Ken Kishida

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Clinical importance of assessment of type 2 diabetes mellitus with visceral obesity. A Japanese perspective
    Ken Kishida
    Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, 2 2 B 5, Yamada oka, Suita, Osaka 565 0871, Japan
    Curr Diabetes Rev 8:84-91. 2012
  2. doi request reprint Adiponectin as a routine clinical biomarker
    Ken Kishida
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan Electronic address
    Best Pract Res Clin Endocrinol Metab 28:119-30. 2014
  3. pmc High serum C1q-binding adiponectin levels in male patients with acute coronary syndrome
    Ken Kishida
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Cardiovasc Diabetol 13:9. 2014
  4. pmc Correlation of circulating C1q and C1q-binding adiponectin concentrations with aging in males: a preliminary report
    Hideaki Nakatsuji
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Diabetol Metab Syndr 5:17. 2013
  5. pmc Low serum eicosapentaenoic acid / arachidonic acid ratio in male subjects with visceral obesity
    Kana Inoue
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Nutr Metab (Lond) 10:25. 2013
  6. pmc Serum C1q- binding adiponectin in maintenance hemodialysis patients
    Ken Kishida
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 B 5, Yamada oka, Suita, Osaka 565 0871, Japan
    BMC Nephrol 14:50. 2013
  7. doi request reprint Visceral adiposity as a target for the management of the metabolic syndrome
    Ken Kishida
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
    Ann Med 44:233-41. 2012
  8. pmc Sleep-wake cycle irregularities in type 2 diabetics
    Tomoko Nakanishi-Minami
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, 565 0871, Japan
    Diabetol Metab Syndr 4:18. 2012
  9. ncbi request reprint Importance of assessing the effect of statins on the function of high- density lipoproteins on coronary plaque
    Ken Kishida
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Cardiovasc Hematol Disord Drug Targets 12:28-34. 2012
  10. ncbi request reprint Molecular mechanisms of diabetes and atherosclerosis: role of adiponectin
    Ken Kishida
    Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, 2 2 B 5, Yamada oka, Suita, Osaka 565 0871, Japan
    Endocr Metab Immune Disord Drug Targets 12:118-31. 2012

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Clinical importance of assessment of type 2 diabetes mellitus with visceral obesity. A Japanese perspective
    Ken Kishida
    Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, 2 2 B 5, Yamada oka, Suita, Osaka 565 0871, Japan
    Curr Diabetes Rev 8:84-91. 2012
    ..For clinically meaningful prevention/reduction in the rate of future ACVD in T2DM, it may be important to stratify T2DM subjects into those with and without visceral obesity and design specific management protocols for each group...
  2. doi request reprint Adiponectin as a routine clinical biomarker
    Ken Kishida
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan Electronic address
    Best Pract Res Clin Endocrinol Metab 28:119-30. 2014
    ..This review article focuses on the significance of adiponectin as a clinical biomarker of obesity-related diseases. Routine measurement of adiponectin in patients with lifestyle-related diseases is highly recommended. ..
  3. pmc High serum C1q-binding adiponectin levels in male patients with acute coronary syndrome
    Ken Kishida
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Cardiovasc Diabetol 13:9. 2014
    ..We investigated the comparative evaluation of serum C1q-APN levels in males with ACS, stable angina pectoris (SAP) versus controls...
  4. pmc Correlation of circulating C1q and C1q-binding adiponectin concentrations with aging in males: a preliminary report
    Hideaki Nakatsuji
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Diabetol Metab Syndr 5:17. 2013
    ..Adiponectin and C1q form a protein complex in human blood, and that serum C1q and C1q-binding adiponectin (C1q-APN) concentrations can be measured. We investigated circulating C1q and C1q-APN levels in Japanese men including elderly men...
  5. pmc Low serum eicosapentaenoic acid / arachidonic acid ratio in male subjects with visceral obesity
    Kana Inoue
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Nutr Metab (Lond) 10:25. 2013
    ..The present study investigated the correlation between EPA, docosahexaenoic acid (DHA), AA parameters and clinical features in male subjects...
  6. pmc Serum C1q- binding adiponectin in maintenance hemodialysis patients
    Ken Kishida
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 B 5, Yamada oka, Suita, Osaka 565 0871, Japan
    BMC Nephrol 14:50. 2013
    ....
