Jun Miyoshi

Summary

Affiliation: Osaka Medical Center for Cancer and Cardiovascular Diseases
Country: Japan

Publications

  1. doi request reprint Structural and functional associations of apical junctions with cytoskeleton
    Jun Miyoshi
    Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Biochim Biophys Acta 1778:670-91. 2008
  2. ncbi request reprint Dual role of DENN/MADD (Rab3GEP) in neurotransmission and neuroprotection
    Jun Miyoshi
    Department of Molecular Biology, Osaka Medical Centre for Cancer and Cardiovascular Diseases, Osaka 537 8511, Japan
    Trends Mol Med 10:476-80. 2004
  3. ncbi request reprint Molecular perspective on tight-junction assembly and epithelial polarity
    Jun Miyoshi
    Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Nakamichi 1 3 2, Higashinari ku, Osaka 537 8511, Japan
    Adv Drug Deliv Rev 57:815-55. 2005
  4. pmc Involvement of afadin in barrier function and homeostasis of mouse intestinal epithelia
    Miki Tanaka-Okamoto
    Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537 8511, Japan
    J Cell Sci 124:2231-40. 2011
  5. ncbi request reprint Nectin and nectin-like molecules: biology and pathology
    Jun Miyoshi
    Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Am J Nephrol 27:590-604. 2007
  6. ncbi request reprint Expression of S100A6 and S100A4 in matched samples of human colorectal mucosa, primary colorectal adenocarcinomas and liver metastases
    Keiko Komatsu
    Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Oncology 63:192-200. 2002
  7. ncbi request reprint Transforming growth factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells
    Hiroyuki Nakamura
    Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Cancer Lett 220:95-9. 2005
  8. doi request reprint Increased susceptibility to spontaneous lung cancer in mice lacking LIM-domain only 7
    Miki Tanaka-Okamoto
    Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Cancer Sci 100:608-16. 2009
  9. pmc A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses
    Kazuhiko Yamaguchi
    Laboratory for Memory and Learning, Brain Science Institute BSI, Institute of Physical and Chemical Research RIKEN, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 99:14536-41. 2002
  10. ncbi request reprint Up-regulation of loricrin expression by cell adhesion molecule nectin-1 through Rap1-ERK signaling in keratinocytes
    Kotaro Wakamatsu
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 282:18173-81. 2007

Collaborators

  • Yoshimi Takai
  • Masahiro Inoue
  • Mutsuko Mukai
  • Shigenobu Yonemura
  • Hiroyuki Nakamura
  • Kohei Murata
  • R Ishihara
  • Junko Iida
  • Toshihisa Ohtsuka
  • Masatoshi Takeichi
  • Miki Tanaka-Okamoto
  • Hiroyoshi Ishizaki
  • Ayuko Sakane
  • Akira Mizoguchi
  • Maiko Inagaki
  • Takuya Sasaki
  • Tomoyuki Honda
  • Kenji Irie
  • Yu Itoh
  • Keiko Hori
  • Hitomi Komura
  • Hironori Higashio
  • Hisakazu Ogita
  • Kotaro Wakamatsu
  • Joann M Taylor
  • Toshiaki Sakisaka
  • Hideru Togashi
  • Richard M Gibson
  • Keiko Komatsu
  • Kazuhiko Yamaguchi
  • Sachiko Onishi
  • Min Wei
  • Hideki Wanibuchi
  • Akihiro Hosoi
  • Noriyuki Nishimura
  • Satoshi Orita
  • Wataru Ikeda
  • Noriko Okabe
  • Miri Yoon
  • Anna Zago
  • Hajime Iizuka
  • Hiroyuki Ishizaki
  • Akemi Ishida-Yamamoto
  • Klaus Pfeffer
  • Nanette Susmarski
  • Patricia G Spear
  • Erick Lin
  • Carl F Ware
  • Emi Kiyokage
  • Noriko Kumazawa
  • Mihoko Kajita
  • Tomohiro Yamada
  • Kazunori Toida
  • Shinji Manabe
  • Takayuki Yoshida
  • Takashi Hoshino
  • Tetsuro Kayahara
  • Haruyuki Kamiya
  • Toshiya Manabe
  • Eiji Inoue
  • Koji Morimoto
  • Payal N Gandhi
  • Martha Konieczkowski
  • Amy L Wilson-Delfosse
  • John R Sedor
  • Xiaofeng Tong
  • Masao Kameyama
  • Yoshihiro Hirata
  • Shingo Ishiguro
  • Miki Tanaka
  • Kumi Kaneko
  • Masako Ayaki
  • Masaharu Tatsuta

