Takashi Kudo

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint FAD-linked presenilin-1 mutants impede translation regulation under ER stress
    Yuka Yasuda
    Division of Psychiatry and Behavioral Proteomics, Department of Post Genomics and Diseases, Course of Advanced Medicine, Graduate School of Medicine, Osaka University, 2 2, Yamadaoka, Siuta, Osaka, Japan
    Biochem Biophys Res Commun 296:313-8. 2002
  2. ncbi request reprint Altered localization of amyloid precursor protein under endoplasmic reticulum stress
    Takashi Kudo
    Division of Psychiatry, Course of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Biochem Biophys Res Commun 344:525-30. 2006
  3. ncbi request reprint [A molecular chaperone inducer as potential therapeutic agent for neurodegenerative disease]
    Takashi Kudo
    Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2 2 Yamadaoka, Suita, 565 0871 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 27:63-7. 2007
  4. ncbi request reprint The unfolded protein response is involved in the pathology of Alzheimer's disease
    Takashi Kudo
    Department of Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Ann N Y Acad Sci 977:349-55. 2002
  5. ncbi request reprint A molecular chaperone inducer protects neurons from ER stress
    T Kudo
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Cell Death Differ 15:364-75. 2008
  6. ncbi request reprint [ER stress and psychiatric disorders]
    Takashi Kudo
    Laboratory Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, D3, 2 2 Yamadaoka, Suita 565 0871, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 29:1-5. 2009
  7. ncbi request reprint [Therapeutic strategies for Alzheimer disease based on endoplasmic reticulum stress]
    Takashi Kudo
    Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 30:163-8. 2010
  8. ncbi request reprint Are cerebrovascular factors involved in Alzheimer's disease?
    T Kudo
    Department of Clinical Neuroscience, Psychiatry, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Neurobiol Aging 21:215-24. 2000
  9. ncbi request reprint Tau protein is a potential biological marker for normal pressure hydrocephalus
    T Kudo
    Department of Clinical Neuroscience and Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan
    Psychiatry Clin Neurosci 54:199-202. 2000
  10. doi request reprint Association study of KIBRA gene with memory performance in a Japanese population
    Yuka Yasuda
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    World J Biol Psychiatry 11:852-7. 2010

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint FAD-linked presenilin-1 mutants impede translation regulation under ER stress
    Yuka Yasuda
    Division of Psychiatry and Behavioral Proteomics, Department of Post Genomics and Diseases, Course of Advanced Medicine, Graduate School of Medicine, Osaka University, 2 2, Yamadaoka, Siuta, Osaka, Japan
    Biochem Biophys Res Commun 296:313-8. 2002
    ....
  2. ncbi request reprint Altered localization of amyloid precursor protein under endoplasmic reticulum stress
    Takashi Kudo
    Division of Psychiatry, Course of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Biochem Biophys Res Commun 344:525-30. 2006
    ..These findings suggest that induction of BiP/GRP78 during ER stress may be one of the regulatory mechanisms of Abeta generation...
  3. ncbi request reprint [A molecular chaperone inducer as potential therapeutic agent for neurodegenerative disease]
    Takashi Kudo
    Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2 2 Yamadaoka, Suita, 565 0871 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 27:63-7. 2007
    ..Taken together, BIX induces BiP to prevent neuronal death by ER stress, suggesting that it may be a potential therapeutic agent for cerebral diseases caused by ER stress...
  4. ncbi request reprint The unfolded protein response is involved in the pathology of Alzheimer's disease
    Takashi Kudo
    Department of Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Ann N Y Acad Sci 977:349-55. 2002
    ..Experimental manipulation of IRE1, PERK, or eIF2alpha phosphorylation or GRP78 expression might allow the development of therapeutic strategies for FAD...
  5. ncbi request reprint A molecular chaperone inducer protects neurons from ER stress
    T Kudo
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Cell Death Differ 15:364-75. 2008
    ..Considering these results together, it appears that BIX induces BiP to prevent neuronal death by ER stress, suggesting that it may be a potential therapeutic agent for cerebral diseases caused by ER stress...
  6. ncbi request reprint [ER stress and psychiatric disorders]
    Takashi Kudo
    Laboratory Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, D3, 2 2 Yamadaoka, Suita 565 0871, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 29:1-5. 2009
    ..Another report showed that ER stress is involved in sleep disturbances...
  7. ncbi request reprint [Therapeutic strategies for Alzheimer disease based on endoplasmic reticulum stress]
    Takashi Kudo
    Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 30:163-8. 2010
    ....
  8. ncbi request reprint Are cerebrovascular factors involved in Alzheimer's disease?
    T Kudo
    Department of Clinical Neuroscience, Psychiatry, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Neurobiol Aging 21:215-24. 2000
    ....
