Research Topics
Genomes and GenesSpecies
| Shigetada KawabataSummaryAffiliation: Osaka University Country: Japan Publications
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Detail Information
Publications
Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific contentFumito Maruyama
Division of Bacteriology, Department of Infectious Diseases Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
BMC Genomics 10:358. 2009..While the pathogenicity of this species is distinct from other human pathogenic streptococci, the species-specific evolution of the genus Streptococcus and its genomic diversity are poorly understood...
Nucleotide sequence and molecular characterization of a gene encoding GTP-binding protein from Streptococcus gordoniiS Kawabata
Department of Oral Microbiology, Osaka University Faculty of Dentistry, Japan
FEMS Microbiol Lett 156:211-6. 1997..The nucleotide binding assay demonstrated that recombinant Sgg bound [32P]GTP but not [32P]ATP, [32P]CTP, or [32P]UTP. These findings indicate that Sgg is a member of the G protein superfamily in the genus Streptococcus...- A novel, anchorless streptococcal surface protein that binds to human immunoglobulinsShigetada Kawabata
Department of Oral and Molecular Microbiology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, 565 0871, Osaka, Japan
Biochem Biophys Res Commun 296:1329-33. 2002..The sib35 gene was found in all GAS strains examined, but not in oral, group B, C, or G streptococcal strains. These results suggest that Sib35 is a unique immunoglobulin-binding protein in GAS... - Targeted salivary gland immunization with plasmid DNA elicits specific salivary immunoglobulin A and G antibodies and serum immunoglobulin G antibodies in miceS Kawabata
Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
Infect Immun 67:5863-8. 1999..These results indicate that TSG immunization with plasmid DNA may represent a genetic immunization strategy against infection by oral and pharyngeal pathogens that may invade local, mucosal surfaces... - Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in miceS Kawabata
Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
Infect Immun 69:924-30. 2001..pyogenes than did nonimmunized mice (P < 0.001). These results indicate that FBP54 is a promising vaccine for the prevention of S. pyogenes infections... - The Streptococcus pyogenes capsule is required for adhesion of bacteria to virus-infected alveolar epithelial cells and lethal bacterial-viral superinfectionShigefumi Okamoto
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
Infect Immun 72:6068-75. 2004..These results suggest that the capsule plays a key role in the invasion of host tissues by GAS following superinfection with IAV and GAS... 
Biofilm formation or internalization into epithelial cells enable Streptococcus pyogenes to evade antibiotic eradication in patients with pharyngitisTaiji Ogawa
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
Microb Pathog 51:58-68. 2011..These findings suggest that S. pyogenes isolated from patients with recurrent streptococcal pharyngitis have emm type-specific features that allow escape from eradication by antibiotics...- Involvement of T6 pili in biofilm formation by serotype M6 Streptococcus pyogenesKeiji Richard Kimura
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
J Bacteriol 194:804-12. 2012..Taken together, our results show the potential role of FCT type 1 pili in the pathogenesis of GAS infections... - Molecular and biological characterization of histidine triad protein in group A streptococciEiji Kunitomo
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
Microbes Infect 10:414-23. 2008..These results indicate that the novel histidine triad protein HtpA is a candidate vaccine for GAS infection... - Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formationNobuo Okahashi
Department of Oral Frontier Biology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
Microb Pathog 50:148-54. 2011..These results indicate that pilus proteins are members of saliva-binding proteins of oral S. sanguinis, and suggest the involvement of pili in its colonization on saliva-coated tooth surfaces and in the human oral cavity... - PfbA, a novel plasmin- and fibronectin-binding protein of Streptococcus pneumoniae, contributes to fibronectin-dependent adhesion and antiphagocytosisMasaya Yamaguchi
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
J Biol Chem 283:36272-9. 2008..These results suggest that PfbA is an important factor in the development of pneumococcal infections... - Systemic immunization with streptococcal immunoglobulin-binding protein Sib 35 induces protective immunity against group: a Streptococcus challenge in miceShigefumi Okamoto
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1-8 Yamada-oka, Suita-Osaka 565-0871, Japan
Vaccine 23:4852-9. 2005..Immunization with Sib 35 enhanced survival rates in mice challenged with a GAS strain, while exhibiting no toxicity in hosts. We conclude that Sib 35 is a promising vaccine for prevention of GAS infections... - Protective immunity against Streptococcus pyogenes challenge in mice after immunization with fibronectin-binding proteinYutaka Terao
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Japan
