Eiji Ishimura

Summary

Affiliation: Osaka City University
Country: Japan

Publications

  1. ncbi Significant positive association between parathyroid hormone and fat mass and lean mass in chronic hemodialysis patients
    Eiji Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Clin Endocrinol Metab 98:1264-70. 2013
  2. ncbi Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis
    Shinya Nakatani
    Department of Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Nephrol Dial Transplant 27:1889-97. 2012
  3. ncbi Increasing body fat mass in the first year of hemodialysis
    E Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan Shirasagi Hospital Kidney Center, Osaka, Japan
    J Am Soc Nephrol 12:1921-6. 2001
  4. ncbi Glycemic control and survival of diabetic hemodialysis patients--importance of lower hemoglobin A1C levels
    E Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Diabetes Res Clin Pract 83:320-6. 2009
  5. ncbi Cross-sectional association of serum phosphate with carotid intima-medial thickness in hemodialysis patients
    Eiji Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Kidney Dis 45:859-65. 2005
  6. ncbi Different risk factors for vascular calcification in end-stage renal disease between diabetics and nondiabetics: the respective importance of glycemic and phosphate control
    Eiji Ishimura
    Osaka City University Graduate School of Medicine, Osaka, Japan
    Kidney Blood Press Res 31:10-5. 2008
  7. ncbi Serum magnesium concentration is a significant predictor of mortality in maintenance hemodialysis patients
    Eiji Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Magnes Res 20:237-44. 2007
  8. ncbi Body fat mass in hemodialysis patients
    Eiji Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine and Shirasagi Hospital Kidney Center, Osaka, Japan
    Am J Kidney Dis 41:S137-41. 2003
  9. ncbi Significant association between the presence of peripheral vascular calcification and lower serum magnesium in hemodialysis patients
    E Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Clin Nephrol 68:222-7. 2007
  10. ncbi Urinary albumin excretion associated with arterial wall stiffness rather than thickness in type 2 diabetic patients
    Eiji Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Nephrol 20:204-11. 2007