  9. ncbi request reprint Tau protein is a potential biological marker for normal pressure hydrocephalus
    T Kudo
    Department of Clinical Neuroscience and Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan
    Psychiatry Clin Neurosci 54:199-202. 2000
    ..These results suggest that CSF tau may be useful as a biological marker for NPH to determine the level of neuronal degeneration...
  10. doi request reprint Association study of KIBRA gene with memory performance in a Japanese population
    Yuka Yasuda
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    World J Biol Psychiatry 11:852-7. 2010
    ..KIBRA is highly expressed in the brain and kidneys, and is reported to be involved in synaptic plasticity. Therefore, we first tried to replicate the association between the SNP and memory performance in a Japanese subjects...
  11. doi request reprint The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 116:126-32. 2010
    ..003). We conclude that the genetic variants in the CHI3L1 gene have ethnic heterogeneity and confer a susceptibility to schizophrenia in Asian populations...
  12. doi request reprint The AKT1 gene is associated with attention and brain morphology in schizophrenia
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    World J Biol Psychiatry 14:100-13. 2013
    ..A meta-analysis of the associations between genetic variants in the AKT1 gene and schizophrenia found that a single nucleotide polymorphism (SNP5; rs2494732) was associated with schizophrenia in Asian populations...
  13. doi request reprint The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel
    Kohji Mori
    Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Psychogeriatrics 10:117-23. 2010
    ..Thus, one might evaluate compounds by analyzing the generation ratio of the βAPP intracellular domain (AICD) species (ε-cleavage-derived), instead of that of Aβ42...
  14. doi request reprint Involvement of endoplasmic reticulum stress in tauopathy
    Yukako Sakagami
    Department of Psychiatry, Osaka University Graduate School of Medicine, D3 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 430:500-4. 2013
    ..This mechanism may provide clue to treatment for tauopathy...
  15. doi request reprint Processes of beta-amyloid and intracellular cytoplasmic domain generation by presenilin/gamma-secretase
    Shinji Tagami
    Department of Post Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurodegener Dis 5:160-2. 2008
    ..Gamma-/S4 and epsilon-cleavages have diversity, and produce a number of Abeta/Nbeta and AICD species. S3 cleavage diversity has been recently identified. It is significant that each cleavage occurs with strict precision, not randomly...
  16. doi request reprint SORL1 is genetically associated with Alzheimer disease in a Japanese population
    Ryo Kimura
    Department of Psychiatry, Osaka General Medical Center, Osaka, Japan
    Neurosci Lett 461:177-80. 2009
    ..This risk was evident in non-carriers of the apolipoprotein E-epsilon 4 allele, but not in its carriers. Our results support the evidence that genetic variants of SORL1 affect susceptibility to late-onset AD...
  17. doi request reprint The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Suite, Osaka, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:1459-64. 2010
    ..018). In contrast, there was no genotype effect for any index in the healthy control subjects (P > 0.05). Our data suggest that rs1344706 may be related to memory dysfunction in schizophrenia. © 2010 Wiley-Liss, Inc...
  18. doi request reprint Decrease of dynamin 2 levels in late-onset Alzheimer's disease alters Abeta metabolism
    Eiichiro Kamagata
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Biochem Biophys Res Commun 379:691-5. 2009
    ..These data suggest that DNM2 expression is reduced in LOAD, which results in the accumulation of APP in lipid raft-rich plasma membranes. Consequently, Abeta secretion may increase in LOAD neurons...
  19. pmc Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death
    Junichi Hitomi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Cell Biol 165:347-56. 2004
    ..Thus, caspase-4 can function as an ER stress-specific caspase in humans, and may be involved in pathogenesis of Alzheimer's disease...
  20. doi request reprint Involvement of puromycin-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) mutant tau
    Kentaro Yanagi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Psychogeriatrics 9:157-66. 2009
    ..Together, the data suggest that attenuated proteolysis of FTDP-17 mutant tau may be explained by increased phosphorylation levels, resulting in resistance to proteolysis...
  21. doi request reprint Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death
    Kiyoko Kato
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Psychogeriatrics 11:90-7. 2011
    ..In the present study, we report on the possible role of PKC in cell survival during conditions of stress through phosphorylation of the X-linked inhibitor of apoptosis protein (XIAP)...
  22. ncbi request reprint The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease
    Ryo Kimura
    Department of Psychiatry, Osaka University Graduate School of Medicine, 2 2 D3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Hum Mol Genet 16:15-23. 2007
    ..Our result indicates that DYRK1A could be a key molecule bridging between beta-amyloid production and tau phosphorylation in AD...
  23. pmc Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1
    Shinji Tagami
    Department of Post Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, D3, Yamada oka 2 2, Suita, Osaka 565 0871, Japan
    Mol Cell Biol 28:165-76. 2008
    ....