J Infect Dis 192:2081-91. 2005..CONCLUSION: The Fn-binding RD and N terminus of FbaA are potential vaccine candidates for M1 strains of S. pyogenes infection... - Streptococcus pyogenes infection induces septic arthritis with increased production of the receptor activator of the NF-kappaB ligandAtsuo Sakurai
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
Infect Immun 71:6019-26. 2003..These results suggest that GAS can colonize in the joints and induce bacterial arthritis. Local RANKL production in the infected joints may be involved in bone destruction... - Group A streptococcus adheres to pharyngeal epithelial cells with salivary proline-rich proteins via GrpE chaperone proteinJumpei Murakami
Division of Special Care Dentistry, Osaka University Graduate School of Dentistry, Suita, Osaka, 565 0871, Japan
J Biol Chem 287:22266-75. 2012.... - Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunityYutaka Terao
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
J Biol Chem 283:6253-60. 2008..This suggests that SpeB contributes to the escape of S. pyogenes from phagocytosis at the site of initial infection, allowing it to invade host tissues during severe infections... - Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolutionIchiro Nakagawa
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka 565 0871, Japan
Genome Res 13:1042-55. 2003.... - Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patientsYutaka Terao
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka 565 0871, Japan
J Biol Chem 277:47428-35. 2002..Moreover, mortality was decreased in mice infected with the mutant strain in comparison to the wild type. These data suggest that FbaB is etiologically involved in the development of invasive streptococcal diseases... - Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza Streptococcus pyogenes superinfectionShigefumi Okamoto
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1-8 Yamada-oka Suita, 565-0871, Japan
Vaccine 22:2887-93. 2004..These findings suggest that formalin-inactivated IAV vaccine may be useful for prevention of secondary bacterial infections following prior IAV exposure... - Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesionNobuo Okahashi
Department of Oral Frontier Biology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
Biochem Biophys Res Commun 391:1192-6. 2010..In addition, ATCC10556, a standard S. sanguinis strain, was unable to produce pili due to defective pilus genes, which indicates a diversity of pilus expression among various S. sanguinis strains... - Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cellsYutaka Terao
Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
Infect Immun 70:993-7. 2002..pyogenes M types. An Lbp-deficient mutant showed a significantly lower efficiency of adhesion to HEp-2 cells than did the wild-type strain. These results indicate that Lbp is one of the important S. pyogenes adhesins... - Nrc of Streptococcus pneumoniae suppresses capsule expression and enhances anti-phagocytosisMasaya Yamaguchi
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
Biochem Biophys Res Commun 390:155-60. 2009..These results suggest that Spd0729 is not a cytolysin, though it plays crucial roles in anti-phagocytosis and regulation of capsule expression. Thus, we named Spd0729 as a negative regulator of capsular polysaccharide synthesis (Nrc)... - Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domainsYuki Itsuki
Department of Pharmacology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
FEBS Lett 582:2365-70. 2008..These results raise the possibility that RPAP3, together with Monad, may function as a novel modulator of apoptosis pathway... - [Virulence factors in Streptococcus pyogenes infection]Shigetada Kawabata
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka
Nippon Saikingaku Zasshi 60:365-74. 2005 - Role of Streptococcus sanguinis sortase A in bacterial colonizationMasaya Yamaguchi
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita-shi, Osaka-Fu 565-0871, Japan
Microbes Infect 8:2791-6. 2006..Furthermore, they demonstrate that SrtA of S. sanguinis plays important roles in bacterial colonization... - α-Enolase of Streptococcus pneumoniae induces formation of neutrophil extracellular trapsYuka Mori
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, 565 0871, Japan
J Biol Chem 287:10472-81. 2012..Furthermore, we found that myoblast antigen 24.1D5, which expressed on the surface of neutrophils, bound to α-enolase of S. pneumoniae... - Assembly mechanism of FCT region type 1 pili in serotype M6 Streptococcus pyogenesMasanobu Nakata
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka, 565 0871, Japan
J Biol Chem 286:37566-77. 2011.... - S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cellsTomoko Sumitomo
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan
J Med Microbiol 61:101-8. 2012..These results indicate S-CMC as a probable inhibitor targeting numerous epithelial receptors that interact with S. pneumoniae... - Infection by Streptococcus pyogenes induces the receptor activator of NF-kappaB ligand expression in mouse osteoblastic cellsNobuo Okahashi
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Japan
Infect Immun 71:948-55. 2003..These results suggest that infection of osteoblasts by S. pyogenes stimulates RANKL production and may trigger bone destruction in infected bone tissue... - Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cellsIchiro Nakagawa
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka, Japan
