Norihiro Nakamura

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation
    Norihiro Nakamura
    Department of Biological Science, Graduate School of Science, Osaka University, Machikaneyama, Toyonaka, Osaka 560 0043, Japan
    J Biol Chem 280:1561-72. 2005
  2. ncbi A novel kinesin-like protein, KIF1Bbeta3 is involved in the movement of lysosomes to the cell periphery in non-neuronal cells
    Masafumi Matsushita
    Department of Biological Sciences, Graduate School of Science, Osaka University, Machikaneyama cho 1 16, Toyonaka City, Osaka, Japan 560 0043
    Traffic 5:140-51. 2004
  3. ncbi The fourth transmembrane domain of the Helicobacter pylori Na+/H+ antiporter NhaA faces a water-filled channel required for ion transport
    Naoyuki Kuwabara
    Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043, Japan
    J Biol Chem 279:40567-75. 2004
  4. ncbi Characterization of the ion transport activity of the budding yeast Na+/H+ antiporter, Nha1p, using isolated secretory vesicles
    Ryuichi Ohgaki
    Department of Biological Sciences, Graduate School of Science, Osaka University, Machikaneyama, Toyonaka, Osaka 560 0043, Japan
    Biochim Biophys Acta 1712:185-96. 2005
  5. ncbi A novel membrane protein capable of binding the Na+/H+ antiporter (Nha1p) enhances the salinity-resistant cell growth of Saccharomyces cerevisiae
    Keiji Mitsui
    Department of Biological Sciences, Graduate School of Science, Osaka University, Machikaneyama cho 1 16, Toynaka City, Osaka 560 0043, Japan
    J Biol Chem 279:12438-47. 2004
  6. ncbi A conserved domain in the tail region of the Saccharomyces cerevisiae Na+/H+ antiporter (Nha1p) plays important roles in localization and salinity-resistant cell-growth
    Keiji Mitsui
    Department of Biological Sciences, Graduate School of Science, Osaka University, 1 16 Machikaneyama cho, Toyonaka City, Osaka 560 0043
    J Biochem 135:139-48. 2004
  7. ncbi Two nuclear export signals specify the cytoplasmic localization of calcineurin B homologous protein 1
    Mana Nagita
    Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043
    J Biochem 134:919-25. 2003
  8. doi A membrane-proximal region in the C-terminal tail of NHE7 is required for its distribution in the trans-Golgi network, distinct from NHE6 localization at endosomes
    Naomi Fukura
    Department of Biological Science, Graduate School of Science, Osaka University, Machikaneyama cho 1 1, Toyonaka City, Osaka, 560 0043, Japan
    J Membr Biol 234:149-58. 2010
  9. ncbi Detection of oligomerization and conformational changes in the Na+/H+ antiporter from Helicobacter pylori by fluorescence resonance energy transfer
    Akira Karasawa
    Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043, Japan
    J Biol Chem 280:41900-11. 2005
  10. ncbi Oligomerization of the Saccharomyces cerevisiae Na+/H+ antiporter Nha1p: implications for its antiporter activity
    Keiji Mitsui
    Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka City, Osaka 560 0043, Japan
    Biochim Biophys Acta 1720:125-36. 2005

Collaborators

  • Hiroshi Kanazawa
  • Hiroki Inoue
  • Hironobu Morisaka
  • Mitsuyoshi Ueda
  • Keiji Mitsui
  • Hiroshi Kuwahara
  • Yumi Tsuboi
  • Ryuichi Ohgaki
  • Masafumi Matsushita
  • Naomi Fukura
  • Shinya Kamauchi
  • Akira Karasawa
  • Naoyuki Kuwabara
  • Mana Nagita
  • Hidetomo Yasui
  • Rie Kinoshita
  • Fumihiro Ochi
  • Yoshihide Doi
  • Shingo Tanaka
  • Miho Matsumoto
  • Jun Ichi Kamei
  • Megumi Haga
  • Satoshi Ujike
  • Shigeru Sakajo
  • Atsuo Tanaka

