Anna Kinoshita

Summary

Affiliation: Osaka City University
Country: Japan

Publications

  1. pmc Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats
    Yoshiyuki Tago
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Toxicol Pathol 23:245-51. 2010
  2. ncbi request reprint Inhibition of rat urinary bladder carcinogenesis by the antiangiogenic drug TNP-470
    Hideki Wanibuchi
    Department of Pathology, Osaka City University Medical School, Abeno Ku, Osaka 545 8585, Japan
    Asian Pac J Cancer Prev 7:101-7. 2006
  3. ncbi request reprint Understanding arsenic carcinogenicity by the use of animal models
    Hideki Wanibuchi
    Department of Pathology, Osaka City University Medical School, Osaka 545 8585, Japan
    Toxicol Appl Pharmacol 198:366-76. 2004
  4. ncbi request reprint Effects of cessation of alcohol exposure on rat hepatocarcinogenesis
    Hideki Wanibuchi
    Department of Pathology, Osaka City University Medical School, Abeno Ku, Osaka 545 8585, Japan
    Asian Pac J Cancer Prev 7:122-6. 2006
  5. ncbi request reprint Existence of no hepatocarcinogenic effect levels of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline with or without coadministration with ethanol
    Hideki Wanibuchi
    Department of Pathology, Osaka City University Medical School, Osaka, 545 8585, Japan
    Toxicol Pathol 34:232-6. 2006
  6. ncbi request reprint Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression
    Anna Kinoshita
    Department of Pathology, Osaka City University Medical School, Abeno Ku, Asahi machi 1 4 3, Osaka 545 8585, Japan
    Carcinogenesis 24:1389-99. 2003
  7. ncbi request reprint Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: a possible reactive oxygen species mechanism
    Takayuki Nishikawa
    Department of Pathology, Osaka City University Medical School, Osaka, Japan
    Int J Cancer 100:136-9. 2002
  8. ncbi request reprint Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: possible mechanisms
    Masahiko Kushida
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, 1 98, 3 Chome, Kasugade Naka, Konohana ku, Osaka 554 8558, Japan
    Toxicol Appl Pharmacol 208:285-94. 2005
  9. ncbi request reprint Carcinogenicity of dimethylarsinic acid in Ogg1-deficient mice
    Anna Kinoshita
    Department of Pathology, Osaka City University Medical School, Osaka 545 8585, Japan
    Cancer Sci 98:803-14. 2007
  10. ncbi request reprint Elevation of 8-hydroxydeoxyguanosine and cell proliferation via generation of oxidative stress by organic arsenicals contributes to their carcinogenicity in the rat liver and bladder
    Anna Kinoshita
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Toxicol Appl Pharmacol 221:295-305. 2007

