Research Topics
| Anna KinoshitaSummaryAffiliation: Osaka City University Country: Japan Publications
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Detail Information
Publications
Effects of cessation of alcohol exposure on rat hepatocarcinogenesisHideki Wanibuchi
Department of Pathology, Osaka City University Medical School, Abeno Ku, Osaka 545 8585, Japan
Asian Pac J Cancer Prev 7:122-6. 2006..The results also imply the existence of a cumulative exposure time or dose threshold for alcohol if promoting effects of cessation are to be seen on rat hepatocarcinogenesis...- Inhibition of rat urinary bladder carcinogenesis by the antiangiogenic drug TNP-470Hideki Wanibuchi
Department of Pathology, Osaka City University Medical School, Abeno Ku, Osaka 545 8585, Japan
Asian Pac J Cancer Prev 7:101-7. 2006..In conclusion, TNP-470 can inhibit rat urinary bladder carcinogenesis, presumably through its effects on angiogenesis... - Existence of no hepatocarcinogenic effect levels of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline with or without coadministration with ethanolHideki Wanibuchi
Department of Pathology, Osaka City University Medical School, Osaka, 545 8585, Japan
Toxicol Pathol 34:232-6. 2006..The results provided concrete evidence for the existence of no effect levels for hepatocarcinogenicity of MeIQx either in presence or absence of ethanol and, therefore, for a practical threshold for this genotoxic carcinogen... - Understanding arsenic carcinogenicity by the use of animal modelsHideki Wanibuchi
Department of Pathology, Osaka City University Medical School, Osaka 545 8585, Japan
Toxicol Appl Pharmacol 198:366-76. 2004..The results revealed that the adverse effects of arsenic occurred either by promoting and initiating carcinogenesis. These data, as covered in the present review, suggest that several mechanisms may be involved in arsenic carcinogenesis... - Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: a possible reactive oxygen species mechanismTakayuki Nishikawa
Department of Pathology, Osaka City University Medical School, Osaka, Japan
Int J Cancer 100:136-9. 2002..Since hydroxyradicals were found to be generated in the relatively early phase while methylated arsenicals were metabolized in liver, the resultant oxidative stress might have promoted lesion development... - Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expressionAnna Kinoshita
Department of Pathology, Osaka City University Medical School, Abeno-ku, Asahi-machi 1-4-3, Osaka 545-8585, Japan
Carcinogenesis 24:1389-99. 2003..These results indicate that PB exhibits hormetic effect on rat hepatocarcinogenesis initiated with DEN by differentially altering cell proliferation, apoptosis and oxidative DNA damage at high and low doses... - Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: possible mechanismsMasahiko Kushida
Department of Pathology, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan; Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, 1-98, 3-chome, Kasugade-Naka, Konohana-ku, Osaka 554-8558, Japan
Toxicol Appl Pharmacol 208:285-94. 2005.... - Elevation of 8-hydroxydeoxyguanosine and cell proliferation via generation of oxidative stress by organic arsenicals contributes to their carcinogenicity in the rat liver and bladderAnna Kinoshita
Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
Toxicol Appl Pharmacol 221:295-305. 2007..The results indicate that early elevation of 8-OHdG and cell proliferation via generation of oxidative stress by TMAO(V) and DMA(V) contributes to their carcinogenicity in the rat liver and bladder... - Detailed low-dose study of 1,1-bis(p-chlorophenyl)-2,2,2- trichloroethane carcinogenesis suggests the possibility of a hormetic effectTokuo Sukata
Environmental Health Science Laboratory, Sumitomo Chemical Co, Ltd, Osaka, Japan
Int J Cancer 99:112-8. 2002.... - Carcinogenicity of dimethylarsinic acid in Ogg1-deficient miceAnna Kinoshita
Department of Pathology, Osaka City University Medical School, Osaka 545 8585, Japan
Cancer Sci 98:803-14. 2007..Therefore, we strongly suggest that DMA(V) exerts carcinogenicity in the lungs of Ogg1(-/-) mutant mice, with a possible role for persistent accumulation of DNA oxidative adducts... - Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol: evidence for a thresholdMasahiko Kushida
Department of Pathology, Osaka City University Medical School, Abeno-ku, Japan
Cancer Sci 96:747-57. 2005..The results demonstrated that ethanol dose-dependently promotes hepatocarcinogenesis induced by MeIQx, but with no adverse influence at doses of 1% or less, comparable to sensible drinking levels in humans... - Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with the possible role for hepatic detoxifying enzymesRawiwan Puatanachokchai
Department of Pathology, Osaka City University Medical School, Abeno-ku, Asahi-machi 1-4-3, Osaka 545-8585, Japan
Cancer Lett 240:102-13. 2006..The possible mechanism involves induction of detoxifying enzymes at low dose, influencing free radical production and oxidative stress, and consequently pathological change in the liver... - Lack of preventive efficacy of FK228, a histone deacetylase inhibitor, against N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in p53+/- and p53+/+ miceMin Wei
Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
Anticancer Res 24:785-90. 2004..The efficacy of FK228, a histone deacetylase inhibitor that is currently under early clinical trials for cancer therapy, against N-butyl-N-(4-hydroxybutyl)- nitrosamine (BBN) -induced mouse urinary bladder carcinogenesis was examined... - Liver tumorigenicity of trimethylarsine oxide in male Fischer 344 rats--association with oxidative DNA damage and enhanced cell proliferationJun Shen
