Ichiro Nakagawa

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Regulated expression of the Shiga toxin B gene induces apoptosis in mammalian fibroblastic cells
    I Nakagawa
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka, 565 0871, Japan
    Mol Microbiol 33:1190-9. 1999
  2. ncbi request reprint Autophagy defends cells against invading group A Streptococcus
    Ichiro Nakagawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Science 306:1037-40. 2004
  3. ncbi request reprint Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells
    Ichiro Nakagawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka, Japan
    Cell Microbiol 6:939-52. 2004
  4. pmc Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution
    Ichiro Nakagawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka 565 0871, Japan
    Genome Res 13:1042-55. 2003
  5. ncbi request reprint Identification of a new variant of fimA gene of Porphyromonas gingivalis and its distribution in adults and disabled populations with periodontitis
    I Nakagawa
    Department of Oral Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Periodontal Res 37:425-32. 2002
  6. ncbi request reprint Infection and pathogenesis of a murine strain of Escherichia coli with genetically introduced Shiga toxin type I operon in conventional mice
    Ichiro Nakagawa
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka, 565 0871, Japan
    Microb Pathog 33:63-72. 2002
  7. ncbi request reprint Cytochrome c-mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes-infected epithelial cells
    I Nakagawa
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, 1 8 Yamadaoka, Suita Osaka, 565 0871 Japan
    Cell Microbiol 3:395-405. 2001
  8. pmc Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene
    I Nakagawa
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
    J Clin Microbiol 38:1909-14. 2000
  9. pmc Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells
    Ichiro Nakagawa
    Department of Oral Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Infect Immun 70:277-85. 2002
  10. ncbi request reprint Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype
    Takahiro Kato
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    Cell Microbiol 9:753-65. 2007

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Regulated expression of the Shiga toxin B gene induces apoptosis in mammalian fibroblastic cells
    I Nakagawa
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka, 565 0871, Japan
    Mol Microbiol 33:1190-9. 1999
    ..These apoptotic changes were abrogated by pretreatment with Z-VAD-fmk. These results suggest that the transfected Stx1B gene induces apoptosis by activating the caspase cascade after Stx1B expression in the cytoplasm...
  2. ncbi request reprint Autophagy defends cells against invading group A Streptococcus
    Ichiro Nakagawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Science 306:1037-40. 2004
    ..In autophagy-deficient Atg5-/- cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens...
  3. ncbi request reprint Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells
    Ichiro Nakagawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka, Japan
    Cell Microbiol 6:939-52. 2004
    ....
  4. pmc Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution
    Ichiro Nakagawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka 565 0871, Japan
    Genome Res 13:1042-55. 2003
    ....
  5. ncbi request reprint Identification of a new variant of fimA gene of Porphyromonas gingivalis and its distribution in adults and disabled populations with periodontitis
    I Nakagawa
    Department of Oral Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Periodontal Res 37:425-32. 2002
    ..91) and mentally disabled populations (OR 4.00). These findings suggest that P. gingivalis with type Ib fimA is closely associated with the progression of periodontitis, similar to organisms with type II and IV fimA...
  6. ncbi request reprint Infection and pathogenesis of a murine strain of Escherichia coli with genetically introduced Shiga toxin type I operon in conventional mice
    Ichiro Nakagawa
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka, 565 0871, Japan
    Microb Pathog 33:63-72. 2002
    ..These results suggest that E. coli BME/Stx1 can colonize the mouse intestine under natural environment, and induced systemic neural changes and inflammation in the intestine and kidneys...
  7. ncbi request reprint Cytochrome c-mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes-infected epithelial cells
    I Nakagawa
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, 1 8 Yamadaoka, Suita Osaka, 565 0871 Japan
    Cell Microbiol 3:395-405. 2001
    ..g. Shigella and Salmonella species...
  8. pmc Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene
    I Nakagawa
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
    J Clin Microbiol 38:1909-14. 2000
    ..Thus, a new type of fimA gene is now established, and the fimA genotyping could be useful in determining the disease-associated genotypes of P. gingivalis involved in the development of adult periodontitis...
  9. pmc Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells
    Ichiro Nakagawa
    Department of Oral Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Infect Immun 70:277-85. 2002
    ..These results suggest that type II FimA can bind to epithelial cells most efficiently through specific host receptors...
