Hirotsugu Iwatani

..Finally, the quantitative change of O-glycan composition is a novel marker of therapeutic response of IgAN...

..The downregulated genes include the polymeric Ig receptor (pIgR) which was reportedly involved in single nucleotide polymorphism (SNP) of Japanese IgAN patients...

..The origin, localization and role of kidney stem cells are under investigation. We also discuss potential applications of embryonic stem cells and induced pluripotent stem cells in kidney regeneration...

..However, the gene expression difference between the tonsils in patients with IgAN and those in control patients is not established...

..However, in nondiabetic kidney disease, urinary type IV collagen (u-IVc) levels have not been extensively investigated. The aim of this study was to evaluate u-IVc levels in various nephropathies except diabetic nephropathy...

..CONCLUSION: These findings implicate that Hoechst(low) cells in the kidney may have potentials for hematopoietic and nonhematopoietic lineages, but are not stem cells for renal cells, especially mesangial and tubular cells...

..We sought to determine whether specialist care can actually be associated with better survival rates in a nationwide Japanese dialysis cohort...

..This result suggests that plasma concentration of olmesartan medoxomil does not decrease during hemodialysis, and that it is not necessary to change prescription on hemodialysis day or not...

..Identification of the genetic factor contributing to hypertension in patients with chronic kidney disease may potentially refine a therapeutic strategy...

..CONCLUSION: These results indicate that PDGF-B plays a critical role to direct bone marrow-derived cells toward mesangial-like cells both in vitro and in vivo...

..However, little information is available about an effect of cigarette smoking on progression of primary kidney diseases, including immunoglobulin A (IgA) nephropathy...

..These results indicate that fetal cells are engrafted to maternal hematopoietic system without apparent injury and they also contribute to the repairing process of maternal liver and kidney...

..Urinary sodium excretion varies during the day. It is unknown whether expression levels of cell-cell junctions in the kidney are dynamic and associated with urinary sodium excretion...

..In order to test the hypothesis that the usage of EPO in predialysis CKD patients may ameliorate the progression of renal disease, we conducted a macro-level observational study dealing with all Japanese predialysis CKD patients...

..The aims of the present study were to evaluate the effectiveness of plasma exchange and discuss its indication...

..The accuracy for the detection of coronary stenosis by multidetector row computed tomography (MDCT) has been getting more recognition. However, the usefulness of MDCT in patients with chronic kidney disease (CKD) has not been confirmed...

..We have reported that alteration of N-linked oligosaccharides of immunoglobulin (Ig) G is a novel diagnostic marker of IBD. Oligosaccharide alterations of IgA, however, have not been investigated in IBD patients...

..Although multiple studies have shown that sleep duration is a predictor of cardiovascular diseases and mortality, few studies have reported an association between sleep duration and chronic kidney disease...

..Management Immunosuppressants and corticosteroids...

..The data suggest that clock-controlled Kid-1 regulates the cell cycle of proliferating renal tubular epithelial cells through ERK phosphorylation...

..Our findings suggest that tubular luminal fetuin-A works as a natural inhibitor against calcification in the proximal tubules under PTH-loaded condition...

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..In this study, we investigated the role of adiponectin for kidney disease in a subtotal nephrectomized mouse model...

..He rapidly entered remission after assistance through DFPP, suggesting the potential efficacy of DFPP for Wegener's granulomatosis, especially with pulmonary bleeding...

..The results obtained from PAN nephrosis rats might be applicable to human renal diseases...