Shokei Kim

Summary

Affiliation: Osaka City University
Country: Japan

Publications

  1. ncbi request reprint Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases
    S Kim
    Department of Pharmacology, Osaka City University Medical School, Abeno Ku, Osaka, Japan
    Pharmacol Rev 52:11-34. 2000
  2. ncbi request reprint Beneficial effects of combined blockade of ACE and AT1 receptor on intimal hyperplasia in balloon-injured rat artery
    Shokei Kim
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    Arterioscler Thromb Vasc Biol 22:1299-304. 2002
  3. ncbi request reprint Stress and vascular responses: mitogen-activated protein kinases and activator protein-1 as promising therapeutic targets of vascular remodeling
    Shokei Kim
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    J Pharmacol Sci 91:177-81. 2003
  4. ncbi request reprint Effects of combination of ACE inhibitor and angiotensin receptor blocker on cardiac remodeling, cardiac function, and survival in rat heart failure
    S Kim
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    Circulation 103:148-54. 2001
  5. ncbi request reprint In vivo activation of rat aortic platelet-derived growth factor and epidermal growth factor receptors by angiotensin II and hypertension
    S Kim
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    Arterioscler Thromb Vasc Biol 20:2539-45. 2000
  6. ncbi request reprint Cardiovascular effects of combination of perindopril, candesartan, and amlodipine in hypertensive rats
    S Kim
    Department of Pharmacology, Osaka City University Medical School, Abeno Ku, Osaka, Japan
    Hypertension 35:769-74. 2000
  7. ncbi request reprint Effects of aldosterone receptor antagonist and angiotensin II type I receptor blocker on cardiac transcriptional factors and mRNA expression in rats with myocardial infarction
    Ryo Matsumoto
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Japan
    Circ J 68:376-82. 2004
  8. ncbi request reprint Beneficial effects of combination of ACE inhibitor and angiotensin II type 1 receptor blocker on cardiac remodeling in rat myocardial infarction
    Yasuhiro Nakamura
    Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Cardiovasc Res 57:48-54. 2003
  9. ncbi request reprint Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia
    Yasukatsu Izumi
    Department of Pharmacology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno, Osaka 545 8585, Japan
    Circulation 108:2812-8. 2003
  10. ncbi request reprint Involvement of apoptosis signal-regulating kinase-1 on angiotensin II-induced monocyte chemoattractant protein-1 expression
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Arterioscler Thromb Vasc Biol 24:270-5. 2004

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases
    S Kim
    Department of Pharmacology, Osaka City University Medical School, Abeno Ku, Osaka, Japan
    Pharmacol Rev 52:11-34. 2000
    ..However, there are still unresolved questions and controversies on the mechanism of Ang II-mediated cardiovascular and renal diseases...
  2. ncbi request reprint Beneficial effects of combined blockade of ACE and AT1 receptor on intimal hyperplasia in balloon-injured rat artery
    Shokei Kim
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    Arterioscler Thromb Vasc Biol 22:1299-304. 2002
    ..The present study was undertaken to elucidate the effect of the ACE inhibitor and the angiotensin II type 1 (AT1) receptor antagonist in combination on neointimal hyperplasia after balloon injury...
  3. ncbi request reprint Stress and vascular responses: mitogen-activated protein kinases and activator protein-1 as promising therapeutic targets of vascular remodeling
    Shokei Kim
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    J Pharmacol Sci 91:177-81. 2003
    ..MAP kinases and c-Jun seem to be the promising therapeutic target for vascular remodeling...
  4. ncbi request reprint Effects of combination of ACE inhibitor and angiotensin receptor blocker on cardiac remodeling, cardiac function, and survival in rat heart failure
    S Kim
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    Circulation 103:148-54. 2001
    ..We compared the effects of an ACE inhibitor, an angiotensin receptor blocker (ARB), and their combination on diastolic heart failure in Dahl salt-sensitive (DS) rats...
  5. ncbi request reprint In vivo activation of rat aortic platelet-derived growth factor and epidermal growth factor receptors by angiotensin II and hypertension
    S Kim
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    Arterioscler Thromb Vasc Biol 20:2539-45. 2000
    ..Thus, the aortic PDGF beta-receptor, activated by ACE-mediated Ang II, seems to be responsible for vascular remodeling in hypertensive rats...