  24. doi request reprint Apolipoprotein E and central nervous system disorders: reviews of clinical findings
    Masatoshi Takeda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Psychiatry Clin Neurosci 64:592-607. 2010
    ..The pathogenic role of ApoE-4 is still to be clarified; however, diverse evidence suggests that ApoE may play pleiotropic functions in dementia and central nervous system disorders...
  25. doi request reprint Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor
    Naohiro Itoh
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Neurodegener Dis 6:230-9. 2009
    ..Therefore, the data demonstrate that Dx-E represents a novel Abeta-reducing process which could have fewer side effects than secretase inhibitors...
  26. doi request reprint Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers
    Nuripa Jenishbekovna Aidaralieva
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Hum Genet 53:296-302. 2008
    ..We propose that the DNM2 gene is a novel susceptibility gene for LOAD...
  27. ncbi request reprint Novel function of PS2V: change in conformation of tau proteins
    Atsuko Nishikawa
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka, Japan
    Biochem Biophys Res Commun 318:435-8. 2004
    ..In this manuscript, we make the first report of PS2V alterations in the conformation of the tau protein (unknown form of tau) in the human neuroblastoma cell line...
  28. ncbi request reprint Induction of neuronal death by ER stress in Alzheimer's disease
    Taiichi Katayama
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka, University, Suita, Osaka 565 0871, Japan
    J Chem Neuroanat 28:67-78. 2004
    ..Caspase-4 also seems to act upstream of the beta-amyloid-induced ER stress pathway, suggesting that activation of caspase-4 might mediate neuronal cell death in AD...
  29. ncbi request reprint Amyloid-beta down-regulates XIAP expression in human SH-SY5Y neuroblastoma cells
    Hidenaga Yamamori
    Division of Psychiatry and Behavioral Proteomics, Department of Post Genomics and Diseases, Course of Advanced Medicine, Osaka University, Graduate School of Medicine D 3, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neuroreport 15:851-4. 2004
    ..These results suggest that down-regulation of XIAP expression in response to subtoxic, more physiological concentrations (100-500 nM) of Abeta(1-42) increases vulnerability to oxidative stress...
  30. pmc The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system
    Kanta Yanagida
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    EMBO Mol Med 1:223-35. 2009
    ..Based on these results, we propose the relative level of APL1beta28 in the CSF as a candidate surrogate marker for the relative level of Abeta42 production in the brain...
  31. doi request reprint Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 109:80-5. 2009
    ..However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population...
  32. doi request reprint Association between CAG repeat length in the PPP2R2B gene and Alzheimer disease in the Japanese population
    Ryo Kimura
    Department of Psychiatry, Osaka General Medical Center, 3 1 56 Bandai Higashi, Sumiyoshi ku, Osaka 558 8558, Japan
    Neurosci Lett 487:354-7. 2011
    ..The results suggest that CAG repeat lengths in the PPP2R2B gene may be potential genetic markers for AD susceptibility in the Japanese population...
  33. ncbi request reprint [Involvement of unfolded protein responses in neurodegeneration]
    Takashi Kudo
    Department of Clinical Neuroscience and Psychiatry, Osaka Universit Graduate School of Medicine, 2 2, Yamadaoka, Suita, 565 0871 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 23:105-9. 2003
    ..Recent reports have also shown that Parkinson disease and polyglutamine diseases are relevant to ER stress. Therefore it is suggested that the ER stress story is the common mechanism for neurodegerative disorders...
  34. ncbi request reprint [Biological markers for Alzheimer disease]
    Toshihisa Tanaka
    Department of Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine
    Seishin Shinkeigaku Zasshi 105:387-92. 2003
    ..The result suggests that protein oxidation is highly involved in AD and that this method might be useful to differentiate AD from other neurological disease...
  35. pmc Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1
    Masayasu Okochi
    Department of Post Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, 565 0871 Osaka, Japan
    EMBO J 21:5408-16. 2002
    ..Considering these similarities between intramembranous processing of Notch and betaAPP, we conclude that these proteins are cleaved by a common mechanism utilizing the same protease, i.e. PS/gamma-secretase...
  36. ncbi request reprint Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response
    T Katayama
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 1:479-85. 1999
    ..These results show that mutations in PS1 may increase vulnerability to ER stress by altering the UPR signalling pathway...
  37. pmc Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier
    Takashi Morihara
    Department of Psychiatry, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 111:2638-43. 2014
    ..This unique combination of distinct mouse strains and model mice with transcriptomics is expected to be useful for the study of genetic mechanisms of other complex diseases. ..