Collaborators

Detail Information

Publications32

  1. pmc Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats
    Yoshiyuki Tago
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Toxicol Pathol 23:245-51. 2010
    ..79 g/kg BW/day and >1.85 g/kg BW/day, respectively) under the conditions of the present study...
  2. ncbi request reprint Inhibition of rat urinary bladder carcinogenesis by the antiangiogenic drug TNP-470
    Hideki Wanibuchi
    Department of Pathology, Osaka City University Medical School, Abeno Ku, Osaka 545 8585, Japan
    Asian Pac J Cancer Prev 7:101-7. 2006
    ..In conclusion, TNP-470 can inhibit rat urinary bladder carcinogenesis, presumably through its effects on angiogenesis...
  3. ncbi request reprint Understanding arsenic carcinogenicity by the use of animal models
    Hideki Wanibuchi
    Department of Pathology, Osaka City University Medical School, Osaka 545 8585, Japan
    Toxicol Appl Pharmacol 198:366-76. 2004
    ..The results revealed that the adverse effects of arsenic occurred either by promoting and initiating carcinogenesis. These data, as covered in the present review, suggest that several mechanisms may be involved in arsenic carcinogenesis...
  4. ncbi request reprint Effects of cessation of alcohol exposure on rat hepatocarcinogenesis
    Hideki Wanibuchi
    Department of Pathology, Osaka City University Medical School, Abeno Ku, Osaka 545 8585, Japan
    Asian Pac J Cancer Prev 7:122-6. 2006
    ..The results also imply the existence of a cumulative exposure time or dose threshold for alcohol if promoting effects of cessation are to be seen on rat hepatocarcinogenesis...
  5. ncbi request reprint Existence of no hepatocarcinogenic effect levels of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline with or without coadministration with ethanol
    Hideki Wanibuchi
    Department of Pathology, Osaka City University Medical School, Osaka, 545 8585, Japan
    Toxicol Pathol 34:232-6. 2006
    ..The results provided concrete evidence for the existence of no effect levels for hepatocarcinogenicity of MeIQx either in presence or absence of ethanol and, therefore, for a practical threshold for this genotoxic carcinogen...
  6. ncbi request reprint Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression
    Anna Kinoshita
    Department of Pathology, Osaka City University Medical School, Abeno Ku, Asahi machi 1 4 3, Osaka 545 8585, Japan
    Carcinogenesis 24:1389-99. 2003
    ..These results indicate that PB exhibits hormetic effect on rat hepatocarcinogenesis initiated with DEN by differentially altering cell proliferation, apoptosis and oxidative DNA damage at high and low doses...
  7. ncbi request reprint Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: a possible reactive oxygen species mechanism
    Takayuki Nishikawa
    Department of Pathology, Osaka City University Medical School, Osaka, Japan
    Int J Cancer 100:136-9. 2002
    ..Since hydroxyradicals were found to be generated in the relatively early phase while methylated arsenicals were metabolized in liver, the resultant oxidative stress might have promoted lesion development...
  8. ncbi request reprint Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: possible mechanisms
    Masahiko Kushida
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, 1 98, 3 Chome, Kasugade Naka, Konohana ku, Osaka 554 8558, Japan
    Toxicol Appl Pharmacol 208:285-94. 2005
    ....
  9. ncbi request reprint Carcinogenicity of dimethylarsinic acid in Ogg1-deficient mice
    Anna Kinoshita
    Department of Pathology, Osaka City University Medical School, Osaka 545 8585, Japan
    Cancer Sci 98:803-14. 2007
    ..Therefore, we strongly suggest that DMA(V) exerts carcinogenicity in the lungs of Ogg1(-/-) mutant mice, with a possible role for persistent accumulation of DNA oxidative adducts...
  10. ncbi request reprint Elevation of 8-hydroxydeoxyguanosine and cell proliferation via generation of oxidative stress by organic arsenicals contributes to their carcinogenicity in the rat liver and bladder
    Anna Kinoshita
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Toxicol Appl Pharmacol 221:295-305. 2007
    ..The results indicate that early elevation of 8-OHdG and cell proliferation via generation of oxidative stress by TMAO(V) and DMA(V) contributes to their carcinogenicity in the rat liver and bladder...
  11. ncbi request reprint Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol: evidence for a threshold
    Masahiko Kushida
    Department of Pathology, Osaka City University Medical School, Abeno Ku, Japan
    Cancer Sci 96:747-57. 2005
    ..The results demonstrated that ethanol dose-dependently promotes hepatocarcinogenesis induced by MeIQx, but with no adverse influence at doses of 1% or less, comparable to sensible drinking levels in humans...
  12. ncbi request reprint Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with the possible role for hepatic detoxifying enzymes
    Rawiwan Puatanachokchai
    Department of Pathology, Osaka City University Medical School, Abeno Ku, Asahi machi 1 4 3, Osaka 545 8585, Japan
    Cancer Lett 240:102-13. 2006
    ..The possible mechanism involves induction of detoxifying enzymes at low dose, influencing free radical production and oxidative stress, and consequently pathological change in the liver...
  13. ncbi request reprint Detailed low-dose study of 1,1-bis(p-chlorophenyl)-2,2,2- trichloroethane carcinogenesis suggests the possibility of a hormetic effect
    Tokuo Sukata
    Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, Osaka, Japan
    Int J Cancer 99:112-8. 2002
    ....
  14. ncbi request reprint Lack of preventive efficacy of FK228, a histone deacetylase inhibitor, against N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in p53+/- and p53+/+ mice
    Min Wei
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Anticancer Res 24:785-90. 2004
    ..The efficacy of FK228, a histone deacetylase inhibitor that is currently under early clinical trials for cancer therapy, against N-butyl-N-(4-hydroxybutyl)- nitrosamine (BBN) -induced mouse urinary bladder carcinogenesis was examined...
  15. ncbi request reprint Liver tumorigenicity of trimethylarsine oxide in male Fischer 344 rats--association with oxidative DNA damage and enhanced cell proliferation
