Shigetada Kawabata

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content
    Fumito Maruyama
    Division of Bacteriology, Department of Infectious Diseases Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    BMC Genomics 10:358. 2009
  2. ncbi request reprint Nucleotide sequence and molecular characterization of a gene encoding GTP-binding protein from Streptococcus gordonii
    S Kawabata
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Japan
    FEMS Microbiol Lett 156:211-6. 1997
  3. ncbi request reprint A novel, anchorless streptococcal surface protein that binds to human immunoglobulins
    Shigetada Kawabata
    Department of Oral and Molecular Microbiology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Biochem Biophys Res Commun 296:1329-33. 2002
  4. pmc Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in mice
    S Kawabata
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
    Infect Immun 69:924-30. 2001
  5. pmc Targeted salivary gland immunization with plasmid DNA elicits specific salivary immunoglobulin A and G antibodies and serum immunoglobulin G antibodies in mice
    S Kawabata
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
    Infect Immun 67:5863-8. 1999
  6. doi request reprint Biofilm formation or internalization into epithelial cells enable Streptococcus pyogenes to evade antibiotic eradication in patients with pharyngitis
    Taiji Ogawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Microb Pathog 51:58-68. 2011
  7. pmc The Streptococcus pyogenes capsule is required for adhesion of bacteria to virus-infected alveolar epithelial cells and lethal bacterial-viral superinfection
    Shigefumi Okamoto
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    Infect Immun 72:6068-75. 2004
  8. pmc Involvement of T6 pili in biofilm formation by serotype M6 Streptococcus pyogenes
    Keiji Richard Kimura
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Bacteriol 194:804-12. 2012
  9. doi request reprint Molecular and biological characterization of histidine triad protein in group A streptococci
    Eiji Kunitomo
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Microbes Infect 10:414-23. 2008
  10. doi request reprint Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation
    Nobuo Okahashi
    Department of Oral Frontier Biology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Microb Pathog 50:148-54. 2011

Collaborators

Detail Information

Publications46

  1. pmc Comparative genomic analyses of Streptococcus mutans provide insights into chromosomal shuffling and species-specific content
    Fumito Maruyama
    Division of Bacteriology, Department of Infectious Diseases Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    BMC Genomics 10:358. 2009
    ..While the pathogenicity of this species is distinct from other human pathogenic streptococci, the species-specific evolution of the genus Streptococcus and its genomic diversity are poorly understood...
  2. ncbi request reprint Nucleotide sequence and molecular characterization of a gene encoding GTP-binding protein from Streptococcus gordonii
    S Kawabata
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Japan
    FEMS Microbiol Lett 156:211-6. 1997
    ..The nucleotide binding assay demonstrated that recombinant Sgg bound [32P]GTP but not [32P]ATP, [32P]CTP, or [32P]UTP. These findings indicate that Sgg is a member of the G protein superfamily in the genus Streptococcus...
  3. ncbi request reprint A novel, anchorless streptococcal surface protein that binds to human immunoglobulins
    Shigetada Kawabata
    Department of Oral and Molecular Microbiology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Biochem Biophys Res Commun 296:1329-33. 2002
    ..The sib35 gene was found in all GAS strains examined, but not in oral, group B, C, or G streptococcal strains. These results suggest that Sib35 is a unique immunoglobulin-binding protein in GAS...
  4. pmc Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in mice
    S Kawabata
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
    Infect Immun 69:924-30. 2001
    ..pyogenes than did nonimmunized mice (P < 0.001). These results indicate that FBP54 is a promising vaccine for the prevention of S. pyogenes infections...
  5. pmc Targeted salivary gland immunization with plasmid DNA elicits specific salivary immunoglobulin A and G antibodies and serum immunoglobulin G antibodies in mice
    S Kawabata
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
    Infect Immun 67:5863-8. 1999
    ..These results indicate that TSG immunization with plasmid DNA may represent a genetic immunization strategy against infection by oral and pharyngeal pathogens that may invade local, mucosal surfaces...
  6. doi request reprint Biofilm formation or internalization into epithelial cells enable Streptococcus pyogenes to evade antibiotic eradication in patients with pharyngitis
    Taiji Ogawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Microb Pathog 51:58-68. 2011
    ..These findings suggest that S. pyogenes isolated from patients with recurrent streptococcal pharyngitis have emm type-specific features that allow escape from eradication by antibiotics...