  6. ncbi request reprint Cardiovascular effects of combination of perindopril, candesartan, and amlodipine in hypertensive rats
    S Kim
    Department of Pharmacology, Osaka City University Medical School, Abeno Ku, Osaka, Japan
    Hypertension 35:769-74. 2000
    ....
  7. ncbi request reprint Effects of aldosterone receptor antagonist and angiotensin II type I receptor blocker on cardiac transcriptional factors and mRNA expression in rats with myocardial infarction
    Ryo Matsumoto
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Japan
    Circ J 68:376-82. 2004
    ....
  8. ncbi request reprint Beneficial effects of combination of ACE inhibitor and angiotensin II type 1 receptor blocker on cardiac remodeling in rat myocardial infarction
    Yasuhiro Nakamura
    Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Cardiovasc Res 57:48-54. 2003
    ..In this study, we compared the effects of an ACE inhibitor (temocapril), an ARB (CS-866), and their combination on cardiac remodeling after MI...
  9. ncbi request reprint Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia
    Yasukatsu Izumi
    Department of Pharmacology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno, Osaka 545 8585, Japan
    Circulation 108:2812-8. 2003
    ..Therefore, we first examined the role of ASK1 in vascular remodeling...
  10. ncbi request reprint Involvement of apoptosis signal-regulating kinase-1 on angiotensin II-induced monocyte chemoattractant protein-1 expression
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Arterioscler Thromb Vasc Biol 24:270-5. 2004
    ..To elucidate these molecular mechanisms, angiotensin II-induced expression of MCP-1 was examined in cultured rat neonatal ventricular cardiomyocytes and fibroblasts by adenovirus gene transfer...
  11. ncbi request reprint Involvement of c-Jun NH2 terminal kinase and p38MAPK in rapamycin-mediated inhibition of neointimal formation in rat carotid arteries
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Osaka, Japan
    J Cardiovasc Pharmacol 46:519-25. 2005
    ..Therefore, we examined the effects of rapamycin on MAPK and transcriptional factors in cultured human coronary artery smooth muscle cells (CASMC) and in balloon-injured rat carotid arteries...
  12. ncbi request reprint Magnesium supplementation prevents experimental chronic cyclosporine a nephrotoxicity via renin-angiotensin system independent mechanism
    Toshihiro Asai
    Department of Pharmacology, Osaka City University Medical School, Abeno, Japan
    Transplantation 74:784-91. 2002
    ..Experiments were conducted to further elucidate upstream mechanism of the beneficial effects upon CsA nephrotoxicity...
  13. ncbi request reprint Role of JNK, p38, and ERK in platelet-derived growth factor-induced vascular proliferation, migration, and gene expression
    Yumei Zhan
    Department of Pharmacology, Osaka City University Medical School, Asahimachi, Abeno, Osaka 545 8585, Japan
    Arterioscler Thromb Vasc Biol 23:795-801. 2003
    ....
  14. ncbi request reprint Combination treatment with a calcium channel blocker and an angiotensin blocker in a rat systolic heart failure model with hypertension
    Masashi Namba
    Department of Pharmacology, Osaka City University Medical School, Japan
    Hypertens Res 25:461-6. 2002
    ..However, further studies will be needed before reaching any definitive conclusion on the efficacy of this combination therapy in patients with heart failure...
  15. ncbi request reprint Role of c-Jun NH2-terminal kinase in G-protein-coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Mol Cell Cardiol 38:583-92. 2005
    ..In conclusion, G-protein-coupled receptor agonist-induced PAI-1 expression is partially mediated through JNK activation...
  16. ncbi request reprint Activation of transcription factors AP-1 and NF-kappaB in chronic cyclosporine A nephrotoxicity: role in beneficial effects of magnesium supplementation
    Toshihiro Asai
    Department of Urology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno, Osaka 545 8585, Japan
    Transplantation 75:1040-4. 2003
    ....
  17. ncbi request reprint Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling
    Yasuhiro Izumiya
    Department of Pharmacology, Osaka City University Graduate School of Medical Science, 1 4 3 Asahimachi, Abeno, Osaka 545 8585, Japan
    Circ Res 93:874-83. 2003
    ..These results provided the first in vivo evidence that ASK1 is the critical signaling molecule for Ang II-induced cardiac hypertrophy and remodeling. Thus, ASK1 is proposed to be a potential therapeutic target for cardiac diseases...
