Akira Kitabatake

Summary

Affiliation: Osaka Medical College
Country: Japan

Publications

  1. ncbi request reprint Familial hypercholesterolemia with multiple large tendinous xanthomas and advanced coronary artery atherosclerosis
    Fumio Terasaki
    Department of Cardiology, Osaka Medical College, Japan
    Intern Med 52:577-81. 2013
  2. doi request reprint Sarcoidosis does not belong to or overlap with immunoglobulin G4-related diseases based on an assessment of serum immunoglobulin G4 levels in cardiac and noncardiac sarcoidosis
    Fumio Terasaki
    Department of Cardiology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    Hum Pathol 43:818-25. 2012
  3. ncbi request reprint Myocardial inflammatory cell infiltrates in cases of dilated cardiomyopathy: light microscopic, immunohistochemical, and virological analyses of myocardium specimens obtained by partial left ventriculectomy
    F Terasaki
    Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan
    J Card Surg 14:141-6. 1999
  4. ncbi request reprint A case of cardiomyopathy showing progression from the hypertrophic to the dilated form: association of Mt8348A-->G mutation in the mitochondrial tRNA(Lys) gene with severe ultrastructural alterations of mitochondria in cardiomyocytes
    F Terasaki
    Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan
    Jpn Circ J 65:691-4. 2001
  5. ncbi request reprint Enhanced expression of type 1 helper T-cell cytokines in the myocardium of active cardiac sarcoidosis
    Fumio Terasaki
    Department of Internal Medicine III, Osaka Medical College, Takatsuki, Japan
    Circ J 72:1303-7. 2008
  6. ncbi request reprint Enhanced expression of myeloid-related protein complex (MRP8/14) in macrophages and multinucleated giant cells in granulomas of patients with active cardiac sarcoidosis
    Fumio Terasaki
    Department of Internal Medicine III, Osaka Medical College, 2 7 Daigaku machi, Takatsuki 569 8686, Japan
    Circ J 71:1545-50. 2007
  7. ncbi request reprint Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy
    Fumio Terasaki
    Department of Internal Medicine III, Osaka Medical College, Takatsuki, Japan
    Circ J 71:327-30. 2007
  8. ncbi request reprint Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients
    Naotsugu Oyama
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 70:362-3. 2006
  9. ncbi request reprint Loss of insulin receptor substrate-1 signaling induces the cardiovascular and proteo(fibrino)lytic system derangements typical of insulin resistance
    Tomoo Furumoto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Coron Artery Dis 16:117-23. 2005
  10. ncbi request reprint Evaluation of effects of polymorphism for metabolic enzymes on pharmacokinetics of carvedilol by population pharmacokinetic analysis
    Yoh Takekuma
    Laboratory of Pharmcotherapeutic Information, Department of Biopharmaceutical Sciences and Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 chome, Kita ku, Sapporo 060 0812, Japan
    Biol Pharm Bull 30:537-42. 2007

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Familial hypercholesterolemia with multiple large tendinous xanthomas and advanced coronary artery atherosclerosis
    Fumio Terasaki
    Department of Cardiology, Osaka Medical College, Japan
    Intern Med 52:577-81. 2013
    ....
  2. doi request reprint Sarcoidosis does not belong to or overlap with immunoglobulin G4-related diseases based on an assessment of serum immunoglobulin G4 levels in cardiac and noncardiac sarcoidosis
    Fumio Terasaki
    Department of Cardiology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    Hum Pathol 43:818-25. 2012
    ....
  3. ncbi request reprint Myocardial inflammatory cell infiltrates in cases of dilated cardiomyopathy: light microscopic, immunohistochemical, and virological analyses of myocardium specimens obtained by partial left ventriculectomy
    F Terasaki
    Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan
    J Card Surg 14:141-6. 1999
    ....
  4. ncbi request reprint A case of cardiomyopathy showing progression from the hypertrophic to the dilated form: association of Mt8348A-->G mutation in the mitochondrial tRNA(Lys) gene with severe ultrastructural alterations of mitochondria in cardiomyocytes
    F Terasaki
    Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan
    Jpn Circ J 65:691-4. 2001
    ....
  5. ncbi request reprint Enhanced expression of type 1 helper T-cell cytokines in the myocardium of active cardiac sarcoidosis
    Fumio Terasaki
    Department of Internal Medicine III, Osaka Medical College, Takatsuki, Japan
    Circ J 72:1303-7. 2008
    ..Various cytokines are involved in the pathogenesis of sarcoidosis, but their expression in the myocardium has not been documented for cardiac sarcoidosis...
