Norifumi Kawada

Summary

Affiliation: Osaka City University
Country: Japan

Publications

  1. ncbi Attenuation of acute and chronic liver injury in rats by iron-deficient diet
    Kohji Otogawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno, Osaka, Japan
    Am J Physiol Regul Integr Comp Physiol 294:R311-20. 2008
  2. ncbi Induction of microRNA-214-5p in human and rodent liver fibrosis
    Masashi Iizuka
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3, Asahimachi, Abeno, Osaka 545 8585, Japan
    Fibrogenesis Tissue Repair 5:12. 2012
  3. ncbi MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis
    Tomohiro Ogawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno, Osaka, Japan
    Gut 61:1600-9. 2012
  4. ncbi Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population
    Yoshio Sumida
    Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan
    BMC Gastroenterol 12:2. 2012
  5. ncbi A case of primary small cell carcinoma of the liver that was treated with chemotherapy
    Hiroyasu Morikawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3, Asahimachi, Abeno, Osaka, 545 8585, Japan
    Hepatol Int 2:500-4. 2008
  6. ncbi Role of oxidative stress and Kupffer cells in hepatic fibrosis
    Norifumi Kawada
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Abeno, Osaka, Japan
    J Gastroenterol Hepatol 22:S85-6. 2007
  7. ncbi Human hepatic stellate cells are resistant to apoptosis: implications for human fibrogenic liver disease
    N Kawada
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Asahimachi, Abeno, Japan
    Gut 55:1073-4. 2006
  8. ncbi Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis
    Kohji Otogawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3, Asahimachi, Abeno, Osaka 545 8585, Japan
    Am J Pathol 170:967-80. 2007
  9. ncbi Herb medicine Inchin-ko-to (TJ-135) regulates PDGF-BB-dependent signaling pathways of hepatic stellate cells in primary culture and attenuates development of liver fibrosis induced by thioacetamide administration in rats
    Yukihiro Imanishi
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno, Osaka 545-8585, Japan
    J Hepatol 41:242-50. 2004
  10. ncbi Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice
    Hiroaki Okuyama
    Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Hepatol 42:117-23. 2005

Detail Information

Publications93

  1. ncbi Attenuation of acute and chronic liver injury in rats by iron-deficient diet
    Kohji Otogawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno, Osaka, Japan
    Am J Physiol Regul Integr Comp Physiol 294:R311-20. 2008
    ..The results obtained in this study support the clinical usefulness of an iron-reduced diet for the improvement of liver disorders induced by chronic hepatitis C and alcoholic/nonalcoholic steatohepatitis...
  2. ncbi Induction of microRNA-214-5p in human and rodent liver fibrosis
    Masashi Iizuka
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3, Asahimachi, Abeno, Osaka 545 8585, Japan
    Fibrogenesis Tissue Repair 5:12. 2012
    ..abstract:..
  3. ncbi MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis
    Tomohiro Ogawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno, Osaka, Japan
    Gut 61:1600-9. 2012
    ..MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer...
  4. ncbi Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population
    Yoshio Sumida
    Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan
    BMC Gastroenterol 12:2. 2012
    ..We validated the performance of FIB4 index in a Japanese cohort with NAFLD...
  5. ncbi A case of primary small cell carcinoma of the liver that was treated with chemotherapy
    Hiroyasu Morikawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3, Asahimachi, Abeno, Osaka, 545 8585, Japan
    Hepatol Int 2:500-4. 2008
    ..We discuss the clinical course and therapy of extra-pulmonary SCC and review the literature of the cases previously reported...
  6. ncbi Role of oxidative stress and Kupffer cells in hepatic fibrosis
    Norifumi Kawada
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Abeno, Osaka, Japan
    J Gastroenterol Hepatol 22:S85-6. 2007
    ..It is speculated that Kupffer cells/macrophages may play an important role in triggering the generation of oxidative stress in this model. Thus, this rabbit model is proposed for use in the molecular analysis of human NASH...
  7. ncbi Human hepatic stellate cells are resistant to apoptosis: implications for human fibrogenic liver disease
    N Kawada
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Asahimachi, Abeno, Japan
    Gut 55:1073-4. 2006
  8. ncbi Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis
    Kohji Otogawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3, Asahimachi, Abeno, Osaka 545 8585, Japan
    Am J Pathol 170:967-80. 2007
    ....
