Taiichi Katayama

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death
    Junichi Hitomi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Cell Biol 165:347-56. 2004
  2. ncbi request reprint Induction of neuronal death by ER stress in Alzheimer's disease
    Taiichi Katayama
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka, University, Suita, Osaka 565 0871, Japan
    J Chem Neuroanat 28:67-78. 2004
  3. ncbi request reprint Role of ARF4L in recycling between endosomes and the plasma membrane
    Taiichi Katayama
    Department of Anatony and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Cell Mol Neurobiol 24:137-47. 2004
  4. pmc Dysbindin regulates the transcriptional level of myristoylated alanine-rich protein kinase C substrate via the interaction with NF-YB in mice brain
    Hiroaki Okuda
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    PLoS ONE 5:e8773. 2010
  5. ncbi request reprint HMGA1a: sequence-specific RNA-binding factor causing sporadic Alzheimer's disease-linked exon skipping of presenilin-2 pre-mRNA
    Takayuki Manabe
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Genes Cells 12:1179-91. 2007
  6. doi request reprint Familial amyotrophic lateral sclerosis (FALS)-linked SOD1 mutation accelerates neuronal cell death by activating cleavage of caspase-4 under ER stress in an in vitro model of FALS
    Yoshihisa Koyama
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Neurochem Int 57:838-43. 2010
  7. pmc TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression
    Hironori Takamura
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan
    PLoS ONE 7:e51912. 2012
  8. doi request reprint Induction of amyloid beta accumulation by ER calcium disruption and resultant upregulation of angiogenic factors in ARPE19 cells
    Yoshihisa Koyama
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Invest Ophthalmol Vis Sci 49:2376-83. 2008
  9. ncbi request reprint Novel function of PS2V: change in conformation of tau proteins
    Atsuko Nishikawa
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka, Japan
    Biochem Biophys Res Commun 318:435-8. 2004
  10. ncbi request reprint Metals accelerate production of the aberrant splicing isoform of the presenilin-2
    Shinsuke Matsuzaki
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Osaka, Japan
    J Neurochem 88:1345-51. 2004

Detail Information

Publications49

  1. pmc Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death
    Junichi Hitomi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Cell Biol 165:347-56. 2004
    ..Thus, caspase-4 can function as an ER stress-specific caspase in humans, and may be involved in pathogenesis of Alzheimer's disease...
  2. ncbi request reprint Induction of neuronal death by ER stress in Alzheimer's disease
    Taiichi Katayama
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka, University, Suita, Osaka 565 0871, Japan
    J Chem Neuroanat 28:67-78. 2004
    ..Caspase-4 also seems to act upstream of the beta-amyloid-induced ER stress pathway, suggesting that activation of caspase-4 might mediate neuronal cell death in AD...
  3. ncbi request reprint Role of ARF4L in recycling between endosomes and the plasma membrane
    Taiichi Katayama
    Department of Anatony and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Cell Mol Neurobiol 24:137-47. 2004
    ..These findings indicate that ARF4L drive the transport of cargo protein and subsequent fusion of recycling vesicles with the plasma membrane for maintenance of the cell surface...
  4. pmc Dysbindin regulates the transcriptional level of myristoylated alanine-rich protein kinase C substrate via the interaction with NF-YB in mice brain
    Hiroaki Okuda
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    PLoS ONE 5:e8773. 2010
    ..Using the yeast-two-hybrid screening system, we examined the candidate proteins interacting with Dysbindin and revealed one of these candidates to be the transcription factor NF-YB...
  5. ncbi request reprint HMGA1a: sequence-specific RNA-binding factor causing sporadic Alzheimer's disease-linked exon skipping of presenilin-2 pre-mRNA
    Takayuki Manabe
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Genes Cells 12:1179-91. 2007
    ..These results provide insights into the molecular basis for PS2V-associated neurodegenerative diseases that are initiated by specific RNA binding of HMGA1a...