Detail Information

Publications22

  1. doi request reprint Structural and functional associations of apical junctions with cytoskeleton
    Jun Miyoshi
    Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Biochim Biophys Acta 1778:670-91. 2008
    ..Here we describe how subcellular protein interactions are coordinated to induce changes in actin organization and dynamics, in response to the status of apical junctions...
  2. ncbi request reprint Dual role of DENN/MADD (Rab3GEP) in neurotransmission and neuroprotection
    Jun Miyoshi
    Department of Molecular Biology, Osaka Medical Centre for Cancer and Cardiovascular Diseases, Osaka 537 8511, Japan
    Trends Mol Med 10:476-80. 2004
    ..Recent research supports an important role for DENN/MADD in neuroprotection: reduced endogenous DENN/MADD expression and enhanced pro-apoptotic signalling has been found in brains affected by Alzheimer's disease...
  3. ncbi request reprint Molecular perspective on tight-junction assembly and epithelial polarity
    Jun Miyoshi
    Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Nakamichi 1 3 2, Higashinari ku, Osaka 537 8511, Japan
    Adv Drug Deliv Rev 57:815-55. 2005
    ..This review discusses how these adhesion systems interact with each other to form apical junctional complexes, and how they reorganize the actin cytoskeleton in a multistage process of cell adhesion, migration, and polarization...
  4. pmc Involvement of afadin in barrier function and homeostasis of mouse intestinal epithelia
    Miki Tanaka-Okamoto
    Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537 8511, Japan
    J Cell Sci 124:2231-40. 2011
    ..These findings suggest that afadin plays crucial roles, independently of the role as the nectin-afadin module, in barrier function and homeostasis of the intestinal epithelia once the epithelial structure has been established...
  5. ncbi request reprint Nectin and nectin-like molecules: biology and pathology
    Jun Miyoshi
    Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Am J Nephrol 27:590-604. 2007
    ..Here we summarize our knowledge of nectins and Necls and discuss cell adhesion biology in the kidney...
  6. ncbi request reprint Expression of S100A6 and S100A4 in matched samples of human colorectal mucosa, primary colorectal adenocarcinomas and liver metastases
    Keiko Komatsu
    Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Oncology 63:192-200. 2002
    ..This gave us the advantage of directly comparing levels of S100A6 and S100A4 expression within the same genetic background...
  7. ncbi request reprint Transforming growth factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells
    Hiroyuki Nakamura
    Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Cancer Lett 220:95-9. 2005
    ..LMO7 had PDZ and LIM domains, while LMO7S had only PDZ domain. TGF-beta1 up-regulated expression levels of LMO7 and LMO7S. LMO7 expression was up-regulated in the highly metastatic clone MM1...
  8. doi request reprint Increased susceptibility to spontaneous lung cancer in mice lacking LIM-domain only 7
    Miki Tanaka-Okamoto
    Department of Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Cancer Sci 100:608-16. 2009
    ..These results suggest that LMO7 can act as a tumor suppressor whose deficiency confers a genetic predisposition to naturally occurring lung cancer...
  9. pmc A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses
    Kazuhiko Yamaguchi
    Laboratory for Memory and Learning, Brain Science Institute BSI, Institute of Physical and Chemical Research RIKEN, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 99:14536-41. 2002
    ..Because Rab3A reportedly down-regulates Ca(2+)-triggered fusion of synaptic vesicles, these results provide evidence for a role of Rab3 GEP in the postdocking process distinct from Rab3A activation...
  10. ncbi request reprint Up-regulation of loricrin expression by cell adhesion molecule nectin-1 through Rap1-ERK signaling in keratinocytes
    Kotaro Wakamatsu
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 282:18173-81. 2007
    ..These results indicate that nectin-1 plays a key role in the expression of loricrin in the epidermis...
  11. doi request reprint Establishment of cell polarity by afadin during the formation of embryoid bodies