  38. pmc Laughter and humor as complementary and alternative medicines for dementia patients
    Masatoshi Takeda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan
    BMC Complement Altern Med 10:28. 2010
    ..The number of dementia patients has increased worldwide, with an estimated 13.7 million dementia patients in the Asia Pacific region alone. This number is expected to increase to 64.6 million by the year 2050...
  39. pmc Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer's disease in the mild cognitive impairment stage
    Hiroaki Kazui
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Dement Geriatr Cogn Disord Extra 1:20-30. 2011
    ..These results should help clinicians to distinguish ES combined with AD-aMCI from ES alone...
  40. ncbi request reprint Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct
    Akio Fukumori
    Division of Psychiatry and Behavioral Proteomics, Department of Post Genomics and Diseases, Osaka University Graduate School of Medicine, Osaka, Japan
    Biochemistry 45:4907-14. 2006
    ..These results suggest that the precision of cleavage by the PS/gamma-secretase complex may be physiologically regulated by the subcellular location and conditions...
  41. doi request reprint KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort
    Noriyuki Hayashi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Japan
    Dement Geriatr Cogn Disord 30:302-8. 2010
    ..Importantly, the association between KIBRA and episodic memory in AD has never been addressed. In this study, we investigated whether the KIBRA rs17070145 SNP influences AD episodic memory and the disease in a Japanese cohort...
  42. doi request reprint Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress
    Teruhiko Mitsuda
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 415:519-25. 2011
    ..This study is the first report identifying the transcription factor regulating Sig-1Rs expression...
  43. pmc Novel therapeutic strategies for neurodegenerative disease
    Hitoshi Tanimukai
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Psychogeriatrics 9:103-9. 2009
    ....
  44. ncbi request reprint Biological markers as outcome measures for Alzheimer's disease interventions--real problems and future possibilities
    Masatoshi Takeda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Japan
    Int Psychogeriatr 19:391-400. 2007
    ..In this study we examine whether the mechanism of secretase activity will offer a new surrogate marker of AD...
  45. doi request reprint Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3zeta protein
    Golam Sadik
    Department of Psychiatry, Osaka University, Yamadaoka, Suita, Japan
    Biochem Biophys Res Commun 383:37-41. 2009
    ..The significant aggregation of 4R-tau by 14-3-3zeta suggests that 14-3-3 may act as an inducer in the generation of 4R-tau-predominant neurofibrillary tangles in tauopathies...
  46. ncbi request reprint Hematopoietic prostaglandin D synthase and DP1 receptor are selectively upregulated in microglia and astrocytes within senile plaques from human patients and in a mouse model of Alzheimer disease
    Ikuko Mohri
    FrDepartment of Mental Health and Environmental Effects Research, The Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Neuropathol Exp Neurol 66:469-80. 2007
    ....
  47. pmc Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes
    Shinsuke Noso
    Department of Endocrinology, Metabolism, and Diabetes, Kinki University School of Medicine, Osaka, Japan
    Diabetes 59:2579-87. 2010
    ..Here, we report the role of the insulin transactivator MafA in the expression of insulin in the thymus and susceptibility to type 1 diabetes...
  48. ncbi request reprint Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations
    T Katayama
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    J Biol Chem 276:43446-54. 2001
    ..Taken together, these observations suggested that PS1 mutations could affect signaling pathways controlled by each of the respective ER-stress transducers, possibly through a gain-of-function...
  49. ncbi request reprint Possible role of scavenger receptor SRCL in the clearance of amyloid-beta in Alzheimer's disease
    Kenji Nakamura
    Department of Biochemistry andMolecular Biology, Division of Molecular Regenerative Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Neurosci Res 84:874-90. 2006
    ..These findings suggest that SRCL could be the receptor involved in the binding or clearing of Abeta by glial and vascular/perivascular cells in AD...
  50. ncbi request reprint Paclitaxel induces neurotoxicity through endoplasmic reticulum stress
    Hitoshi Tanimukai
    Osaka University Hospital, Oncology Center, 2 15 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 437:151-5. 2013
    ..Our results suggest that Px induces neurotoxicity in part through activating the ER stress response. Our findings should contribute to novel approaches regarding the mechanism of Px-induced neurotoxicity, including chemobrain...
  51. ncbi request reprint Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia
    Hidetoshi Takahashi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Neurosci Res 62:187-94. 2008
    ..This did not correlate with any clinical variable in each group. Our results indicate that PPI and habituation of ASR are impaired in Asian patients with schizophrenia...
  52. ncbi request reprint The cytosolic inclusion bodies that consist of splice variants that lack exon 5 of the presenilin-2 gene differ obviously from Hirano bodies observed in the brain from sporadic cases of Alzheimer's disease patients
    Takayuki Manabe
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurosci Lett 328:198-200. 2002
    ..This observation suggests the possibility that PS2V-composed inclusions are a novel inclusion body, compared with other pathological characteristics previously reported in the SAD brain. We named this inclusion body the 'PS2V body'...