  9. ncbi Herb medicine Inchin-ko-to (TJ-135) regulates PDGF-BB-dependent signaling pathways of hepatic stellate cells in primary culture and attenuates development of liver fibrosis induced by thioacetamide administration in rats
    Yukihiro Imanishi
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno, Osaka 545-8585, Japan
    J Hepatol 41:242-50. 2004
    ..CONCLUSIONS: TJ-135 and emodin regulate PDGF-dependent events in stellate cells and attenuate the development of liver fibrosis. Their clinical use may be beneficial for the therapy of human liver fibrosis...
  10. ncbi Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice
    Hiroaki Okuyama
    Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Hepatol 42:117-23. 2005
    ..CONCLUSIONS: Thioredoxin has a potential to attenuate hepatic fibrosis via suppressing oxidative stress and inhibiting proliferation of stellate cells...
  11. ncbi Apoptosis of T cells in the hepatic fibrotic tissue of the rat: a possible inducing role of hepatic myofibroblast-like cells
    Sawako Kobayashi
    Department of Anatomy, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno Ku, 545 8585, Osaka, Japan
    Cell Tissue Res 311:353-64. 2003
    ....
  12. ncbi Mutational patterns of hepatitis B virus genome and clinical outcomes after emergence of drug-resistant variants during lamivudine therapy: analyses of the polymerase gene and full-length sequences
    Masaru Enomoto
    Department of Hepatology, Osaka City University Medical School, Asahimachi, Abeno Ku, Osaka, Japan
    J Med Virol 79:1664-70. 2007
    ..In conclusion, mutational patterns of HBV DNA at the time of emergence of YMDD variants were apparently unrelated to the clinical outcomes in Japanese patients with chronic hepatitis B during lamivudine therapy...
  13. ncbi Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis
    Kazuki Nakatani
    Department of Anatomy, Graduate School of Medicine, Osaka City University, Japan
    Lab Invest 84:91-101. 2004
    ..These results indicate that Cygb/STAP is a tissue globin uniquely localized in splanchnic fibroblastic cell lineage and may play a role in fibrotic organ disorder...
  14. ncbi Frequent detection of hepatitis B virus DNA in hepatocellular carcinoma of patients with sustained virologic response for hepatitis C virus
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Med Virol 81:1009-14. 2009
    ..Mutation in 'a' determinant of HBsAg was found in three HCC of group A. Occult HBV infection may be one of the most important risk factors in hepatocarcinogenesis of Japanese patients with sustained virologic response...
  15. ncbi A human-type nonalcoholic steatohepatitis model with advanced fibrosis in rabbits
    Tomohiro Ogawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3, Asahimachi, Abeno, Osaka 545 8585, Japan
    Am J Pathol 177:153-65. 2010
    ..Ezetimibe blunted the development of NASH in this model, suggesting its potential clinical usefulness for human steatohepatitis...
  16. ncbi Real-time tissue elastography as a tool for the noninvasive assessment of liver stiffness in patients with chronic hepatitis C
    Hiroyasu Morikawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno, Osaka 545 8585, Japan
    J Gastroenterol 46:350-8. 2011
    ....
  17. ncbi Rho kinase inhibitor Y27632 affects initial heart myofibrillogenesis in cultured chick blastoderm
    Hirokazu Sakata
    Department of Anatomy and Cell Biology, Graduate School of Medicine, Osaka City University, Asahimachi, Osaka, Japan
    Dev Dyn 236:461-72. 2007
    ..These results suggest that ROCK plays a role in the formation of initial heart myofibrillogenesis by means of actin-myosin assembly, and focal adhesion/costamere and cell-cell adhesion...
  18. ncbi Differences in molecular alterations of hepatocellular carcinoma between patients with a sustained virological response and those with hepatitis C virus infection
    Takehiro Hayashi
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Liver Int 29:126-32. 2009
    ..We compared molecular alterations in hepatocellular carcinoma (HCC) between patients with a sustained virological response (SVR) to IFN and patients with HCV...
  19. ncbi Clinical role of FDG-PET for HCC: relationship of glucose metabolic indicator to Japan Integrated Staging (JIS) score
    Etsushi Kawamura
    Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Hepatogastroenterology 55:582-6. 2008
    ....
  20. ncbi [Drug-induced liver injury caused by an herbal medicine, bofu-tsu-sho-san]
    Hiroyuki Motoyama
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan
    Nihon Shokakibyo Gakkai Zasshi 105:1234-9. 2008
    ..The liver biopsy specimen revealed features of acute hepatitis. Physicians should be aware that bofu-tsu-sho-san can cause liver injury, as this drug is commonly used as an over-the-counter medicine...
