Seiji Mabuchi

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc Vascular endothelial growth factor is a promising therapeutic target for the treatment of clear cell carcinoma of the ovary
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Cancer Ther 9:2411-22. 2010
  2. doi request reprint Post-treatment follow-up procedures in cervical cancer patients previously treated with radiotherapy
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Arch Gynecol Obstet 286:179-85. 2012
  3. pmc Nedaplatin: a radiosensitizing agent for patients with cervical cancer
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Chemother Res Pract 2011:963159. 2011
  4. doi request reprint A phase I study of concurrent weekly carboplatin and paclitaxel combined with intensity-modulated pelvic radiotherapy as an adjuvant treatment for early-stage cervical cancer patients with positive pelvic lymph nodes
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Gynecol Cancer 23:1279-86. 2013
  5. doi request reprint Elevated white blood cell count at the time of recurrence diagnosis is an indicator of short survival in patients with recurrent cervical cancer
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Int J Gynecol Cancer 22:1545-51. 2012
  6. ncbi request reprint Comparison of the prognoses of FIGO stage I to stage II adenosquamous carcinoma and adenocarcinoma of the uterine cervix treated with radical hysterectomy
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Gynecol Cancer 22:1389-97. 2012
  7. doi request reprint Impact of histological subtype on survival of patients with surgically-treated stage IA2-IIB cervical cancer: adenocarcinoma versus squamous cell carcinoma
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Gynecol Oncol 127:114-20. 2012
  8. ncbi request reprint G-CSF induces focal intense bone marrow FDG uptake mimicking multiple bone metastases from uterine cervical cancer: a case report and review of the literature
    S Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Eur J Gynaecol Oncol 33:316-7. 2012
  9. doi request reprint The activity of trabectedin as a single agent or in combination with everolimus for clear cell carcinoma of the ovary
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Clin Cancer Res 17:4462-73. 2011
  10. doi request reprint Prognostic factors for survival in patients with recurrent cervical cancer previously treated with radiotherapy
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Gynecol Cancer 20:834-40. 2010

Collaborators

Detail Information

Publications60

  1. pmc Vascular endothelial growth factor is a promising therapeutic target for the treatment of clear cell carcinoma of the ovary
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Cancer Ther 9:2411-22. 2010
    ..Bevacizumab may be efficacious not only as a first-line treatment but also as a second-line treatment of recurrent disease in patients previously treated with cisplatin...
  2. doi request reprint Post-treatment follow-up procedures in cervical cancer patients previously treated with radiotherapy
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Arch Gynecol Obstet 286:179-85. 2012
    ..We investigated the role of physical examination, CT scan, chest X-ray, and Pap smear in the routine follow-up program for cervical cancer patients previously treated with radiotherapy...
  3. pmc Nedaplatin: a radiosensitizing agent for patients with cervical cancer
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Chemother Res Pract 2011:963159. 2011
    ..Further investigations in randomized controlled trials are therefore needed...
  4. doi request reprint A phase I study of concurrent weekly carboplatin and paclitaxel combined with intensity-modulated pelvic radiotherapy as an adjuvant treatment for early-stage cervical cancer patients with positive pelvic lymph nodes
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Gynecol Cancer 23:1279-86. 2013
    ....
  5. doi request reprint Elevated white blood cell count at the time of recurrence diagnosis is an indicator of short survival in patients with recurrent cervical cancer
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Int J Gynecol Cancer 22:1545-51. 2012
    ..The aim of this study was to investigate the prognostic significance of elevated white blood cell (WBC) count at the time of the diagnosis of cervical cancer recurrence...
  6. ncbi request reprint Comparison of the prognoses of FIGO stage I to stage II adenosquamous carcinoma and adenocarcinoma of the uterine cervix treated with radical hysterectomy
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Gynecol Cancer 22:1389-97. 2012
    ..To evaluate the significance of adenosquamous carcinoma (ASC) compared with adenocarcinoma (AC) in the survival of surgically treated early-stage cervical cancer...