  10. ncbi request reprint Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype
    Takahiro Kato
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    Cell Microbiol 9:753-65. 2007
    ..In a mouse abscess model, the type II clones significantly induced serum IL-1beta and IL-6, as well as other infectious symptoms. These results suggest that type II fimbriae are a critical determinant of P. gingivalis virulence...
  11. pmc Porphyromonas gingivalis induces receptor activator of NF-kappaB ligand expression in osteoblasts through the activator protein 1 pathway
    Nobuo Okahashi
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Osaka Suita 565 0871, Japan
    Infect Immun 72:1706-14. 2004
    ..These results suggest that P. gingivalis infection induces RANKL expression in osteoblasts through AP-1 signaling pathways and cysteine proteases of the organism are involved in RANKL production...
  12. pmc Streptococcus pyogenes infection induces septic arthritis with increased production of the receptor activator of the NF-kappaB ligand
    Atsuo Sakurai
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Infect Immun 71:6019-26. 2003
    ..These results suggest that GAS can colonize in the joints and induce bacterial arthritis. Local RANKL production in the infected joints may be involved in bone destruction...
  13. pmc Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae
    Ichiro Nakagawa
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Infect Immun 74:3773-82. 2006
    ..gingivalis efficiently invades epithelial cells and degrades focal adhesion components with Arg-gingipain, which results in cellular impairment during wound healing and periodontal tissue regeneration...
  14. pmc Association between epithelial cell death and invasion by microspheres conjugated to Porphyromonas gingivalis vesicles with different types of fimbriae
    Hiroaki Inaba
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Infect Immun 74:734-9. 2006
    ..Cell death was induced by MS, though becoming less frequent over time, with invasion efficiency partially related to cell death and gingipains likely the major cause...
  15. pmc Development of a PCR method for rapid identification of new Streptococcus mutans serotype k strains
    Kazuhiko Nakano
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 1 8 Yamada oka, Suita, Osaka 565 0871, Japan
    J Clin Microbiol 42:4925-30. 2004
    ..These results indicate that this new PCR method is effective for identification of subjects with S. mutans serotype k...
  16. pmc Streptococcus mutans clonal variation revealed by multilocus sequence typing
    Kazuhiko Nakano
    Departments of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 1 8 Yamada oka, Suita, Osaka 565 0871, Japan
    J Clin Microbiol 45:2616-25. 2007
    ..In conclusion, the superior discriminatory capacity of this MLST scheme for S. mutans may have important practical implications...
  17. ncbi request reprint Distribution of Porphyromonas gingivalis fimA genotypes in Japanese children and adolescents
    Kiyoko Tamura
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Periodontol 76:674-9. 2005
    ..A majority of the P. gingivalis organisms isolated from periodontitis patients are type II, followed by type IV, while type I is prevalent in healthy adults...
  18. ncbi request reprint Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patients
    Yutaka Terao
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka 565 0871, Japan
    J Biol Chem 277:47428-35. 2002
    ..Moreover, mortality was decreased in mice infected with the mutant strain in comparison to the wild type. These data suggest that FbaB is etiologically involved in the development of invasive streptococcal diseases...
  19. pmc Infection by Streptococcus pyogenes induces the receptor activator of NF-kappaB ligand expression in mouse osteoblastic cells
    Nobuo Okahashi
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Japan
    Infect Immun 71:948-55. 2003
    ..These results suggest that infection of osteoblasts by S. pyogenes stimulates RANKL production and may trigger bone destruction in infected bone tissue...
  20. ncbi request reprint Inhibitory effects of tumor necrosis factor-alpha on migration of human periodontal ligament cells
    Akane Takemura
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Periodontol 77:883-90. 2006
    ..In the present study, we examined the effects of TNF-alpha on migration and proliferation of human periodontal ligament (PDL) cells...
  21. pmc Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells
    Yutaka Terao
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
    Infect Immun 70:993-7. 2002
    ..pyogenes M types. An Lbp-deficient mutant showed a significantly lower efficiency of adhesion to HEp-2 cells than did the wild-type strain. These results indicate that Lbp is one of the important S. pyogenes adhesins...