  53. ncbi request reprint Abnormal distribution of neurofilament L in neurons with Alzheimer's disease
    Y Nakamura
    Department of Neuropsychiatry, Osaka University Medical School, Japan
    Neurosci Lett 225:201-4. 1997
    ..These observations suggest the involvement of neurofilament proteins on the pathology of Alzheimer's disease in a different way than tau protein...
  54. ncbi request reprint Major phosphorylation site (Ser55) of neurofilament L by cyclic AMP-dependent protein kinase in rat primary neuronal culture
    Y Nakamura
    Department of Clinical Neuroscience, Psychiatry, Osaka University Graduate School of Medicine, Suita Shi, Japan
    J Neurochem 74:949-59. 2000
    ..As a consequence, NF-L may be phosphorylated at Ser55 by PKA or by a PKA-like kinase in vivo; however, the phosphorylation level of Ser55 may be modulated by certain phosphatases sensitive to okadaic acid...
  55. ncbi request reprint Localized phosphorylation of vimentin by rho-kinase in neuroblastoma N2a cells
    Y Nakamura
    Department of Clinical Neuroscience, Psychiatry, Osaka University Graduate School of Medicine, Yamadaoka 565 0871, Japan
    Genes Cells 5:823-37. 2000
    ..It is involved in the agonist-induced neurite retraction of neuronal cells, and phosphorylates vimentin at Ser-38 and Ser-71 resulting in in vitro disassembly of the filaments...
  56. ncbi request reprint IPP isomerase, an enzyme of mevalonate pathway, is preferentially expressed in postnatal cortical neurons and induced after nerve transection
    T Morihara
    Department of Neuropsychiatry, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Brain Res Mol Brain Res 67:231-8. 1999
    ..Taken together, these results suggest that elevation of IPP isomerase mRNA levels in neurons contributes to construction of nerve fibers both during the postnatal period in the cortex and their regeneration...
  57. ncbi request reprint Casein kinase II is responsible for phosphorylation of NF-L at Ser-473
    Y Nakamura
    Department of Clinical Neuroscience, Psychiatry, Osaka University Graduate School of Medicine, Suita Shi, Japan
    FEBS Lett 455:83-6. 1999
    ..This result may support the suggestion that CK II is the kinase responsible for Ser-473 phosphorylation. Despite many reports showing that CK I mediates phosphorylation of neurofilaments, CK II may phosphorylate NF-L in vivo...
  58. ncbi request reprint [The role of lipid metabolism in Alzheimer's disease]
    Kouzin Kamino
    Division of Psychiatry and Behavioral Proteomics, Department of Post Genomics and Diseases, Osaka University Graduate School of Medicine, 2 2, D3, Yamadaoka, Suita, 565 0871 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 22:103-10. 2002
    ..The regulation of lipid metabolism in and outside the brain could be a therapeutic and preventive target for Alzheimer's disease...
  59. ncbi request reprint [ER stress and neuropsychiatric disease]
    Takashi Kudo
    Department of Psychiatry, Osaka University Graduate School of Medicine
    Seishin Shinkeigaku Zasshi 114:115-23. 2012
    ..A molecular chaperone inducer (BIX), which we recently invented, prevents neuronal death by ER stress, suggesting that it may be a potential therapeutic agent for neuropsychiatric diseases by ER stress...
  60. ncbi request reprint Regional cerebral blood flow in the assessment of major depression and Alzheimer's disease in the early elderly
    Kazushi Hanada
    Department of Neuropsychiatry, Kinki University School of Medicine, Osaka, Japan
    Nucl Med Commun 27:535-41. 2006
    ..Alzheimer's disease and major depression are representative diseases that present forgetfulness and a depressive mood. It is often difficult to make a differential diagnosis between the two in the initial phase...
  61. ncbi request reprint Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2
    N Sato
    Department of Anatomy, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
    J Biol Chem 276:2108-14. 2001
    ..These findings suggest that the aberrant splicing of the PS2 gene may be implicated in the neuropathology of sporadic AD...
  62. ncbi request reprint Microstructural changes of the nucleus accumbens due to increase of estradiol level during menstrual cycle contribute to recurrent manic episodes--a single case study
    Kiwamu Matsuoka
    Department of Psychiatry, Nara Medical University, 840 Shijocho, Kashihara, Nara 634 8522, Japan Department of Psychiatry, National Hospital Organization Yamato Mental Medical Center, Yamatokoriyama, Japan
    Psychiatry Res 221:149-54. 2014
    ..Our findings provide a clue for understanding how fluctuations in gonadal hormone may amplify or ameliorate the symptomatology of psychiatric disorders related to the menstrual cycle. ..
