S Kuroda

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein
    S Kuroda
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, 567 0047, Japan
    J Cell Biol 144:403-11. 1999
  2. ncbi request reprint Involvement of epidermal growth factor-like domain of NELL proteins in the novel protein-protein interaction with protein kinase C
    S Kuroda
    Institute of Scientific and Industrial Research, Osaka University, Osaka, 567 0047, Japan
    Biochem Biophys Res Commun 265:752-7. 1999
  3. ncbi request reprint Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth
    K Miyoshi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Japan
    Mol Psychiatry 8:685-94. 2003
  4. ncbi request reprint Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2
    S Kuroda
    Institute of Scientific and Industrial Research, Osaka University, Osaka, 567 0047, Japan
    Biochem Biophys Res Commun 265:79-86. 1999
  5. ncbi request reprint ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain
    N Nakagawa
    Department of Structural Molecular Biology, Osaka University, Japan
    Biochem Biophys Res Commun 272:505-12. 2000
  6. ncbi request reprint Identification of polymerized-albumin receptor domain in the pre-S2 region of hepatitis B virus surface antigen M protein
    Y Itoh
    Biology Research Laboratories, Takeda Chemical Industries, Ltd, Osaka, Japan
    J Biotechnol 23:71-82. 1992
  7. ncbi request reprint Novel subtype of human angiotensin II type 1 receptor: cDNA cloning and expression
    H Konishi
    Pharmaceutical Group, Takeda Chemical Ind, Ltd, Osaka, Japan
    Biochem Biophys Res Commun 199:467-74. 1994
  8. ncbi request reprint Expression of CSF-1 receptor on TRAP-positive multinuclear cells around the erupting molars in rats
    M Kawakami
    Department of Orthodontics, Faculty of Dentistry, Osaka University, Suita, Japan
    J Craniofac Genet Dev Biol 19:213-20. 1999
  9. ncbi request reprint Physicochemical and immunological characterization of hepatitis B virus envelope particles exclusively consisting of the entire L (pre-S1 + pre-S2 + S) protein
    T Yamada
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research SANKEN, Osaka University, 8 1 Mihogaoka, 567 0047, Ibaraki, Japan
    Vaccine 19:3154-63. 2001
  10. ncbi request reprint Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain
    R Inatome
    Departments of Biochemistry, Kobe University School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 275:27291-302. 2000

Detail Information

Publications48

  1. pmc Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein
    S Kuroda
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, 567 0047, Japan
    J Cell Biol 144:403-11. 1999
    ....
  2. ncbi request reprint Involvement of epidermal growth factor-like domain of NELL proteins in the novel protein-protein interaction with protein kinase C
    S Kuroda
    Institute of Scientific and Industrial Research, Osaka University, Osaka, 567 0047, Japan
    Biochem Biophys Res Commun 265:752-7. 1999
    ....
  3. ncbi request reprint Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth
    K Miyoshi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Japan
    Mol Psychiatry 8:685-94. 2003
    ..As there is a high level of DISC1 expression in developing rat brain, dysfunction of DISC1 may confer susceptibility to psychiatric illnesses through abnormal development of the nervous system...
  4. ncbi request reprint Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2
    S Kuroda
    Institute of Scientific and Industrial Research, Osaka University, Osaka, 567 0047, Japan
    Biochem Biophys Res Commun 265:79-86. 1999
    ..Thus, it is likely that the NELL proteins also participate in the growth, differentiation, and oncogenesis of cancer cell lines...
  5. ncbi request reprint ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain
    N Nakagawa
    Department of Structural Molecular Biology, Osaka University, Japan
    Biochem Biophys Res Commun 272:505-12. 2000
    ....
  6. ncbi request reprint Identification of polymerized-albumin receptor domain in the pre-S2 region of hepatitis B virus surface antigen M protein
    Y Itoh
    Biology Research Laboratories, Takeda Chemical Industries, Ltd, Osaka, Japan
    J Biotechnol 23:71-82. 1992
    ..Immune electron microscopy showed that the purified antibodies could aggregate HBV particles. Therefore, it was speculated that the PAR domain overlapped with the dominant virus-neutralizing and virus-protecting epitopes...
