Tetsuji Naka

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation
    Y Kawazoe
    Department of Medicine III, Osaka University Medical School, Osaka, Japan
    J Exp Med 193:263-9. 2001
  2. ncbi request reprint SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo
    T Naka
    Department of Molecular Medicine, Osaka Graduate School of Medicine, Suita City, Osaka, Japan
    Immunity 14:535-45. 2001
  3. pmc Joint disease caused by defective gp130-mediated STAT signaling
    Tetsuji Naka
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Japan
    Arthritis Res 4:154-6. 2002
  4. pmc The paradigm of IL-6: from basic science to medicine
    Tetsuji Naka
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Japan
    Arthritis Res 4:S233-42. 2002
  5. ncbi request reprint SOCS-1 participates in negative regulation of LPS responses
    Reiko Nakagawa
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Japan
    Immunity 17:677-87. 2002
  6. doi request reprint SOCS-1 gene delivery cooperates with cisplatin plus pemetrexed to exhibit preclinical antitumor activity against malignant pleural mesothelioma
    Kota Iwahori
    Laboratory for Immune Signal, National Institute of Biomedical Innovation, Osaka, Japan
    Int J Cancer 132:459-71. 2013
  7. doi request reprint iTRAQ-based proteomic identification of leucine-rich alpha-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases
    Satoshi Serada
    Laboratory for Immune Signal, National Institute of Biomedical Innovation, 7 6 8 Saito Asagi, Ibaragi, Osaka, Japan
    Ann Rheum Dis 69:770-4. 2010
  8. ncbi request reprint Luteolin, a flavonoid, inhibits CD40 ligand expression by activated human basophils
    Toru Hirano
    Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka, Japan
    Int Arch Allergy Immunol 140:150-6. 2006
  9. ncbi request reprint Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A
    Shinya Matsuzaki
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan Laboratory for Immune Signal, National Institute of Biomedical Innovation, Osaka, Japan
    Int J Cancer 134:1796-809. 2014
  10. doi request reprint Blockade of interleukin-6 signaling suppresses not only th17 but also interphotoreceptor retinoid binding protein-specific Th1 by promoting regulatory T cells in experimental autoimmune uveoretinitis
    Hiroshi Haruta
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan
    Invest Ophthalmol Vis Sci 52:3264-71. 2011

Detail Information

Publications69

  1. pmc Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation
    Y Kawazoe
    Department of Medicine III, Osaka University Medical School, Osaka, Japan
    J Exp Med 193:263-9. 2001
    ..These findings suggest that SSI-1 acts as a negative feedback factor also in the insulin signal transduction pathway through the suppression of IRS-1 phosphorylation...
  2. ncbi request reprint SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo
    T Naka
    Department of Molecular Medicine, Osaka Graduate School of Medicine, Suita City, Osaka, Japan
    Immunity 14:535-45. 2001
    ....
  3. pmc Joint disease caused by defective gp130-mediated STAT signaling
    Tetsuji Naka
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Japan
    Arthritis Res 4:154-6. 2002
    ..These findings may be beneficial in the elucidation of the cause and the treatment of rheumatoid arthritis in humans...
  4. pmc The paradigm of IL-6: from basic science to medicine
    Tetsuji Naka
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Japan
    Arthritis Res 4:S233-42. 2002
    ..On the basis of the findings, a new therapeutic approach to block the IL-6 signal using humanized anti-IL-6R antibody for rheumatoid arthritis, Castleman's disease, and multiple myeloma has been attempted...
  5. ncbi request reprint SOCS-1 participates in negative regulation of LPS responses
    Reiko Nakagawa
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Japan
    Immunity 17:677-87. 2002
    ....