  6. ncbi request reprint Enhanced expression of myeloid-related protein complex (MRP8/14) in macrophages and multinucleated giant cells in granulomas of patients with active cardiac sarcoidosis
    Fumio Terasaki
    Department of Internal Medicine III, Osaka Medical College, 2 7 Daigaku machi, Takatsuki 569 8686, Japan
    Circ J 71:1545-50. 2007
    ..The expression of MRP8/14 in patients with cardiac sarcoidosis and idiopathic dilated cardiomyopathy (DCM) was investigated...
  7. ncbi request reprint Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy
    Fumio Terasaki
    Department of Internal Medicine III, Osaka Medical College, Takatsuki, Japan
    Circ J 71:327-30. 2007
    ..Therefore, the expression of TN-C might be useful for detecting the clinical characteristics of, and ventricular remodeling in, dilated cardiomyopathy (DCM)...
  8. ncbi request reprint Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients
    Naotsugu Oyama
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 70:362-3. 2006
    ..There are few biological markers, which strictly show the severity of congestive heart failure (CHF)...
  9. ncbi request reprint Loss of insulin receptor substrate-1 signaling induces the cardiovascular and proteo(fibrino)lytic system derangements typical of insulin resistance
    Tomoo Furumoto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Coron Artery Dis 16:117-23. 2005
    ..This study was performed to determine whether induction of cardiac manifestations typical of insulin resistance and increased PAI-1 expression occur developmentally or post-developmentally as a result of loss of IRS-1-mediated signaling...
  10. ncbi request reprint Evaluation of effects of polymorphism for metabolic enzymes on pharmacokinetics of carvedilol by population pharmacokinetic analysis
    Yoh Takekuma
    Laboratory of Pharmcotherapeutic Information, Department of Biopharmaceutical Sciences and Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 chome, Kita ku, Sapporo 060 0812, Japan
    Biol Pharm Bull 30:537-42. 2007
    ..It was estimated that UGT2B7*3 decreased the clearance of carvedilol by 37%, but UGT2B7*2 did not show any effect. Clearance in the patients who have intermediate activity of CYP2D6 was decreased by 39%...
  11. ncbi request reprint Altered expression of endothelin and its receptors in the brain of SHR-SP at malignant hypertensive stage
    Subrina Jesmin
    Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    J Cardiovasc Pharmacol 44:S11-5. 2004
    ..Downregulation of the endothelin-B receptor may cause suppression of endothelium-derived relaxing factors in the brain of SHR-SP and be an underlying factor in their stroke susceptibility...
  12. ncbi request reprint Brain expression of VEGF and its receptors in SHR-SP and effects of an endothelin blocker
    Subrina Jesmin
    Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    J Cardiovasc Pharmacol 44:S160-4. 2004
    ....
  13. ncbi request reprint The calcium channel antagonist benidipine reduces plasma and cardiac endothelin-1 levels in type II diabetic rat model
    Subrina Jesmin
    Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    J Cardiovasc Pharmacol 44:S49-53. 2004
    ..Our results suggest that ET-1 plays a pivotal role in the pathogenesis of cardiac complications at the insulin-resistant stage of diabetes mellitus, and that benidipine treatment may have a beneficial effect on these complications...
  14. ncbi request reprint Effects of endothelin receptor antagonist on expression of AT1 and AT2 receptors in the heart of SHR-SP
    Subrina Jesmin
    Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    J Cardiovasc Pharmacol 44:S59-63. 2004
    ....
  15. ncbi request reprint Chronic beta-adrenergic receptor stimulation enhances the expression of G-Protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes
    Naotsugu Oyama
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 69:987-90. 2005
    ....
  16. ncbi request reprint Cardioprotective effect of perfluorochemical emulsion for cardiac preservation after six-hour cold storage
    Mitsuhiro Isaka
    Department of Cardiovascular Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    ASAIO J 51:434-9. 2005
    ..01). This study suggests that PFOB emulsion is beneficial for the cardioprotection of donor hearts, allowing a prolonged cardiac storage time...
  17. pmc No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population
    Shinpei Nonen
    Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Br J Clin Pharmacol 60:414-7. 2005
    ..We investigated the correlation of adrenergic receptor polymorphisms, alpha(2c)Del322-325, beta(1)Ser49Gly and beta(1)Arg389Gly, with the risk of heart failure in the Japanese population...
  18. ncbi request reprint Rationale and design of a randomized trial to assess the effects of beta-blocker in diastolic heart failure; Japanese Diastolic Heart Failure Study (J-DHF)
    Masatsugu Hori
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Japan
    J Card Fail 11:542-7. 2005
    ....
  19. ncbi request reprint Increased plasma concentrations of N-terminal pro-brain natriuretic peptide reflect the presence of mildly reduced left ventricular diastolic function in hypertension
    Tomoo Furumoto
    Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Coron Artery Dis 17:45-50. 2006
    ..This study was designed to determine whether increased plasma concentrations of N-terminal pro-brain natriuretic peptide sensitively reflect abnormal diastolic function associated with hypertension...
