Hiroaki Miki


Affiliation: Osaka University
Country: Japan


  1. Gulerez I, Funato Y, Wu H, Yang M, Kozlov G, Miki H, et al. Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis. EMBO Rep. 2016;17:1890-1900 pubmed
    ..The identification of phosphocysteine as a regulatory modification opens new perspectives for signaling by protein phosphatases. ..
  2. Yamazaki D, Hasegawa A, Funato Y, Tran H, Mori M, Mori Y, et al. Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia. Oncogene. 2019;: pubmed publisher
    ..Collectively, these results establish the functional interplay between Mg2+ and Ca2+ in the colon epithelia, which is crucial for maintaining the dynamic homeostasis of the epithelial tissue. ..
  3. Yoshida A, Funato Y, Miki H. Phosphatase of regenerating liver maintains cellular magnesium homeostasis. Biochem J. 2018;475:1129-1139 pubmed publisher
    ..Collectively, these results implicate PRL in maintaining cellular Mg2+ homeostasis. ..
  4. Hirata Y, Funato Y, Takano Y, Miki H. Mg2+-dependent interactions of ATP with the cystathionine-β-synthase (CBS) domains of a magnesium transporter. J Biol Chem. 2014;289:14731-9 pubmed publisher
    ..Interactions with ATP, which mostly forms complexes with Mg(2+) in cells, may account for the rapid Mg(2+) transport by CNNM family proteins. ..
  5. Hirata Y, Funato Y, Miki H. Basolateral sorting of the Mg²⁺ transporter CNNM4 requires interaction with AP-1A and AP-1B. Biochem Biophys Res Commun. 2014;455:184-9 pubmed publisher
    ..These results imply that CNNM4 is sorted to the basolateral membrane by the complementary function of AP-1A and AP-1B. ..
  6. Yamazaki D, Miyata H, Funato Y, Fujihara Y, Ikawa M, Miki H. The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and is essential for reproduction. J Cell Sci. 2016;129:1940-9 pubmed publisher
    ..Furthermore, we confirm the importance of CNNM4 in sperm by generating germ-cell-specific Cnnm4-deficient mice. These results suggest a new role of CNNM4 in sperm Ca(2+) homeostasis. ..
  7. Yamazaki D, Funato Y, Miyata H, Ikawa M, Miki H. Complementary role of CNNM2 in sperm motility and Ca(2+) influx during capacitation. Biochem Biophys Res Commun. 2016;474:441-446 pubmed publisher
    ..Thus, sperm motility and Ca(2+) response were more severely affected in sperm from Cnnm2(+/?); Cnnm4(?/?) mice than in those from Cnnm4(?/?) mice, implicating CNNM2 in regulating these processes. ..