  7. pmc The Streptococcus pyogenes capsule is required for adhesion of bacteria to virus-infected alveolar epithelial cells and lethal bacterial-viral superinfection
    Shigefumi Okamoto
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    Infect Immun 72:6068-75. 2004
    ..These results suggest that the capsule plays a key role in the invasion of host tissues by GAS following superinfection with IAV and GAS...
  8. pmc Involvement of T6 pili in biofilm formation by serotype M6 Streptococcus pyogenes
    Keiji Richard Kimura
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Bacteriol 194:804-12. 2012
    ..Taken together, our results show the potential role of FCT type 1 pili in the pathogenesis of GAS infections...
  9. doi request reprint Molecular and biological characterization of histidine triad protein in group A streptococci
    Eiji Kunitomo
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Microbes Infect 10:414-23. 2008
    ..These results indicate that the novel histidine triad protein HtpA is a candidate vaccine for GAS infection...
  10. doi request reprint Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation
    Nobuo Okahashi
    Department of Oral Frontier Biology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Microb Pathog 50:148-54. 2011
    ..These results indicate that pilus proteins are members of saliva-binding proteins of oral S. sanguinis, and suggest the involvement of pili in its colonization on saliva-coated tooth surfaces and in the human oral cavity...
  11. pmc Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation
    Tomoko Sumitomo
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, 565 0871, Japan
    J Biol Chem 288:13317-24. 2013
    ..Group A Streptococcus (GAS) translocates across the host epithelial barrier...
  12. pmc Streptococcus pyogenes infection induces septic arthritis with increased production of the receptor activator of the NF-kappaB ligand
    Atsuo Sakurai
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Infect Immun 71:6019-26. 2003
    ..These results suggest that GAS can colonize in the joints and induce bacterial arthritis. Local RANKL production in the infected joints may be involved in bone destruction...
  13. ncbi request reprint Systemic immunization with streptococcal immunoglobulin-binding protein Sib 35 induces protective immunity against group: a Streptococcus challenge in mice
    Shigefumi Okamoto
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamada oka, Suita Osaka 565 0871, Japan
    Vaccine 23:4852-9. 2005
    ..Immunization with Sib 35 enhanced survival rates in mice challenged with a GAS strain, while exhibiting no toxicity in hosts. We conclude that Sib 35 is a promising vaccine for prevention of GAS infections...
  14. ncbi request reprint Protective immunity against Streptococcus pyogenes challenge in mice after immunization with fibronectin-binding protein
    Yutaka Terao
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Japan
    J Infect Dis 192:2081-91. 2005
    ..We examined the functional domain and protective antigenicity of the Fn-binding protein FbaA...
  15. pmc PfbA, a novel plasmin- and fibronectin-binding protein of Streptococcus pneumoniae, contributes to fibronectin-dependent adhesion and antiphagocytosis
    Masaya Yamaguchi
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
    J Biol Chem 283:36272-9. 2008
    ..These results suggest that PfbA is an important factor in the development of pneumococcal infections...
  16. pmc Cysteine proteinase from Streptococcus pyogenes enables evasion of innate immunity via degradation of complement factors
    Mariko Honda-Ogawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 288:15854-64. 2013
    ..These results suggest that SpeB can interrupt the human complement system via degrading the C1-INH, thus enabling S. pyogenes to evade eradication in a hostile environment...
  17. pmc Group A streptococcus adheres to pharyngeal epithelial cells with salivary proline-rich proteins via GrpE chaperone protein
    Jumpei Murakami
    Division of Special Care Dentistry, Osaka University Graduate School of Dentistry, Suita, Osaka, 565 0871, Japan
    J Biol Chem 287:22266-75. 2012
    ....
  18. ncbi request reprint Vaccination with formalin-inactivated influenza vaccine protects mice against lethal influenza Streptococcus pyogenes superinfection
    Shigefumi Okamoto
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamada oka Suita, 565 0871, Japan
    Vaccine 22:2887-93. 2004
    ..These findings suggest that formalin-inactivated IAV vaccine may be useful for prevention of secondary bacterial infections following prior IAV exposure...
  19. ncbi request reprint Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patients
    Yutaka Terao
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka 565 0871, Japan
    J Biol Chem 277:47428-35. 2002
    ..Moreover, mortality was decreased in mice infected with the mutant strain in comparison to the wild type. These data suggest that FbaB is etiologically involved in the development of invasive streptococcal diseases...