  7. doi request reprint Visceral adiposity as a target for the management of the metabolic syndrome
    Ken Kishida
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
    Ann Med 44:233-41. 2012
    ..This review article discusses visceral adiposity as a key player in the syndrome. Visceral fat reduction with life-style modification is a potentially useful strategy in the prevention of ACVD in patients with the metabolic syndrome...
  8. pmc Sleep-wake cycle irregularities in type 2 diabetics
    Tomoko Nakanishi-Minami
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, 565 0871, Japan
    Diabetol Metab Syndr 4:18. 2012
    ..abstract:..
  9. ncbi request reprint Importance of assessing the effect of statins on the function of high- density lipoproteins on coronary plaque
    Ken Kishida
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Cardiovasc Hematol Disord Drug Targets 12:28-34. 2012
    ....
  10. ncbi request reprint Molecular mechanisms of diabetes and atherosclerosis: role of adiponectin
    Ken Kishida
    Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, 2 2 B 5, Yamada oka, Suita, Osaka 565 0871, Japan
    Endocr Metab Immune Disord Drug Targets 12:118-31. 2012
    ....
  11. pmc Metabolic syndrome correlates intracoronary stenosis detected by multislice computed tomography in male subjects with sleep-disordered breathing
    Tomoko Nakanishi-Minami
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Diabetol Metab Syndr 4:6. 2012
    ..abstract:..
  12. pmc High prevalence of gastroesophageal reflux symptoms in type 2 diabetics with hypoadiponectinemia and metabolic syndrome
    Ayumu Hirata
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Nutr Metab (Lond) 9:4. 2012
    ..abstract:..
  13. pmc Cross-sectional and longitudinal study of association between circulating thiobarbituric acid-reacting substance levels and clinicobiochemical parameters in 1,178 middle-aged Japanese men - the Amagasaki Visceral Fat Study
    Yukiyoshi Okauchi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Nutr Metab (Lond) 8:82. 2011
    ..abstract:..
  14. ncbi request reprint Successful surgical treatment of an infected right coronary artery aneurysm-to-right ventricle fistula after sirolimus-eluting stent implantation
    Ken Kishida
    Department of Cardiology, Rinku General Medical Center, Izumisano, Suita
    Intern Med 46:865-71. 2007
    ..SESs may play a potential role in locally blunting the innate response to bacterial agents...
  15. pmc Clinical significance of visceral fat reduction through health education in preventing atherosclerotic cardiovascular disease - Lesson from the Amagasaki Visceral Fat Study: A Japanese perspective
    Ken Kishida
    Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, 2 2 B5 Yamada oka, Suita, Osaka 565 0871, Japan
    Nutr Metab (Lond) 8:57. 2011
    ..The health education that includes voluntary lifestyle modification aimed at reducing visceral fat could be useful in preventing cardiovascular events in the metabolic syndrome...
  16. pmc Adaptation to fasting by glycerol transport through aquaporin 7 in adipose tissue
    Norikazu Maeda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 B5 Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 101:17801-6. 2004
    ..Our findings indicate that the lack of effective glycerol transport from adipocytes by glycerol gateway molecule causes defective adaptation to prolonged fasting...
  17. ncbi request reprint Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease
    Koji Ohashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    J Am Coll Cardiol 43:1195-200. 2004
    ..This study examined the association of mutations in adiponectin gene with the prevalence of coronary artery disease (CAD)...
  18. ncbi request reprint Association of hypoadiponectinemia with impaired vasoreactivity
    Noriyuki Ouchi
    Department of Internal Medicine, Graduate School of Medicine, Osaka University, 2 2, Yamada oka, Suita, 565 0671 Osaka, Japan
    Hypertension 42:231-4. 2003
    ..Our observations suggest that hypoadiponectinemia is associated with impaired endothelium-dependent vasorelaxation and that the measurement of plasma adiponectin level might be helpful as a marker of endothelial dysfunction...
  19. pmc Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase
    Toshiyuki Hibuse
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 B5 Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 102:10993-8. 2005
    ..A series of our results indicate that AQP7 disruption elevates adipose glycerol kinase activity, accelerates triglycerides synthesis in adipocytes, and, finally, develops obesity...