  22. ncbi request reprint Inhibitory effects of Porphyromonas gingivalis fimbriae on interactions between extracellular matrix proteins and cellular integrins
    Ichiro Nakagawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    Microbes Infect 7:157-63. 2005
    ..gingivalis cells. These results suggest that P. gingivalis fimbriae compete with ECM proteins for alphavbeta3- and alpha5beta1-integrins, and inhibit integrin/ECM protein-related cellular functions...
  23. ncbi request reprint Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis
    Atsuo Amano
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Periodontal Res 39:136-42. 2004
    ..In this short review, variations of fimbriae in relation to microbial pathogenesis are discussed...
  24. pmc Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice
    Shigefumi Okamoto
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Virol 77:4104-12. 2003
    ..Our results indicate that prior infection with influenza A virus induces a lethal synergism, resulting in the induction of invasive S. pyogenes infection in mice...
  25. ncbi request reprint A novel, anchorless streptococcal surface protein that binds to human immunoglobulins
    Shigetada Kawabata
    Department of Oral and Molecular Microbiology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Biochem Biophys Res Commun 296:1329-33. 2002
    ..The sib35 gene was found in all GAS strains examined, but not in oral, group B, C, or G streptococcal strains. These results suggest that Sib35 is a unique immunoglobulin-binding protein in GAS...
  26. ncbi request reprint Autophagy in innate immunity against intracellular bacteria
    Atsuo Amano
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka
    J Biochem 140:161-6. 2006
    ..aureus were resistant to autophagic degradation. The present review focuses on the protective function of autophagy against bacterial invasion of cells...
  27. ncbi request reprint [Genetic analysis and virulence factors of group A streptococci that cause severe invasive infectious diseases]
    Shigeyuki Hamada
    Tanpakushitsu Kakusan Koso 50:253-61. 2005
  28. pmc Demonstration of Streptococcus mutans with a cell wall polysaccharide specific to a new serotype, k, in the human oral cavity
    Kazuhiko Nakano
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 1 8 Yamada oka, Suita, Osaka 565 0871, Japan
    J Clin Microbiol 42:198-202. 2004
    ..These results indicate that S. mutans serotype k strains are present in the oral cavity in humans and may be able to survive longer in blood owing to their low susceptibility to phagocytosis...
  29. ncbi request reprint [Host defense mechanism by autophagy]
    Ichiro Nakagawa
    Osaka University Graduate School of Dentistry, Department of Oral and Molecular Microbiology
    Nihon Saikingaku Zasshi 60:485-9. 2005
  30. ncbi request reprint Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial membrane vesicle
    Kayoko Tsuda
    Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920 1192, Japan
    Cell Struct Funct 30:81-91. 2005
    ..These results suggest that P. gingivalis accomplishes its internalization utilizing membrane lipid raft and cytoskeletal functions of the target cells...
  31. ncbi request reprint [Genome sequence of an invasive M3 strain of Streptococcus pyogenes]
    Ichiro Nakagawa
    Division of Bacteriology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo
    Nihon Saikingaku Zasshi 61:317-24. 2006
  32. doi request reprint Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13
    Atsuo Sakurai
    Division of Bacteriology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 373:450-4. 2008
    ..These results suggest that MMP-13 plays an important role in the destruction of infected joints during the development of septic arthritis...
  33. ncbi request reprint Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation
    Eiki Yamasaki
    PRESTO, Japan Science and Technology Corporation, Saitama 332 0012, Japan
    J Biol Chem 281:11250-9. 2006
    ..These results suggest that VacA acts through different signaling pathways to induce apoptosis via Bax activation, independent of vacuolation...
  34. ncbi request reprint MitoKATP-channel opener protects against neuronal death in rat venous ischemia
    Ichiro Nakagawa
    Institute for Neurosurgical Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Neurosurgery 57:334-40; discussion 334-40. 2005
    ..In a model of venous ischemia, widespread penumbra-like low flow areas are created, which are susceptible to cortical spreading depression. Thus, we studied effects of mitoKATP channels on infarct size in this model...
  35. ncbi request reprint Role of Hrs in maturation of autophagosomes in mammalian cells
    Keiichi Tamai
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Biochem Biophys Res Commun 360:721-7. 2007
    ..Based on these results, we propose a novel function of Hrs, as a crucial player in the maturation of autophagosomes...