Detail Information

Publications16

  1. ncbi Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation
    Norihiro Nakamura
    Department of Biological Science, Graduate School of Science, Osaka University, Machikaneyama, Toyonaka, Osaka 560 0043, Japan
    J Biol Chem 280:1561-72. 2005
    ..We propose that the specific NHE isoforms contribute to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell...
  2. ncbi A novel kinesin-like protein, KIF1Bbeta3 is involved in the movement of lysosomes to the cell periphery in non-neuronal cells
    Masafumi Matsushita
    Department of Biological Sciences, Graduate School of Science, Osaka University, Machikaneyama cho 1 16, Toyonaka City, Osaka, Japan 560 0043
    Traffic 5:140-51. 2004
    ..These results indicate that KIF1Bbeta3 is involved in the translocation of lysosomes from perinuclear regions to the cell periphery...
  3. ncbi The fourth transmembrane domain of the Helicobacter pylori Na+/H+ antiporter NhaA faces a water-filled channel required for ion transport
    Naoyuki Kuwabara
    Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043, Japan
    J Biol Chem 279:40567-75. 2004
    ..Furthermore, residues Ile-142 to Phe-144 may be important for the conformational change that accompanies ion transport in NhaA...
  4. ncbi Characterization of the ion transport activity of the budding yeast Na+/H+ antiporter, Nha1p, using isolated secretory vesicles
    Ryuichi Ohgaki
    Department of Biological Sciences, Graduate School of Science, Osaka University, Machikaneyama, Toyonaka, Osaka 560 0043, Japan
    Biochim Biophys Acta 1712:185-96. 2005
    ..The ion selectivity and the stoichiometry suggest a unique physiological role of Nha1p which is distinct from that of other known Na+/H+ antiporters...
  5. ncbi A novel membrane protein capable of binding the Na+/H+ antiporter (Nha1p) enhances the salinity-resistant cell growth of Saccharomyces cerevisiae
    Keiji Mitsui
    Department of Biological Sciences, Graduate School of Science, Osaka University, Machikaneyama cho 1 16, Toynaka City, Osaka 560 0043, Japan
    J Biol Chem 279:12438-47. 2004
    ..These observations suggest that Cos3p is a novel membrane protein that can enhance salinity-resistant cell growth by interacting with the C1+C2 domain of Nha1p and thereby possibly activating the antiporter activity of this protein...
  6. ncbi A conserved domain in the tail region of the Saccharomyces cerevisiae Na+/H+ antiporter (Nha1p) plays important roles in localization and salinity-resistant cell-growth
    Keiji Mitsui
    Department of Biological Sciences, Graduate School of Science, Osaka University, 1 16 Machikaneyama cho, Toyonaka City, Osaka 560 0043
    J Biochem 135:139-48. 2004
    ..Based on the overall similarity of the two-domain structure of Nha1p to that of mammalian Na(+)/H(+) antiporters, the functional importance of domains proximal to the membrane region is discussed...
  7. ncbi Two nuclear export signals specify the cytoplasmic localization of calcineurin B homologous protein 1
    Mana Nagita
    Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043
    J Biochem 134:919-25. 2003
    ..These results suggest that after CHP1 has entered the nucleus, it is exported to the cytoplasm in an NES-dependent manner...
  8. doi A membrane-proximal region in the C-terminal tail of NHE7 is required for its distribution in the trans-Golgi network, distinct from NHE6 localization at endosomes
    Naomi Fukura
    Department of Biological Science, Graduate School of Science, Osaka University, Machikaneyama cho 1 1, Toyonaka City, Osaka, 560 0043, Japan
    J Membr Biol 234:149-58. 2010
    ..These results suggest that two membrane proximal regions (residues 533-559 and 563-568) play an important role in targeting NHE7 to the TGN...
  9. ncbi Detection of oligomerization and conformational changes in the Na+/H+ antiporter from Helicobacter pylori by fluorescence resonance energy transfer
    Akira Karasawa
    Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043, Japan
    J Biol Chem 280:41900-11. 2005
    ..Dynamic interactions between HPNhaA monomers were detectable in membranes by FRET analysis, thus providing a new approach to study dynamic conformational changes in NhaA during antiport activity...
  10. ncbi Oligomerization of the Saccharomyces cerevisiae Na+/H+ antiporter Nha1p: implications for its antiporter activity
    Keiji Mitsui
    Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka City, Osaka 560 0043, Japan
    Biochim Biophys Acta 1720:125-36. 2005
    ..These results support the notion that Nha1p exists in membranes as a dimer and that the interaction of its monomers is important for its antiporter activity...
  11. ncbi Nuclear localization of the serine/threonine kinase DRAK2 is involved in UV-induced apoptosis
    Hiroshi Kuwahara
    Department of Biological Sciences, Graduate School of Science, Osaka University, 1 1 Machikaneyama cho, Toyonaka, Osaka 560 0043, Japan
    Biol Pharm Bull 29:225-33. 2006
    ..Knockdown of DRAK2 expression by siRNA partially suppressed UV-induced apoptosis. These results suggest that DRAK2 plays a role in UV induced apoptosis...
  12. ncbi The apoptosis-inducing protein kinase DRAK2 is inhibited in a calcium-dependent manner by the calcium-binding protein CHP
    Hiroshi Kuwahara
    Department of Biological Science, Graduate School of Science, Osaka University, Machikaneyama, Toyonaka, Osaka 560 0043
    J Biochem 134:245-50. 2003
    ..These observations suggest that CHP negatively regulates the apoptosis-inducing protein kinase DRAK2 in a manner that depends on intracellular Ca(2+)-concentration...
  13. ncbi Identification of membrane domains of the Na+/H+ antiporter (NhaA) protein from Helicobacter pylori required for ion transport and pH sensing
    Yumi Tsuboi
    Department of Biological Sciences, Graduate School of Science, Osaka University, Machikaneyama cho 1 16, Toyonaka City, Osaka, Japan 560 0043
    J Biol Chem 278:21467-73. 2003
    ....
  14. ncbi Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium
    Hiroki Inoue
    Department of Biological Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan
    Biol Pharm Bull 26:148-55. 2003
    ..These results suggest that CHP2 functions in the absorptive epithelium for the intestine with NHE(s)...
  15. ncbi Structurally and functionally conserved domains in the diverse hydrophilic carboxy-terminal halves of various yeast and fungal Na+/H+ antiporters (Nha1p)
    Shinya Kamauchi
    Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka, 560 0043, Japan
    J Biochem 131:821-31. 2002
    ..The results in this study suggest that the diverse hydrophilic region of yeast and fungal Nha1p has six conserved domains with conserved functions in terms of expression of Nha1p activity...
  16. ncbi KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles
    Norihiro Nakamura
    Department of Biological Science, Graduate School of Science, Osaka University, Machikaneyama, Toyonaka, Osaka 560 0043, Japan
    J Biochem 132:483-91. 2002
    ..These results suggest that KIF1Bbeta2, a novel CHP-interacting molecular motor, mediates the transport of synaptic vesicles in neuronal cells...