  20. doi request reprint High serum C1q-adiponectin/total adiponectin ratio correlates with coronary artery disease in Japanese type 2 diabetics
    Ayumu Hirata
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Metabolism 62:578-85. 2013
    ..Adiponectin and C1q form a protein complex in blood, and serum C1q-binding adiponectin (C1q-APN) can be measured. We investigated the correlation between C1q-APN and CAD in patients with type 2 diabetes mellitus (T2DM)...
  21. ncbi request reprint Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages
    Masahiro Kumada
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circulation 109:2046-9. 2004
    ..The present study was designed to elucidate the effects of adiponectin on matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in human monocyte-derived macrophages...
  22. ncbi request reprint Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue
    Noriyuki Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circulation 107:671-4. 2003
    ..The present study investigated the association between adiponectin and CRP in the blood stream and adipose tissue...
  23. ncbi request reprint Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9
    Hiroshi Kuriyama
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Japan
    Diabetes 51:2915-21. 2002
    ..Our results indicate that coordinated regulations of fat-specific AQPap/7 and liver-specific AQP9 should be crucial to determine glucose metabolism in physiology and insulin resistance...
  24. ncbi request reprint Reduction of visceral fat correlates with the decrease in the number of obesity-related cardiovascular risk factors in Japanese with Abdominal Obesity (VACATION-J Study)
    Aki Hiuge-Shimizu
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Atheroscler Thromb 19:1006-18. 2012
    ..The present study investigated whether one-year reduction of the visceral fat area (VFA) correlates with a decrease in the number of such factors in Japanese with or without visceral fat accumulation...
  25. doi request reprint Nocturnal reduction in circulating adiponectin concentrations related to hypoxic stress in severe obstructive sleep apnea-hypopnea syndrome
    Yasuhiko Nakagawa
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 B 5, Yamada oka, Suita, Osaka, 565 0871, Japan
    Am J Physiol Endocrinol Metab 294:E778-84. 2008
    ..Nocturnal reduction in adiponectin in severe OSAHS may be an important risk for cardiovascular events or other OSAHS-related diseases during sleep...
  26. doi request reprint Reciprocal regulation of natriuretic peptide receptors by insulin in adipose cells
    Hideaki Nakatsuji
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 B5 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 392:100-5. 2010
    ..This study suggests that insulin may efficiently promote lipogenesis partly by reducing the lipolytic action of ANP through the opposite regulation of NPR-1 and NPR-3...
  27. ncbi request reprint Absolute value of bioelectrical impedance analysis-measured visceral fat area with obesity-related cardiovascular risk factors in Japanese workers
    Yukiyoshi Okauchi
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Atheroscler Thromb 17:1237-45. 2010
    ....
  28. ncbi request reprint Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein
    Hitoshi Nishizawa
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes 51:2734-41. 2002
    ..Our results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of insulin resistance and atherosclerosis in men...
  29. ncbi request reprint Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis
    Morihiro Matsuda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 277:37487-91. 2002
    ..The current study suggests an adipo-vascular axis, a direct link between fat and artery. A therapeutic strategy to increase plasma adiponectin should be useful in preventing vascular restenosis after angioplasty...
  30. doi request reprint Characteristics of sleep-disordered breathing in Japanese patients with type 2 diabetes mellitus
    Susumu Kashine
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Metabolism 59:690-6. 2010
    ..The present results of prevalence of SDB may be relevant to the higher incidence of cardiovascular disease in diabetic patients, which need to be clarified in future studies...
  31. ncbi request reprint Divergent effects of soy protein diet on the expression of adipocytokines
    Azumi Nagasawa
    Department of Molecular Science and Internal Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan
    Biochem Biophys Res Commun 311:909-14. 2003
    ..Our data suggest that dietary SPI alters the gene expressions in adipose tissue and has beneficial effects on the expression of adipocytokines...
  32. ncbi request reprint Coexistence of visceral fat accumulation and sleep-disordered breathing correlates with coronary artery disease
    Yasuhiko Nakagawa
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Atheroscler Thromb 19:728-35. 2012
    ..The aim of the present study was to determine the significance of excess visceral fat, SDB and circulating levels of biomarkers in CAD in Japanese men...