  7. doi request reprint Impact of histological subtype on survival of patients with surgically-treated stage IA2-IIB cervical cancer: adenocarcinoma versus squamous cell carcinoma
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Gynecol Oncol 127:114-20. 2012
    ..To evaluate the significance of adenocarcinoma (AC) compared with squamous cell carcinoma (SCC) with regard to the survival of surgically-treated early stage cervical cancer patients...
  8. ncbi request reprint G-CSF induces focal intense bone marrow FDG uptake mimicking multiple bone metastases from uterine cervical cancer: a case report and review of the literature
    S Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Eur J Gynaecol Oncol 33:316-7. 2012
    ....
  9. doi request reprint The activity of trabectedin as a single agent or in combination with everolimus for clear cell carcinoma of the ovary
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Clin Cancer Res 17:4462-73. 2011
    ..The objective of this study was to evaluate the antitumor efficacy of trabectedin in clear cell carcinoma (CCC) of the ovary, which is regarded as an aggressive, chemoresistant, histologic subtype...
  10. doi request reprint Prognostic factors for survival in patients with recurrent cervical cancer previously treated with radiotherapy
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Gynecol Cancer 20:834-40. 2010
    ..The aim of this study was to identify the prognostic factors and to establish a model for the prediction of life expectancy in patients with recurrent cervical cancer that had previously been treated with radiotherapy...
  11. doi request reprint Concurrent weekly nedaplatin, external beam radiotherapy and high-dose-rate brachytherapy in patients with FIGO stage IIIb cervical cancer: a comparison with a cohort treated by radiotherapy alone
    Seiji Mabuchi
    Departments of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan
    Gynecol Obstet Invest 69:224-32. 2010
    ....
  12. doi request reprint The activity of carboplatin and paclitaxel for recurrent cervical cancer after definitive radiotherapy
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Gynecol Oncol 113:200-4. 2009
    ..The aim of this study was to evaluate the efficacy of paclitaxel-carboplatin (TC) for recurrent cervical cancer after definitive radiotherapy and to compare the results with non-taxane containing platinum-based chemotherapies (NTP)...
  13. doi request reprint The first 2 cases of granulocyte colony-stimulating factor producing adenocarcinoma of the uterine cervix
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Int J Gynecol Pathol 29:483-7. 2010
    ..These cases strongly indicate the aggressive nature of the G-CSF-producing cervical adenocarcinomas...
  14. doi request reprint Postoperative whole pelvic radiotherapy plus concurrent chemotherapy versus extended-field irradiation for early-stage cervical cancer patients with multiple pelvic lymph node metastases
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Gynecol Oncol 120:94-100. 2011
    ....
  15. doi request reprint Pretreatment leukocytosis is an indicator of poor prognosis in patients with cervical cancer
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Gynecol Oncol 122:25-32. 2011
    ..The aim of this study was to investigate the prognostic value of pretreatment leukocytosis in patients with cervical cancer in relation to well-established conventional risk factors...
  16. ncbi request reprint Targeting mTOR signaling pathway in ovarian cancer
    S Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Curr Med Chem 18:2960-8. 2011
    ..In this report, we review the scientific rationale and evidence for the potential clinical benefits provided by mTOR inhibitor therapy for patients with epithelial ovarian cancer...
  17. doi request reprint Radical hysterectomy with adjuvant radiotherapy versus definitive radiotherapy alone for FIGO stage IIB cervical cancer
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Gynecol Oncol 123:241-7. 2011
    ..The aim of this study was to compare the treatment outcomes and adverse effects of radical hysterectomy followed by adjuvant radiotherapy with definitive radiotherapy alone in patients with FIGO stage IIB cervical cancer...
  18. doi request reprint Postoperative concurrent nedaplatin-based chemoradiotherapy improves survival in early-stage cervical cancer patients with adverse risk factors
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Gynecol Oncol 115:482-7. 2009
    ..The aim of this study was to evaluate the efficacy of postoperative nedaplatin-based concurrent chemoradiotherapy (CCRT) in patients with FIGO stage IA2-IIB cervical cancer with adverse risk factors...
