Michio Murata


Affiliation: Osaka University
Country: Japan


  1. Ando J, Kinoshita M, Cui J, Yamakoshi H, Dodo K, Fujita K, et al. Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy. Proc Natl Acad Sci U S A. 2015;112:4558-63 pubmed publisher
  2. Nakane T, Hanashima S, Suzuki M, Saiki H, Hayashi T, Kakinouchi K, et al. Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent. Proc Natl Acad Sci U S A. 2016;113:13039-13044 pubmed
    ..These results pave the way for de novo structure determination of membrane proteins, which often diffract poorly, even with the brightest XFEL beams. ..
  3. Hayashi T, Tsuchikawa H, Umegawa Y, Murata M. Small structural alterations greatly influence the membrane affinity of lipophilic ligands: Membrane interactions of bafilomycin A1 and its desmethyl derivative bearing 19F-labeling. Bioorg Med Chem. 2019;27:1677-1682 pubmed publisher
    ..Our results revealed significant differences in membrane affinity and dynamics among ligands having different inhibitory potencies, suggesting the specific contribution of ligand-membrane interactions to their biological activity. ..
  4. Yano Y, Hanashima S, Yasuda T, Tsuchikawa H, Matsumori N, Kinoshita M, et al. Sphingomyelin Stereoisomers Reveal That Homophilic Interactions Cause Nanodomain Formation. Biophys J. 2018;115:1530-1540 pubmed publisher
    ..The homophilic interactions of sphingomyelins could be mainly responsible for the formation of the domains of nanometer size, which may correspond to the small sphingomyelin/Cho-based rafts that temporally occur in biological membranes. ..
  5. Cui J, Matsuoka S, Kinoshita M, Matsumori N, Sato F, Murata M, et al. Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior. Bioorg Med Chem. 2015;23:2989-94 pubmed publisher
  6. Cui J, Lethu S, Yasuda T, Matsuoka S, Matsumori N, Sato F, et al. Phosphatidylcholine bearing 6,6-dideuterated oleic acid: a useful solid-state (2)H NMR probe for investigating membrane properties. Bioorg Med Chem Lett. 2015;25:203-6 pubmed publisher
    ..It has been successfully utilized for the comparison of membrane properties between sphingomyelin (SM) and dihydrosphingomyelin (DHSM) membranes. ..
  7. Cornelio K, Espiritu R, Hanashima S, Todokoro Y, Malabed R, Kinoshita M, et al. Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol. Biochim Biophys Acta Biomembr. 2019;1861:228-235 pubmed publisher
  8. Yamamoto T, Umegawa Y, Tsuchikawa H, Matsumori N, Hanashima S, Murata M, et al. Role of polyol moiety of amphotericin B in ion channel formation and sterol selectivity in bilayer membrane. Bioorg Med Chem. 2015;23:5782-8 pubmed publisher
    ..Additionally, the flexible polyol leads to destabilization of the whole macrolactone ring conformation, resulting in a loss of sterol selectivity. ..
  9. Cui J, Kawatake S, Umegawa Y, Lethu S, Yamagami M, Matsuoka S, et al. Stereoselective synthesis of the head group of archaeal phospholipid PGP-Me to investigate bacteriorhodopsin-lipid interactions. Org Biomol Chem. 2015;13:10279-84 pubmed publisher
    ..These results together suggest that the bisphosphate moiety plays a role in the proper functioning of bR through the lipid-protein interaction. ..

More Information


  1. Cui J, Kawatake S, Umegawa Y, Lethu S, Yamagami M, Matsuoka S, et al. Correction: Stereoselective synthesis of the head group of archaeal phospholipid PGP-Me to investigate bacteriorhodopsin-lipid interactions. Org Biomol Chem. 2015;13:10578 pubmed publisher
    ..Correction for 'Stereoselective synthesis of the head group of archaeal phospholipid PGP-Me to investigate bacteriorhodopsin-lipid interactions' by Jin Cui, et al., Org. Biomol. Chem., 2015, DOI: 10.1039/c5ob01252j. ..
  2. Engberg O, Yasuda T, Hautala V, Matsumori N, Nyholm T, Murata M, et al. Lipid Interactions and Organization in Complex Bilayer Membranes. Biophys J. 2016;110:1563-1573 pubmed publisher
    ..Taken together, both the fluorescence spectroscopy and (2)H NMR data suggest that the complex five-component membranes displayed lateral heterogeneity, at least in the lower temperature regimen examined. ..
  3. Kawatake S, Umegawa Y, Matsuoka S, Murata M, Sonoyama M. Evaluation of diacylphospholipids as boundary lipids for bacteriorhodopsin from structural and functional aspects. Biochim Biophys Acta. 2016;1858:2106-2115 pubmed publisher
  4. Hossain M, Hanashima S, Nomura T, Lethu S, Tsuchikawa H, Murata M, et al. Synthesis and Th1-immunostimulatory activity of ?-galactosylceramide analogues bearing a halogen-containing or selenium-containing acyl chain. Bioorg Med Chem. 2016;24:3687-95 pubmed publisher
    ..These synthetic analogues would be efficient X-ray crystallographic probes to disclose precise atomic positions of alkyl carbons and lipid-protein interactions in KRN7000/CD1d complexes. ..
  5. Malabed R, Hanashima S, Murata M, Sakurai K. Sterol-recognition ability and membrane-disrupting activity of Ornithogalum saponin OSW-1 and usual 3-O-glycosyl saponins. Biochim Biophys Acta Biomembr. 2017;1859:2516-2525 pubmed publisher
  6. Hasegawa F, Kawamura K, Tsuchikawa H, Murata M. Stable C-N axial chirality in 1-aryluracil scaffold and differences in in vitro metabolic clearance between atropisomers of PDE4 inhibitor. Bioorg Med Chem. 2017;25:4506-4511 pubmed publisher
    ..This finding demonstrates the potential utility of stable C-N bond atropisomers in the development of chiral drugs. ..