  21. ncbi Chemiluminescence enzyme immunoassay for monitoring hepatitis C virus core protein during interferon-alpha2b and ribavirin therapy in patients with genotype 1 and high viral loads
    Masaru Enomoto
    Department of Hepatology, Osaka City University Medical School, Osaka, Japan
    J Med Virol 77:77-82. 2005
    ..13 log10/day) than in 13 patients with no response (0.028 log10/day, P = 0.042). The wide linear range of the HCV core protein assay is appropriate for measuring viral loads during therapy with IFN-alpha and ribavirin...
  22. ncbi A randomized pilot trial of oral branched-chain amino acids in early cirrhosis: validation using prognostic markers for pre-liver transplant status
    Etsushi Kawamura
    Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Liver Transpl 15:790-7. 2009
    ..4% (7 of 23 patients) at 3 years, P = 0.043]; only ascites was significant individually. In conclusion, early interventional oral BCAAs might prolong the liver transplant waiting period by preserving hepatic reserve in cirrhosis...
  23. ncbi Lamivudine and IFN-beta sequential therapy in HBe antigen-positive patients with chronic hepatitis B virus genotype C infection
    Masaru Enomoto
    Department of Hepatology, Osaka City University Medical School, Osaka 545 8585, Japan
    J Interferon Cytokine Res 27:201-7. 2007
    ..Patients who were young or who had a favorable virologic response to lamivudine were more likely to have a sustained response...
  24. ncbi Carbenoxolone inhibits DNA synthesis and collagen gene expression in rat hepatic stellate cells in culture
    Naoki Uyama
    Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, 54-Kawaracho, Shogoin, Sakyoku, Kyoto 606-8507, Japan
    J Hepatol 39:749-55. 2003
    ..CONCLUSIONS: Carbenoxolone reduced the DNA synthesis and the expression of collagen alpha1(I) mRNA in activated HSCs independently of its pharmacological action as gap-junction blocker...
  25. ncbi Sulfur-containing amino acids attenuate the development of liver fibrosis in rats through down-regulation of stellate cell activation
    Hiroko Matsui
    Department of Anatomy, Graduate School of Medicine, Osaka City University, Osaka, Japan
    J Hepatol 40:917-25. 2004
    ..Stellate cells were found to express methionine adenosyltransferase 2A. CONCLUSIONS: l-Cysteine and l-methionine regulate the activation of stellate cells. Their oral supply aids the suppression of the progression of liver fibrosis...
  26. ncbi Noninvasive laboratory tests proposed for predicting cirrhosis in patients with chronic hepatitis C are also useful in patients with non-alcoholic steatohepatitis
    Hideki Fujii
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    J Gastroenterol 44:608-14. 2009
    ..We assessed whether noninvasive laboratory tests designed to predict the risk of cirrhosis in patients with chronic hepatitis C virus (HCV) infection could be used in patients with NASH...
  27. ncbi Immunohistochemical detection of Fas and apoptosis in type-1 autoimmune hepatitis
    Shuichi Seki
    Third Department of Internal Medicine, Osaka City University Medical School, 1 4 3 Asahimachi, Abenoku, Osaka 545 8585, Japan
    Hepatogastroenterology 50:1274-7. 2003
    ..The relationship between Fas expression and clinicopathological findings including the occurrence of apoptosis was also investigated...
  28. ncbi Effect of mosapride citrate on gastric emptying in interferon-induced gastroparesis
    Etsushi Kawamura
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Dig Dis Sci 57:1510-6. 2012
    ..Current therapeutic options are limited. We evaluated the efficacy of mosapride for IFN-induced gastroparesis...
  29. ncbi Expression of perilipin and adipophilin in nonalcoholic fatty liver disease; relevance to oxidative injury and hepatocyte ballooning
    Hideki Fujii
    Department of Hepatology, Osaka City University Graduate School of Medicine, Japan
    J Atheroscler Thromb 16:893-901. 2009
    ..We investigated the expressions of perilipin and adipophilin and their relation to inflammation, fibrosis, hepatocellular ballooning, and oxidized phosphatidylcholine (oxPC) localization in human NAFLD...
  30. ncbi Optimal duration of additional therapy after biochemical and virological responses to lamivudine in patients with HBeAg-negative chronic hepatitis B: a randomized trial
    Masaru Enomoto
    Department of Hepatology, Graduate School of Medicine, Osaka City University Medical School, Osaka, Japan
    Hepatol Res 38:954-9. 2008
    ....
  31. ncbi Suppression of type I collagen production by microRNA-29b in cultured human stellate cells
    Tomohiro Ogawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Biochem Biophys Res Commun 391:316-21. 2010
    ..It is anticipated that miR-29b will be used for the regulation of stellate cell activation and lead to antifibrotic therapy...