  63. ncbi request reprint Induced HMGA1a expression causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease
    T Manabe
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Japan
    Cell Death Differ 10:698-708. 2003
    ..HMGA1a levels were significantly increased in the brain tissue from sporadic AD patients. We propose a novel mechanism of sporadic AD that involves HMGA1a-induced aberrant splicing of PS2 pre-mRNA in the absence of any mutations...
  64. ncbi request reprint A protective role of unfolded protein response in mouse ischemic acute kidney injury
    Worapat Prachasilchai
    Department of Veterinary Pharmacology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan
    Eur J Pharmacol 592:138-45. 2008
    ..Molecules involved in the unfolded protein response may offer new opportunities for pharmacological intervention against renal ischemia-reperfusion injury, which is an important cause of acute kidney injury...
  65. ncbi request reprint Molecular cloning and characterization of a novel UDP-Gal:GalNAc(alpha) peptide beta 1,3-galactosyltransferase (C1Gal-T2), an enzyme synthesizing a core 1 structure of O-glycan
    Takashi Kudo
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Central 2, Open Space Laboratory, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8586, Japan
    J Biol Chem 277:47724-31. 2002
    ..These results indicated that C1Gal-T2 is the second candidate for core 1 synthase that plays an important role in synthesizing O-glycans in digestive organs...
  66. ncbi request reprint Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen
    Yan Zhang
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Central 2, Open Space Laboratory, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    J Biol Chem 278:573-84. 2003
    ..pp-GalNAc-T13 would be a major enzyme responsible for the synthesis of O-glycan and specifically the Tn antigen epitope in neurons...
  67. ncbi request reprint Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1)
    Kentaro Tanemura
    Laboratory for Alzheimer Disease and Neural Architecture, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    J Biol Chem 281:5037-41. 2006
    ....
  68. ncbi request reprint Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc
    Takashi Sato
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory Central 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    J Biol Chem 278:47534-44. 2003
    ..These results suggest that beta 4GalNAc-T3 could transfer GalNAc residues, producing N,N'-diacetylgalactosediamine structures at least in N-glycans and probably in both N- and O-glycans...
  69. ncbi request reprint [Biological markers for diagnosis of Alzheimer's disease]
    Masatoshi Takeda
    Seishin Shinkeigaku Zasshi 106:1610-4. 2004
  70. ncbi request reprint Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2
    Hua Qin Wang
    Neurology Unit, Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
    Hum Mol Genet 14:1889-902. 2005
    ..Excessive pro-apoptotic activity of PS1/2 may play a role in the pathogenesis of FAD...
  71. ncbi request reprint Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia
    Dayan B Goodenowe
    Phenomenome Discoveries Inc, Saskatoon, Saskatchewan, Canada
    J Lipid Res 48:2485-98. 2007
    ..The putative roles that PlsEtn biochemistry play in the etiology of cholinergic degeneration, amyloid accumulation, and dementia are discussed...
  72. ncbi request reprint [Drug therapy for aged patients with Alzheimer disease]
    Takashi Kudo
    Seishin Shinkeigaku Zasshi 106:62-7. 2004
  73. pmc MafA is a key regulator of glucose-stimulated insulin secretion
    Chuan Zhang
    Institute of Basic Medical Sciences and Laboratory Animal Resource Center, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    Mol Cell Biol 25:4969-76. 2005
    ..Further analysis revealed that insulin 1, insulin 2, Pdx1, Beta2, and Glut-2 transcripts are diminished in MafA-deficient mice. These results show that MafA is a key regulator of glucose-stimulated insulin secretion in vivo...
  74. ncbi request reprint [Biological diagnositic markers for Alzheimer's disease]
    Masatoshi Takeda
    Nihon Ronen Igakkai Zasshi 42:279-81. 2005
  75. ncbi request reprint Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans
    Toshie Iwai
    Laboratory of Gene Function Analysis, Institute of Molecular and Cell Biology, National Institute of Advanced Industrial Science and Technology AIST, Open Space Laboratory C 2, 1 1 1 Umezono, Japan
    J Biol Chem 277:12802-9. 2002
    ..We concluded that beta3Gn-T6 is the most logical candidate for the core 3 synthase, which plays an important role in the synthesis of mucin-type O-glycans in digestive organs...
  76. pmc Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells
    Toshie Iwai
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, OSL C 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Proc Natl Acad Sci U S A 102:4572-7. 2005
    ..v. injection of the transfectants into nude mice was significantly suppressed. These findings indicated that the core structures of O-glycans are profoundly involved in the metastatic capacity of cancer cells...