  19. doi request reprint Use of monoclonal antibodies in the treatment of ovarian cancer
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Curr Opin Obstet Gynecol 22:3-8. 2010
    ..One of the promising approaches that may improve patient outcome is the use of monoclonal antibodies (mAbs)...
  20. pmc mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Cancer Res 15:5404-13. 2009
    ..This study aimed to examine the role of mTOR as a therapeutic target in clear cell carcinoma of the ovary, which is regarded as an aggressive, chemoresistant histologic subtype...
  21. doi request reprint Maintenance treatment with bevacizumab prolongs survival in an in vivo ovarian cancer model
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Cancer Res 14:7781-9. 2008
    ..We hypothesized that treatment with bevacizumab, a humanized recombinant anti-VEGF monoclonal antibody, could enhance antitumor response to cisplatin and prolong survival in a murine ovarian cancer model...
  22. ncbi request reprint Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian cancer cell lines
    Akiko Kimura
    Department of Obstetrics and Gynecology, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Oncogene 23:4505-15. 2004
    ..Thus, the phosphorylation of Akt is a key event in the induction of telomerase activity by E(2) in human ovarian cancer cells...
  23. ncbi request reprint Inhibition of inhibitor of nuclear factor-kappaB phosphorylation increases the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Medical School, Osaka, Japan
    Clin Cancer Res 10:7645-54. 2004
    ....
  24. ncbi request reprint Tamoxifen inhibits cell proliferation via mitogen-activated protein kinase cascades in human ovarian cancer cell lines in a manner not dependent on the expression of estrogen receptor or the sensitivity to cisplatin
    Seiji Mabuchi
    Departmentof Obstetrics and Gynecology, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    Endocrinology 145:1302-13. 2004
    ....
  25. doi request reprint Impact of the addition of concurrent chemotherapy to pelvic radiotherapy in surgically treated stage IB1-IIB cervical cancer patients with intermediate-risk or high-risk factors: a 13-year experience
    Mika Okazawa
    Department of Gynecology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka University Graduate School of Medicine, Japan
    Int J Gynecol Cancer 23:567-75. 2013
    ..To identify groups of patients who derive clinical benefit from postoperative adjuvant concurrent chemoradiotherapy (CCRT), we retrospectively investigated the survival outcomes of surgically treated early-stage cervical cancer patients...
  26. ncbi request reprint Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin
    Emi Arimoto-Ishida
    Department of Obstetrics and Gynecology, Osaka University Medical School, Suita, Japan
    Endocrinology 145:2014-22. 2004
    ..Our findings suggest that cisplatin causes the phosphorylation of FKHRL1 via a phosphatidylinositol 3-kinase/Akt cascade, and inhibition of this cascade sensitizes ovarian cancer cells to cisplatin...
  27. ncbi request reprint Inhibition of phosphatidylinositol 3-kinase increases efficacy of cisplatin in in vivo ovarian cancer models
    Tsuyoshi Ohta
    Department of Obstetrics and Gynecology, Yamagata University, School of Medicine, Japan
    Endocrinology 147:1761-9. 2006
    ..In accordance with the previously reported in vitro results, these in vivo results support the idea that combination therapy with cisplatin and a PI3K inhibitor would increase the therapeutic efficacy of cisplatin...
  28. doi request reprint miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression
    Chifumi Ohyagi-Hara
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Pathol 182:1876-89. 2013
    ....
  29. ncbi request reprint Estrogen and raloxifene inhibit the monocytic chemoattractant protein-1-induced migration of human monocytic cells via nongenomic estrogen receptor alpha
    Namiko Yada-Hashimoto
    Department of Obstetrics and Gynecology, School of Medicine, Osaka University, Osaka, Japan
    Menopause 13:935-41. 2006
    ..To investigate the effects of estradiol (E2) and raloxifene on the migration of human monocytic THP-1 cells to endothelium...