Department of Pathology, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
Carcinogenesis 24:1827-35. 2003..These results indicate that TMAO exerts liver tumorigenicity with possible mechanistic roles for oxidative DNA damage and enhanced cell proliferation... - Lack of promoting effects of phenobarbital at low dose on diethylnitrosamine-induced hepatocarcinogenesis in TGF-alpha transgenic miceRawiwan Puatanachokchai
Department of Pathology, Osaka City University Medical School, 1-4-3 Asahi-machi, Osaka 545-8585, Japan
Asian Pac J Cancer Prev 7:274-8. 2006..One possible mechanism of phenobarbital carcinogenicity might be influenced by cytochrome P450 system exhibiting a strong promoting activity for liver of mice... - Analysis of gene expression in different stages of MeIQx-induced rat hepatocarcinogenesisJin Seok Kang
Department of Pathology, Osaka City University Medical School, Abeno Ku, Osaka 545 8585, Japan
Oncol Rep 17:747-52. 2007..In conclusion, molecular signatures of MeIQx-induced tumors clearly vary from that of age-matched normal liver, but no such shift is evident at early stages of hepatocarcinogenesis... - A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in responseJun Shen
Department of Pathology, Osaka City University Medical School, 1-4-3, Asahi-machi, Osaka 545-8585, Japan
Toxicol Appl Pharmacol 210:171-80. 2006..However, the potential carcinogenic effects of MMA(III) need to be further elucidated... - High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N, N-dibutylnitrosamineTakayuki Nishikawa
Department of Pathology, Osaka City University Medical School, 1 4 3, Asahimachi, Abeno Ku, Osaka 545 8585, Japan
Cancer Lett 194:45-54. 2003.... - N-acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stageMotome Nishikawa-Ogawa
Department of Pathology, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
Carcinogenesis 27:982-8. 2006..The studies indicate that NAC can serve as a chemopreventive agent for rat hepatocarcinogenesis induced by MeIQx by reducing cell proliferation, which may involve IGF-I and iNOS downregulation... - Lack of large intestinal carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine at low doses in rats initiated with azoxymethaneKenichiro Doi
Department of Pathology, Osaka City University Medical School, Osaka, Japan
Int J Cancer 115:870-8. 2005..These novel findings may provide evidence of a low-dose potential for PhIP, with a no-observed effect level speculated to be 10 ppm in the present initiation-promotion experimental model... - Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogensShoji Fukushima
Department of Pathology, Osaka City University Medical School, Osaka, Japan
Carcinogenesis 26:1835-45. 2005..Carcinogens can elicit a variety of changes via multiple genetic and epigenetic lesions, contributing to cellular carcinogenesis... - Evaluation of the toxicity of mastic gum with 13 weeks dietary administration to F344 ratsJin Seok Kang
Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Osaka, Japan
Food Chem Toxicol 45:494-501. 2007..67% in the diet... - Current and emerging challenges in toxicopathology: carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogensShoji Fukushima
First Department of Pathology, Osaka City University Medical School, Abeno Ku, Asahi machi 1 4 3, Osaka 545 8585, Japan
Toxicol Appl Pharmacol 207:225-9. 2005..Dimethylarsinic acid, one of organic arsenics, was found to be carcinogenic in rat bladder using DMBDD model and carcinogenicity test... - Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1Anna Kinoshita
First Department of Pathology, Osaka City University Medical School, Abeno Ku, Asahi machi 1 4 3, Osaka 545 8585, Japan
Carcinogenesis 23:341-9. 2002.... - Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disasterKeiichirou Morimura
Department of Pathology, Osaka City University Medical School, Osaka, Japan
Oncol Rep 11:881-6. 2004..These results point to possible distinct molecular carcinogenic pathways of bladder cancer formation, before and after the Chernobyl disaster, on the basis of variation in p53 gene alteration... - Urinary bladder lesions induced by persistent chronic low-dose ionizing radiationAlina Romanenko
Department of Pathology, Institute of Urology, Academy of Medical Sciences of Ukraine, Kiev, Ukraine
Cancer Sci 94:328-33. 2003..Alterations in the p38 MAPK cascade and accumulation of NF-kappa B subunits could be crucial early molecular events in the pathogenesis of Chernobyl cystitis... - Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accidentAlina M Romanenko
Department of Pathology, Academy of Medical Sciences of Ukraine, Kiev, Ukraine
Cancer Sci 97:1168-74. 2006..Our findings suggest that FGFR and EGFR signaling pathways, associated with p53 and Raf-1 activation, may contribute to multistage urothelial carcinogenesis caused by irradiation, through autocrine or paracrine growth stimulation... - Involvement of ubiquitination and sumoylation in bladder lesions induced by persistent long-term low dose ionizing radiation in humansAlina M Romanenko
Department of Pathology, Institute of Urology, Academy of Medical Sciences of Ukraine, Ukraine
J Urol 175:739-43. 2006.... - Aberrant expression of E-cadherin and beta-catenin in association with transforming growth factor-beta1 in urinary bladder lesions in humans after the Chernobyl accidentAlina Romanenko
Department of Pathology, Institute of Urology, Academy of Medical Sciences of Ukraine, 9a, Yu Kotzubinsky Street, 04053, Kiev, Ukraine
Cancer Sci 97:45-50. 2006..Furthermore, TGF-beta1 overexpression and alteration in E-cadherin/beta-catenin complexes in bladder urothelium might play a crucial role in urinary bladder carcinogenesis in humans exposed to long-term low-dose ionizing radiation...