  20. ncbi request reprint [Future perspectives of beta-blockers in chronic heart failure]
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 64:921-6. 2006
    ..This trial may serve as a tailored approach for Japanese physicians in the clinical management of heart failure...
  21. ncbi request reprint Prognosis and prognostic factors in patients with idiopathic dilated cardiomyopathy in Japan
    Katsuyuki Miura
    Department of Epidemiology and Public Health, Kanazawa Medical University, Ishikawa, Japan
    Circ J 72:343-8. 2008
    ..There have been few large-scale nationwide studies investigating both the prognosis and the prognostic factors of idiopathic dilated cardiomyopathy (IDC). A predictive score that can be used in clinical practice has not been established...
  22. ncbi request reprint Allograft inflammatory factor-1 augments macrophage phagocytotic activity and accelerates the progression of atherosclerosis in ApoE-/- mice
    Tetsuya Mishima
    Division of Immunobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Int J Mol Med 21:181-7. 2008
    ..These results suggest that enhanced AIF-1 expression leads to augmented incorporation of degenerated LDL by macrophages and promotes development of atherosclerotic vasculopathy...
  23. ncbi request reprint Lower prevalence of circulating natural killer T cells in patients with angina: a potential novel marker for coronary artery disease
    Yasuhiro Andoh
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Coron Artery Dis 17:523-8. 2006
    ..Thus, whether the prevalence of natural killer T cells in peripheral blood is altered in patients with angina pectoris and its correlation with coronary risk factors was determined...
  24. ncbi request reprint Long-term combined therapy with an angiotensin type I receptor blocker and an angiotensin converting enzyme inhibitor prolongs survival in dilated cardiomyopathy
    Toshihiro Shimizu
    Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Jpn Heart J 43:531-43. 2002
    ..05) as well as group C (P<0.001). It is concluded that combined therapy improved cardiac function and survival compared to placebo or enalapril monotherapy...
  25. ncbi request reprint Role of left ventricular regional diastolic abnormalities for global diastolic dysfunction in patients with hypertrophic cardiomyopathy
    Kazutomo Goto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Am Soc Echocardiogr 19:857-64. 2006
    ..The usefulness of Doppler strain rate imaging for assessment of left ventricular regional diastolic function has not been fully determined...
  26. ncbi request reprint Reduced oxidative metabolic response in dysfunctional myocardium with preserved glucose metabolism but with impaired contractile reserve
    Keiichiro Yoshinaga
    Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Nucl Med 45:1885-91. 2004
    ....
  27. ncbi request reprint Images in cardiovascular medicine. Left ventricular asynchrony caused by an intramuscular lipoma: computed tomographic and magnetic resonance detection
    Naotsugu Oyama
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Circulation 107:e200-1. 2003
  28. ncbi request reprint [The epidemiology of heart failure in Japan]
    Hiroshi Okamoto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    Nihon Rinsho 61:709-14. 2003
    ..Patients were older and less severely affected, partly explaining the improvement in survival. In the subgroups treated with ACE inhibitors and beta blockers, calculated ten-year survival rate reached over 90%...
  29. ncbi request reprint Adenovirus-mediated gene transfer of ICOSIg fusion protein ameliorates ongoing experimental autoimmune myocarditis
    Yutaka Matsui
    Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Hum Gene Ther 14:521-32. 2003
    ..This study indicates that ICOS/ICOSL costimulation makes an important contribution to the progression of EAM and that the blockade of this pathway by gene transfer has therapeutic potential for ongoing autoimmune myocarditis...
  30. ncbi request reprint VEGF-mediated angiogenesis is impaired by angiotensin type 1 receptor blockade in cardiomyopathic hamster hearts
    Toshihiro Shimizu
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Cardiovasc Res 58:203-12. 2003
    ....
  31. ncbi request reprint Sensitive method of detecting myocardial ischemia during dobutamine stress echocardiography
    Satoshi Yamada
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 67:317-22. 2003
    ..Dobutamine-induced ischemia is characterized by an early-systolic asynchrony rather than a change in overall wall excursion and CK can provide an objective assessment of ischemia developing during DSE...
  32. ncbi request reprint Altered microvasculature is involved in remodeling processes in cardiomyopathic hamsters
    Toshihiro Shimizu
    The Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, Japan
    Jpn Heart J 44:111-26. 2003
    ..We examined the relation between cardiac function and the microvasculature, including angiogenic factors, in BIO TO2...
  33. ncbi request reprint Effects of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on beta-adrenoceptor signaling in heart failure produced by myocardial Infarction in rabbits: reversal of altered expression of beta-adrenoceptor kinase and G
    Takao Makino
    Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    J Pharmacol Exp Ther 304:370-9. 2003
    ..This may be important for the beneficial effects of these agents in HF...