  30. doi request reprint Peripheral quantitative computed tomography is useful to monitor response to alendronate therapy in postmenopausal women
    Kenjiro Sawada
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Bone Miner Metab 27:175-81. 2009
    ..Collectively, our preliminary clinical trial showed that pQCT might be useful to monitor response to alendronate therapy, especially at the radius, and it might explain why alendronate prevents Colles' fracture...
  31. ncbi request reprint Inhibition of NFkappaB increases the efficacy of cisplatin in in vitro and in vivo ovarian cancer models
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Medical School, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 279:23477-85. 2004
    ..These results suggest that combination therapy of cisplatin with the NFkappaB inhibitor should increase the therapeutic efficacy of cisplatin...
  32. doi request reprint Prediction of progression-free survival and response to paclitaxel plus carboplatin in patients with recurrent or advanced cervical cancer
    Takeshi Hisamatsu
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Gynecol Cancer 22:623-9. 2012
    ..The aim of this study was to identify predictors of the response to paclitaxel-carboplatin chemotherapy (TC) in recurrent or patients with advanced cervical cancer...
  33. doi request reprint The prognostic significance of multiple pelvic node metastases in cervical cancer patients treated with radical hysterectomy plus adjuvant chemoradiotherapy
    Mika Okazawa
    Department of Gynecology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Int J Gynecol Cancer 22:490-7. 2012
    ..We investigated the prognostic significance of multiple pelvic node metastases in cervical cancer patients who were treated with radical hysterectomy plus adjuvant chemoradiotherapy...
  34. doi request reprint Fasudil inhibits lysophosphatidic acid-induced invasiveness of human ovarian cancer cells
    Seiji Ogata
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Gynecol Cancer 19:1473-80. 2009
    ..Our findings suggest that fasudil might be useful to prevent the progression of ovarian cancer in clinical settings...
  35. pmc Potential role of mTORC2 as a therapeutic target in clear cell carcinoma of the ovary
    Takeshi Hisamatsu
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Cancer Ther 12:1367-77. 2013
    ..Moreover, mTORC2-targeted therapy may be efficacious in a first-line setting as well as for second-line treatment of recurrent disease developing after RAD001-treatment...
  36. ncbi request reprint Estrogen inhibits paclitaxel-induced apoptosis via the phosphorylation of apoptosis signal-regulating kinase 1 in human ovarian cancer cell lines
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    Endocrinology 145:49-58. 2004
    ..Thus, treatment of ovarian cancer with paclitaxel might be less effective in the setting of postoperative estrogen replacement therapy...
  37. doi request reprint Squamous cell carcinoma of the uterine cervix producing granulocyte colony-stimulating factor: a report of 4 cases and a review of the literature
    Yuri Matsumoto
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine 2 2 Yamadaoka, Suita, Osaka 565 0871 Japan
    Int J Gynecol Cancer 20:417-21. 2010
    ..All patients died from disease progression in less than 15 months. These cases strongly indicate the aggressive nature of the G-CSF-producing cervical cancer...
  38. doi request reprint Up-regulation of alpha5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation
    Emi Arimoto-Ishida
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Endocrinology 150:4306-15. 2009
    ..This finding should help us reach a better understanding of the pathogenesis of critical gestational diseases, such as preeclampsia...
  39. doi request reprint Dose-volume histogram predictors of chronic gastrointestinal complications after radical hysterectomy and postoperative concurrent nedaplatin-based chemoradiation therapy for early-stage cervical cancer
    Fumiaki Isohashi
    Department of Radiation Oncology, Osaka University Hospital, Suita, Osaka, Japan
    Int J Radiat Oncol Biol Phys 85:728-34. 2013
    ....
  40. ncbi request reprint Peripheral quantitative computed tomography (pQCT) is useful for monitoring bone mineral density of the patients who receive hormone replacement therapy
    Kenjiro Sawada
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Maturitas 56:343-9. 2007
    ....