  18. ncbi request reprint Differential contribution of three mitogen-activated protein kinases to PDGF-BB-induced mesangial cell proliferation and gene expression
    Hitomi Kawano
    Department of Pharmacology, Osaka City University Medical School, Japan
    J Am Soc Nephrol 14:584-92. 2003
    ..Thus, three MAP kinases seem to contribute to progression of glomerular disease via different molecular mechanisms...
  19. ncbi request reprint Inhibition of nuclear factor-kappaB activation by pyrrolidine dithiocarbamate prevents chronic FK506 nephropathy
    Satoshi Tamada
    Department of Urology, Osaka City University, Osaka, Japan
    Kidney Int 63:306-14. 2003
    ....
  20. ncbi request reprint Transmitral inflow pattern assessed by Doppler echocardiography in angiotensin II type 1A receptor knockout mice with myocardial infarction
    Yasuhiro Nakamura
    Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Circ J 66:192-6. 2002
    ..05). mRNA expressions of ANP, BNP, collagen I and collagen III in the non-infarcted LV and RV of KO-MI were significantly lower than WT-MI. In conclusion, transmitral inflow abnormalities in KO-MI were attenuated compared with WT-MI...
  21. ncbi request reprint Enhancement of glomerular platelet-derived growth factor beta-receptor tyrosine phosphorylation in hypertensive rats and its inhibition by calcium channel blocker
    Yumei Zhan
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    Hypertens Res 25:295-301. 2002
    ....
  22. ncbi request reprint Role of intrarenal angiotensin-converting enzyme in nephropathy of type II diabetic rats
    Masaru Taniguchi
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    Hypertens Res 25:287-94. 2002
    ....
  23. ncbi request reprint Effects of FK506 on acute allograft rejection in transplanted rat heart: the role of mitogen-activated protein kinases, AP-1 and NF-kappaB
    Takanobu Aoyama
    Second Department of Surgery, Osaka City University Medical School, Japan
    Osaka City Med J 49:1-10. 2003
    ..These results suggest that the signal transduction pathways may play important roles in acute allograft rejection in rat cardiac transplantation...
  24. ncbi request reprint Stroke prevention: is it possible? If so, which antihypertensive agent should be used?
    Shokei Kim
    Department of Pharmacology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Curr Med Res Opin 19:442-4. 2003
    ..Results with the angiotensin receptor blockers (ARBs) in clinical trials (LIFE and SCOPE) support the findings in animal models that ARBs may be a promising therapeutic option for prevention of stroke and possibly, cognitive decline...
  25. ncbi request reprint A specific chymase inhibitor, NK3201, suppresses bleomycin-induced pulmonary fibrosis in hamsters
    Masato Sakaguchi
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 589 8686, Japan
    Eur J Pharmacol 493:173-6. 2004
    ..The ratio of fibrotic area to total area in NK3201-treated hamsters was significantly decreased to 54.0% of the ratio in placebo-treated hamsters. Therefore, NK3201 may be useful in the prevention of pulmonary fibrosis...
  26. ncbi request reprint Mechanisms of angiotensin II type 1 receptor blocker for anti-atherosclerotic effect in monkeys fed a high-cholesterol diet
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan
    J Hypertens 21:361-9. 2003
    ....
  27. ncbi request reprint Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine
    Takashi Omura
    Department of Internal Medicine and Cardiology, Osaka City University Medical School, Osaka, Japan
    Hypertension 39:81-6. 2002
    ..In conclusion, we provide the first evidence that DNJun inhibits cardiomyocyte hypertrophy through inhibition of AP-1 transcriptional activity...
  28. pmc Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells
    Takafumi Nakao
    Department of Pharmacology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Br J Pharmacol 136:975-84. 2002
    ..We conclude that, in spite of their similar biological effects, they are differentially regulated at the level of MAPK activity in bone marrow stromal cells...
  29. ncbi request reprint Effects of dominant-negative c-Jun on platelet-derived growth factor-induced vascular smooth muscle cell proliferation
    Yumei Zhan
    Department of Pharmacology, Osaka City University Medical School, Osaka, Japan
    Arterioscler Thromb Vasc Biol 22:82-8. 2002
    ....
  30. ncbi request reprint Molecular mechanism and role of endothelial monocyte chemoattractant protein-1 induction by vascular endothelial growth factor
    Motoko Yamada
    Department of Pharmacology, Osaka City University Medical School, Abeno, Osaka, Japan
    Arterioscler Thromb Vasc Biol 23:1996-2001. 2003
    ....