  20. pmc Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution
    Ichiro Nakagawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka 565 0871, Japan
    Genome Res 13:1042-55. 2003
    ....
  21. ncbi request reprint Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity
    Yutaka Terao
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Biol Chem 283:6253-60. 2008
    ..This suggests that SpeB contributes to the escape of S. pyogenes from phagocytosis at the site of initial infection, allowing it to invade host tissues during severe infections...
  22. doi request reprint Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion
    Nobuo Okahashi
    Department of Oral Frontier Biology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Biochem Biophys Res Commun 391:1192-6. 2010
    ..In addition, ATCC10556, a standard S. sanguinis strain, was unable to produce pili due to defective pilus genes, which indicates a diversity of pilus expression among various S. sanguinis strains...
  23. doi request reprint Nrc of Streptococcus pneumoniae suppresses capsule expression and enhances anti-phagocytosis
    Masaya Yamaguchi
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 390:155-60. 2009
    ..These results suggest that Spd0729 is not a cytolysin, though it plays crucial roles in anti-phagocytosis and regulation of capsule expression. Thus, we named Spd0729 as a negative regulator of capsular polysaccharide synthesis (Nrc)...
  24. pmc Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells
    Yutaka Terao
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
    Infect Immun 70:993-7. 2002
    ..pyogenes M types. An Lbp-deficient mutant showed a significantly lower efficiency of adhesion to HEp-2 cells than did the wild-type strain. These results indicate that Lbp is one of the important S. pyogenes adhesins...
  25. doi request reprint Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains
    Yuki Itsuki
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    FEBS Lett 582:2365-70. 2008
    ..These results raise the possibility that RPAP3, together with Monad, may function as a novel modulator of apoptosis pathway...
  26. ncbi request reprint Role of Streptococcus sanguinis sortase A in bacterial colonization
    Masaya Yamaguchi
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita Shi, Osaka fu 565 0871, Japan
    Microbes Infect 8:2791-6. 2006
    ..Furthermore, they demonstrate that SrtA of S. sanguinis plays important roles in bacterial colonization...
  27. ncbi request reprint [Virulence factors in Streptococcus pyogenes infection]
    Shigetada Kawabata
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka
    Nihon Saikingaku Zasshi 60:365-74. 2005
  28. pmc α-Enolase of Streptococcus pneumoniae induces formation of neutrophil extracellular traps
    Yuka Mori
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, 565 0871, Japan
    J Biol Chem 287:10472-81. 2012
    ..Furthermore, we found that myoblast antigen 24.1D5, which expressed on the surface of neutrophils, bound to α-enolase of S. pneumoniae...
  29. pmc Assembly mechanism of FCT region type 1 pili in serotype M6 Streptococcus pyogenes
    Masanobu Nakata
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka, 565 0871, Japan
    J Biol Chem 286:37566-77. 2011
    ....
  30. doi request reprint S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells
    Tomoko Sumitomo
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Med Microbiol 61:101-8. 2012
    ..These results indicate S-CMC as a probable inhibitor targeting numerous epithelial receptors that interact with S. pneumoniae...
  31. pmc Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier
    Tomoko Sumitomo
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 286:2750-61. 2011
    ..Our data indicate a potential function of SLS that facilitates GAS invasion into deeper tissues via degradation of epithelial intercellular junctions in concert with the host cysteine protease calpain...
  32. pmc Infection by Streptococcus pyogenes induces the receptor activator of NF-kappaB ligand expression in mouse osteoblastic cells
    Nobuo Okahashi
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Japan
    Infect Immun 71:948-55. 2003
    ..These results suggest that infection of osteoblasts by S. pyogenes stimulates RANKL production and may trigger bone destruction in infected bone tissue...
  33. ncbi request reprint Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells
    Ichiro Nakagawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka, Japan
    Cell Microbiol 6:939-52. 2004
    ....
  34. doi request reprint Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis
    Taiji Ogawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    FEMS Microbiol Lett 318:143-51. 2011
    ..Moreover, the present S. pyogenes organisms were less susceptible to antibiotics, which raises caution about their appropriate use in clinical practice...
  35. ncbi request reprint Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils
    Yutaka Terao
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:14215-23. 2006
    ..Together, these results indicate that the multifunctional protein Plr/SDH/GAPDH has additional functions that help S. pyogenes escape detection by the host immune system...