Cell Microbiol 6:939-52. 2004.... - Streptolysin S contributes to group A streptococcal translocation across an epithelial barrierTomoko Sumitomo
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
J Biol Chem 286:2750-61. 2011..Our data indicate a potential function of SLS that facilitates GAS invasion into deeper tissues via degradation of epithelial intercellular junctions in concert with the host cysteine protease calpain... - Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophilsYutaka Terao
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
J Biol Chem 281:14215-23. 2006..Together, these results indicate that the multifunctional protein Plr/SDH/GAPDH has additional functions that help S. pyogenes escape detection by the host immune system... - Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitisTaiji Ogawa
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
FEMS Microbiol Lett 318:143-51. 2011..Moreover, the present S. pyogenes organisms were less susceptible to antibiotics, which raises caution about their appropriate use in clinical practice... - Long-term survival of salivary streptococci on dental devices made of ethylene vinyl acetateTaiji Ogawa
Department of Prosthodontics, Osaka University Graduate School of Dentistry, Osaka, Japan
Int J Oral Sci 4:14-8. 2012..For effective hygienic storage of dental devices made of EVA, washing with sterilized water is important to remove absorbed salivary compounds along with storage in a ventilated environment... - Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cellsIchiro Nakagawa
Department of Oral Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
Infect Immun 70:277-85. 2002..These results suggest that type II FimA can bind to epithelial cells most efficiently through specific host receptors... - Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in miceShigefumi Okamoto
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita-Osaka, Japan
J Virol 77:4104-12. 2003..Our results indicate that prior infection with influenza A virus induces a lethal synergism, resulting in the induction of invasive S. pyogenes infection in mice... - MicroRNA fragments derived from Streptococcus pyogenes enable activation of neutrophil phagocytosis: in vitro studyTaiji Ogawa
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8, Yamadaoka, Suita, Osaka 565 0871, Japan
Microbes Infect 15:212-8. 2013..In conclusion, microRNA fragments derived from S. pyogenes have a high homology to the human genome and contribute to enhancement of the host immune system... - [Genetic analysis and virulence factors of group A streptococci that cause severe invasive infectious diseases]Shigeyuki Hamada
Tanpakushitsu Kakusan Koso 50:253-61. 2005 - Infection and pathogenesis of a murine strain of Escherichia coli with genetically introduced Shiga toxin type I operon in conventional miceIchiro Nakagawa
Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka, 565 0871, Japan
Microb Pathog 33:63-72. 2002..These results suggest that E. coli BME/Stx1 can colonize the mouse intestine under natural environment, and induced systemic neural changes and inflammation in the intestine and kidneys... - Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturationMakio Saeki
Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Osaka 565 0871, Japan
J Biol Chem 282:11786-94. 2007..These results suggest that calcineurin B potentiates the activation of procaspase-3 by accelerating its proteolytic maturation... - Proapoptotic effect of proteolytic activation of matrix metalloproteinases by Streptococcus pyogenes thiol proteinase (Streptococcus pyrogenic exotoxin B)Fumio Tamura
Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Infect Immun 72:4836-47. 2004..pyogenes infection. These results suggest that SpeB or SpeB-activated MMPs contribute to tissue damage and streptococcal invasion in the host via extracellular release of TNF-alpha and sFasL... - Silkworm pathogenic bacteria infection model for identification of novel virulence genesChikara Kaito
Graduate School of Pharmaceutical Sciences, University of Tokyo, 3 1, 7 chome, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Mol Microbiol 56:934-44. 2005..S. pyogenes cvfA-disrupted mutants produced less exotoxin and had attenuated virulence in both silkworms and mice. These results indicate that the silkworm-infection model is useful for identifying bacterial virulence genes... - The Streptococcus pyogenes serotype M49 Nra-Ralp3 transcriptional regulatory network and its control of virulence factor expression from the novel eno ralp3 epf sagA pathogenicity regionBernd Kreikemeyer
Department of Medical Microbiology and Hospital Hygiene, University Hospital, Schillingallee 70, D 18057 Rostock, Germany
Infect Immun 75:5698-710. 2007..All of these regions are transcriptionally linked, adding another level of complexity to the known GAS growth phase-dependent regulatory network... - Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse B lymphocytesShigefumi Okamoto
Laboratory of Virology and Vaccinology, National Institute of Biomedical Innovation, Ibaraki Osaka, Japan
FEMS Microbiol Lett 281:73-80. 2008..Furthermore, Sib35 induced the differentiation of B cells to immunoglobulin-producing plasma cells and B cell line proliferation. These results suggest that Sib35 functions as a streptococcal mitogen of mouse B cells...