Hiroaki Kazui

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer's disease?
    Mamoru Hashimoto
    Hyogo Institute for Aging Brain and Cognitive Disorders, Hyogo, Japan
    Am J Psychiatry 162:676-82. 2005
  2. doi request reprint Predictors of the disappearance of triad symptoms in patients with idiopathic normal pressure hydrocephalus after shunt surgery
    Hiroaki Kazui
    Department of Psychiatry, Osaka University Graduate School of Medicine, D3 2 2, Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Neurol Sci 328:64-9. 2013
  3. pmc The value of the cerebrospinal fluid tap test for predicting shunt effectiveness in idiopathic normal pressure hydrocephalus
    Masatsune Ishikawa
    Normal Pressure Hydrocephalus Center, Otowa Hospital, Kyoto, Japan
    Fluids Barriers CNS 9:1. 2012
  4. doi request reprint Neuroimaging studies in patients with Charles Bonnet Syndrome
    Hiroaki Kazui
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Psychogeriatrics 9:77-84. 2009
  5. ncbi request reprint Everyday memory impairment of patients with mild cognitive impairment
    Hiroaki Kazui
    Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, Osaka, Japan
    Dement Geriatr Cogn Disord 19:331-7. 2005
  6. ncbi request reprint Symptoms underlying unawareness of memory impairment in patients with mild Alzheimer's disease
    Hiroaki Kazui
    Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, Suita Shi, Osaka, Japan
    J Geriatr Psychiatry Neurol 19:3-12. 2006
  7. ncbi request reprint Effectiveness of a clinical pathway for the diagnosis and treatment of dementia and for the education of families
    Hiroaki Kazui
    Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, Japan
    Int J Geriatr Psychiatry 19:892-7. 2004
  8. ncbi request reprint Nature of personal semantic memory: evidence from Alzheimer's disease
    Hiroaki Kazui
    Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center at Himeji, Himeji, Japan
    Neuropsychologia 41:981-8. 2003
  9. ncbi request reprint Enhancement of declarative memory by emotional arousal and visual memory function in Alzheimer's disease
    Hiroaki Kazui
    Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center at Himeji, Hyogo, Japan
    J Neuropsychiatry Clin Neurosci 15:221-6. 2003
  10. doi request reprint Decreased α event-related synchronization in the left posterior temporal cortex in schizophrenia: a magnetoencephalography-beamformer study
    Koji Ikezawa
    Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Neurosci Res 71:235-43. 2011

Detail Information

Publications64

  1. ncbi request reprint Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer's disease?
    Mamoru Hashimoto
    Hyogo Institute for Aging Brain and Cognitive Disorders, Hyogo, Japan
    Am J Psychiatry 162:676-82. 2005
    ..The purpose of the present study was to determine whether donepezil has a neuroprotective effect in Alzheimer's disease by using the rate of hippocampal atrophy as a surrogate marker of disease progression...
  2. doi request reprint Predictors of the disappearance of triad symptoms in patients with idiopathic normal pressure hydrocephalus after shunt surgery
    Hiroaki Kazui
    Department of Psychiatry, Osaka University Graduate School of Medicine, D3 2 2, Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Neurol Sci 328:64-9. 2013
    ..None of the neuroimaging examinations predicted the disappearance of symptoms after shunt surgery in this study...
  3. pmc The value of the cerebrospinal fluid tap test for predicting shunt effectiveness in idiopathic normal pressure hydrocephalus
    Masatsune Ishikawa
    Normal Pressure Hydrocephalus Center, Otowa Hospital, Kyoto, Japan
    Fluids Barriers CNS 9:1. 2012
    ..abstract:..
  4. doi request reprint Neuroimaging studies in patients with Charles Bonnet Syndrome
    Hiroaki Kazui
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Psychogeriatrics 9:77-84. 2009
    ..In addition, the results indicate that not only eye pathology, but also dysfunction in the primary and secondary visual cortices could result in deprivation of external visual stimuli...