  6. doi request reprint SOCS-1 gene delivery cooperates with cisplatin plus pemetrexed to exhibit preclinical antitumor activity against malignant pleural mesothelioma
    Kota Iwahori
    Laboratory for Immune Signal, National Institute of Biomedical Innovation, Osaka, Japan
    Int J Cancer 132:459-71. 2013
    ..These results suggest that SOCS-1 gene delivery has a potent antitumor effect against MPM and a potential for clinical use in combination with cisplatin plus pemetrexed...
  7. doi request reprint iTRAQ-based proteomic identification of leucine-rich alpha-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases
    Satoshi Serada
    Laboratory for Immune Signal, National Institute of Biomedical Innovation, 7 6 8 Saito Asagi, Ibaragi, Osaka, Japan
    Ann Rheum Dis 69:770-4. 2010
    ..To identify a novel serum biomarker of disease activity in inflammatory autoimmune disorders...
  8. ncbi request reprint Luteolin, a flavonoid, inhibits CD40 ligand expression by activated human basophils
    Toru Hirano
    Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka, Japan
    Int Arch Allergy Immunol 140:150-6. 2006
    ..We have previously shown that flavonoids such as luteolin, apigenin and fisetin inhibit interleukin 4 and interleukin 13 production. In this study, we investigated whether luteolin can suppress CD40 ligand expression by basophils...
  9. ncbi request reprint Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A
    Shinya Matsuzaki
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan Laboratory for Immune Signal, National Institute of Biomedical Innovation, Osaka, Japan
    Int J Cancer 134:1796-809. 2014
    ..These results indicate that enhanced expression of Anx A4 confers platinum resistance by promoting efflux of platinum drugs via ATP7A. ..
  10. doi request reprint Blockade of interleukin-6 signaling suppresses not only th17 but also interphotoreceptor retinoid binding protein-specific Th1 by promoting regulatory T cells in experimental autoimmune uveoretinitis
    Hiroshi Haruta
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Japan
    Invest Ophthalmol Vis Sci 52:3264-71. 2011
    ..Furthermore, Treg was needed to inhibit Th1 responses and ocular inflammation in IL-6KO mice. Protective effects of IL-6 signaling blockade in EAU involve not only Th17 cell inhibition but also IRBP-specific Treg cell promotion...
  11. ncbi request reprint Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses
    Satoshi Hohki
    Department of Ophthalmology, Osaka University Medical School, E7, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Exp Eye Res 91:162-70. 2010
    ..IL-6 blockade may thus represent an alternative therapy for patients with ocular inflammation who are refractory to anti-TNF mAb therapy...
  12. pmc Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT
    Akihiro Kimura
    Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Department of Molecular Medicine, Graduate School of Medicine, Osaka University, Suita City, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 102:17089-94. 2005
    ..These findings suggest that the JAK-STAT pathway participates in LPS-induced IL-6 production and that SOCS-1 suppresses LPS signaling by regulating JAK-STAT...
  13. ncbi request reprint A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo
    Minoru Fujimoto
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Int Immunol 14:1343-50. 2002
    ..These results suggest that SOCS-1 plays a regulatory role in both T(h)1 and T(h)2 polarizations...
  14. doi request reprint Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+ T-cell responses in murine colitis
    Fumitaka Terabe
    Laboratory for Immune Signal, National Institute of Biomedical Innovation, Osaka, Japan
    Inflamm Bowel Dis 17:491-502. 2011
    ..It is, however, unclear if the efficacy and mechanisms of both agents are different in CD therapy...
  15. ncbi request reprint SOCS-2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells
    Xinshou Ouyang
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    J Cell Physiol 207:428-36. 2006
    ....
  16. doi request reprint Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis
    Satoshi Serada
    Laboratory for Immune Signal, National Institute of Biomedical Innovation, Osaka, Japan
    Inflamm Bowel Dis 18:2169-79. 2012
    ....
  17. doi request reprint Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma
    Kota Iwahori
    Laboratory for Immune Signal, National Institute of Biomedical Innovation, Osaka, Japan
    Int J Cancer 129:1005-17. 2011
    ..These findings demonstrate that overexpression of SOCS3 has a potent antitumor effect against MPM both in vitro and in vivo and indicate the potential for clinical use of SOCS3 for MPM treatment...