  7. ncbi request reprint Novel subtype of human angiotensin II type 1 receptor: cDNA cloning and expression
    H Konishi
    Pharmaceutical Group, Takeda Chemical Ind, Ltd, Osaka, Japan
    Biochem Biophys Res Commun 199:467-74. 1994
    ..The 2.4-knt AT1bR mRNA is expressed in the lung, placenta and liver, and differs from AT1aR mRNA in its tissue distribution. The AT1bR expressed in COS-7 cells is pharmacologically distinct from the human AT1aR...
  8. ncbi request reprint Expression of CSF-1 receptor on TRAP-positive multinuclear cells around the erupting molars in rats
    M Kawakami
    Department of Orthodontics, Faculty of Dentistry, Osaka University, Suita, Japan
    J Craniofac Genet Dev Biol 19:213-20. 1999
    ..These findings suggested that CSF-1 directly enhances the influx of osteoclasts adjacent to the erupting tooth, resulting in the formation of an eruption pathway...
  9. ncbi request reprint Physicochemical and immunological characterization of hepatitis B virus envelope particles exclusively consisting of the entire L (pre-S1 + pre-S2 + S) protein
    T Yamada
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research SANKEN, Osaka University, 8 1 Mihogaoka, 567 0047, Ibaraki, Japan
    Vaccine 19:3154-63. 2001
    ..These results show the high ability of L particles to induce all antibodies against HBV env proteins, hence promising the future application of L particles for the next generation HB vaccine...
  10. ncbi request reprint Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain
    R Inatome
    Departments of Biochemistry, Kobe University School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 275:27291-302. 2000
    ....
  11. ncbi request reprint The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1
    R Maesaki
    Division of Structural Biology, Nara Institute of Science and Technology, Japan
    Mol Cell 4:793-803. 1999
    ..Sequence analysis based on the structure suggests that the ACC finger fold is widespread in Rho effector proteins...
  12. ncbi request reprint Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins
    S Lim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yusong Ku, Daejon, 305 701, Korea
    Mol Cell Neurosci 17:385-97. 2001
    ....
  13. pmc Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt
    T Kitamura
    Second Department of Internal Medicine, Kobe University School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    Mol Cell Biol 19:6286-96. 1999
    ..These results suggest that PDE3B is a physiological substrate of Akt and that Akt-mediated phosphorylation of PDE3B on serine-273 is important for insulin-induced activation of PDE3B...
  14. ncbi request reprint Identification and characterization of PRKCBP1, a candidate RACK-like protein
    S C Fossey
    Molecular Genetics Program, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Mamm Genome 11:919-25. 2000
    ..The results of this analysis suggest that PRKCBP1 coding variations are uncommon and do not contribute to Type II diabetes in the general population...
  15. ncbi request reprint Cloning and characterization of human Sep1 (hSEP1) gene and cytoplasmic localization of its product
    Y Sato
    AGENE Research Institute, Kamakura, Kanagawa, Japan
    DNA Res 5:241-6. 1998
    ..hSEP1p is localized in the cytoplasm as examined by cytochemical and Western blot analyses of fractionated cellular extracts. The biological function of hSEP1p was discussed in correlation with its cytoplasmic localization...
  16. ncbi request reprint Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins
    H Konishi
    Biosignal Research Center, Kobe University, Japan
    Biochem Biophys Res Commun 216:526-34. 1995
    ..These results suggest that the pleckstrin homology domains of RAC protein kinase family could associate more than one protein to regulate the activity and/or intracellular distribution of this enzyme family by different ways...