  6. doi request reprint Familial amyotrophic lateral sclerosis (FALS)-linked SOD1 mutation accelerates neuronal cell death by activating cleavage of caspase-4 under ER stress in an in vitro model of FALS
    Yoshihisa Koyama
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Neurochem Int 57:838-43. 2010
    ..These findings show that ER stress in L84V SOD1-expressing human cells causes the aggregation and inclusion bodies of L84V SOD1 to induce neuronal death through the accelerated cleavage of caspase-4...
  7. pmc TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression
    Hironori Takamura
    Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Suita, Osaka, Japan
    PLoS ONE 7:e51912. 2012
    ..These results suggest that TRAP1 regulates the expression of fission proteins and controls mitochondrial fusion/fission, which affects mitochondrial/cellular function...
  8. doi request reprint Induction of amyloid beta accumulation by ER calcium disruption and resultant upregulation of angiogenic factors in ARPE19 cells
    Yoshihisa Koyama
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Invest Ophthalmol Vis Sci 49:2376-83. 2008
    ..To investigate the intracellular mechanisms that induce amyloid beta (Abeta) accumulation and angiogenesis in the human retinal pigment epithelial cell line ARPE19...
  9. ncbi request reprint Novel function of PS2V: change in conformation of tau proteins
    Atsuko Nishikawa
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka, Japan
    Biochem Biophys Res Commun 318:435-8. 2004
    ..In this manuscript, we make the first report of PS2V alterations in the conformation of the tau protein (unknown form of tau) in the human neuroblastoma cell line...
  10. ncbi request reprint Metals accelerate production of the aberrant splicing isoform of the presenilin-2
    Shinsuke Matsuzaki
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Osaka, Japan
    J Neurochem 88:1345-51. 2004
    ..These results suggest that exposure to some metals can accelerate and enhance PS2V generation, and that hypoxia plus chronic exposure to metals may promote the development of AD...
  11. doi request reprint Dysbindin engages in c-Jun N-terminal kinase activity and cytoskeletal organization
    Kyoko Kubota
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Biochem Biophys Res Commun 379:191-5. 2009
    ..These findings suggest that dysbindin plays a key role in coordinating JNK signaling and actin cytoskeleton required for neural development...
  12. doi request reprint DBZ (DISC1-binding zinc finger protein)-deficient mice display abnormalities in basket cells in the somatosensory cortices
    Yoshihisa Koyama
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Chem Neuroanat 53:1-10. 2013
    ..Furthermore, in the somatosensory cortices of DBZ KO mice, the level of mRNAs for the gamma-aminobutyric acid-synthesizing enzymes GAD67 was decreased. These findings show that DBZ is involved in the morphogenesis of basket cells. ..
  13. ncbi request reprint RA410/Sly1 suppresses MPP+ and 6-hydroxydopamine-induced cell death in SH-SY5Y cells
    Yoshio Bando
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Neurobiol Dis 18:143-51. 2005
    ..These results suggest that RA410/Sly1 plays an important cytoprotective role in MPP+ and 6-OHDA-induced cellular perturbation...
  14. ncbi request reprint Novel interaction between HMGA1a and StIP1 in murine terminally differentiated retina
    Hiroaki Okuda
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Mol Cell Neurosci 33:81-7. 2006
    ....
  15. doi request reprint Role of the PACAP-PAC1-DISC1 and PACAP-PAC1-stathmin1 systems in schizophrenia and bipolar disorder: novel treatment mechanisms?
    Taiichi Katayama
    Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Pharmacogenomics 10:1967-78. 2009
    ..The possibility that the regulation of these two systems could lead to new treatments for schizophrenia is also discussed...
  16. ncbi request reprint Possible involvement of the expression and phosphorylation of N-Myc in the induction of HMGA1a by hypoxia in the human neuroblastoma cell line
    Takeshi Yanagita
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka, Japan
    Neurosci Lett 374:47-52. 2005
    ..Such signal consolidation processes could play a role in neuronal survival after hypoxia in neurons...