  18. ncbi request reprint Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases
    Minoru Fujimoto
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Int Immunol 16:303-14. 2004
    ..These findings suggest that dysfunction of SOCS-1 can be a pathogenic factor of systemic autoimmune diseases such as SLE...
  19. ncbi request reprint Molecular mechanism underlying the antiproliferative effect of suppressor of cytokine signaling-1 in non-small-cell lung cancer cells
    Kazuki Shimada
    Laboratory for Immune Signal, National Institute of Biomedical Innovation, Osaka, Japan Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 104:1483-91. 2013
    ....
  20. ncbi request reprint Luteolin, a flavonoid, inhibits AP-1 activation by basophils
    Toru Hirano
    Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 340:1-7. 2006
    ..These results provide a fundamental structure of flavonoids for IL-4 inhibition and demonstrate a novel action of flavonoids that suppresses the activation of AP-1...
  21. pmc Periostin facilitates skin sclerosis via PI3K/Akt dependent mechanism in a mouse model of scleroderma
    Lingli Yang
    Department of Dermatology, Osaka University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 7:e41994. 2012
    ..Periostin, a novel matricellular protein, is recently reported to play a crucial role in tissue remodeling and is highly expressed under fibrotic conditions. This study was undertaken to assess the role of periostin in scleroderma...
  22. doi request reprint Plasma membrane proteomics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer
    Takuhei Yokoyama
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Cancer 132:472-84. 2013
    ..The combination of biotinylation-based enrichment of cell-surface proteins and iTRAQ analysis should be a useful screening method for future discovery of potential therapeutic targets...
  23. ncbi request reprint Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses
    Minoru Fujimoto
    National Institute of Biomedical Innovation, Osaka, Japan
    Arthritis Rheum 58:3710-9. 2008
    ....
  24. pmc IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells
    Akihiro Kimura
    Laboratory of Immune Regulation, Osaka University Graduate School of Frontier Biosciences, 1 3, Yamada oka, Suita, Osaka, 565 0871, Japan
    Proc Natl Acad Sci U S A 104:12099-104. 2007
    ..In contrast, both Stat1 and Stat3 remained to be activated in naïve T cells cultured with DCCM. These findings represent a different basis for Th17 differentiation from naïve T cells...
  25. ncbi request reprint Transcriptional complex formation of c-Fos, STAT3, and hepatocyte NF-1 alpha is essential for cytokine-driven C-reactive protein gene expression
    Teppei Nishikawa
    Health Care Center, Osaka University, Department of Respiratory Medicine, Allergy, Rheumatic Diseases, Graduate School of Medicine, Osaka, Japan
    J Immunol 180:3492-501. 2008
    ..Our findings fully explain the clinical results of IL-6 blocking therapy and are expected to contribute to the development of a therapeutic strategy for chronic inflammatory diseases...
  26. doi request reprint Antiproliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells
    Yoshihito Souma
    Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Cancer 131:1287-96. 2012
    ..These results suggest that SOCS-1 gene methylation is a critical step in the development of GC, and enforced expression of SOCS-1 may represent a novel therapeutic approach for the treatment of GC...
  27. ncbi request reprint Osteoblast differentiation is impaired in SOCS-1-deficient mice
    Tatsuo Abe
    Department of Molecular Medicine, Graduate School of Osaka University Medical School, Suita, Japan
    J Bone Miner Metab 24:283-90. 2006
    ..However, a dramatic decrease was observed in the expression level of the late marker [osteocalcin (OC)] of osteoblasts. Our findings thus demonstrate that SOCS-1 regulates osteoblast differentiation in the later stage...