  5. ncbi request reprint Everyday memory impairment of patients with mild cognitive impairment
    Hiroaki Kazui
    Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, Osaka, Japan
    Dement Geriatr Cogn Disord 19:331-7. 2005
    ..7% of NC, thus demonstrating the usefulness of the RBMT for diagnosing MCI patients. Prospective memory tasks were not useful for detecting the patients with MCI...
  6. ncbi request reprint Symptoms underlying unawareness of memory impairment in patients with mild Alzheimer's disease
    Hiroaki Kazui
    Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, Suita Shi, Osaka, Japan
    J Geriatr Psychiatry Neurol 19:3-12. 2006
    ..Thus, existing treatments for memory impairment and delusions may be beneficial for increasing the awareness of mild AD patients of their cognitive impairment...
  7. ncbi request reprint Effectiveness of a clinical pathway for the diagnosis and treatment of dementia and for the education of families
    Hiroaki Kazui
    Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, Japan
    Int J Geriatr Psychiatry 19:892-7. 2004
    ..We established a CP for a series of medical practices (diagnosis, treatment, establishment of a care system, and caregiver education) for patients with dementia hospitalized for a three-week period, and evaluated its usefulness...
  8. ncbi request reprint Nature of personal semantic memory: evidence from Alzheimer's disease
    Hiroaki Kazui
    Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center at Himeji, Himeji, Japan
    Neuropsychologia 41:981-8. 2003
    ..This result supports the hypotheses that personal semantic memory has features of both episodic and semantic memory, and that semantic memory is transformed from episodic memory...
  9. ncbi request reprint Enhancement of declarative memory by emotional arousal and visual memory function in Alzheimer's disease
    Hiroaki Kazui
    Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center at Himeji, Hyogo, Japan
    J Neuropsychiatry Clin Neurosci 15:221-6. 2003
    ....
  10. doi request reprint Decreased α event-related synchronization in the left posterior temporal cortex in schizophrenia: a magnetoencephalography-beamformer study
    Koji Ikezawa
    Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Neurosci Res 71:235-43. 2011
    ..This upper alpha ERS deficit may indicate left temporal dysfunction and visual-information processing impairment in schizophrenia, and upon further confirmation it might represent a neurophysiological state marker of the disorder...
  11. doi request reprint Association study of KIBRA gene with memory performance in a Japanese population
    Yuka Yasuda
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    World J Biol Psychiatry 11:852-7. 2010
    ..KIBRA is highly expressed in the brain and kidneys, and is reported to be involved in synaptic plasticity. Therefore, we first tried to replicate the association between the SNP and memory performance in a Japanese subjects...
  12. doi request reprint The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Suite, Osaka, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:1459-64. 2010
    ..018). In contrast, there was no genotype effect for any index in the healthy control subjects (P > 0.05). Our data suggest that rs1344706 may be related to memory dysfunction in schizophrenia. © 2010 Wiley-Liss, Inc...
  13. doi request reprint The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 116:126-32. 2010
    ..003). We conclude that the genetic variants in the CHI3L1 gene have ethnic heterogeneity and confer a susceptibility to schizophrenia in Asian populations...
  14. doi request reprint Reversibility of brain morphology after shunt operations and preoperative clinical symptoms in patients with idiopathic normal pressure hydrocephalus
    Tamiki Wada
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan
    Psychogeriatrics 13:41-8. 2013
    ..We investigated the relationship between reversibility of brain morphology after shunt operations and preoperative clinical symptoms in iNPH patients...
  15. doi request reprint The AKT1 gene is associated with attention and brain morphology in schizophrenia
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    World J Biol Psychiatry 14:100-13. 2013
    ..A meta-analysis of the associations between genetic variants in the AKT1 gene and schizophrenia found that a single nucleotide polymorphism (SNP5; rs2494732) was associated with schizophrenia in Asian populations...
  16. doi request reprint Discriminant analysis in schizophrenia and healthy subjects using prefrontal activation during frontal lobe tasks: a near-infrared spectroscopy
    Michiyo Azechi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 117:52-60. 2010
    ..Our findings suggest that NIRS measurement could be applied to differentiate patients with schizophrenia from healthy subjects...
  17. doi request reprint Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Am J Med Genet B Neuropsychiatr Genet 159:405-13. 2012
    ....
  18. doi request reprint The KCNH2 gene is associated with neurocognition and the risk of schizophrenia
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka, Japan
    World J Biol Psychiatry 14:114-20. 2013
    ..The aims of this study were to investigate whether the KCNH2 polymorphism is associated with schizophrenia-related neurocognitive deficits and to confirm the association between the variant and schizophrenia...
  19. doi request reprint A promoter variant in the chitinase 3-like 1 gene is associated with serum YKL-40 level and personality trait
    Hidenaga Yamamori
    Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurosci Lett 513:204-8. 2012
    ..0054). These findings suggest possible associations between the SNP in the CHI3L1 gene, the risk for schizophrenia, and higher serum YKL-40 levels and personality traits in a Japanese population...
  20. doi request reprint Frontal shift of posterior alpha activity is correlated with cognitive impairment in early Alzheimer's disease: a magnetoencephalography-beamformer study
    Ryouhei Ishii
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    Psychogeriatrics 10:138-43. 2010
    ..However, MEG has rarely been used to explore functional abnormalities that may represent state markers in patients with Alzheimer's disease (AD)...
  21. doi request reprint Predictors of prolonged hospital stay for the treatment of severe neuropsychiatric symptoms in patients with dementia: a cohort study in multiple hospitals
    Hiromichi Sugiyama
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    Int Psychogeriatr 25:1365-73. 2013
    ..Consequently, patients with severe BPSD usually wait for a long time to be admitted. There is a need to identify factors related to long hospitalization to better manage resources of a psychiatric hospital...
  22. doi request reprint Personality traits and schizophrenia: evidence from a case-control study and meta-analysis
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Psychiatry Res 198:7-11. 2012
    ..23 for PS, and those of the character traits were -0.96 for SD, -0.47 for CO and 0.61 for ST. These findings suggest that patients with schizophrenia have a unique temperament and character profile compared with the general population...
  23. pmc The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 7:e35696. 2012
    ..Schizotypal personality disorder has a strong familial relationship with schizophrenia. Several susceptibility genes for schizophrenia have been related to schizotypal traits...
  24. doi request reprint Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects
    Hidetoshi Takahashi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Psychophysiology 47:831-7. 2010
    ..The total SPQ score, cognitive/perceptual score, and interpersonal score correlated negatively with PPI at SnR of +16 and +20 dB. We conclude that PPI is associated with the trait of schizotypy in healthy Asian subjects...
  25. doi request reprint KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort
    Noriyuki Hayashi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Japan
    Dement Geriatr Cogn Disord 30:302-8. 2010
    ..Importantly, the association between KIBRA and episodic memory in AD has never been addressed. In this study, we investigated whether the KIBRA rs17070145 SNP influences AD episodic memory and the disease in a Japanese cohort...
  26. doi request reprint The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1309-15. 2011
    ..013). These data suggest that the SIGMAR1 polymorphism is associated with an increased risk of schizophrenia and differential activation of the PFC...
  27. doi request reprint Global cerebral hypoperfusion in preclinical stage of idiopathic normal pressure hydrocephalus
    Masahiko Takaya
    Department of Psychiatry, Osaka University Graduate School of Medicine, National Hospital Organization Osaka National Hospital, Osaka, Japan
    J Neurol Sci 298:35-41. 2010
    ..These results suggest that factors other than rCBF in the resting state are responsible for the occurrence of objective symptoms of iNPH...
  28. ncbi request reprint Cognitive impairment in patients with idiopathic normal pressure hydrocephalus
    Atsushi Ogino
    Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, Suita City, Japan
    Dement Geriatr Cogn Disord 21:113-9. 2006
    ..Recognition of these features contributes to an early diagnosis, which can lead to a better prognosis...
  29. doi request reprint Classification of delusions in Alzheimer's disease and their neural correlates
    Keiko Nomura
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan
    Psychogeriatrics 12:200-10. 2012
    ..In this retrospective study, we classified AD delusions and investigated their neural correlates by using single-photon emission computed tomography data...
  30. doi request reprint Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene
    Yuka Yasuda
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurosci Lett 495:216-20. 2011
    ..30). These results suggest that the genetic variation in ZNF804A might increase susceptibility not only for schizophrenia but also for schizotypal personality traits in healthy subjects...
  31. doi request reprint No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis
    Ryota Hashimoto
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka, Japan
    Schizophr Res 129:80-4. 2011
    ..28). The meta-analysis did not reveal an association between the four examined SNPs and schizophrenia. Our data did not support genetic variants in the PCM1 gene as a susceptibility locus for schizophrenia...
  32. doi request reprint Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 109:80-5. 2009
    ..However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population...
  33. ncbi request reprint Validation of grading scale for evaluating symptoms of idiopathic normal-pressure hydrocephalus
    Yoshihiko Kubo
    Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, Osaka, Japan
    Dement Geriatr Cogn Disord 25:37-45. 2008
    ..The purpose of this study was to assess the reliability and validity of this scale in 38 patients with iNPH...
  34. doi request reprint Induced oscillatory responses during the Sternberg's visual memory task in patients with Alzheimer's disease and mild cognitive impairment
    Ryu Kurimoto
    Department of Psychiatry, Osaka University Graduate School of Medicine, 2 2 D3, Yamadaoka, Suita, Osaka 565 0871, Japan
    Neuroimage 59:4132-40. 2012
    ....
  35. doi request reprint Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia
    Hidetoshi Takahashi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Neurosci Res 62:187-94. 2008
    ..This did not correlate with any clinical variable in each group. Our results indicate that PPI and habituation of ASR are impaired in Asian patients with schizophrenia...
  36. doi request reprint Association between milder brain deformation before a shunt operation and improvement in cognition and gait in idiopathic normal pressure hydrocephalus
    Daisuke Yamamoto
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan
    Dement Geriatr Cogn Disord 35:197-207. 2013
    ..The rate of change of vVS/vHCM was positively correlated with improvement in the WT. The improvements of gait and cognitive function were larger in iNPH patients with milder deformation of the brain before shunt operation...
  37. doi request reprint Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers
    Nuripa Jenishbekovna Aidaralieva
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Hum Genet 53:296-302. 2008
    ..We propose that the DNM2 gene is a novel susceptibility gene for LOAD...
  38. pmc Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 7:e29780. 2012
    ....
  39. doi request reprint Neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus
    Yumiko Kito
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, D3 2 2 Yamadaoka, Suita City, Osaka, Japan
    Behav Neurol 21:165-74. 2009
    ..To clarify the characteristics of neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus (iNPH)...
  40. doi request reprint Protein synthesis in the posterior cingulate cortex in Alzheimer's disease
    Tetsuhiko Yoshida
    Division of Psychiatry, Course of Internal Medicine, Osaka University Graduate School of Medicine, Suita City, Japan
    Psychogeriatrics 11:40-5. 2011
    ..We carried out the present preliminary study to investigate whether a decline of cerebral blood flow (CBF) in the PCC in early to moderate AD was accompanied with that of cerebral protein synthesis (CPS)...
  41. doi request reprint Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects
    Hidetoshi Takahashi
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashicho, Kodaira, Tokyo 1878553, Japan
    Neurosci Res 72:187-93. 2012
    ..Our results suggest that impaired sensorimotor gating, evaluated as lower PPI of ASR, of healthy subjects is correlated with self transcendence, the character which is closely related with schizophrenia and schizotypy...
  42. ncbi request reprint [Validity of the Japanese version of Rivermead Behavioural Memory Test for evaluation of everyday memory function in patients with mild Alzheimer's disease]
    Akemi Matsuda
    Divisions of Neurorehabilitation, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho Ko, Himeji, 670 0981 Hyogo, Japan
    No To Shinkei 54:673-8. 2002
    ..To validate the Japanese version of Rivermead Behavioural Memory Test (RBMT) in evaluating everyday memory function in patients with mild Alzheimer's disease (AD)...
  43. doi request reprint Influence of the NRGN gene on intellectual ability in schizophrenia
    Kazutaka Ohi
    1 Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan 2 Core Research for Evolutionary Science and Technology CREST of Japan Science and Technology Agency JST, Saitama, Japan 3 National Hospital Organization, Yamato Mental Medical Center, Nara, Japan
    J Hum Genet 58:700-5. 2013
    ..Our findings suggest that the genetic risk variant in the neurogranin gene may be related to reduced intellectual ability. ..
  44. doi request reprint Effect of shunt operation on idiopathic normal pressure hydrocephalus patients in reducing caregiver burden: evidence from SINPHONI
    Hiroaki Kazui
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Japan kazui psy med osaka u ac jp
    Dement Geriatr Cogn Disord 31:363-70. 2011
    ..We examined whether they also reduce caregiver burden...
  45. ncbi request reprint Association between cognitive impairment and gait disturbance in patients with idiopathic normal pressure hydrocephalus
    Noriko Miyoshi
    Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, Osaka, Japan
    Dement Geriatr Cogn Disord 20:71-6. 2005
    ..The present results indicate that frontal lobe functions were impaired in patients with iNPH and that cognitive impairment was closely associated with gait disturbance in patients with iNPH...
  46. pmc The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    Behav Brain Funct 9:40. 2013
    ..To date, the role of these SNPs on gray matter (GM) volumes remains unclear...
  47. doi request reprint Possible roles of the dominant uncinate fasciculus in naming objects: a case report of intraoperative electrical stimulation on a patient with a brain tumour
    Keiko Nomura
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita City, Osaka 565 0871, Japan
    Behav Neurol 27:229-34. 2013
    ..The continuous perseveration appears to be due to disturbances in word production and a failure to inhibit an appropriate response. These findings in this case suggest that the dominant UF has multiple roles in the naming of objects. ..
  48. ncbi request reprint [Language and semantic memory impairment in a patient with motor neuron disease and semantic dementia: a case report]
    Yumiko Kito
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Suita Shi, Osaka, Japan
    Brain Nerve 62:625-30. 2010
    ..The characteristics of his language symptoms might be related to the specific pattern of brain hypoperfusion, which might be commonly observed in patients with dementia and MND...
  49. pmc Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer's disease in the mild cognitive impairment stage
    Hiroaki Kazui
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Dement Geriatr Cogn Disord Extra 1:20-30. 2011
    ..These results should help clinicians to distinguish ES combined with AD-aMCI from ES alone...
  50. ncbi request reprint Effect of linearization correction on statistical parametric mapping (SPM): a 99mTc-HMPAO brain perfusion SPECT study in mild Alzheimer's disease
    M Ashik B Ansar
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Japan
    Ann Nucl Med 20:511-7. 2006
    ..We performed 99mTc-HMPAO SPECT in mild AD patients and analyzed the effect of linearization correction for washout of the tracer on the detectability of abnormal perfusion...
  51. doi request reprint Impaired regional hemodynamic response in schizophrenia during multiple prefrontal activation tasks: a two-channel near-infrared spectroscopy study
    Koji Ikezawa
    Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2 2 Yamadaoka, Suita, Osaka, 565 0871 Japan
    Schizophr Res 108:93-103. 2009
    ....
  52. ncbi request reprint [The validation of a Japanese version of the Everyday Memory Checklist]
    Hiroaki Kazui
    Osaka University Graduate School of Medicine, Course of Advanced Medicine, Department of Post Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, D 3 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    No To Shinkei 55:317-25. 2003
    ..to assess everyday memory problems, and examined its reliability and validity in assessing brain-damaged patients with memory deficits...
  53. doi request reprint Association between quality of life of demented patients and professional knowledge of care workers
    Hiroaki Kazui
    Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    J Geriatr Psychiatry Neurol 21:72-8. 2008
    ....
  54. ncbi request reprint Neural basis of fear conditioning induced by video clip: positron emission tomography study
    Talant K Doronbekov
    Division of Psychiatry and Behavioral Proteomics, Department of Post Genomics and Diseases, Course of Advanced Medicine, Osaka University Graduate School of Medicine, 2 2 D3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Psychiatry Clin Neurosci 59:155-62. 2005
    ..Thus, these regions seem to have a critical role in fear conditioning...
  55. ncbi request reprint Accelerated hippocampal atrophy in Alzheimer's disease with apolipoprotein E epsilon4 allele
    Etsuro Mori
    Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
    Ann Neurol 51:209-14. 2002
    ....
  56. doi request reprint Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier
    Takashi Morihara
    Department of Psychiatry, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 111:2638-43. 2014
    ..This unique combination of distinct mouse strains and model mice with transcriptomics is expected to be useful for the study of genetic mechanisms of other complex diseases. ..
  57. ncbi request reprint The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease
    Ryo Kimura
    Department of Psychiatry, Osaka University Graduate School of Medicine, 2 2 D3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Hum Mol Genet 16:15-23. 2007
    ..Our result indicates that DYRK1A could be a key molecule bridging between beta-amyloid production and tau phosphorylation in AD...
  58. ncbi request reprint [Cognitive impairment in patients with idiopathic normal pressure hydrocephalus]
    Hiroaki Kazui
    Division of Psychiatry, Course of Internal Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Brain Nerve 60:225-31. 2008
    ..However, damage of periventricular structures, such as corpus callosum, frontal subcortical and cortical areas, thalamus, basal ganglia and hippocampus, could be associated with cognitive impairment of iNPH...
  59. pmc The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system
    Kanta Yanagida
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    EMBO Mol Med 1:223-35. 2009
    ..Based on these results, we propose the relative level of APL1beta28 in the CSF as a candidate surrogate marker for the relative level of Abeta42 production in the brain...
  60. ncbi request reprint [Validity of the Rivermead Behavioural Memory Test for evaluation of everyday memory function in patients with mild cognitive impairment]
    Hiroaki Kazui
    Nihon Ronen Igakkai Zasshi 41:171-4. 2004
  61. ncbi request reprint Guidelines for management of idiopathic normal pressure hydrocephalus
    Masatsune Ishikawa
    Kitano Hospital, Japan
    Neurol Med Chir (Tokyo) 48:S1-23. 2008
    ..The use of programmable valves at shunt surgeries is recommended. Flowcharts for diagnosis, preoperative assessment, and prevention for complications of shunt surgery are made to promote a wide use of them...
  62. ncbi request reprint One-year change in cerebral glucose metabolism in patients with Alzheimer's disease
    Nobutsugu Hirono
    Department of Psychology, Kobegakuin University, 518 Arise, Ikawadani, Nishi ku, Kobe, 651 2180, Japan
    J Neuropsychiatry Clin Neurosci 16:488-92. 2004
    ..Glucose metabolism in these regions may be a useful measure of the progression of AD and a valid surrogate outcome measure of clinical drug trials...
  63. ncbi request reprint Polymorphism of the regulatory region of the presenilin-2 gene in sporadic Alzheimer's disease: a case-control study
    Wenxiang Quan
    Department of Psychiatry and Neurology, Kobe Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe, and Hyogo Institute of Aging Brain and Cognitive Disorders, Himeji Brain and Heart Center, Japan
    J Neurol Sci 240:71-5. 2006
    ..The purpose of this study was to determine whether Alzheimer's disease is associated with the presenilin-2 gene polymorphism and the apolipoprotein E genotype in an extended case-control study...
  64. ncbi request reprint Frontal-lobe syndrome and psychosis after damage to the brainstem dopaminergic nuclei
    Yoshiyuki Nishio
    Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Neurol Sci 260:271-4. 2007
    ..We suggest that the patient's cognitive and behavioral disturbances were associated with disruption of ascending dopaminergic projections to the frontal-subcortical circuits...