  17. ncbi request reprint Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis
    Futoshi Yukioka
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurochem Int 52:683-7. 2008
    ..To sum up our data, the familial AD-linked PS1 mutation accelerates the cleavage of caspase-4 under the ER stress and results in the activation of caspase-9 and caspase-3, apoptosis signal, without releasing cytochrome-c...
  18. ncbi request reprint JAB1 participates in unfolded protein responses by association and dissociation with IRE1
    Kayoko Oono
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Neurochem Int 45:765-72. 2004
    ..These results suggested that JAB1 may act as a key molecule in selecting the UPR or cell death by association and dissociation with IRE1alpha...
  19. doi request reprint Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress
    Shinsuke Matsuzaki
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Neurochem Int 56:352-6. 2010
    ..These results suggest that the disturbance of Ca(2+) homeostasis induced by ER stress should cause the activation of caspase-4 resulting in the neural cell death...
  20. ncbi request reprint Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12
    Junichi Hitomi
    Department of Anatomy and Neuroscience, Osaka University Medical School, Japan
    Neurosci Lett 357:127-30. 2004
    ..These findings suggested that activation of ER-resident caspase-12 indirectly activates cytoplasmic caspase-3 and might be important in ER stress-induced neuronal apoptosis...
  21. ncbi request reprint The unfolded protein response is involved in the pathology of Alzheimer's disease
    Takashi Kudo
    Department of Psychiatry and Behavioral Science, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Ann N Y Acad Sci 977:349-55. 2002
    ..Experimental manipulation of IRE1, PERK, or eIF2alpha phosphorylation or GRP78 expression might allow the development of therapeutic strategies for FAD...
  22. pmc Plasma corticosterone activates SGK1 and induces morphological changes in oligodendrocytes in corpus callosum
    Shingo Miyata
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 6:e19859. 2011
    ..Our data strongly suggest that these abnornalities of oligodendrocytes are possibly related to depression-like symptoms...
  23. pmc Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations
    Kohei Yamada
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 5:e8596. 2010
    ..These results suggest that up-regulation of stathmin1 in the dentate gyrus, secondary to PACAP deficiency, may create abnormal neuronal circuits that cause abnormal behavior...
  24. ncbi request reprint Monomeric A beta and metals reduce their cytotoxicities to each other
    Shinsuke Matsuzaki
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka, Japan
    Biochem Biophys Res Commun 358:540-4. 2007
    ..Taken together, the metals and monomeric Abeta40 affect on each other and cause the reduction of their cell toxicity...
  25. doi request reprint DISC1-kendrin interaction is involved in centrosomal microtubule network formation
    Shoko Shimizu
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 377:1051-6. 2008
    ..These findings suggest that the DISC1-kendrin interaction plays a key role in the microtubule dynamics...
  26. pmc An in vitro model for Lewy body-like hyaline inclusion/astrocytic hyaline inclusion: induction by ER stress with an ALS-linked SOD1 mutation
    Satoru Yamagishi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 2:e1030. 2007
    ..We conclude that the LBHI/Ast-HI seen in human patients with mutant SOD1-linked FALS may arise from ER dysfunction...
  27. doi request reprint DBZ, a CNS-specific DISC1 binding protein, positively regulates oligodendrocyte differentiation
    Shoko Shimizu
    Department of Molecular Neuropsychiatry, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan Division of Molecular Brain Science, Research Institute of Traditional Asian Medicine, Kinki University, Osaka Sayama, Osaka, Japan
    Glia 62:709-24. 2014
    ..These results strongly indicate that OL differentiation in rodents is regulated by DBZ...