  77. ncbi request reprint A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer
    Hiroyasu Ishida
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Central 2 OSL, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    FEBS Lett 579:71-8. 2005
    ..Beta3Gn-T8 could be an enzyme involved in the synthesis of poly-N-acetyllactosamine on beta1-6 branched N-glycans in colon cancer...
  78. ncbi request reprint Cholesterol diet enhances daily rhythm of Pai-1 mRNA in the mouse liver
    Takashi Kudo
    Department of Pharmacology, School of Science and Engineering, Waseda University, Higashifushimi 2 7 5, Nishitokyo shi, Tokyo 202 0021, Japan
    Am J Physiol Endocrinol Metab 287:E644-51. 2004
    ..Therefore, the risk or high frequency of acute atherothrombotic events in the morning still seems to be a factor that may be augmented under conditions of hypercholesterolemia...
  79. ncbi request reprint Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease
    Yoshio Bando
    Department of Anatomy, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Neurochem Int 46:11-8. 2005
    ..These results suggest that a close association exists between PKR and extrastriatal degeneration in PD and HD pathology...
  80. ncbi request reprint Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    J Biol Chem 278:41519-27. 2003
    ....
  81. ncbi request reprint Daily injection of insulin attenuated impairment of liver circadian clock oscillation in the streptozotocin-treated diabetic mouse
    Koji Kuriyama
    Department of Pharmacology, School of Science and Engineering, Waseda University, Higashifusimi 2 7 5, Nishitokyo Shi 202 0021, Japan
    FEBS Lett 572:206-10. 2004
    ..Insulin injection can recover dampened oscillation of the peripheral clock depending on its injection time...
  82. ncbi request reprint Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T15
    Lamei Cheng
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology AIST, Central 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    FEBS Lett 566:17-24. 2004
    ..These results clearly indicated that pp-GalNAc-T15 is a novel member of the human pp-GalNAc-T family with unique catalytic activity...
  83. pmc Normal embryonic and germ cell development in mice lacking alpha 1,3-fucosyltransferase IX (Fut9) which show disappearance of stage-specific embryonic antigen 1
    Takashi Kudo
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory, Tsukuba, Ibaraki 305 8568, Japan
    Mol Cell Biol 24:4221-8. 2004
    ..Therefore, we conclude that expression of the SSEA-1 epitope in the developing mouse embryo is not essential for embryogenesis in vivo...
  84. ncbi request reprint Chondroitin sulfate synthase-3. Molecular cloning and characterization
    Toshikazu Yada
    Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
    J Biol Chem 278:39711-25. 2003
    ..These results indicate that CSS3 is a glycosyltransferase having both glucuronyltransferase and N-acetylgalactosaminyltransferase activities. It may make a contribution to CS biosynthesis that differs from that of CSS1...
  85. ncbi request reprint Elevated transcript level of hyaluronan synthase1 gene correlates with poor prognosis of human colon cancer
    Yoichi Yamada
    Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi, Japan
    Clin Exp Metastasis 21:57-63. 2004
    ..Our current results therefore suggest that HAS1 plays a role in the malignant progression of human colon cancer cells...
  86. ncbi request reprint A focused microarray approach to functional glycomics: transcriptional regulation of the glycome
    Elena M Comelli
    Department of Molecular Biology and Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Glycobiology 16:117-31. 2006
    ..The glycogene chip reported in this study is available to the scientific community through the Consortium for Functional Glycomics (CFG) (http://www.functionalglycomics.org)...
  87. ncbi request reprint Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine
    Masanori Gotoh
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory, C 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    J Biol Chem 277:38179-88. 2002
    ..This enzyme could play a role in the synthesis of chondroitin sulfate as a glucuronyltransferase...
  88. ncbi request reprint Alpha1,3-fucosyltransferase IX (Fut9) determines Lewis X expression in brain
    Shoko Nishihara
    Division of Cell Biology, Institute of Life Science, Soka University, Tangi cho, Hachioji, Tokyo 192 8577, Japan
    Glycobiology 13:445-55. 2003
    ..Immunohistochemistry with anti-Fut9 monoclonal antibody revealed the distribution of the Lex structure. These results showed that Fut9 is the most responsible enzyme for the synthesis of Lex in brain...
  89. ncbi request reprint Meningoventriculitis caused by Streptococcus pluranimalium in a neonatal calf of premature birth
    Yukio M Seimiya
    Iwate Prefecture Central Livestock Hygiene Service Center, Takizawa mura, Iwate, Japan
    J Vet Med Sci 69:657-60. 2007
    ..Streptococcus pluranimalium was isolated from the brain and cerebrospinal fluid. These results suggest that the animal suffered from meningoventriculitis with septicemic S. pluranimalium infection...