  28. doi request reprint Targeting annexin A4 to counteract chemoresistance in clear cell carcinoma of the ovary
    Ayako Kim
    National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    Expert Opin Ther Targets 14:963-71. 2010
    ..Targeting of annexin A4 may represent a future strategy to counteract resistance to chemotherapy in ovarian CCC...
  29. doi request reprint New findings of kinase switching in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis
    Tsuyoshi Takahashi
    Department of Surgery, Osaka University Graduate School of Medicine, Suita, Japan Laboratory for Immune Signal, National Institute of Biomedical Innovation, Ibaraki, Japan
    Int J Cancer 133:2737-43. 2013
    ..Additionally, we showed that the iTRAQ-based quantitative phosphotyrosine-focused phosphoproteomic approach is a powerful method for screening phosphoproteins associated with drug resistance. ..
  30. ncbi request reprint Proteomics-based identification of alpha-enolase as a tumor antigen in non-small lung cancer
    Ping He
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Cancer Sci 98:1234-40. 2007
    ..Therefore, autoantibodies against alpha-enolase may constitute a promising biomarker for NSCLC...
  31. ncbi request reprint Periostin accelerates human malignant melanoma progression by modifying the melanoma microenvironment
    Yorihisa Kotobuki
    Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Japan Laboratory for Immune Signal, National Institute of Biomedical Innovation, Ibaraki, Japan
    Pigment Cell Melanoma Res 27:630-9. 2014
    ..These results indicate that NHDF-derived POSTN accelerates melanoma progression and might be a promising therapeutic target for malignant melanoma. ..
  32. ncbi request reprint IL-18 gene polymorphisms affect IL-18 production capability by monocytes
    Junsuke Arimitsu
    Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 342:1413-6. 2006
    ..Thus, the genetic capacity to produce more IL-18 in response to stimuli may affect the onset of asthma...
  33. doi request reprint Lectin-based immunoassay for aberrant IgG glycosylation as the biomarker for Crohn's disease
    Shinichiro Shinzaki
    Department of Molecular Biochemistry and Clinical Investigation, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Inflamm Bowel Dis 19:321-31. 2013
    ..The present study aimed to establish a simple detection system for aberrant glycosylated IgG based on lectin-oligosaccharide interactions...
  34. doi request reprint Dysregulation of melanocyte function by Th17-related cytokines: significance of Th17 cell infiltration in autoimmune vitiligo vulgaris
    Yorihisa Kotobuki
    Department of Dermatology Integrated Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Pigment Cell Melanoma Res 25:219-30. 2012
    ..Our results provide evidence of the influence of a complex Th17 cell-related cytokine environment in local depigmentation in addition to CD8(+) cell-mediated melanocyte destruction in autoimmune vitiligo...
  35. doi request reprint Megakaryocyte potentiating factor as a tumor marker of malignant pleural mesothelioma: evaluation in comparison with mesothelin
    Kota Iwahori
    Department of Respiratory Medicine, Allergy, and Rheumatic Diseases, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Lung Cancer 62:45-54. 2008
    ..We developed a novel enzyme-linked immunosorbent assay (ELISA) system to compare the diagnostic efficacy of MPF and MSLN in MPM and control groups...
  36. doi request reprint Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice
    Jiro Horino
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int Immunol 20:753-62. 2008
    ..Our findings suggest that SOCS-1, particularly in T cells, prevents the development of DSS-induced colitis in mice by inhibiting IFN-gamma/STAT1 signaling and by subsequently regulating Treg cell development...
  37. ncbi request reprint Suppressor of cytokine signaling 1 suppresses muscle differentiation through modulation of IGF-I receptor signal transduction
    Makiko Inaba
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita City, Osaka, Japan
    Biochem Biophys Res Commun 328:953-61. 2005
    ..Collectively, these findings suggest that SOCS1 suppresses muscle differentiation through negative feedback regulation of IGF-I receptor-mediated signaling...