  32. ncbi Expression of connective tissue growth factor in the human liver with idiopathic portal hypertension
    Hiroyasu Morikawa
    Department of Hepatology, Osaka City University Graduate School of Medicine, Asahimachi, Osaka, Japan
    Mol Med 13:240-5. 2007
    ..Six (8%) of the 76 patients with IPH had serum CTGF levels greater than 80 ng/mL, far exceeding the level of any patient with cirrhosis. In conclusion, overexpression of CTGF is one of the most important features of IPH...
  33. ncbi Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice
    Le Thi Thanh Thuy
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Am J Pathol 179:1050-60. 2011
    ..These results suggest that Cygb deficiency induces susceptibility to cancer development in the liver and lungs of mice exposed to DEN. Thus, globins such as Cygb will shed new light on the biological features of organ carcinogenesis...
  34. ncbi Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet
    Yong ping Mu
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka 545 8585, Japan
    Lab Invest 90:245-56. 2010
    ..ER stress appears and disappears in association with the generation and regression of steatohepatitis, respectively, with fibrosis...
  35. ncbi Close correlation of liver stiffness with collagen deposition and presence of myofibroblasts in non-alcoholic fatty liver disease
    Mami Mori
    Department of Hepatology, Graduate School of Medicine, Osaka City University Central Clinical Laboratory, Osaka City University Medical School Hospital, Osaka, Japan
    Hepatol Res 41:897-903. 2011
    ..390, P = 0.0184) and α-smooth muscle actin-positive area (r = 0.333, P = 0.0471). Conclusions:  Liver stiffness measurement by transient elastography is valuable for evaluating fibrotic progression in NAFLD...
  36. ncbi Does a late evening meal reduce the risk of hepatocellular carcinoma among patients with chronic hepatitis C?
    Satoko Ohfuji
    Department of Public Health, Osaka City University Graduate School of Medicine, Osaka, Japan
    Hepatol Res 38:860-8. 2008
    ..Further studies with larger study sizes are needed to corroborate these findings...
  37. ncbi [Rabbit model for the study of human NASH]
    Kohji Otogawa
    Department of Hepatology, Osaka City University
    Nippon Rinsho 64:1043-7. 2006
    ..Many TUNEL-positive cells were seen in the liver of high fat rabbits. We discuss the usefulness of this model for the molecular analysis of human..
  38. ncbi Usefulness of transient elastography for assessment of liver fibrosis in chronic hepatitis B: Regression of liver stiffness during entecavir therapy
    Masaru Enomoto
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Hepatol Res 40:853-61. 2010
    ..7) to 3.9 (3.2-4.4) ng/mL (P = 0.015), respectively. Conclusion:  Liver stiffness measurement can be useful for monitoring regression of liver fibrosis during entecavir treatment in patients with chronic hepatitis B virus infection...
  39. ncbi Suppression of hepatic stellate cell activation by microRNA-29b
    Yumiko Sekiya
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Biochem Biophys Res Commun 412:74-9. 2011
    ..These results suggested that miR-29b is involved in the activation of HSCs and could be a candidate molecule for suppressing their activation and consequent liver fibrosis...
  40. ncbi Inflammation and fibrogenesis in steatohepatitis
    Hideki Fujii
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3, Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    J Gastroenterol 47:215-25. 2012
    ..Information on the basic pathogenesis of NASH with a focus on the generation of inflammation and fibrosis will be discussed...
  41. ncbi Response-guided therapy for patients with chronic hepatitis who have high viral loads of hepatitis C virus genotype 2
    Yasunori Yamaguchi
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hepatol Res 42:549-57. 2012
    ..Conclusions:  16 weeks of combination therapy could achieve an adequate antiviral effect for RVR patients. Extending therapy could not significantly improve SVR rate in non-RVR patients...
  42. ncbi Rho kinases regulate endothelial invasion and migration during valvuloseptal endocardial cushion tissue formation
    Masahide Sakabe
    Department of Anoatomy, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Dev Dyn 235:94-104. 2006
    ..These results suggest that ROCKs have a critical role in the mesenchymal cell invasion/migration that occurs at the late onset of EMT...
  43. ncbi Effect of S-adenosyl-L-methionine on the activation, proliferation and contraction of hepatic stellate cells
    Hiroko Matsui
    Department of Anatomy, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Eur J Pharmacol 509:31-6. 2005
    ..Thus, SAM regulates the activation of hepatic stellate cells and may clinically contribute to therapy targeted at human liver fibrosis...