    Hitomi Komura
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    Genes Cells 13:79-90. 2008
    ..These results indicate that afadin organizes the formation of cell-cell junctions by regulating cell polarization in early embryonic development...
  12. pmc Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery
    Hideru Togashi
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    J Cell Biol 174:141-51. 2006
    ..These results suggest that the axon-biased localization of N1 and its trans-interaction with N3 in cooperation with the cadherin machinery is critical for the ordered association of axons and dendrites...
  13. ncbi request reprint Involvement of nectins in the formation of puncta adherentia junctions and the mossy fiber trajectory in the mouse hippocampus
    Tomoyuki Honda
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Mol Cell Neurosci 31:315-25. 2006
    ..In addition, the abnormal mossy fiber trajectory was observed. These results indicate that nectins are involved in the formation of PAJs, which maintain the proper mossy fiber trajectory...
  14. doi request reprint Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation
    Yoshimi Takai
    Department of Biochemistry and Molecular Biology, Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    Nat Rev Mol Cell Biol 9:603-15. 2008
    ....
  15. ncbi request reprint Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells
    Hironori Higashio
    Department of Biochemistry, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
    J Immunol 180:4774-84. 2008
    ..These results suggest that the Doc2alpha-Muunc13-4 system regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells...
  16. doi request reprint Analysis on the emerging role of Rab3 GTPase-activating protein in Warburg Micro and Martsolf syndrome
    Ayuko Sakane
    Department of Biochemistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Methods Enzymol 438:131-9. 2008
    ..Here, we describe the procedures for the measurement of the GTP-bound pool of Rab3A with pull-down assay using mouse brains and the biochemical method for the measurement of glutamate release from mouse synaptosomes...
  17. pmc Alternative entry receptors for herpes simplex virus and their roles in disease
    Joann M Taylor
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Cell Host Microbe 2:19-28. 2007
    ..This study illustrates the value of mutant mice for understanding receptor contributions to disease caused by a human virus...
  18. ncbi request reprint An activating mutant of Cdc42 that fails to interact with Rho GDP-dissociation inhibitor localizes to the plasma membrane and mediates actin reorganization
    Richard M Gibson
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Exp Cell Res 301:211-22. 2004
    ....
  19. ncbi request reprint Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development
    Maiko Inagaki
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Development 132:1525-37. 2005
    ....
  20. ncbi request reprint Role of cell adhesion molecule nectin-3 in spermatid development
    Maiko Inagaki
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Genes Cells 11:1125-32. 2006
    ..These results indicate that the heterophilic trans-interaction between nectin-2 and nectin-3 is essential for the formation and maintenance of Sertoli-spermatid junctions that plays a critical role in spermatid development...
  21. pmc Rab3 GTPase-activating protein regulates synaptic transmission and plasticity through the inactivation of Rab3
    Ayuko Sakane
    Department of Biochemistry, Institute of Health Biosciences, University of Tokushima Graduate School, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Proc Natl Acad Sci U S A 103:10029-34. 2006
    ..Thus, Rab3 GAP regulates synaptic transmission and plasticity by limiting the amount of the GTP-bound form of Rab3A...
  22. pmc Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites
    Junko Iida
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushiima, Tokyo, Japan
    Mol Cell Biol 27:4388-405. 2007
    ..These data indicate that S-SCAMalpha is a scaffold required to activate RhoA protein in response to NMDA receptor signaling in dendrites...