Detail Information

Publications136 found, 100 shown here

  1. ncbi Significant positive association between parathyroid hormone and fat mass and lean mass in chronic hemodialysis patients
    Eiji Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Clin Endocrinol Metab 98:1264-70. 2013
    ..It is also not known whether fat mass or lean mass is associated with serum PTH among these patients. In the present study, we examined the association of intact PTH with fat mass and lean mass in hemodialysis patients...
  2. ncbi Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis
    Shinya Nakatani
    Department of Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Nephrol Dial Transplant 27:1889-97. 2012
    ..The purpose of the present study was to identify altered protein expression profiles in diabetic glomeruli using formalin-fixed paraffin-embedded (FFPE) kidney tissues from diabetic patients...
  3. ncbi Increasing body fat mass in the first year of hemodialysis
    E Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan Shirasagi Hospital Kidney Center, Osaka, Japan
    J Am Soc Nephrol 12:1921-6. 2001
    ..More general, dual x-ray absorptiometry assessment of body fat mass was found to be useful for evaluating the nutritional status of hemodialysis patients...
  4. ncbi Glycemic control and survival of diabetic hemodialysis patients--importance of lower hemoglobin A1C levels
    E Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Diabetes Res Clin Pract 83:320-6. 2009
    ..The significance of hemoglobin A1C (HbA1C) on the survival of diabetic hemodialysis patients still remains controversial. We investigated the impact of HbA1C on the survival...
  5. ncbi Cross-sectional association of serum phosphate with carotid intima-medial thickness in hemodialysis patients
    Eiji Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Kidney Dis 45:859-65. 2005
    ..Although an increased serum phosphate concentration is a significant risk factor for vascular calcification, it is unclear whether serum phosphate level is a risk factor for increased arterial wall thickness in hemodialysis patients...
  6. ncbi Different risk factors for vascular calcification in end-stage renal disease between diabetics and nondiabetics: the respective importance of glycemic and phosphate control
    Eiji Ishimura
    Osaka City University Graduate School of Medicine, Osaka, Japan
    Kidney Blood Press Res 31:10-5. 2008
    ..Thus, the importance of glycemic and phosphate control is suggested to be emphasized in diabetic and nondiabetic ESRD patients, respectively, for prevention of the progression of vascular calcification...
  7. ncbi Serum magnesium concentration is a significant predictor of mortality in maintenance hemodialysis patients
    Eiji Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Magnes Res 20:237-44. 2007
    ..0 mEq/L, i.e. 0.50 mmol/L used in most countries), one of the strong contributors to the serum magnesium concentrations of dialysis patients...
  8. ncbi Body fat mass in hemodialysis patients
    Eiji Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine and Shirasagi Hospital Kidney Center, Osaka, Japan
    Am J Kidney Dis 41:S137-41. 2003
    ..Changes in body fat mass in a large number of hemodialysis patients is unknown...
  9. ncbi Significant association between the presence of peripheral vascular calcification and lower serum magnesium in hemodialysis patients
    E Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Clin Nephrol 68:222-7. 2007
    ..The aim of the present study was to examine the association between serum magnesium levels and vascular calcification in hemodialysis patients...
  10. ncbi Urinary albumin excretion associated with arterial wall stiffness rather than thickness in type 2 diabetic patients
    Eiji Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Nephrol 20:204-11. 2007
    ..The aim of this study was to determine which of the 2 aspects of atherosclerosis, arterial thickening or stiffness, has more effect on levels of microalbuminuria in type 2 diabetic patients...
  11. ncbi Renal insufficiency accelerates atherosclerosis in patients with type 2 diabetes mellitus
    E Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Am J Kidney Dis 38:S186-90. 2001
    ....
  12. ncbi C-reactive protein is a significant predictor of vascular calcification of both aorta and hand arteries
    Eiji Ishimura
    Osaka City University Graduate School of Medicine, Osaka, Japan
    Semin Nephrol 24:408-12. 2004
    ....
  13. ncbi Different risk factors for peripheral vascular calcification between diabetic and non-diabetic haemodialysis patients--importance of glycaemic control
    E Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Diabetologia 45:1446-8. 2002
    ..We compared factors affecting peripheral vascular calcification between haemodialysis patients with and without diabetes...
  14. ncbi Serum levels of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, and 25-hydroxyvitamin D in nondialyzed patients with chronic renal failure
    E Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Kidney Int 55:1019-27. 1999
    ..In patients with chronic renal failure (CRF), abnormalities in vitamin D metabolism are known to be present, and several factors could contribute to the abnormalities...
  15. ncbi Effect of cinacalcet on bone mineral density of the radius in hemodialysis patients with secondary hyperparathyroidism
    E Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, Japan
    Clin Nephrol 76:259-65. 2011
    ..Cortical bone, rather than cancellous bone, was particularly affected by cinacalcet treatment...
  16. ncbi Relationship between fat mass and serum high-sensitivity C-reactive protein levels in prevalent hemodialysis patients
    Eiji Ishimura
    Department of Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Nephron Clin Pract 119:c283-8. 2011
    ..Little is known about the relationship between fat mass distribution and chronic inflammation in dialysis patients, in whom chronic inflammation is related to morbidity and mortality...
  17. ncbi Paraarticular trabecular bone loss at the ultradistal radius and increased arterial stiffening in postmenopausal patients with rheumatoid arthritis
    Kazumasa Tanaka
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, and Senboku Second Hospital, Asahi-machi, Osaka, Japan
    J Rheumatol 33:652-8. 2006