  44. ncbi Laparoscopic observation of 2 cases of nodular regenerative hyperplasia of the liver
    Hideki Fujii
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Gastrointest Endosc 65:171-3. 2007
  45. ncbi Emerging antiviral drugs for hepatitis C virus
    Masaru Enomoto
    Department of Hepatology, Osaka City University Medical School, Osaka, Japan
    Rev Recent Clin Trials 4:179-84. 2009
    ..Herein we review recent progress in the development of new treatments under investigation in clinical trials, including specifically targeted antiviral therapy for HCV such as NS3/4A protease and NS5B polymerase inhibitors...
  46. ncbi Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation
    Yumiko Sekiya
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    J Cell Physiol 226:2535-42. 2011
    ..IFN-induced miR-195 was involved in these processes. These observations reveal a new mechanistic aspect of the antifibrotic effect of IFNs in the liver...
  47. ncbi BMP-7 opposes TGF-beta1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2
    Nobuhiro Izumi
    Department of Surgery, Graduate School of Medicine, Osaka City University, Osaka 545 8585, Japan
    Am J Physiol Lung Cell Mol Physiol 290:L120-6. 2006
    ..In conclusion, these data demonstrate that BMP-7 antagonizes the TGF-beta1-dependent fibrogenic activity of mouse pulmonary myofibroblastic cells by inducing Id2 and Id3...
  48. ncbi Prospective study of reactivation of hepatitis B virus in patients with rheumatoid arthritis who received immunosuppressive therapy: evaluation of both HBsAg-positive and HBsAg-negative cohorts
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    J Gastroenterol 46:556-64. 2011
    ..This study also evaluated guidelines for determining HBV reactivation in patients with RA...
  49. ncbi Localization of oxidized phosphatidylcholine in nonalcoholic fatty liver disease: impact on disease progression
    Yoshihiro Ikura
    Department of Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Hepatology 43:506-14. 2006
    ..In conclusion, distinct localization of oxPC in liver tissues suggest that neutrophil myeloperoxidase-derived oxidative stress may be crucial in the formation of oxPC and the progression of steatotic liver disease...
  50. ncbi Changes in sequences of core region, interferon sensitivity-determining region and interferon and ribavirin resistance-determining region of hepatitis C virus genotype 1 during interferon-alpha and ribavirin therapy, and efficacy of retreatment
    Ritsuzo Kozuka
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka Center for the Advancement of Higher Education, Faculty of Engineering, Kinki University, Hiroshima, Japan
    Hepatol Res 42:1157-67. 2012
    ..Conclusion:  Sequences of the core region and ISDR sometimes change during anti-HCV therapy, potentially affecting the outcomes of retreatment...
  51. ncbi Thiopurine S-methyltransferase gene polymorphism in Japanese patients with autoimmune liver diseases
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Liver Int 27:95-100. 2007
    ..We investigated the genotypic status of TPMT to evaluate the risk of azathioprine-related adverse effects in Japanese patients with different liver diseases, including autoimmune hepatitis (AIH)...
  52. ncbi A case of sclerosing cholangitis with autoimmune pancreatitis evaluated by FDG-PET
    Etsushi Kawamura
    Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Ann Nucl Med 21:223-8. 2007
    ....
  53. ncbi Two cases of hepatocellular adenomatosis treated with transcatheter arterial embolization
    Sawako Kobayashi
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3, Asahimachi, Abeno, Osaka, 545 8585, Japan
    Hepatol Int 3:416-20. 2009
    ..After TAE, most parts of the adenomas showed necrotic change. These cases suggest that TAE is an effective treatment of hepatocellular adenomatosis...
  54. ncbi Favorable factors for re-treatment with pegylated interferon α2a plus ribavirin in patients with high viral loads of genotype 1 hepatitis C virus
    Akihiro Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine Department of Hepatology Osaka City General Hospital Department of Gastroenterology and Hepatology, Osaka City Juso Hospital, Osaka Internal Medicine, Izumi Municipal Hospital, Izumi Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hepatol Res 41:1169-77. 2011
    ..Re-treatment is a particularly useful option for patients who achieve early viral clearance during previous therapy...
  55. ncbi Nutritional status in relation to lifestyle in patients with compensated viral cirrhosis
    Fumikazu Hayashi
    Department of Medical Nutrition, Graduate School of Life Science, Osaka City University, Osaka 558 8585, Japan
    World J Gastroenterol 18:5759-70. 2012
    ..To assess the nourishment status and lifestyle of non-hospitalized patients with compensated cirrhosis by using noninvasive methods...
  56. ncbi High prevalence of gastroesophageal reflux symptoms in patients with non-alcoholic fatty liver disease associated with serum levels of triglyceride and cholesterol but not simple visceral obesity
    Yoshiko Fujikawa
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Digestion 86:228-37. 2012
    ..However, other characteristic factors different from visceral obesity are associated with the pathogenesis of NAFLD. We investigated the prevalence of GERD symptoms in patients with NAFLD and its associated risk factors...