  38. ncbi request reprint Suppressor of cytokine signalling-1 gene silencing in acute myeloid leukaemia and human haematopoietic cell lines
    Dai Watanabe
    Laboratory of Immune Regulation, Osaka University Graduate School of Frontier Biosciences, 1 3 Yamada oka, Suita City, Osaka 565 0871, Japan
    Br J Haematol 126:726-35. 2004
    ..These findings indicate that SOCS-1 is frequently silenced in haematopoietic malignancies, mainly as a result of hypermethylation, and suggest that SOCS-1 may be able to function as a tumour suppressor...
  39. ncbi request reprint SOCS-1 suppresses TNF-alpha-induced apoptosis through the regulation of Jak activation
    Akihiro Kimura
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamada oka, Suita, Osaka, 565 0871, Japan
    Int Immunol 16:991-9. 2004
    ..Taken together, these results suggest that SOCS-1 inhibits TNF-alpha-induced apoptosis through regulation of Jaks...
  40. doi request reprint Serum HE4 as a diagnostic and prognostic marker for lung cancer
    Kota Iwahori
    Laboratory for Immune Signal, National Institute of Biomedical Innovation, 7 6 8 Saito Asagi, Ibaraki, Osaka 567 0085, Japan
    Tumour Biol 33:1141-9. 2012
    ..These findings suggest that serum HE4 is a potential diagnostic and prognostic marker for lung cancer patients...
  41. doi request reprint Proteomic analysis of autoantigens associated with systemic lupus erythematosus: Anti-aldolase A antibody as a potential marker of lupus nephritis
    Satoshi Serada
    Functional Proteomics Group, Osaka University Graduate School of Frontier Biosciences, Osaka, Japan
    Proteomics Clin Appl 1:185-91. 2007
    ..Therefore, these results indicate that autoantibodies against aldolase A may serve as an alternative clinical biomarker of SLE associated with nephritis...
  42. doi request reprint Annexin A4 is a promising therapeutic target for the treatment of platinum-resistant cancers
    Shinya Matsuzaki
    Osaka University Graduate School of Medicine, Department of Obstetrics and Gynecology, 2 2 Yamadaoka Suita, Osaka 565 0871, Japan
    Expert Opin Ther Targets 18:403-14. 2014
    ..Determining the mechanism underlying platinum resistance may aid in the identification of therapeutic targets for the treatment of platinum-resistant tumours...
  43. doi request reprint Blockade of interleukin-6 receptor alleviates disease in mouse model of scleroderma
    Shun Kitaba
    Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Am J Pathol 180:165-76. 2012
    ..Our results indicate that IL-6 contributes to BLM induced dermal sclerosis and that IL-6 receptor-specific monoclonal Ab may improve the symptoms of scleroderma by suppressing fibroblast activation...
  44. ncbi request reprint Negative regulation of cytokine and TLR signalings by SOCS and others
    Tetsuji Naka
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Adv Immunol 87:61-122. 2005
  45. doi request reprint Enhanced expression of Annexin A4 in clear cell carcinoma of the ovary and its association with chemoresistance to carboplatin
    Ayako Kim
    Department of Obstetrics and Gynaecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Cancer 125:2316-22. 2009
    ..These results demonstrate that Anx A4 confers chemoresistance in ovarian cancer cells in part by enhancing drug efflux. Thus, Anx A4 may represent a novel therapeutic target of chemoresistance in patients with ovarian CCC...
  46. ncbi request reprint Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas
    Hisaki Nagai
    Department of Molecular Biology and Pathology, Institute of Gerontology, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki 211 0063, Japan
    J Hum Genet 48:65-9. 2003
    ..The results suggest that hypermethylation may play an important role in silencing the SOCS-1 gene, not only in adult HCCs, but also in liver tumors arising in childhood...
  47. pmc Therapeutic strategies in epithelial ovarian cancer
    Ayako Kim
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Exp Clin Cancer Res 31:14. 2012
    ..A few recent studies demonstrated positive results of bevacizumab on progression-free survival in ovarian cancer patients, however, investigation of molecular targeting drugs in patients with ovarian cancer are still underway...