  36. pmc Long-term survival of salivary streptococci on dental devices made of ethylene vinyl acetate
    Taiji Ogawa
    Department of Prosthodontics, Osaka University Graduate School of Dentistry, Osaka, Japan
    Int J Oral Sci 4:14-8. 2012
    ..For effective hygienic storage of dental devices made of EVA, washing with sterilized water is important to remove absorbed salivary compounds along with storage in a ventilated environment...
  37. pmc Influenza A virus-infected hosts boost an invasive type of Streptococcus pyogenes infection in mice
    Shigefumi Okamoto
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Virol 77:4104-12. 2003
    ..Our results indicate that prior infection with influenza A virus induces a lethal synergism, resulting in the induction of invasive S. pyogenes infection in mice...
  38. pmc Functional differences among FimA variants of Porphyromonas gingivalis and their effects on adhesion to and invasion of human epithelial cells
    Ichiro Nakagawa
    Department of Oral Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Infect Immun 70:277-85. 2002
    ..These results suggest that type II FimA can bind to epithelial cells most efficiently through specific host receptors...
  39. doi request reprint MicroRNA fragments derived from Streptococcus pyogenes enable activation of neutrophil phagocytosis: in vitro study
    Taiji Ogawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8, Yamadaoka, Suita, Osaka 565 0871, Japan
    Microbes Infect 15:212-8. 2013
    ..In conclusion, microRNA fragments derived from S. pyogenes have a high homology to the human genome and contribute to enhancement of the host immune system...
  40. ncbi request reprint [Genetic analysis and virulence factors of group A streptococci that cause severe invasive infectious diseases]
    Shigeyuki Hamada
    Tanpakushitsu Kakusan Koso 50:253-61. 2005
  41. ncbi request reprint Infection and pathogenesis of a murine strain of Escherichia coli with genetically introduced Shiga toxin type I operon in conventional mice
    Ichiro Nakagawa
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka, 565 0871, Japan
    Microb Pathog 33:63-72. 2002
    ..These results suggest that E. coli BME/Stx1 can colonize the mouse intestine under natural environment, and induced systemic neural changes and inflammation in the intestine and kidneys...
  42. ncbi request reprint Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation
    Makio Saeki
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 282:11786-94. 2007
    ..These results suggest that calcineurin B potentiates the activation of procaspase-3 by accelerating its proteolytic maturation...
  43. pmc Proapoptotic effect of proteolytic activation of matrix metalloproteinases by Streptococcus pyogenes thiol proteinase (Streptococcus pyrogenic exotoxin B)
    Fumio Tamura
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Infect Immun 72:4836-47. 2004
    ..pyogenes infection. These results suggest that SpeB or SpeB-activated MMPs contribute to tissue damage and streptococcal invasion in the host via extracellular release of TNF-alpha and sFasL...
  44. ncbi request reprint Silkworm pathogenic bacteria infection model for identification of novel virulence genes
    Chikara Kaito
    Graduate School of Pharmaceutical Sciences, University of Tokyo, 3 1, 7 chome, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Microbiol 56:934-44. 2005
    ..S. pyogenes cvfA-disrupted mutants produced less exotoxin and had attenuated virulence in both silkworms and mice. These results indicate that the silkworm-infection model is useful for identifying bacterial virulence genes...
  45. pmc The Streptococcus pyogenes serotype M49 Nra-Ralp3 transcriptional regulatory network and its control of virulence factor expression from the novel eno ralp3 epf sagA pathogenicity region
    Bernd Kreikemeyer
    Department of Medical Microbiology and Hospital Hygiene, University Hospital, Schillingallee 70, D 18057 Rostock, Germany
    Infect Immun 75:5698-710. 2007
    ..All of these regions are transcriptionally linked, adding another level of complexity to the known GAS growth phase-dependent regulatory network...
  46. doi request reprint Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse B lymphocytes
    Shigefumi Okamoto
    Laboratory of Virology and Vaccinology, National Institute of Biomedical Innovation, Ibaraki Osaka, Japan
    FEMS Microbiol Lett 281:73-80. 2008
    ..Furthermore, Sib35 induced the differentiation of B cells to immunoglobulin-producing plasma cells and B cell line proliferation. These results suggest that Sib35 functions as a streptococcal mitogen of mouse B cells...