    Jun Shen
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Carcinogenesis 24:1827-35. 2003
    ..These results indicate that TMAO exerts liver tumorigenicity with possible mechanistic roles for oxidative DNA damage and enhanced cell proliferation...
  16. ncbi request reprint Lack of promoting effects of phenobarbital at low dose on diethylnitrosamine-induced hepatocarcinogenesis in TGF-alpha transgenic mice
    Rawiwan Puatanachokchai
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Osaka 545 8585, Japan
    Asian Pac J Cancer Prev 7:274-8. 2006
    ..One possible mechanism of phenobarbital carcinogenicity might be influenced by cytochrome P450 system exhibiting a strong promoting activity for liver of mice...
  17. ncbi request reprint Analysis of gene expression in different stages of MeIQx-induced rat hepatocarcinogenesis
    Jin Seok Kang
    Department of Pathology, Osaka City University Medical School, Abeno Ku, Osaka 545 8585, Japan
    Oncol Rep 17:747-52. 2007
    ..In conclusion, molecular signatures of MeIQx-induced tumors clearly vary from that of age-matched normal liver, but no such shift is evident at early stages of hepatocarcinogenesis...
  18. ncbi request reprint High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N, N-dibutylnitrosamine
    Takayuki Nishikawa
    Department of Pathology, Osaka City University Medical School, 1 4 3, Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Cancer Lett 194:45-54. 2003
    ....
  19. ncbi request reprint A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in response
    Jun Shen
    Department of Pathology, Osaka City University Medical School, 1 4 3, Asahi machi, Osaka 545 8585, Japan
    Toxicol Appl Pharmacol 210:171-80. 2006
    ..However, the potential carcinogenic effects of MMA(III) need to be further elucidated...
  20. ncbi request reprint N-acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage
    Motome Nishikawa-Ogawa
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Carcinogenesis 27:982-8. 2006
    ..The studies indicate that NAC can serve as a chemopreventive agent for rat hepatocarcinogenesis induced by MeIQx by reducing cell proliferation, which may involve IGF-I and iNOS downregulation...
  21. ncbi request reprint Lack of large intestinal carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine at low doses in rats initiated with azoxymethane
    Kenichiro Doi
    Department of Pathology, Osaka City University Medical School, Osaka, Japan
    Int J Cancer 115:870-8. 2005
    ..These novel findings may provide evidence of a low-dose potential for PhIP, with a no-observed effect level speculated to be 10 ppm in the present initiation-promotion experimental model...
  22. ncbi request reprint Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens
    Shoji Fukushima
    Department of Pathology, Osaka City University Medical School, Osaka, Japan
    Carcinogenesis 26:1835-45. 2005
    ..Carcinogens can elicit a variety of changes via multiple genetic and epigenetic lesions, contributing to cellular carcinogenesis...
  23. ncbi request reprint Evaluation of the toxicity of mastic gum with 13 weeks dietary administration to F344 rats
    Jin Seok Kang
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Osaka, Japan
    Food Chem Toxicol 45:494-501. 2007
    ..67% in the diet...
  24. ncbi request reprint Current and emerging challenges in toxicopathology: carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogens
    Shoji Fukushima
    First Department of Pathology, Osaka City University Medical School, Abeno Ku, Asahi machi 1 4 3, Osaka 545 8585, Japan
    Toxicol Appl Pharmacol 207:225-9. 2005
    ..Dimethylarsinic acid, one of organic arsenics, was found to be carcinogenic in rat bladder using DMBDD model and carcinogenicity test...
  25. ncbi request reprint Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1
    Anna Kinoshita
    First Department of Pathology, Osaka City University Medical School, Abeno Ku, Asahi machi 1 4 3, Osaka 545 8585, Japan
    Carcinogenesis 23:341-9. 2002
    ....
  26. ncbi request reprint Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster
    Keiichirou Morimura
    Department of Pathology, Osaka City University Medical School, Osaka, Japan
    Oncol Rep 11:881-6. 2004
    ..These results point to possible distinct molecular carcinogenic pathways of bladder cancer formation, before and after the Chernobyl disaster, on the basis of variation in p53 gene alteration...
  27. ncbi request reprint Urinary bladder lesions induced by persistent chronic low-dose ionizing radiation
    Alina Romanenko
    Department of Pathology, Institute of Urology, Academy of Medical Sciences of Ukraine, Kiev, Ukraine
    Cancer Sci 94:328-33. 2003
    ..Alterations in the p38 MAPK cascade and accumulation of NF-kappa B subunits could be crucial early molecular events in the pathogenesis of Chernobyl cystitis...
  28. ncbi request reprint Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident
    Alina M Romanenko
    Department of Pathology, Academy of Medical Sciences of Ukraine, Kiev, Ukraine
    Cancer Sci 97:1168-74. 2006
    ..Our findings suggest that FGFR and EGFR signaling pathways, associated with p53 and Raf-1 activation, may contribute to multistage urothelial carcinogenesis caused by irradiation, through autocrine or paracrine growth stimulation...
  29. ncbi request reprint Involvement of ubiquitination and sumoylation in bladder lesions induced by persistent long-term low dose ionizing radiation in humans
    Alina M Romanenko
    Department of Pathology, Institute of Urology, Academy of Medical Sciences of Ukraine, Ukraine
    J Urol 175:739-43. 2006
    ....
  30. ncbi request reprint Aberrant expression of E-cadherin and beta-catenin in association with transforming growth factor-beta1 in urinary bladder lesions in humans after the Chernobyl accident
    Alina Romanenko
    Department of Pathology, Institute of Urology, Academy of Medical Sciences of Ukraine, 9a, Yu Kotzubinsky Street, 04053, Kiev, Ukraine
    Cancer Sci 97:45-50. 2006
    ..Furthermore, TGF-beta1 overexpression and alteration in E-cadherin/beta-catenin complexes in bladder urothelium might play a crucial role in urinary bladder carcinogenesis in humans exposed to long-term low-dose ionizing radiation...