  48. doi request reprint Aberrant expression of glycosylation in juvenile gastrointestinal stromal tumors
    Tsuyoshi Takahashi
    Department of Surgery, Osaka University Graduate School of Medicine, Suita, Japan
    Proteomics Clin Appl 2:1246-54. 2008
    ..This suggests that the difference in KIT is generated by post-translational modification and may play a role in the progression of juvenile GIST...
  49. pmc Overexpression of PIAS3 suppresses cell growth and restores the drug sensitivity of human lung cancer cells in association with PI3-K/Akt inactivation
    Yoshitaka Ogata
    Department of Respiratory Medicine, Allergy, and Rheumatic Diseases, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Neoplasia 8:817-25. 2006
    ..These results indicate that PIAS3 may be an attractive candidate for targeting the JAK/STAT and PI3-K/Akt signaling pathways in cancer treatment...
  50. ncbi request reprint Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils
    Toru Hirano
    Third Department of Internal Medicine, Osaka University Medical School, 2 2 Yamada oka, Suita City, Osaka 565 0871, Japan
    Int Arch Allergy Immunol 134:135-40. 2004
    ..We additionally investigated whether flavonoids suppress leukotriene C4 synthesis by basophils and IL-4 synthesis by T cells in response to anti-CD3 antibody...
  51. ncbi request reprint Implication of SOCS-1 gene methylation in acute myeloid leukaemia
    Dai Watanabe
    Br J Haematol 127:608-9. 2004
  52. pmc SOCS1 regulates CCR7 expression and migration of CD4+ T cells into peripheral tissues
    Cheng Rong Yu
    Laboratory of Immunology, Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:1190-8. 2008
    ....
  53. ncbi request reprint Activation of signal transducer and activator transcription 3 and expression of suppressor of cytokine signal 1 during liver regeneration in rats
    Shigeru Sakuda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    J Hepatol 36:378-84. 2002
    ..The aims of this study were to identify STAT3-activated cells and to clarify the expression of suppressor of cytokine signal (SOCS), a negative feedback molecule of STAT3, after PH...
  54. ncbi request reprint Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers
    Toshiaki Komazaki
    Department of Molecular Biology and Department of Pathology, Institute of Gerontology, Nippon Medical School, 1 396 Kosugi cho, Nakahara ku, Kawasaki 211 8533, Japan
    Jpn J Clin Oncol 34:191-4. 2004
    ..The purpose of the present work was to analyze the expression of the SOCS-1 gene and identify inactivation of this gene by methylation in pancreatic cancers...
  55. ncbi request reprint Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration
    Ekihiro Seki
    First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    Hepatology 41:443-50. 2005
    ..In conclusion, the TLR/MyD88 pathway is essential for incidental liver restoration, particularly its early phase...
  56. pmc Involvement of SIK3 in glucose and lipid homeostasis in mice
    Tatsuya Uebi
    Laboratory of Cell Signaling and Metabolic Disease, National Institute of Biomedical Innovation, Ibaraki, Osaka, Japan
    PLoS ONE 7:e37803. 2012
    ..In conclusion, SIK3 is a novel energy regulator that modulates cholesterol and bile acid metabolism by coupling with retinoid metabolism, and may alter the size of energy storage in mice...
  57. pmc Karyopherin Alpha2 Is Essential for rRNA Transcription and Protein Synthesis in Proliferative Keratinocytes
    Noriko Umegaki-Arao
    Department of Dermatology, Osaka University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 8:e76416. 2013
    ..KPNA2 may be an important promoter of ribosomal RNA and protein synthesis in tumor cells. ..
