Y Kajimoto

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. pmc Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells
    Y Kajimoto
    First Department of Medicine, Osaka University School of Medicine, Suita 565, Japan
    J Clin Invest 100:1840-6. 1997
  2. ncbi request reprint Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription
    H Watada
    First Department of Medicine, Osaka University School of Medicine, Suita, 565, Japan
    Biochem Biophys Res Commun 229:746-51. 1996
  3. ncbi request reprint Identification of amino-acid polymorphism within the leucine zipper motif of mouse transcription factor A1
    Y Kajimoto
    First Department of Medicine, Osaka University School of Medicine, Suita, Japan
    Gene 139:247-9. 1994
  4. ncbi request reprint Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis
    T Miyatsuka
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Biochem Biophys Res Commun 310:1017-25. 2003
  5. ncbi request reprint Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan
    M Waguri
    Second Department of Internal Medicine, Osaka University Medical School, Suita, Japan
    Diabetes 46:1281-90. 1997
  6. ncbi request reprint Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity
    Y Kajimoto
    First Department of Medicine, Osaka University School of Medicine, Japan
    Biochem Biophys Res Commun 219:941-6. 1996
  7. ncbi request reprint Ubiquitous, but variable, expression of two alternatively spliced mRNAs encoding mouse homologues of transcription factors E47 and E12
    H Watada
    First Department of Medicine, Osaka University School of Medicine, Suita, Japan
    Gene 153:255-9. 1995
  8. ncbi request reprint Expression of CD38 gene, but not of mitochondrial glycerol-3-phosphate dehydrogenase gene, is impaired in pancreatic islets of GK rats
    T Matsuoka
    First Department of Medicine, Osaka University School of Medicine, Suita, Japan
    Biochem Biophys Res Commun 214:239-46. 1995
  9. ncbi request reprint The Arg192 isoform of paraoxonase with low sarin-hydrolyzing activity is dominant in the Japanese
    Y Yamasaki
    First Department of Medicine, Osaka University School of Medicine, Japan
    Hum Genet 101:67-8. 1997
  10. ncbi request reprint A missense mutation of Pax4 gene (R121W) is associated with type 2 diabetes in Japanese
    Y Shimajiri
    First Department of Medicine, Wakayama University of Medical Science, Wakayama, Japan
    Diabetes 50:2864-9. 2001

Collaborators

Detail Information

Publications14

  1. pmc Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells
    Y Kajimoto
    First Department of Medicine, Osaka University School of Medicine, Suita 565, Japan
    J Clin Invest 100:1840-6. 1997
    ..This means that other components constituting the transcription-controlling machinery need to be evaluated in order to understand the molecular basis of impaired insulin biosynthesis such as that observed due to glucose toxicity...
  2. ncbi request reprint Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription
    H Watada
    First Department of Medicine, Osaka University School of Medicine, Suita, 565, Japan
    Biochem Biophys Res Commun 229:746-51. 1996
    ..These observations suggest the involvement of PDX-1 in human IAPP gene regulation, which seems to be mediated through at least two A element-like cis-motifs in the gene promoter...
  3. ncbi request reprint Identification of amino-acid polymorphism within the leucine zipper motif of mouse transcription factor A1
    Y Kajimoto
    First Department of Medicine, Osaka University School of Medicine, Suita, Japan
    Gene 139:247-9. 1994
    ..Interestingly, the location and pattern of aa deletions are identical to those previously described for the aa polymorphism within the human counterpart, E47 (E12) [Kamps et al., Cell 60 (1990) 547-555]...
  4. ncbi request reprint Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis
    T Miyatsuka
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Biochem Biophys Res Commun 310:1017-25. 2003
    ..The conditional PDX-1 transgenic mouse system developed in this study appeared to be useful for efficient screening of PDX-1 responsive somatic tissues and cells...
  5. ncbi request reprint Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan
    M Waguri
    Second Department of Internal Medicine, Osaka University Medical School, Suita, Japan
    Diabetes 46:1281-90. 1997
    ..In conclusion, the regeneration process of beta-cells varied by circumstance. Our mouse model is useful for studying the mechanism of regeneration, since differentiation and proliferation could be analyzed separately in one pancreas...
  6. ncbi request reprint Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity
    Y Kajimoto
    First Department of Medicine, Osaka University School of Medicine, Japan
    Biochem Biophys Res Commun 219:941-6. 1996
    ..These observations suggest the involvement of multiple enzymes in the regulation of cADPR concentrations in pancreatic islet cells...
  7. ncbi request reprint Ubiquitous, but variable, expression of two alternatively spliced mRNAs encoding mouse homologues of transcription factors E47 and E12
    H Watada
    First Department of Medicine, Osaka University School of Medicine, Suita, Japan
    Gene 153:255-9. 1995
    ..The variation in the A1/kA1 expression ratios, on the other hand, supports the idea that A1 (E47) and kA1 (E12) each have some unique roles in the functions of these E2A gene-encoded bHLH proteins...
  8. ncbi request reprint Expression of CD38 gene, but not of mitochondrial glycerol-3-phosphate dehydrogenase gene, is impaired in pancreatic islets of GK rats
    T Matsuoka
    First Department of Medicine, Osaka University School of Medicine, Suita, Japan
    Biochem Biophys Res Commun 214:239-46. 1995
    ..These observations support the idea that multiple defects of the glucose-responsive insulin secreting machinery are involved in the development of diabetes in GK rats...
  9. ncbi request reprint The Arg192 isoform of paraoxonase with low sarin-hydrolyzing activity is dominant in the Japanese
    Y Yamasaki
    First Department of Medicine, Osaka University School of Medicine, Japan
    Hum Genet 101:67-8. 1997
    ..Thus, there seems to be a racial difference in vulnerability to toxic nerve agents, such as sarin. The dominance of the Arg192 allele in the Japanese population probably worsened the tragedy of March 1995 in the Tokyo subway...
  10. ncbi request reprint A missense mutation of Pax4 gene (R121W) is associated with type 2 diabetes in Japanese
    Y Shimajiri
    First Department of Medicine, Wakayama University of Medical Science, Wakayama, Japan
    Diabetes 50:2864-9. 2001
    ..This work provides significant implications for the Pax4 gene as one of the predisposing genes for type 2 diabetes in the Japanese...
  11. pmc Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a transcriptional repressor in the pancreas
    Y Fujitani
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Mol Cell Biol 19:8281-91. 1999
    ....
  12. ncbi request reprint Structure of the chicken insulin-like growth factor I gene reveals conserved promoter elements
    Y Kajimoto
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 266:9724-31. 1991
    ..These observations represent the first thorough characterization of an IGF-I gene and provide an impetus for discerning the mechanisms by which IGF-I expression is regulated during growth, development, and differentiation...
  13. ncbi request reprint Structure and expression of a chicken insulin-like growth factor I precursor
    Y Kajimoto
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Mol Endocrinol 3:1907-13. 1989
    ..In the chicken, as in rats and humans, IGF-I mRNA is synthesized in multiple tissues, including liver, brain, skeletal muscle, and heart.(ABSTRACT TRUNCATED AT 250 WORDS)..
  14. ncbi request reprint Mutation of the Pax6 gene causes impaired glucose-stimulated insulin secretion
    A Kuroda
    Diabetologia 47:2039-41. 2004