  17. ncbi request reprint Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta
    H Konishi
    Biosignal Research Center, Faculty of Science Kobe University, Japan
    Biochem Biophys Res Commun 205:817-25. 1994
    ..Immunoprecipitation analysis revealed that RAC-PK alpha and beta associate with protein kinase C zeta through the pleckstrin homology domain in vitro, suggesting the interaction between RAC-PK and protein kinase C...
  18. ncbi request reprint Protein-protein interaction of zinc finger LIM domains with protein kinase C
    S Kuroda
    Biosignal Research Center, Kobe University, Kobe 657, Japan
    J Biol Chem 271:31029-32. 1996
    ..These results suggest that the LIM domain is one of the targets of PKC and that the LIM-PKC interaction may shed light on undefined roles of LIM domain-containing proteins...
  19. ncbi request reprint Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers
    M Sone
    Department of Molecular Genetics, National Institute of Neuroscience NIN, National Center of Neurology and Psychiatry NCNP, Kodaira, Tokyo, Japan
    Science 275:543-7. 1997
    ..Thus, SIF proteins may regulate synaptic differentiation through the organization of the actin cytoskeleton by activating Rho-like GTPases...
  20. ncbi request reprint Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins
    C Tokunaga
    Biosignal Research Center, Faculty of Science, Kobe University, Japan
    Biochem Biophys Res Commun 244:353-9. 1998
    ..These results suggest that RBCK1 protein might be a transcription factor that has a role in the signaling pathway through PKC...
  21. ncbi request reprint Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue
    K Ihara
    Divisions of Structural Biology, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 01, Japan
    J Biol Chem 273:9656-66. 1998
    ..These structural differences provide an insight into specific interaction sites with the effectors, as well as with modulators such as guanine nucleotide exchange factor (GEF) and guanine nucleotide dissociation inhibitor (GDI)...
  22. ncbi request reprint Molecular cloning and characterization of RBCK2, a splicing variant of a RBCC family protein, RBCK1
    C Tokunaga
    Biosignal Research Center, Kobe University, Japan
    FEBS Lett 435:11-5. 1998
    ..These results suggest that RBCK2 may inhibit the transcriptional activity of RBCK1 probably through complex formation with RBCK1...
  23. ncbi request reprint The pleckstrin homology domain of RAC protein kinase associates with the regulatory domain of protein kinase C zeta
    H Konishi
    Biosignal Research Center, Kobe University, Japan
    Biochem Biophys Res Commun 205:1770-5. 1994
    ..The protein-protein interaction between RAC protein kinase and protein kinase C through the pleckstrin homology domain might be important for the regulation of these protein kinases...
  24. ncbi request reprint The covalent structure of the small subunit from Pseudomonas putida amine dehydrogenase reveals the presence of three novel types of internal cross-linkages, all involving cysteine in a thioether bond
    I Vandenberghe
    Laboratorium voor Eiwitbiochemie en Eiwitengineering, K L Ledeganckstraat, 35, 9000 Gent, Belgium
    J Biol Chem 276:42923-31. 2001
    ..The thioether type bond in all four of these adducts has never been found in other proteins. CTQ is a novel cofactor in the series of the recently discovered quinone cofactors...
  25. ncbi request reprint Identification of missense mutation (G365R) of the butyrylcholinesterase (BCHE) gene in a Japanese patient with familial cholinesterasemia
    N Sakamoto
    Department of Internal Medicine, Harima Hospital of Ishikawajima-Harima Heavy Industries, Health Insurance Society, 3-5-15 Asahi, Aioi, Hyogo, 678-0031, Japan
    Kobe J Med Sci 47:153-60. 2001
    ..DNA sequence analysis of the propositus demonstrated a point mutation at codon 365 (GGA-CGA), resulting in a Gly-Arg substitution. A family study showed her son and daughter to have the same mutation...
  26. ncbi request reprint Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen
    S Ibe
    Faculty of Science and Technology, Department of Applied Biological Science, Science University of Tokyo, Noda, Chiba 278 8510, Japan
    Genes Cells 6:815-24. 2001
    ..Using an anti-TdT antibody column, TdT has been purified as a member of a megadalton protein complex from rat thymus. The N region would be synthesized with the large protein complex...