  28. ncbi request reprint GRP94 (94 kDa glucose-regulated protein) suppresses ischemic neuronal cell death against ischemia/reperfusion injury
    Yoshio Bando
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Osaka, Japan
    Eur J Neurosci 18:829-40. 2003
    ..These results confirmed that GRP94 could suppress ischemic injury to neurons, suggesting that gene transfer of GRP94 into the brain may have therapeutic potential in the treatment of cerebrovascular disease...
  29. pmc DISC1 (disrupted-in-schizophrenia-1) regulates differentiation of oligodendrocytes
    Tsuyoshi Hattori
    Department of Molecular Neuropsychiatry, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 9:e88506. 2014
    ..We also identified involvement of Sox10 and Nkx2.2 in the DISC1 regulatory pathway of oligodendrocyte differentiation, both well-known transcription factors involved in the regulation of myelin genes. ..
  30. pmc Yokukansan inhibits neuronal death during ER stress by regulating the unfolded protein response
    Toru Hiratsuka
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Japan
    PLoS ONE 5:e13280. 2010
    ..Therefore, we examined the effect of Yokukansan on ER stress-induced neurotoxicity and on familial AD-linked presenilin-1 mutation-associated cell death...
  31. ncbi request reprint Local protein synthesis by BDNF is potentiated in hippocampal neurons exposed to ephrins
    Shingo Miyata
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Brain Res Mol Brain Res 134:333-7. 2005
    ....
  32. ncbi request reprint Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed to the down-regulation of dysbindin
    Natsuko Kumamoto
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 345:904-9. 2006
    ..These data suggest that dysbindin might regulate the dopamine release of the dopaminergic system via modulation of the expression of SNAP25...
  33. ncbi request reprint Induction of connective tissue growth factor in retinal pigment epithelium cells by oxidative stress
    Satoshi Matsuda
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Jpn J Ophthalmol 50:229-34. 2006
    ..To investigate whether connective tissue growth factor (CTGF) is upregulated in the retinal pigment epithelium (RPE) by oxidative stress in vitro and in vivo...
  34. pmc The endoplasmic reticulum-resident chaperone heat shock protein 47 protects the Golgi apparatus from the effects of O-glycosylation inhibition
    Shingo Miyata
    Division of Molecular Brain Science, Research Institute of Traditional Asian Medicine, Kinki University, Osakasayama, Osaka, Japan
    PLoS ONE 8:e69732. 2013
    ....
  35. ncbi request reprint The cytosolic inclusion bodies that consist of splice variants that lack exon 5 of the presenilin-2 gene differ obviously from Hirano bodies observed in the brain from sporadic cases of Alzheimer's disease patients
    Takayuki Manabe
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurosci Lett 328:198-200. 2002
    ..This observation suggests the possibility that PS2V-composed inclusions are a novel inclusion body, compared with other pathological characteristics previously reported in the SAD brain. We named this inclusion body the 'PS2V body'...
  36. doi request reprint Mitochondrial TRAP1 regulates the unfolded protein response in the endoplasmic reticulum
    Kana Takemoto
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Neurochem Int 58:880-7. 2011
    ..Thus, the present study revealed that mitochondria could be a potential regulator of the UPR in the ER through mitochondrial TRAP1...
  37. ncbi request reprint FAD-linked presenilin-1 mutants impede translation regulation under ER stress
    Yuka Yasuda
    Division of Psychiatry and Behavioral Proteomics, Department of Post Genomics and Diseases, Course of Advanced Medicine, Graduate School of Medicine, Osaka University, 2 2, Yamadaoka, Siuta, Osaka, Japan
    Biochem Biophys Res Commun 296:313-8. 2002
    ....
  38. ncbi request reprint [Recent progress in 'HMGA1a' which causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease]
    Taiichi Katayama
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University
    Nihon Rinsho 61:677-88. 2003
    ..HMGA1a levels were increased in brain from sAD patients. We propose a novel mechanism of sAD that involves HMGA1a-induced aberrant splicing of PS2 pre-mRNA in the absence of any mutations...