  57. ncbi Macrophage scavenger receptor down-regulates mycobacterial cord factor-induced proinflammatory cytokine production by alveolar and hepatic macrophages
    Yuriko Ozeki
    Department of Host Defense, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Microb Pathog 40:171-6. 2006
    ....
  58. ncbi Analysis of proteins dominantly expressed in hepatic stellate cells of activated phenotype
    Norifumi Kawada
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Methods Mol Med 117:371-9. 2005
    ..In addition, this approach led to the discovery of a novel globin in the vertebrate. Thus, proteomics is a research method for comprehensive understanding of the molecular basis of liver fibrosis...
  59. ncbi Inhibition of the activation of hepatic stellate cells by arundic acid via the induction of cytoglobin
    Wenhao Cui
    Department of Hepatology and Liver Research Center, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Biochem Biophys Res Commun 425:642-8. 2012
    ..The activation of hepatic stellate cells plays a central role in the development of liver fibrosis during chronic liver trauma. The aim of the present study was to identify a compound that inhibits the activation process of stellate cells...
  60. ncbi Quantitative detection of hepatitis B surface antigen by chemiluminescent microparticle immunoassay during lamivudine treatment of chronic hepatitis B virus carriers
    Madoka Kohmoto
    Department of Hepatology, Osaka City University Medical School, Abeno-ku, Osaka, Japan
    J Med Virol 75:235-9. 2005
    ....
  61. ncbi Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathways
    Naoto Maeda
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    J Biol Chem 278:18938-44. 2003
    ..Thus, it appears that galectin-1 and galectin-3, generated by activated HSCs, could participate in beta-galactoside binding and induce different intracellular signaling pathways leading to the proliferation of HSCs...
  62. ncbi High prevalence of hepatitis C virus infection in Airin district, Osaka, Japan: A hospital-based study of 1162 patients
    Yasunori Yamaguchi
    Departments of Hepatology Gastroenterology, Graduate School of Medicine, Osaka City University Department of Internal Medicine, Osaka Socio Medical Center Hospital Izumi Municipal Hospital, Izumi, Osaka, Japan
    Hepatol Res 41:731-7. 2011
    ..Patient education and strict action against illegal drug use are indispensable to prevent the spread of HCV infection from the district...
  63. ncbi Induction of tropomyosin during hepatic stellate cell activation and the progression of liver fibrosis
    Kohji Otogawa
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1 4 3, Asahimachi, Abeno, Osaka, 545 8585, Japan
    Hepatol Int 3:378-83. 2009
    ..These results strongly suggest that tropomyosin is a new marker of activated stellate cells and may serve as a useful diagnostic marker of liver fibrosis...
  64. ncbi Establishment and characteristics of human hepatocellular carcinoma cells with metastasis to lymph nodes
    S Seki
    Third Department of Internal Medicine, Osaka City University Medical School, Japan
    Hepatogastroenterology 46:2812-7. 1999
    ..We examined the expression of molecules that mediate cell-cell or cell-substrate interaction, nm23-H1 expression, and ultrastructural features of several human HCC cell lines...
  65. ncbi Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus
    A Tamori
    Department of Hepatology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    J Viral Hepat 17:123-9. 2010
    ..However, the dosing interval of ADV should be adjusted according to renal function and serum phosphate levels in patients receiving long-term treatment...
  66. ncbi In vivo and in vitro interactions between human colon carcinoma cells and hepatic stellate cells
    S Shimizu
    Department of Surgery, Osaka City University Medical School, Abeno Ku, Osaka 545 8585, Japan
    Jpn J Cancer Res 91:1285-95. 2000
    ....
  67. ncbi Expression of cyclins D1, D2 and E correlates with proliferation of rat stellate cells in culture
    N Kawada
    Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    J Hepatol 30:1057-64. 1999
    ..Regulation of cell cycle progression of cultured rat stellate cells was studied...
  68. ncbi In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation
    K Ikeda
    Department of Anatomy, Osaka City University Medical School, Osaka, Japan
    Hepatology 29:1760-7. 1999
    ....
  69. ncbi Regulation of cell growth by redox-mediated extracellular proteolysis of platelet-derived growth factor receptor beta
    H Okuyama
    Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8397, Japan
    J Biol Chem 276:28274-80. 2001
    ..These results indicated that redox processes impact the cell's response to growth factors by regulating the turnover of growth factor receptors and that "redox therapy" is promising for fibrosis-related disease...
