Masahiro Koseki

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi Impaired insulin secretion in four Tangier disease patients with ABCA1 mutations
    Masahiro Koseki
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Atheroscler Thromb 16:292-6. 2009
  2. ncbi Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-alpha secretion in Abca1-deficient macrophages
    Masahiro Koseki
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Lipid Res 48:299-306. 2007
  3. ncbi Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages
    Kazumi Tsubakio-Yamamoto
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamamdaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 375:390-4. 2008
  4. ncbi Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver
    Fumihiko Matsuura
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 358:1091-5. 2007
  5. ncbi Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver
    Hiroyuki Oku
    Department of Cardiovascular Medicine, Osaka University, Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    FEBS Lett 581:5029-33. 2007
  6. ncbi Senescent phenotypes of skin fibroblasts from patients with Tangier disease
    Fumihiko Matsuura
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 357:493-8. 2007
  7. ncbi Probucol enhances the expression of human hepatic scavenger receptor class B type I, possibly through a species-specific mechanism
    Ken ichi Hirano
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Arterioscler Thromb Vasc Biol 25:2422-7. 2005
  8. ncbi Chylomicron remnants are increased in the postprandial state in CD36 deficiency
    Daisaku Masuda
    Departments of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Lipid Res 50:999-1011. 2009
  9. ncbi Evaluation of a homogeneous assay for measuring LDL-cholesterol in hyperlipidemic serum specimens
    Shizuya Yamashita
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    J Atheroscler Thromb 15:82-6. 2008
  10. ncbi Familial massive tendon xanthomatosis with decreased high-density lipoprotein-mediated cholesterol efflux
    Fumihiko Matsuura
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Metabolism 54:1095-101. 2005

Collaborators

Detail Information

Publications11

  1. ncbi Impaired insulin secretion in four Tangier disease patients with ABCA1 mutations
    Masahiro Koseki
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Atheroscler Thromb 16:292-6. 2009
    ..The aim of the current study was to confirm these findings by the oral glucose tolerance test (OGTT) in human subjects with ABCA1 deficiency...
  2. ncbi Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-alpha secretion in Abca1-deficient macrophages
    Masahiro Koseki
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Lipid Res 48:299-306. 2007
    ..We report here that Abca1-KO macrophages with defective lipid efflux exhibited increased lipid rafts on the cell surface and accelerated TNF-alpha secretion...
  3. ncbi Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages
    Kazumi Tsubakio-Yamamoto
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamamdaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 375:390-4. 2008
    ..In summary, APN might protect against atherosclerosis by increasing apoA-I-mediated cholesterol efflux from macrophages through ABCA1-dependent pathway by the activation of LXRalpha and PPARgamma...
  4. ncbi Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liver
    Fumihiko Matsuura
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 358:1091-5. 2007
    ..Taken together, the current study demonstrates that APN might protect against atherosclerosis by increasing HDL assembly through enhancing ABCA1 pathway and apoA-1 synthesis in the liver...
  5. ncbi Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver
    Hiroyuki Oku
    Department of Cardiovascular Medicine, Osaka University, Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    FEBS Lett 581:5029-33. 2007
    ..The ABCA1 expression in liver was also decreased in APN-KO mice. APN deficiency might cause the impaired HDL assembly by decreasing ABCA1 expression and apoA-I synthesis in the liver...
  6. ncbi Senescent phenotypes of skin fibroblasts from patients with Tangier disease
    Fumihiko Matsuura
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 357:493-8. 2007
    ..Taken together, the current study demonstrates that the late-passaged TD fibroblasts showed senescent phenotype in vitro, which might be related to the increased cardiovascular manifestations in TD patients...
  7. ncbi Probucol enhances the expression of human hepatic scavenger receptor class B type I, possibly through a species-specific mechanism
    Ken ichi Hirano
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Arterioscler Thromb Vasc Biol 25:2422-7. 2005
    ..The aim of the present study was to know the effect of probucol on the expression of SR-BI and the underlying mechanism...
  8. ncbi Chylomicron remnants are increased in the postprandial state in CD36 deficiency
    Daisaku Masuda
    Departments of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Lipid Res 50:999-1011. 2009
    ..These results suggest that CD36-D might increase atherosclerotic risk by enhancing plasma level of CM remnants due to the increased synthesis of lipoproteins smaller than CM in size in the intestine...
  9. ncbi Evaluation of a homogeneous assay for measuring LDL-cholesterol in hyperlipidemic serum specimens
    Shizuya Yamashita
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    J Atheroscler Thromb 15:82-6. 2008
    ..In this study, we examined the reactivity of a homogeneous assay, Cholestest LDL (R) (CT-LDL), with hyperlipemic sera that were classified according to the WHO system...
  10. ncbi Familial massive tendon xanthomatosis with decreased high-density lipoprotein-mediated cholesterol efflux
    Fumihiko Matsuura
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Metabolism 54:1095-101. 2005
    ....
  11. ncbi Defective cholesterol efflux in Werner syndrome fibroblasts and its phenotypic correction by Cdc42, a RhoGTPase
    Zhongyan Zhang
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan
    Exp Gerontol 40:286-94. 2005
    ..These data indicated that the reduced expression of Cdc42 may be responsible for the abnormal lipid transport, which in turn might be related to the cardiovascular manifestations in WS...