tissue inhibitor of metalloproteinases-3 in retinal pigment epithelium cells
    T Takahashi
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Am J Ophthalmol 130:774-81. 2000
    ....
  97. ncbi Influence of abutment substrate and ceramic thickness on the colour of heat-pressed ceramic crowns
    T Nakamura
    Division of Oromaxillofacial Regeneration, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Oral Rehabil 29:805-9. 2002
    ..6 mm thick...
  98. ncbi Novel LPL mutation (L303F) found in a patient associated with coronary artery disease and severe systemic atherosclerosis
    Y Saika
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan
    Eur J Clin Invest 33:216-22. 2003
    ..In this paper, we report a 55-year-old type I hyperlipidaemic patient with a novel missense mutation in the LPL gene...
  99. ncbi Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene
    I Nakagawa
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
    J Clin Microbiol 38:1909-14. 2000
    ..Thus, a new type of fimA gene is now established, and the fimA genotyping could be useful in determining the disease-associated genotypes of P. gingivalis involved in the development of adult periodontitis...
  100. ncbi Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances
    Y Matsuzawa
    Second Department of Internal Medicine, Osaka University Medical School, Japan
    Ann N Y Acad Sci 892:146-54. 1999
    ..Adipocytokines may play important roles in the development of the disorders in Syndrome X...
  101. ncbi Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 20:1595-9. 2000
    ..These results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy...