Yukio Kawahara

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. doi request reprint Quantification of adenosine-to-inosine editing of microRNAs using a conventional method
    Yukio Kawahara
    Laboratory of RNA Function, Graduate School of Medicine, Osaka University, Osaka, Japan
    Nat Protoc 7:1426-37. 2012
  2. pmc TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
    Yukio Kawahara
    Laboratory of RNA Function, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 109:3347-52. 2012
  3. ncbi request reprint Underediting of GluR2 mRNA, a neuronal death inducing molecular change in sporadic ALS, does not occur in motor neurons in ALS1 or SBMA
    Yukio Kawahara
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 54:11-4. 2006
  4. ncbi request reprint Glutamate receptors: RNA editing and death of motor neurons
    Yukio Kawahara
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 427:801. 2004
  5. ncbi request reprint Slow and selective death of spinal motor neurons in vivo by intrathecal infusion of kainic acid: implications for AMPA receptor-mediated excitotoxicity in ALS
    Hui Sun
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Neurochem 98:782-91. 2006
  6. ncbi request reprint Low editing efficiency of GluR2 mRNA is associated with a low relative abundance of ADAR2 mRNA in white matter of normal human brain
    Yukio Kawahara
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur J Neurosci 18:23-33. 2003
  7. ncbi request reprint GluR4c, an alternative splicing isoform of GluR4, is abundantly expressed in the adult human brain
    Yukio Kawahara
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
    Brain Res Mol Brain Res 127:150-5. 2004
  8. ncbi request reprint Expression profile of AMPA receptor subunit mRNA in single adult rat brain and spinal cord neurons in situ
    Hui Sun
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 52:228-34. 2005
  9. ncbi request reprint Novel splice variants of human ADAR2 mRNA: skipping of the exon encoding the dsRNA-binding domains, and multiple C-terminal splice sites
    Yukio Kawahara
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gene 363:193-201. 2005
  10. ncbi request reprint [AMPA receptor-mediated neuronal death and amyotrophic lateral sclerosis]
    Takuto Hideyama
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    No To Shinkei 57:585-98. 2005

Collaborators

  • Shin Kwak
  • Kyoko Ito
  • Shoji Tsuji
  • Yoshiki Sawa
  • Tadamitsu Kishimoto
  • Gen Sobue
  • Masashi Aoki
  • Takuto Hideyama
  • Hui Sun
  • Sen Matsumoto
  • Taisuke Nakahama
  • Keiwa Kin
  • Ichiro Kanazawa
  • Issei Komuro
  • Shinsuke Nanto
  • Kishan Kumar Nyati
  • Nam Trung Nguyen
  • Daisaku Nakatani
  • Ichino Chinen
  • Toshimitsu Hamasaki
  • Hamza Hanieh
  • Praveen Kumar Dubey
  • Soyoung Lee
  • David Millrine
  • Barry Ripley
  • Tetsuhisa Kitamura
  • Yasuhiko Sakata
  • Shinichiro Suna
  • Masaya Usami
  • Masahiko Hara
  • Kamal Chowdhury
  • Kei Torikai
  • Yukitoshi Shirakawa
  • Takashi Daimon
  • Satsuki Fukushima
  • Kazuo Shimamura
  • Shigeru Miyagawa
  • Toru Kuratani

Detail Information

Publications17

  1. doi request reprint Quantification of adenosine-to-inosine editing of microRNAs using a conventional method
    Yukio Kawahara
    Laboratory of RNA Function, Graduate School of Medicine, Osaka University, Osaka, Japan
    Nat Protoc 7:1426-37. 2012
    ..Although it is not as precise as the subcloning method, this procedure enables us to study RNA-editing events of many samples...
  2. pmc TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
    Yukio Kawahara
    Laboratory of RNA Function, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 109:3347-52. 2012
    ..These results support a previously uncharacterized role for TDP-43 in posttranscriptional regulation of miRNA expression in both the nucleus and the cytoplasm...
  3. ncbi request reprint Underediting of GluR2 mRNA, a neuronal death inducing molecular change in sporadic ALS, does not occur in motor neurons in ALS1 or SBMA
    Yukio Kawahara
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 54:11-4. 2006
    ..It seems likely that the death cascade is different among the dying motor neurons in sporadic ALS, familial ALS with mutant SOD1 and SBMA...
  4. ncbi request reprint Glutamate receptors: RNA editing and death of motor neurons
    Yukio Kawahara
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 427:801. 2004
    ....
  5. ncbi request reprint Slow and selective death of spinal motor neurons in vivo by intrathecal infusion of kainic acid: implications for AMPA receptor-mediated excitotoxicity in ALS
    Hui Sun
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Neurochem 98:782-91. 2006
    ..e. calcium-permeable) AMPA receptors. This rat model may be useful in investigating ALS etiology...
  6. ncbi request reprint Low editing efficiency of GluR2 mRNA is associated with a low relative abundance of ADAR2 mRNA in white matter of normal human brain
    Yukio Kawahara
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur J Neurosci 18:23-33. 2003
    ..These results suggest that Q/R site of GluRs editing is regulated in a regional, and hence presumably cell-specific, manner and that the GluR2 Q/R site editing is critically regulated by ADAR2 in human brain...
  7. ncbi request reprint GluR4c, an alternative splicing isoform of GluR4, is abundantly expressed in the adult human brain
    Yukio Kawahara
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
    Brain Res Mol Brain Res 127:150-5. 2004
    ..The GluR4 subunit may play a pivotal role in regulating channel properties as well as trafficking of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors in the adult human brain...
  8. ncbi request reprint Expression profile of AMPA receptor subunit mRNA in single adult rat brain and spinal cord neurons in situ
    Hui Sun
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurosci Res 52:228-34. 2005
    ..The unique AMPA receptor expression profile of motoneurons may render them selectively vulnerable to AMPA receptor-mediated excitotoxicity...
  9. ncbi request reprint Novel splice variants of human ADAR2 mRNA: skipping of the exon encoding the dsRNA-binding domains, and multiple C-terminal splice sites
    Yukio Kawahara
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gene 363:193-201. 2005
    ..Among them, variants containing the long C-terminus are translated in human brains in situ, implying that alternative splicing in the 3' UTR of ADAR2 might regulate translational efficiency and mRNA stability in vivo...
  10. ncbi request reprint [AMPA receptor-mediated neuronal death and amyotrophic lateral sclerosis]
    Takuto Hideyama
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    No To Shinkei 57:585-98. 2005
  11. ncbi request reprint Regulation of glutamate receptor RNA editing and ADAR mRNA expression in developing human normal and Down's syndrome brains
    Yukio Kawahara
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
    Brain Res Dev Brain Res 148:151-5. 2004
    ..ADAR2 mRNA was not overexpressed in the brains of Down's syndrome subjects, nor was there any evidence of changes in the RNA editing efficiency of their GluRs...
  12. ncbi request reprint Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosis
    Shin Kwak
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655 Tokyo, Japan
    J Mol Med (Berl) 83:110-20. 2005
    ..The restoration of this enzyme activity in ALS motor neurons may open the novel strategy for specific ALS therapy...
  13. ncbi request reprint [Implications of microRNA dysfunction in the pathogenesis of ALS]
    Yukio Kawahara
    Laboratory of RNA Function, Graduate School of Medicine, Osaka University
    Rinsho Shinkeigaku 50:979-81. 2010
    ..In addition, the identification of TDP-43-regulated microRNAs associated with motor neuron death is expected to further contribute to the development of novel therapeutic strategies for ALS treatment...
  14. doi request reprint Circulating p53-responsive microRNAs are predictive indicators of heart failure after acute myocardial infarction
    Sen Matsumoto
    Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circ Res 113:322-6. 2013
    ..Although various microRNAs have been proposed as diagnostic indicators for AMI, no microRNAs have been established as predictors of ischemic HF that develops after AMI...
  15. pmc Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17-producing T-helper cell differentiation
    Taisuke Nakahama
    Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, and Laboratory of RNA Function, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 110:11964-9. 2013
    ..Our findings reveal a unique mechanism of AHR-dependent TH17 differentiation that depends on the miR-132/212 cluster. ..
  16. pmc Tissue- and plasma-specific MicroRNA signatures for atherosclerotic abdominal aortic aneurysm
    Keiwa Kin
    Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Am Heart Assoc 1:e000745. 2012
    ..However, little is known about microRNAs involved in AAA pathology. This study examined tissue and plasma microRNAs specifically associated with AAA...
  17. ncbi request reprint Human spinal motoneurons express low relative abundance of GluR2 mRNA: an implication for excitotoxicity in ALS
    Yukio Kawahara
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, Japan
    J Neurochem 85:680-9. 2003
    ..However, the low relative abundance of GluR2 might provide spinal motoneurons with conditions that are easily affected by changes of AMPA receptor properties including deficient GluR2 mRNA editing in ALS...