  41. doi request reprint Efficacy of raloxifene hydrochloride for the prevention of health care problems in patients who undergo surgery for endometrial cancer: a multicenter randomized clinical trial
    Koji Nakamura
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, Gifu Department of Obstetrics and Gynecology, Osaka Police Hospital, Osaka Department of Obstetrics and Gynecology, Kansai Rosai Hospital, Amagasaki, Hyogo and Department of Gynecology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Int J Gynecol Cancer 25:288-95. 2015
    ....
  42. doi request reprint Efficacies and pregnant outcomes of fertility-sparing treatment with medroxyprogesterone acetate for endometrioid adenocarcinoma and complex atypical hyperplasia: our experience and a review of the literature
    Chifumi Ohyagi-Hara
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2, Yamadaoka Suita, Osaka, 5650871, Japan
    Arch Gynecol Obstet 291:151-7. 2015
    ....
  43. doi request reprint Prognostic significance of systemic neutrophil and leukocyte alterations in surgically treated endometrial cancer patients: A monoinstitutional study
    Ryoko Takahashi
    Department of Obstetrics and Gynecology, Osaka University, Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Gynecol Oncol 137:112-8. 2015
    ..The aim of this study was to investigate the prognostic significance of an elevated neutrophil count at the time of the initial diagnosis in patients with surgically treated endometrial cancer...
  44. doi request reprint Combination treatment with trabectedin and irinotecan or topotecan has synergistic effects against ovarian clear cell carcinoma cells
    Mahiru Kawano
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka Department of Obstetrics and Gynecology, Yamagata University Graduate School of Medicine, Yamagata and Department of Biomedical Statistics, Osaka University Graduate School of Medicine, Osaka, Japan
    Int J Gynecol Cancer 24:829-37. 2014
    ....
  45. doi request reprint Reirradiation using high-dose-rate interstitial brachytherapy for locally recurrent cervical cancer: a single institutional experience
    Seiji Mabuchi
    Departments of Obstetrics and Gynecology, and Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Gynecol Cancer 24:141-8. 2014
    ..This study aimed to evaluate the effectiveness and feasibility of reirradiation using high-dose-rate interstitial brachytherapy (HDR-ISBT) in patients with recurrent cervical cancer...
  46. doi request reprint Grave outcome of granulocyte colony-stimulating factor-producing endometrial cancer: a case report and literature review
    Kasumi Yamamoto
    Department of Obstetrics and Gynecology, Belland General Hospital, Sakai, Osaka, Japan
    J Obstet Gynaecol Res 39:1107-10. 2013
    ..We report a case of G-CSF-producing endometrial cancer, which exhibited a grave clinical outcome. Our case strongly indicates the aggressive nature of G-CSF-producing endometrial cancer...
  47. doi request reprint In vitro and in vivo assays to analyze the contribution of Rho kinase in angiogenesis
    Kenjiro Sawada
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Methods Enzymol 439:395-412. 2008
    ....
  48. ncbi request reprint Raloxifene inhibits estrogen-induced up-regulation of telomerase activity in a human breast cancer cell line
    Jun Kawagoe
    Department of Obstetrics and Gynecology, Yamagata University, School of Medicine, Iidanishi, Yamagata, Japan
    J Biol Chem 278:43363-72. 2003
    ....
  49. doi request reprint Efficacy and safety of nedaplatin-based concurrent chemoradiotherapy for FIGO Stage IB2-IVA cervical cancer and its clinical prognostic factors
    Masateru Fujiwara
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, 5650871, Japan
    J Radiat Res 56:305-14. 2015
    ..Histologic type, maximum tumor diameter, and pretreatment hemoglobin level were statistically significant prognostic factors for PFS. ..
  50. ncbi request reprint Treatment of ovarian cancer by monoclonal antibodies
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    Discov Med 9:197-203. 2010
    ..As the preclinical results of mAb's therapeutic effects on ovarian cancer have been encouraging, further investigations are needed to establish a more effective, specific, and less toxic treatment strategy for this malignancy...