  70. ncbi Expression of cellular prion protein in activated hepatic stellate cells
    K Ikeda
    Department of Anatomy, Osaka City University Medical School, Osaka, Japan
    Am J Pathol 153:1695-700. 1998
    ..Immunoelectron microscopy revealed that PrPc resided on the plasma membrane of stellate cells. These results indicate that PrP expression is closely related to stellate cell activation associated with fibrogenic stimuli...
  71. ncbi Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells
    N Kawada
    Department of Hepatology, Graduate School of Medicine, Osaka City University Medical School, Osaka 545 8585, Japan
    J Biol Chem 276:25318-23. 2001
    ..STAP could thus play a role as an antifibrotic scavenger of peroxides in the liver...
  72. ncbi Expression of SPARC by activated hepatic stellate cells and its correlation with the stages of fibrogenesis in human chronic hepatitis
    Kazuki Nakatani
    Department of Anatomy, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Virchows Arch 441:466-74. 2002
    ..The present results indicate that SPARC is expressed by activated HSCs in chronic hepatitis, suggesting the involvement of SPARC in hepatic fibrogenesis after chronic injuries...
  73. ncbi Regulation of cultured rat hepatocyte proliferation by stellate cells
    Naoki Uyama
    Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaracho, Shogoin, Sakyoku, Kyoto 606 8507, Japan
    J Hepatol 36:590-9. 2002
    ..This study using primary culture models was aimed to reveal the stellate cell-derived factors that regulate hepatocyte proliferation...
  74. ncbi Overexpression of thioredoxin prevents acute hepatitis caused by thioacetamide or lipopolysaccharide in mice
    Hiroaki Okuyama
    Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, Japan
    Hepatology 37:1015-25. 2003
    ..In addition to an antioxidant effect, Trx has the potential to protect acute liver injury via an antiapoptotic effect, which mainly inhibits mitochondria-mediated apoptosis signaling...
  75. ncbi Pepstatin A attenuates the inhibitory effect of N-acetyl-L-cysteine on proliferation of hepatic myofibroblasts (stellate cells)
    Tokuko Takashima
    Department of Hepatology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno 545-8585 Osaka, Japan
    Eur J Pharmacol 451:265-70. 2002
    ..These results indicate that pepstatin A hampers the inhibitory effect of N-acetyl-L-cysteine on stellate cell growth by ameliorating growth factor receptor downregulation...
  76. ncbi Regulation by cAMP of STAT1 activation in hepatic stellate cells
    N Kawada
    Department of Internal Medicine, Osaka City University Medical School, Abeno, Osaka, Japan
    Biochem Biophys Res Commun 233:464-9. 1997
    ..The present results indicate that inhibition of STAT1 activation may be one of factors involved in the cAMP-dependent stellate cell growth arrest...
  77. ncbi Development of hepatocellular carcinoma in patients with chronic hepatitis C who had a sustained virological response to interferon therapy: a multicenter, retrospective cohort study of 1124 patients
    S Kobayashi
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Liver Int 27:186-91. 2007
    ..However, HCC develops in some patients who have a sustained virological response (SVR) to IFN therapy. We designed this study to establish a follow-up protocol for patients with CH-C who have SVR to IFN therapy...
  78. ncbi Fluvastatin suppresses oxidative stress and fibrosis in the interstitium of mouse kidneys with unilateral ureteral obstruction
    T Moriyama
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, School of Health and Sport Sciences, Osaka University, Osaka, Japan
    Kidney Int 59:2095-103. 2001
    ..Fluvastatin is an HMG-CoA reductase inhibitor and has been demonstrated to have an antioxidant activity in vitro...
  79. ncbi Regulation of stellate cell proliferation by lipopolysaccharide: role of endogenous nitric oxide
    N Kawada
    Department of Internal Medicine, Osaka City University Medical School, Abeno, Osaka, Japan
    J Gastroenterol Hepatol 13:S6-13. 1998
    ..These results indicate that LPS is potent in modulating stellate cell proliferation by some NO- and cGMP-dependent mechanism...
  80. ncbi The hepatic stellate cell in the post-genomic era
    H Okuyama
    Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, Japan
    Histol Histopathol 17:487-95. 2002
    ..Accumulation of the information on the stellate cell activation would shed light on the establishment of a novel therapeutic strategy against fibrosis of human liver disease...
  81. ncbi Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats
    Kohji Kinoshita
    First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    Gut 56:706-14. 2007
    ..Transforming growth factor-beta (TGFbeta) plays a pivotal role in extracellular matrix production, but bone morphogenetic protein (BMP)-7, a member of the TGFbeta superfamily, can antagonise the fibrogenic activity of TGFbeta...