  39. pmc Lack of dopaminergic inputs elongates the primary cilia of striatal neurons
    Ko Miyoshi
    Department of Child Development and Molecular Brain Science, United Graduate School of Child Development, Osaka University, Suita, Japan Molecular Research Center for Children s Mental Development, United Graduate School of Child Development, Osaka University, Suita, Japan Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    PLoS ONE 9:e97918. 2014
    ..Our results provide the first evidence that the length of neuronal cilia can be modified by the lack of a neurotransmitter's input. ..
  40. pmc Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier
    Takashi Morihara
    Department of Psychiatry, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 111:2638-43. 2014
    ..This unique combination of distinct mouse strains and model mice with transcriptomics is expected to be useful for the study of genetic mechanisms of other complex diseases. ..
  41. ncbi request reprint A secreted type of beta1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase
    Susumu Nakahara
    Department of Biochemistry, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    FASEB J 20:2451-9. 2006
    ..Collectively, these results demonstrate that Golgi-resident GnT-V is cleaved at the transmembrane region by gamma-secretase, and this might control tumor angiogenesis through a novel pathway...
  42. pmc An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease
    Reiko Onuki
    Gene Function Research Center, National Institute of Advanced Industrial Science and Technology, Higashi, Tsukuba Science City, Japan
    EMBO J 23:959-68. 2004
    ..We also detected the accumulation of phosphorylated PKR in the nuclei of autopsied brain tissues in Alzheimer's disease. Thus, PKR might play a role in ER stress-induced apoptosis and in Alzheimer's disease...
  43. pmc The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
    Ekaterina Rogaeva
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, Department, University of Toronto, Toronto, Ontario, Canada
    Nat Genet 39:168-77. 2007
    ..These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease...
  44. ncbi request reprint TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity
    Fusheng Chen
    Department of Medicine, and Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada M5S 3H2
    Nature 440:1208-12. 2006
    ..Here we report that TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes and differentially regulates gamma-secretase cleavage without affecting epsilon-secretase activity...
  45. ncbi request reprint DISC1 localizes to the centrosome by binding to kendrin
    Ko Miyoshi
    Department of Brain Science, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Biochem Biophys Res Commun 317:1195-9. 2004
    ..The present study suggests the possible involvement of DISC1 in the pathophysiology of mental disorders due to its putative effect on centrosomal function...
  46. ncbi request reprint Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes
    Hiroshi Hasegawa
    Centre for Research in Neurodegenerative Diseases, University of Toronto, West Toronto, Ontario M5S 3H2, Canada
    J Biol Chem 279:46455-63. 2004
    ....
  47. ncbi request reprint Role of Herp in the endoplasmic reticulum stress response
    Osamu Hori
    Department of Neuroanatomy Anatomy III, Kanazawa University Graduate School of Medicine, Kanazawa City, Ishikawa 920 8640, Japan
    Genes Cells 9:457-69. 2004
    ..These results indicate that Herp is a short-lived Ub-like protein improving the balance of folding capacity and protein loads in the ER and plays crucial roles for the ER stress resistance in F9 cells...
  48. ncbi request reprint Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain
    Akiko Honda
    Department of Brain Science, Graduate School of Medicine and Dentistry, Okayama University, Okayama 700 8558, Japan
    Brain Res Mol Brain Res 122:89-92. 2004
    ..Both FEZ1 and DISC1 showed high levels of expression, especially in developing hippocampal neurons. These findings suggest the potential involvement of FEZ1 and DISC1 in the formation of hippocampal neural circuits...
  49. ncbi request reprint Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease
    Yoshio Bando
    Department of Anatomy, Asahikawa Medical College, Midorigaoka Higashi 2 1 1 1, Asahikawa 078 8510, Japan
    Neurochem Int 46:11-8. 2005
    ..These results suggest that a close association exists between PKR and extrastriatal degeneration in PD and HD pathology...