  33. doi request reprint High serum S100A8/A9 levels and high cardiovascular complication rate in type 2 diabetics with ultrasonographic low carotid plaque density
    Ayumu Hirata
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes Res Clin Pract 97:82-90. 2012
    ..The present study investigated the relation between serum S100A8/A9 levels and relative plaque density (RPD) of the carotid artery determined by ultrasonography in T2DM...
  34. doi request reprint Relationship between visceral fat accumulation and urinary albumin-creatinine ratio in middle-aged Japanese men
    Sachiko Tamba
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 B 5, Yamada oka, Suita, Osaka 565 0871, Japan
    Atherosclerosis 211:601-5. 2010
    ..The present study investigated the relationship between visceral fat accumulation and urinary albumin-creatinine ratio (UACR) in Japanese men...
  35. ncbi request reprint Health education "Hokenshido" program reduced metabolic syndrome in the Amagasaki visceral fat study. Three-year follow-up study of 3,174 Japanese employees
    Miwa Ryo
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
    Intern Med 50:1643-8. 2011
    ..The aim of this study was to evaluate the effects of health checkup and the health education "Hokenshido" program based on the concept that visceral fat accumulation causes metabolic syndrome (MetS), leading to cardiovascular disease (CVD)...
  36. ncbi request reprint Relationships between circulating adiponectin levels and fat distribution in obese subjects
    Ken Kishida
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
    J Atheroscler Thromb 18:592-5. 2011
    ..The present study investigated circulating adiponectin levels and fat distribution, i.e. subcutaneous fat area (SFA) and visceral fat area (VFA), in obese subjects...
  37. doi request reprint Adiponectin ameliorates hypoxia-induced pulmonary arterial remodeling
    Yasuhiko Nakagawa
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 B 5, Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 382:183-8. 2009
    ....
  38. ncbi request reprint Nocturnal falls of adiponectin levels in sleep apnea with abdominal obesity and impact of hypoxia-induced dysregulated adiponectin production in obese murine mesenteric adipose tissue
    Yasuhiko Nakagawa
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Atheroscler Thromb 18:240-7. 2011
    ..The present study investigated the association between Δadiponectin and fat distribution in OSAS males, and the effect of hypoxic stress on adiponectin production in obese yellow-KKAy mice...
  39. ncbi request reprint Accumulation of adiponectin in inflamed adipose tissues of obese mice
    Hideaki Nakatsuji
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Metabolism 63:542-53. 2014
    ..Obesity often presents with hypoadiponectinemia. However, the mechanism and adiponectin movement in obesity remain uncharacterized. Here we investigated tissue distribution of adiponectin protein in lean and obese mice...
  40. ncbi request reprint Coexistence of visceral fat and multiple risk factor accumulations is strongly associated with coronary artery disease in Japanese (the VACATION-J study)
    Aki Hiuge-Shimizu
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Atheroscler Thromb 19:657-63. 2012
    ..The present study investigated the relationship between multiple risk factor accumulation and CAD in Japanese without and with visceral fat accumulation...
  41. doi request reprint Binding of adiponectin and C1q in human serum, and clinical significance of the measurement of C1q-adiponectin / total adiponectin ratio
    Hideaki Nakatsuji
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Metabolism 62:109-20. 2013
    ..The aim of this study was to examine whether adiponectin and C1q form protein-complex in blood and to know the clinical significance of the C1q-adiponectin (C1q-APN) complex in serum...
  42. doi request reprint Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study)
    Aki Hiuge-Shimizu
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Ann Med 44:82-92. 2012
    ..The present study investigated the gender- and age-specific relationship between obesity-related cardiovascular risk factor accumulation and computed tomography (CT)-measured fat distribution in a large-scale Japanese general population...
  43. ncbi request reprint Disturbed secretion of mutant adiponectin associated with the metabolic syndrome
    Ken Kishida
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, B5, Osaka University, 2 2, Yamadaoka, Suita, 565 0871, Osaka, Japan
    Biochem Biophys Res Commun 306:286-92. 2003
    ..Our results suggest that I164T mutation is associated with hypoadiponectinemia through disturbed secretion into plasma, which may contribute to the development of the metabolic syndrome...