  34. ncbi request reprint Prevalence and predictors of renal artery stenosis in patients undergoing cardiac catheterization
    Takehiro Yamashita
    Division of Cardiology, Kitami Red Cross Hospital, Japan
    Hypertens Res 25:553-7. 2002
    ..We conclude that more attention should be paid to RAS in Japanese patients with hypertension and cardiovascular disease...
  35. ncbi request reprint Blockade of T cell costimulatory signals using adenovirus vectors prevents both the induction and the progression of experimental autoimmune myocarditis
    Yutaka Matsui
    Division of Molecular Immunology, Institute for Genetic Medicine, Sapporo 060 0815, Japan
    J Mol Cell Cardiol 34:279-95. 2002
    ..This study indicates the therapeutic potential of costimulatory pathway blockade by gene-transfer in myocarditis...
  36. ncbi request reprint Serial changes in BMIPP uptake in relation to thallium uptake in the rat myocardium after ischaemia
    Kazuyuki Noriyasu
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Nucl Med Mol Imaging 30:1644-50. 2003
    ..Since BMIPP uptake may change with time after ischaemia, careful interpretation of BMIPP uptake after ischaemia is required in a clinical setting...
  37. ncbi request reprint Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells
    Masanori Takahashi
    Department of Neuroscience, Osaka University Graduate School of Medicine D13, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Circulation 108:2524-9. 2003
    ..In this study, we sought to identify the dedifferentiation factor(s) derived from vascular SMCs (VSMCs)...
  38. ncbi request reprint Blockade of macrophage migration inhibitory factor ameliorates experimental autoimmune myocarditis
    Yutaka Matsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Mol Cell Cardiol 37:557-66. 2004
    ..These results demonstrate an important role of MIF in the pathogenesis of EAM and suggest that MIF blockade may be a promising new strategy for the treatment of myocarditis...
  39. ncbi request reprint Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access
    Koji Sasaki
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mol Pharmacol 66:330-6. 2004
    ..We propose that the Na(+) channel selectivity filter region is a structural determinant for the antiarrhythmic drug sensitivity in addition to gating properties of the indigenous Na(+) channels that govern the state-dependent drug block...
  40. ncbi request reprint Comparisons of the skeletal muscle metabolic abnormalities in the arm and leg muscles of patients with chronic heart failure
    Tatsuya Nagai
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 68:573-9. 2004
    ....
  41. ncbi request reprint Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy
    Yutaka Matsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hypertension 43:1195-201. 2004
    ..Moreover, the effect of Ep on the prevention of cardiac fibrosis, but not cardiac hypertrophy, might be partially mediated through the inhibition of OPN expression...
  42. ncbi request reprint Natural killer T cells accelerate atherogenesis in mice
    Yukihito Nakai
    Division of Immunobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Blood 104:2051-9. 2004
    ..Collectively, we conclude that NKT cells are proatherogenic in mice...
  43. ncbi request reprint Percutaneous coronary intervention for central sleep apnoea with ischaemic cardiomyopathy
    Tetsuo Betsuyaku
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Acta Cardiol 59:63-5. 2004
    ..This is the first case where percutaneous coronary intervention improved sleep apnoea, suggesting that the improved cardiac function led to amelioration of sleep apnoea...
  44. ncbi request reprint Low-dose carvedilol improves left ventricular function and reduces cardiovascular hospitalization in Japanese patients with chronic heart failure: the Multicenter Carvedilol Heart Failure Dose Assessment (MUCHA) trial
    Masatsugu Hori
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Am Heart J 147:324-30. 2004
    ..The efficacy and safety of two doses of carvedilol, a beta-blocker with vasodilator and antioxidant actions, were investigated in Japanese patients with CHF...
  45. ncbi request reprint A newly developed angiotensin II type 1 receptor antagonist, CS866, promotes regression of cardiac hypertrophy by reducing integrin beta1 expression
    Nan Jia
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Hypertens Res 26:737-42. 2003
    ..The correlation between the expression of integrin beta1 and AT1 receptor was significant. Our results also suggest that integrin expression by myocytes might be modulated by angiotensin II via AT1 receptor...
  46. ncbi request reprint Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives
    Jie Dong
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hypertens Res 26:723-9. 2003
    ..These results provide further insights into how inflammation is involved in the atherothrombotic complications observed in hypertensives, which may be ameliorated by HMG-CoA reductase inhibitors...
  47. ncbi request reprint A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease
    Nobumasa Shirai
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Cardiovasc Res 53:348-54. 2002
    ..We have studied the biophysical properties of an IVF mutation (S1710L) that exhibited an unusual clinical phenotype: rate-dependent bundle branch block without manifestation of Brugada-type ECG pattern...