  31. ncbi request reprint [Tendency and prospect of the development of new ARBs]
    Shokei Kim
    Department of Pharmacology, Osaka City University Medical School
    Nihon Rinsho 60:1881-6. 2002
    ..In this review, pharmacological properties and future view of each ARB are described and discussed...
  32. ncbi request reprint Role of hypomagnesemia in chronic cyclosporine nephropathy
    Katsuyuki Miura
    Department of Pharmacology, Osaka City University Medical School, Abeno, Osaka, Japan
    Transplantation 73:340-7. 2002
    ..This experiment was conducted to elucidate the role of hypomagnesemia in the pathogenesis of chronic CsA nephropathy...
  33. ncbi request reprint Induction of gicerin/CD146 in the rat carotid artery after balloon injury
    Shigeki Okumura
    Department of Pharmacology, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
    Biochem Biophys Res Commun 313:902-6. 2004
    ..We found that IGF-1, but not PDGF-BB and bFGF, significantly increases the expression of gicerin protein in A10 cells. These suggest gicerin might be involved in the arteriosclerotic neointima formation in the artery...
  34. ncbi request reprint A novel chymase inhibitor, 4-[1-([bis-(4-methyl-phenyl)-methyl]-carbamoyl)3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), suppressed cardiac fibrosis in cardiomyopathic hamsters
    Shinji Takai
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan
    J Pharmacol Exp Ther 305:17-23. 2003
    ..Therefore, the activation of transforming growth factor-beta by chymase may play an important role in the progression of cardiac fibrosis and cardiac dysfunction in cardiomyopathy...
  35. ncbi request reprint Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity
    Nobuharu Fujii
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Physiol Cell Physiol 287:C200-8. 2004
    ..JNK activation is unlikely to be the major mechanism by which contractile activity increases glycogen synthase activity in skeletal muscle...
  36. ncbi request reprint Nipradilol can prevent left ventricular systolic and diastolic dysfunction after myocardial infarction in rats
    Satoru Izutani
    Department of Internal Medicine, Graduate School of Medicine, Osaka City University, Japan
    Circ J 66:289-93. 2002
    ..In conclusions, nipradilol prevents the cardiac remodeling that is accompanied by systolic and diastolic dysfunction, and inhibits abnormal myocardial gene expression after MI...
  37. ncbi request reprint Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression
    Hideaki Kaneto
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 277:30010-8. 2002
    ..In conclusion, activation of JNK is involved in the reduction of insulin gene expression by oxidative stress, and suppression of the JNK pathway protects beta-cells from oxidative stress...
  38. ncbi request reprint Regulation of IL-11 expression in intestinal myofibroblasts: role of c-Jun AP-1- and MAPK-dependent pathways
    Shigeki Bamba
    Department of Internal Medicine, Shiga Univ of Medical Science, Seta Tukinowa, Otsu 520 2192, Japan
    Am J Physiol Gastrointest Liver Physiol 285:G529-38. 2003
    ..Intestinal SEMFs secreted IL-11 in response to IL-1beta- and TGF-beta1. Mucosal IL-11 secretion might be important as an anti-inflammatory response in the pathogenesis of intestinal inflammation...
  39. ncbi request reprint Fibroblast growth factor-2 stimulates interleukin-6 secretion in human pancreatic periacinar myofibroblasts
    Akira Andoh
    Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
    Pancreas 29:278-83. 2004
    ..In the present study, to evaluate the proinflammatory nature of FGF-2, we investigated the effects of FGF-2 on IL-6 secretion in human pancreatic periacinar myofibroblasts...
  40. ncbi request reprint Dominant negative c-Jun inhibits platelet-derived growth factor-directed migration by vascular smooth muscle cells
    Takeshi Ioroi
    Department of Clinical Pharmacy, Kobe Pharmaceutical University, Kobe, Japan
    J Pharmacol Sci 91:145-8. 2003
    ..Our results provide the first evidence that signaling pathways through c-Jun participates in cell migration induced by PDGF-BB in addition to other MAP kinase pathways in VSMCs...
  41. ncbi request reprint [Scope]
    Shokei Kim
    Department of Pharmacology, Osaka City University Graduate School of Medicine
    Nihon Rinsho 62:644-7. 2004
  42. ncbi request reprint [Vascular remodeling]
    Shokei Kim
    Department of Pharmacology, Osaka City University Graduate School of Medicine
    Nihon Rinsho 62:33-7. 2004