  44. ncbi request reprint Selective contribution of waist circumference reduction on the improvement of sleep-disordered breathing in patients hospitalized with type 2 diabetes mellitus
    Susumu Kashine
    Department of Metabolic Medicine, Osaka University, Japan
    Intern Med 50:1895-903. 2011
    ..We investigated the significance of waist circumference (WC), representing excess visceral fat, body mass index (BMI), glycemic control and other clinical parameters on SDB in T2DM...
  45. ncbi request reprint Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
    Norikazu Maeda
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Nat Med 8:731-7. 2002
    ..Our results indicate that adiponectin/ACRP30 deficiency and high TNF-alpha levels in KO mice reduced muscle FATP-1 mRNA and IRS-1-mediated insulin signaling, resulting in severe diet-induced insulin resistance...
  46. doi request reprint Qualitative score of systemic arteriosclerosis by vascular ultrasonography as a predictor of coronary artery disease in type 2 diabetes
    Ayumu Hirata
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Atherosclerosis 219:623-9. 2011
    ..The aim of the present study was to investigate the association between CAD and systemic arteriosclerosis by qualitative vascular ultrasonography...
  47. doi request reprint Impact of sleep-disordered breathing, visceral fat accumulation and adiponectin levels in patients with night-time onset of acute coronary syndrome
    Yasuhiko Nakagawa
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Am J Cardiol 108:1266-71. 2011
    ..SDB and excess visceral fat are treatable risk factors. Decrease of excess visceral fat and treatment of SDB could be beneficial in in preventing nocturnal cardiac events...
  48. ncbi request reprint [Etiology of atherosclerosis--special reference to humoral and neurogenic factors]
    Ken Kishida
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
    Nihon Rinsho 69:39-44. 2011
    ..These vascular systems should maintain vascular homeostasis in the whole body for preventing atherosclerotic cardiovascular diseases...
  49. ncbi request reprint Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor
    Atsutaka Yasui
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Biochem Biophys Res Commun 364:358-65. 2007
    ..Our results demonstrated that Foxo1 downregulates musclin mRNA expression both in vitro and in vivo, which should explain insulin-mediated upregulation of this gene in muscle cells...
  50. pmc Hyperinsulinemia correlates with low levels of plasma B-type natriuretic peptide in Japanese men irrespective of fat distribution
    Hideaki Nakatsuji
    Department of Metabolic Medicine, Osaka University, Suita, Osaka, Japan
    Cardiovasc Diabetol 11:22. 2012
    ..The present study analyzed the relationships between plasma BNP levels and various clinical variables, including insulin, visceral and subcutaneous fat area (VFA and SFA, respectively), in normal Japanese men...
  51. doi request reprint Three-month treatment with pioglitazone reduces circulating levels of S100A8/A9 (MRP8/14) complex, a biomarker of inflammation, without changes in body mass index, in type 2 diabetics with abdominal obesity
    Hideaki Nakatsuji
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes Res Clin Pract 95:e58-60. 2012
    ..The results showed that pioglitazone reduced circulating S100A8/A9 complex levels, without changing body mass index, in type 2 diabetic patients with abdominal obesity...
  52. doi request reprint Carotid intima-media thickness, but not visceral fat area or adiponectin, correlates with intracoronary stenosis detected by multislice computed tomography in people with type 2 diabetes and hypertension
    Tomoko Nakanishi-Minami
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Diabetes Res Clin Pract 95:e23-6. 2012
    ..The results showed that carotid intima-media thickness, but not visceral fat area or adiponectin, correlated significantly with intracoronary stenosis (p<0.05)...
  53. doi request reprint Dysregulation of glucose, insulin, triglyceride, blood pressure, and oxidative stress after an oral glucose tolerance test in men with abdominal obesity
    Hideaki Nakatsuji
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Metabolism 59:520-6. 2010
    ..05). Evaluation of postprandial changes in obesity-related parameters may be important in preventing atherosclerotic diseases...
  54. ncbi request reprint Circulating adiponectin levels and their associated factors in young lean healthy Japanese women
    Mitsuyoshi Takahara
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 20:57-64. 2013
    ..The aim of the current study was to investigate circulating adiponectin levels and their associated factors in young lean healthy Japanese women...