  51. doi request reprint Targeting interleukin-6 receptor inhibits preterm delivery induced by inflammation
    Atsuko Wakabayashi
    Departments of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Hum Reprod 19:718-26. 2013
    ..Targeting IL-6 signaling could be a promising option for the prevention of PTD and needs to be further explored for future clinical application. ..
  52. doi request reprint First two cases of primary carcinoma of the vagina successfully treated with concurrent weekly carboplatin plus paclitaxel, external beam radiotherapy and high-dose-rate interstitial brachytherapy: a case report and published work review
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Obstet Gynaecol Res 41:156-61. 2015
    ..These cases strongly indicate that definitive chemoradiation involving carboplatin plus paclitaxel may be a reasonable treatment for primary vaginal carcinoma. ..
  53. pmc Interleukin 6 receptor is an independent prognostic factor and a potential therapeutic target of ovarian cancer
    Aki Isobe
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    PLoS ONE 10:e0118080. 2015
    ..The data presented herein suggest a rationale for anti-IL-6/IL-6R therapy to suppress the peritoneal spread of ovarian cancer, and represent evidence of the therapeutic potential of anti-IL-6R therapy for ovarian cancer treatment. ..
  54. ncbi request reprint Usefulness of duloxetine for Paclitaxel-induced peripheral neuropathy treatment in gynecological cancer patients
    Akiko Otake
    Department of Obstetrics and Gynecology, Osaka University, Graduate School of Medicine, Suita, Osaka, Japan
    Anticancer Res 35:359-63. 2015
    ..The present study aimed at evaluating the usefulness and adverse effects of duloxetine treatment for paclitaxel-induced peripheral neuropathy in gynecological cancer patients...
  55. doi request reprint Definitive radiotherapy for primary vaginal cancer: correlation between treatment patterns and recurrence rate
    Naoyuki Kanayama
    Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2 2 D10 Yamadaoka, Suita, Osaka 565 0871, Japan Department of Radiation Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari, Osaka 537 8511, Japan
    J Radiat Res 56:346-53. 2015
    ..Improvement of treatment outcomes in cases of FIGO Stage III or IV remains a significant challenge. ..
  56. doi request reprint Cesarean scar pregnancies successfully treated with methotrexate
    Miho Muraji
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Acta Obstet Gynecol Scand 88:720-3. 2009
    ..It took 7-11 weeks for the beta-hCG level to become undetectable and 12-17 weeks for the cesarean scar pregnancy mass to disappear completely...
  57. pmc Carboplatin and paclitaxel as an initial treatment in patients with stage IVb cervical cancer: a report of 7 cases and a review of the literature
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Gynecol Oncol 21:93-6. 2010
    ..The aim of this study is to evaluate the efficacy of carboplatin-paclitaxel (TC) as an initial treatment in patients with the International Federation of Gynecology and Obstetrics (FIGO) stage IVb cervical cancer...
  58. ncbi request reprint Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel
    Seiji Mabuchi
    Department of Obstetrics and Gynecology, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 277:33490-500. 2002
    ....
  59. pmc Effect of lymphovascular space invasion on survival of stage I epithelial ovarian cancer
    Koji Matsuo
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Los Angeles County Medical Center, and the Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California the Departments of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, University of Tokushima, Tokushima, Niigata University Graduate School of Medicine, Niigata, and Osaka Rosai Hospital, Sakai, Osaka, Japan the Department of Pathology, Mercy Medical Center, Baltimore, Maryland the Departments of Gynecologic Oncology and Pathology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan and the Department of Gynecologic Oncology and Cancer Biology, MD Anderson Cancer Center, University of Texas, and the Center for RNA Interference and non Coding RNA, University of Texas, Houston, Texas
    Obstet Gynecol 123:957-65. 2014
    ..To evaluate the effect of lymphovascular space invasion on survival of patients with early-stage epithelial ovarian cancer...