  27. ncbi request reprint Brain specific human genes, NELL1 and NELL2, are predominantly expressed in neuroblastoma and other embryonal neuroepithelial tumors
    K Maeda
    Departments of Biochemistry and Neurosurgery, Saga Medical School, Saga, Japan
    Neurol Med Chir (Tokyo) 41:582-8; discussion 589. 2001
    ..These results suggest that NELL2 is predominantly expressed in the neuronal cell lineage in the human nervous system. NELL1 is expressed mainly in tumors in the neuronal cell lineage...
  28. ncbi request reprint Identification of novel membrane-bound phospholipase D from Streptoverticillium cinnamoneum, possessing only hydrolytic activity
    C Ogino
    Division of Molecular Science, Graduate School of Science and Technology, Kobe University, Japan
    Biochim Biophys Acta 1530:23-31. 2001
    ..Ogino et al., J. Biochem. 125 (1999) 263-269] and is therefore regarded as a novel prokaryotic PLD...
  29. ncbi request reprint Synergistic effect of fibroblast growth factor-4 in ectopic bone formation induced by bone morphogenetic protein-2
    K Kubota
    Department of Periodontology, Hard Tissue Engineering, Tokyo Dental and Medical University, Japan
    Bone 31:465-71. 2002
    ..Our results indicate that FGF-4 and FGFR signals play important roles during rhBMP-2-induced bone formation. We further suggest that the combination of rhBMP-2 and rhFGF-4 would be useful for bone augmentation...
  30. ncbi request reprint Alanine dehydrogenases from two Bacillus species with distinct thermostabilities: molecular cloning, DNA and protein sequence determination, and structural comparison with other NAD(P)(+)-dependent dehydrogenases
    S Kuroda
    Institute for Chemical Research, Kyoto University, Japan
    Biochemistry 29:1009-15. 1990
    ..Interestingly, several catalytically important residues in lactate and malate dehydrogenases are conserved in the primary structure of alanine dehydrogenases at matched positions with similar mutual distances...
  31. ncbi request reprint Over-expression system for secretory phospholipase D by Streptomyces lividans
    C Ogino
    Division of Molecular Science, Graduate School of Science and Technology, Kobe University, 1 1 Rokkodai, Nada, 657 8501 Kobe, Japan
    Appl Microbiol Biotechnol 64:823-8. 2004
    ..cinnamoneum, which secretes only a small amount of PLD (about 1.1x10(3) U/l, 2 mg/l) along with other extracellular proteins, this heterologous expression system is markedly more efficient in production of secretory PLD...
  32. ncbi request reprint Frequency of early and late-onset dementias in a Japanese memory disorders clinic
    O Yokota
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Eur J Neurol 12:782-90. 2005
    ....
  33. ncbi request reprint Association study of the dihydropyrimidinase-related protein 2 gene and methamphetamine psychosis
    H Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Ann N Y Acad Sci 1074:90-6. 2006
    ..These findings indicate that a genetic variant of the DRP-2 gene may not affect the risk of METH psychosis or any clinical phenotype of the disorder...
  34. ncbi request reprint No association between CART (cocaine- and amphetamine-regulated transcript) gene and methamphetamine dependence
    A Morio
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Ann N Y Acad Sci 1074:411-7. 2006
    ..The present findings suggest that the CART gene may not play a pivotal role in the development of METH dependence and psychosis, at least in a Japanese population...
  35. ncbi request reprint Molecular cloning and expression in Escherichia coli of the cDNA coding for rabbit tumor necrosis factor
    H Ito
    DNA 5:149-56. 1986
    ..The polypeptide produced had the characteristics of purified rabbit serum TNF and caused a necrotic response in a transplanted syngeneic tumor in mice...
  36. ncbi request reprint IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A
    N Sugimoto
    Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, Japan
    J Hum Genet 46:21-5. 2001
    ....