  55. doi request reprint Three-month treatment with pioglitazone reduces circulating C1q-binding adiponectin complex to total-adiponectin ratio, without changes in body mass index, in people with type 2 diabetes
    Hideaki Nakatsuji
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes Res Clin Pract 99:e14-7. 2013
    ..The results indicate 3-month treatment with pioglitazone reduces circulating levels of C1q-APN/total-adiponectin ratio without changes in body mass index...
  56. doi request reprint High circulating levels of S100A8/A9 complex (calprotectin) in male Japanese with abdominal adiposity and dysregulated expression of S100A8 and S100A9 in adipose tissues of obese mice
    Ryohei Sekimoto
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Biochem Biophys Res Commun 419:782-9. 2012
    ..Overexpression of S100A8 and S100A9 in obese adipose tissue may be involved, at least partly, in not only high circulating levels of S100A8/A9 complex in abdominal obesity but also adipose and systemic tissue inflammation...
  57. ncbi request reprint Right-sided acute suppurative thyroiditis caused by infectious endocarditis
    Kana Inoue
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan
    Intern Med 50:2893-7. 2011
    ..A replacement with a prosthetic valve was performed and cured him. It is important to recognize that infectious endocarditis can be a focus of acute suppurative thyroiditis...
  58. ncbi request reprint Correlation between serum C1q-adiponectin/total adiponectin ratio and polyvascular lesions detected by vascular ultrasonography in Japanese type 2 diabetics
    Ayumu Hirata
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Metabolism 62:376-85. 2013
    ..We investigated the relationship between various serum adiponectin parameters and polyvascular atherosclerosis score assessed by vascular ultrasonography, in subjects with type 2 diabetes mellitus (T2DM)...
  59. ncbi request reprint Characteristics of sleep-disordered breathing in Japanese patients with acromegaly
    Susumu Kashine
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Endocr J 59:31-8. 2012
    ..Based on the high incidence of SDB identified in the present study, we recommend that all patients with acromegaly are routinely screened for SDB for early diagnosis and treatment...
  60. doi request reprint Metabolic syndrome correlates with polyvascular lesions detected by systemic vascular ultrasonography in Japanese people with type 2 diabetes
    Ayumu Hirata
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes Res Clin Pract 96:e26-9. 2012
    ..The results showed that the metabolic syndrome correlated with polyvascular lesions detected by systemic vascular ultrasonography in Japanese type 2 diabetics...
  61. ncbi request reprint Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation
    Hidehiko Kondo
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Yamadaoka, Suita, Japan
    Eur J Biochem 269:1814-26. 2002
    ..We suggest that AQPap is responsible for the increase of plasma glycerol during exercise in humans...
  62. pmc A pilot three-month sitagliptin treatment increases serum adiponectin level in Japanese patients with type 2 diabetes mellitus--a randomized controlled trial START-J study
    Toshiyuki Hibuse
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 B 5, Yamada oka, Suita, Osaka 565 0871, Japan
    Cardiovasc Diabetol 13:96. 2014
    ..The aim of the present study was to examine the effect of sitagliptin treatment on serum adiponectin levels in T2DM subjects...
  63. ncbi request reprint Short-term intervention reduces bioelectrical impedance analysis-measured visceral fat in type 2 diabetes mellitus
    Miwa Ryo
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2 2 B 5, Yamada oka, Suita, Osaka, Japan Electronic address
    Diabetes Res Clin Pract 103:e27-9. 2014
    ..The reduction of visceral fat can improve metabolic cardiovascular risk factors, while the reductions in body weight and waist circumference were small and reduction in subcutaneous fat was not significant. ..
  64. ncbi request reprint Increased plasma HB-EGF associated with obesity and coronary artery disease
    Satoru Matsumoto
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, B5, Osaka University, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 292:781-6. 2002
    ..These results suggest that increased plasma HB-EGF derived from the accumulated fat contributes to the higher incidence of vascular disease in obesity, proposing HB-EGF as an adipocytokine directly linking adipovascular axis...
  65. ncbi request reprint Successful use of 111In-pentetrotide scintigraphy for localizing ectopic adrenocorticotropin-producing bronchial carcinoid tumor in a patient with Cushing's syndrome
    Ken Kishida
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka
    Intern Med 42:996-1005. 2003
    ..This case indicates 111In-pentetrotide scintigraphy could be successfully used to identify and localize ectopic adrenocorticotropin-producing bronchial carcinoid...