  82. ncbi Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre/loxP system to antagonise hepatic fibrosis
    Kohji Kinoshita
    First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    Gut 56:396-404. 2007
    ..Activated hepatic stellate cells (HSCs) are an attractive target for antifibrotic therapy based on their key role in extracellular matrix accumulation during liver injury...
  83. ncbi Impaired liver regeneration in mice by lipopolysaccharide via TNF-alpha/kallikrein-mediated activation of latent TGF-beta
    Kuniharu Akita
    First Department of Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Gastroenterology 123:352-64. 2002
    ..CONCLUSIONS: LPS provokes TNF-alpha/PLK-mediated proteolytic activation of latent TGF-beta in hepatic stellate cells, leading to impaired liver regeneration after partial hepatectomy...
  84. ncbi Expression of large tenascin-C splice variants by hepatic stellate cells/myofibroblasts in chronic hepatitis C
    Amro El-Karef
    Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Mie, Japan
    J Hepatol 46:664-73. 2007
    ..Earlier studies have suggested involvement of tenascin-C (TN-C) in liver fibrosis. Here, we examined expression of TN-C variants and types of alternatively spliced fibronectin-type III (FNIII) repeats in chronic hepatitis...
  85. ncbi Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice
    Yutaka Inagaki
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Bohseidai, Isehara 259 1193, Japan
    Hepatology 38:890-9. 2003
    ....
  86. ncbi Typing of hepatic nonparenchymal cells using fibulin-2 and cytoglobin/STAP as liver fibrogenesis-related markers
    Yuko Tateaki
    Laboratory of Developmental Biology, Department of Biological Science, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, 739-8526 Higashihiroshima, Japan
    Histochem Cell Biol 122:41-9. 2004
    ..The present study strongly suggests that Fib(+)/STAP(+) and Fib(-)/STAP(+) NPCs correspond to MFs and activated HSCs, respectively, both of which may contribute to liver fibrogenesis...
  87. ncbi Characterization of vitamin A-storing cells in mouse fibrous kidneys using Cygb/STAP as a marker of activated stellate cells
    Yujiro Kida
    Department of Anatomy II, School of Dental Medicine, Tsurumi University, Yokohama, Japan
    Arch Histol Cytol 70:95-106. 2007
    ....
  88. ncbi Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis
    Yoshiyuki Takahara
    Exploratory and Applied Pharmaceutical Research Department, Pharmaceutical Company, Ajinomoto Co, Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 8681, Japan
    World J Gastroenterol 12:6473-99. 2006
    ..To determine the gene expression profile data for the whole liver during development of dimethylni-trosamine (DMN)-induced hepatic fibrosis...
  89. ncbi Identification of vitamin A-free cells in a stellate cell-enriched fraction of normal rat liver as myofibroblasts
    Tomohiro Ogawa
    Developmental Biology Laboratory, Department of Biological Science, Graduate School of Science, Hiroshima University, 1 3 1 Kagamiyama, Higashihiroshima, Hiroshima, 739 8526, Japan
    Histochem Cell Biol 127:161-74. 2007
    ..In addition, we suggested that the qHSC-enriched fraction included approximately 6% of liver MFs...
  90. ncbi Fatty change in human hepatocellular carcinoma cell lines derived from patients with antibodies to hepatitis C virus
    Shuichi Seki
    Third Department of Internal Medicine, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku, 545-8585 Osaka, Japan
    Hepatogastroenterology 49:340-4. 2002
    ....
  91. ncbi Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice
    Yutaka Inagaki
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Isehara, Japan
    Gastroenterology 129:259-68. 2005
    ..Here we have attempted to suppress hepatic fibrosis by expressing a transforming growth factor beta/Smad antagonist selectively in collagen-producing cells only in the fibrotic liver...
  92. ncbi Characterization of human stellate cell activation-associated protein and its expression in human liver
    Kinji Asahina
    Tissue Regeneration Project, Hiroshima Prefecture Collaboration of Regional Entities for the Advancement of Technological Excellence, Japan Science and Technology Corporation, Japan
    Biochim Biophys Acta 1577:471-5. 2002
    ..Various types of cells including hepatic stellate cells expressed hSTAP mRNA. Recombinant hSTAP was a heme protein with the activity of peroxidase. hSTAP can be used as a marker of quiescent stellate cells in human liver...
  93. ncbi Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect
    Yuval Sheffer
    Institute of Animal Sciences, Volcani Center, P O Box 6, Bet Dagan 50250, Israel
    Mol Cancer Ther 6:570-7. 2007
    ....