  58. ncbi request reprint Regulation of cytokine signaling by SOCS family molecules
    Minoru Fujimoto
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita City, Osaka, Japan
    Trends Immunol 24:659-66. 2003
    ..Moreover, consistent with the pathological actions of cytokines in human diseases, recent lines of evidence also indicate that SOCS molecules are implicated in autoimmunity, allergy and cancers...
  59. pmc Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation
    Yoh Ichi Seki
    Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda City, Chiba 278 0022, Japan
    Proc Natl Acad Sci U S A 99:13003-8. 2002
    ..Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance...
  60. pmc Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells
    Akihiro Kimura
    Laboratory of Immune Regulation, Osaka University Graduate School of Frontier Biosciences, 1 3, Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 105:9721-6. 2008
    ..These results indicate that Ahr participates in Th17 cell differentiation through regulating Stat1 activation, a finding that constitutes additional mechanisms in the modulation of Th17 cell development...
  61. ncbi request reprint Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis
    Hiroyasu Shoda
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Biochem Biophys Res Commun 353:1004-10. 2007
    ....
  62. ncbi request reprint Screening for novel serum biomarker for monitoring disease activity in rheumatoid arthritis using iTRAQ technology-based quantitative proteomic approach
    Satoshi Serada
    Laboratory for Immune Signal, National Institute of Biomedical Innovation, 7 6 8 Saito Asagi, Ibaraki, Osaka, 567 0085, Japan
    Methods Mol Biol 1142:99-110. 2014
    ..Here, we describe the identification of a novel biomarker, which is useful for the evaluation of disease activity in patients with rheumatoid arthritis who were treated with anti-TNF-α therapy. ..
  63. ncbi request reprint Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings
    Ekihiro Seki
    Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    J Hepatol 48:237-45. 2008
    ..Here, we investigated this hypothesis by introducing suppressor of cytokine signaling (SOCS)-1 and SOCS3, potent negative regulators of STAT3 signaling, selectively in hepatocytes...
  64. ncbi request reprint SOCS proteins, cytokine signalling and immune regulation
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nat Rev Immunol 7:454-65. 2007
    ..In this Review we bring together data from recent studies on SOCS proteins and their role in immunity, and propose a cohesive model of how cytokine signalling regulates immune-cell function...
  65. pmc IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis
    Satoshi Serada
    Laboratory for Immune Signal, National Institute of Biomedical Innovation, 7 6 8 Saito Asagi, Ibaraki, Osaka 565 0085, Japan
    Proc Natl Acad Sci U S A 105:9041-6. 2008
    ..These findings indicate that anti-IL-6R mAb treatment might represent a novel therapy for human MS...
  66. doi request reprint Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus
    Hiroshi Yamaguchi
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe, Sakyo, Kyoto 606 8501, Japan
    J Leukoc Biol 83:1300-7. 2008
    ..These results suggested that the aberrant expression of MFG-E8 is involved in the pathoetiology of some cases of hSLE...
  67. doi request reprint Suppressor of cytokine signaling 1 inhibits pulmonary inflammation and fibrosis
    Taku Nakashima
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    J Allergy Clin Immunol 121:1269-76. 2008
    ..Our previous study suggested that SOCS1 regulates collagen synthesis by lung fibroblasts, suggesting a role of SOCS1 in the pathophysiology of pulmonary fibrosis...
  68. ncbi request reprint Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression
    Yukiko Kanatani
    The First Department of Internal Medicine, University of Toyama, 2630 Sugitani Toyama 930 0194, Japan
    Diabetes 56:795-803. 2007
    ....
  69. ncbi request reprint [Role of IL-6 in the development and pathogenesis of CIA and EAE]
    Minoru Fujimoto
    Laboratory for Immune Signal, National Institute of Biomedical Innovation
    Nihon Rinsho Meneki Gakkai Kaishi 31:78-84. 2008
    ..These results indicate that IL-6 is involved in the induction of Th17 cells in vivo, and anti-IL-6R antibody might be a promising therapy of Th17-mediated autoimmune diseases...