  90. ncbi request reprint A novel I-branching beta-1,6-N-acetylglucosaminyltransferase involved in human blood group I antigen expression
    Niro Inaba
    National Institute of Advanced Industrial Science and Technology, Glycogene Function Team, Research Center for Glycoscience, Tsukuba, Ibaraki, Japan
    Blood 101:2870-6. 2003
    ..These findings indicate that the expression of the blood group I antigen in erythrocytes is determined by a novel IGnT3, not by IGnT1 or IGnT2...
  91. ncbi request reprint Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2
    Hiroko Iwasaki
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory C 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    J Biol Chem 278:5613-21. 2003
    ..We found that pp-GalNAc-T2 selectively transferred GalNAc residues to the same five positions. These results strongly suggested that pp-GalNAc-T2 is an essential enzyme for initiation of O-linked glycosylation of the IgA1 hinge region...
  92. ncbi request reprint Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10
    Lamei Cheng
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology AIST, Central 2, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    FEBS Lett 531:115-21. 2002
    ..In a polypeptide GalNAc-transfer assay, recombinant pp-GalNAc-T10 transferred GalNAc onto a panel of mucin-derived peptide substrates. Furthermore, pp-GalNAc-T10 demonstrated strong transferase activity with glycopeptide substrates...
  93. ncbi request reprint Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta
    Masafumi Shimojo
    Laboratory for Alzheimer s Disease, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 283:16488-96. 2008
    ..Our results also provide novel insight into how enhancing the generation of longer Abetas may contribute to Alzheimer disease onset...
  94. ncbi request reprint Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities
    Toshikazu Yada
    Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
    J Biol Chem 278:30235-47. 2003
    ..Sequence analysis based on three-dimensional structure revealed the presence of not typical but significant beta 4-glycosyltransferase architecture...
  95. doi request reprint Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling
    Masamitsu Shimazawa
    Department of Biofunctional Evaluation, Laboratory of Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    J Neurochem 107:279-90. 2008
    ..Hence, Abeta may impair retinal function by reducing activation of NMDA-receptor signaling pathways...
  96. pmc Embryonic stem cells derived from C57BL/6J and C57BL/6N mice
    Yoko Tanimoto
    Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Comp Med 58:347-52. 2008
    ..C57BL/6J ES (B6J-S1UTR and B6J-23UTR) and C57BL/6N ES (B6N-22UTR) cells are available from the cell bank of the BioResource Center at RIKEN Tsukuba Institute (http://www.brc.riken.jp/lab/cell/english/)...
  97. ncbi request reprint Optimization of dosing schedule of daily inhalant dexamethasone to minimize phase shifting of clock gene expression rhythm in the lungs of the asthma mouse model
    Naomi Hayasaka
    Laboratory of Physiology and Pharmacology, School of Science and Engineering, Waseda University, Higashifushimi 2 7 5, Nishitokyo Shi 202 0021, Japan
    Endocrinology 148:3316-26. 2007
    ..This is the first report of a successful protocol that could obtain phase shifts of clock gene expression rhythm in isolated peripheral organs in vivo...
  98. ncbi request reprint Clock mutation facilitates accumulation of cholesterol in the liver of mice fed a cholesterol and/or cholic acid diet
    Takashi Kudo
    Dept of Physiology and Pharmacology, School of Science and Engineering, Waseda University, Higashifushimi 2 7 5, Nishitokyo shi, Tokyo 202 0021, Japan
    Am J Physiol Endocrinol Metab 294:E120-30. 2008
    ..The present findings indicate that normal circadian clock function is important for the regulation of CH homeostasis in the mouse liver, especially in conjunction with a diet containing high CH and CA...
  99. ncbi request reprint Circadian rhythms in the CNS and peripheral clock disorders: the circadian clock and hyperlipidemia
    Takashi Kudo
    Department of Physiology and Pharmacology, School of Science and Engineering, Waseda University, 2 7 5 Higashi fushimi, Nishitokyo shi, Tokyo 202 0071, Japan
    J Pharmacol Sci 103:139-43. 2007
    ..Further experiments are needed to elucidate the detailed mechanism of interaction between clock genes and lipid metabolisms...
  100. ncbi request reprint Mice lacking alpha1,3-fucosyltransferase IX demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors
    Takashi Kudo
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology AIST, Central 2, Open Space Laboratory, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Glycobiology 17:1-9. 2007
    ....
  101. pmc MafB is essential for renal development and F4/80 expression in macrophages
    Takashi Moriguchi
    Institute of Basic Medical Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305 8575, Japan
    Mol Cell Biol 26:5715-27. 2006
    ..These results demonstrate that MafB is essential for podocyte differentiation, renal tubule survival, and F4/80 maturation in a distinct subpopulation of nonadherent mature macrophages...