  37. pmc Requirement of GM2 ganglioside activator for phospholipase D activation
    S Nakamura
    Department of Biochemistry, Kobe University School of Medicine, Kobe 650 0017, Japan
    Proc Natl Acad Sci U S A 95:12249-53. 1998
    ..The mechanism of action of the heat-stable PLD activator protein remains unknown...
  38. ncbi request reprint Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1
    M Hoshino
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Biol Chem 274:17837-44. 1999
    ..These findings suggested that STEF protein participates in the control of cellular events in several developing tissues, possibly changing the actin cytoskeletal network by activating Rac1...
  39. ncbi request reprint Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)
    M Takata
    Second Department of Internal Medicine, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 274:20611-8. 1999
    ..These data suggest that Akt, but not PKClambda, is required for insulin activation of glycogen synthase and for insulin-induced phosphorylation of 4E-BP1...
  40. ncbi request reprint p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase
    K Kobayashi
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630 01, Japan
    J Biol Chem 273:291-5. 1998
    ..Sra-1 was cosedimented with filamentous actin (F-actin), indicating that Sra-1 directly interacts with F-actin. These results suggest that Sra-1 is a novel and specific target for Rac1...
  41. ncbi request reprint An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism
    T Shimizu
    Division of Strucural Biology and Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    J Biol Chem 275:18311-7. 2000
    ..This RHOA-GDP structure reveals an important regulatory role for Mg(2+) and suggests that guanine nucleotide exchange factor may utilize this feature of switch I to produce an open conformation in GDP/GTP exchange...
  42. ncbi request reprint Phosphorylation of ERM proteins at filopodia induced by Cdc42
    N Nakamura
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630 0101, Japan
    Genes Cells 5:571-81. 2000
    ..J. Biol. Chem. 273, 34663- 34666). However, the role of ERM proteins in the formation of filopodia is less well characterized...
  43. ncbi request reprint Synaptic development is controlled in the periactive zones of Drosophila synapses
    M Sone
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    Development 127:4157-68. 2000
    ..We propose that neurotransmission and synaptic growth are primarily regulated in segregated subcellular spaces, active zones and periactive zones, respectively...
  44. ncbi request reprint Biochemical and crystallographic characterization of a Rho effector domain of the protein serine/threonine kinase N in a complex with RhoA
    R Maesaki
    Division of Structural Biology, Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara, 630 0101, Japan
    J Struct Biol 126:166-70. 1999
    ..In solution, RhoA binds to the PKN effector domain with 1:2 stoichiometry in a GTP-dependent manner. The obtained complex crystals diffract to 2.2 A resolution...
  45. ncbi request reprint Human NELL-1 expressed in unilateral coronal synostosis
    K Ting
    Dental Research Institute, University of California, Los Angeles, California, USA
    J Bone Miner Res 14:80-9. 1999
    ..The precise role of this gene is unknown...
  46. ncbi request reprint Comparative analyses of the distribution of various transposable elements in Pyricularia and their activity during and after the sexual cycle
    Y Eto
    Faculty of Agriculture, Kobe University, Japan
    Mol Gen Genet 264:565-77. 2001
    ..These data suggested that MAGGY was the most active of the elements tested for transposition in Pyricularia...
  47. pmc Involvement of IQGAP1, an effector of Rac1 and Cdc42 GTPases, in cell-cell dissociation during cell scattering
    M Fukata
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630-0101, Japan
    Mol Cell Biol 21:2165-83. 2001
    ....
  48. ncbi request reprint Digoxin transport by renal proximal tubule cells is enhanced by adhesive synthetic RGD peptide
    H Ijima
    Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, Nishi ku, Fukuoka, Japan
    Int J Artif Organs 30:25-33. 2007
    ..The purpose of this study was to improve cell adhesion, uniform stable monolayer formation and active transport function by immobilization of arginine-glycine-aspartic acid (RGD) on the culture substratum...