    ..Paraarticular bone loss in the trabecular bone component at the ultradistal radius is a factor significantly associated with increased arterial stiffening in RA patients...
  18. ncbi Influence of nutritional status on serum large N-truncated PTH, but not PTH(1-84) in hemodialysis patients
    Kaori Shidara
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Biomed Pharmacother 61:142-7. 2007
    ..We investigated whether PTH(7-84) and larger N-truncated PTH or PTH(1-84) might be affected by nutritional status in HD patients...
  19. ncbi Intima-media thickness of carotid artery predicts cardiovascular mortality in hemodialysis patients
    Yoshiki Nishizawa
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
    Am J Kidney Dis 41:S76-9. 2003
    ..Previous studies showed that patients with ESRD had increased intima-media thickness of the carotid artery (CA-IMT). In the present study, we examined whether CA-IMT would predict cardiovascular mortality in patients with ESRD...
  20. ncbi Factors associated with cerebral white matter hyperintensities in haemodialysis patients
    Toshihide Naganuma
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Nephrology (Carlton) 17:561-8. 2012
    ....
  21. ncbi Higher serum bone alkaline phosphatase as a predictor of mortality in male hemodialysis patients
    Ikue Kobayashi
    Department of Metabolism, Endocrinology, Molecular Medicine, Osaka City University Graduate School of Medicine, Shirasagi Hospital, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Life Sci 90:212-8. 2012
    ..The purpose of our study was to compare the significance of serum bone alkaline phosphatase (BAP) with that of other bone markers in prediction of all-cause mortality(ACM) in male hemodialysis patients...
  22. ncbi Inflammation and bone resorption as independent factors of accelerated arterial wall thickening in patients with rheumatoid arthritis
    Mayumi Nagata-Sakurai
    Osaka City University Graduate School of Medicine, Osaka, Japan
    Arthritis Rheum 48:3061-7. 2003
    ..CONCLUSION: Patients with RA have a higher rate of increase in thickening of the arterial wall. Inflammation and calcium mobilization are factors closely associated with the accelerated arterial wall changes...
  23. ncbi The clinical significance of serum osteocalcin and N-terminal propeptide of type I collagen in predialysis patients with chronic renal failure
    Takao Tsuchida
    Department of Endocrinology, Metabolism, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Osteoporos Int 16:172-9. 2005
    ..OC and PINP are suggested to be possible parameters for the clinical evaluation of the effect of bone metabolism on BMD...
  24. ncbi Association of glycated albumin, but not glycated hemoglobin, with calcaneus quantitative ultrasound in male hemodialysis patients with type 2 diabetes mellitus
    Shinsuke Yamada
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
    Metabolism 59:390-4. 2010
    ..Furthermore, it is suggested that poor glycemic control might be a significant factor toward decreasing calcaneus SI in T2DM HD patients...
  25. ncbi Association of reduction in bone mineral density with mortality in male hemodialysis patients
    Kaori Kohno
    Department of Metabolism, Osaka City University Graduate School of Medicine, Osaka, Japan
    Calcif Tissue Int 84:180-5. 2009
    ..970, 95% CI 0.945-0.996). Our results suggest that BMD reduction at the UR might be a clinically relevant marker that predicts an increased risk of mortality in male hemodialysis patients...
  26. ncbi Presence of abdominal aortic calcification is significantly associated with all-cause and cardiovascular mortality in maintenance hemodialysis patients
    Senji Okuno
    Kidney Center, Shirasagi Hospital, Osaka, Japan
    Am J Kidney Dis 49:417-25. 2007
    ....
  27. ncbi Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes
    M Emoto
    Second Department of Internal Medicine, Institute of Geriatrics and Medical Science, Osaka City University Medical School, Japan
    Diabetes Care 24:533-8. 2001
    ..To assess the impacts of insulin resistance and renal function on plasma total homocysteine (tHcy) levels in patients with type 2 diabetes with a wide range of nephropathy...
  28. ncbi Clinical usefulness of the serum N-terminal propeptide of type I collagen as a marker of bone formation in hemodialysis patients
    Misako Ueda
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Kidney Dis 40:802-9. 2002
    ..008; PINP-DPD, P = 0.015). CONCLUSION: Serum PINP may provide a better marker of osteoblast function in HD patients and thus be clinically useful for predicting radius bone loss...
  29. ncbi Factors affecting progression of renal failure in patients with type 2 diabetes
    Hideki Ueda
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
    Diabetes Care 26:1530-4. 2003
    ....
  30. ncbi Increased levels of C-reactive protein in hypothyroid patients and its correlation with arterial stiffness in the common carotid artery
    Toshiki Nagasaki
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Biomed Pharmacother 61:167-72. 2007
    ....
  31. ncbi Poor glycemic control is a significant predictor of cardiovascular events in chronic hemodialysis patients with diabetes
    Yoshihiro Tsujimoto
    Inoue Hospital, Osaka, Japan
    Ther Apher Dial 13:358-65. 2009
    ..0046, respectively). In diabetic hemodialysis patients, poor glycemic control is a significant, independent predictor of the emergence of CVD, indicating the importance of careful management of glycemic control in hemodialysis patients...
  32. ncbi Fetuin-A is associated with calcified coronary artery disease
    Katsuhito Mori
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Coron Artery Dis 21:281-5. 2010
    ..As diabetes and uremia make the role of fetuin-A in cardiovascular disease uncertain, we investigated the association between fetuin-A and calcified coronary artery disease in participants without diabetes and renal dysfunction...
  33. ncbi Serum levels of TRAP5b, a new bone resorption marker unaffected by renal dysfunction, as a useful marker of cortical bone loss in hemodialysis patients
    Kaori Shidara
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    Calcif Tissue Int 82:278-87. 2008
    ..9%, respectively, for serum TRAP5b. Measurement of serum TRAP5b, as well as intact OC, may be a clinically relevant assay for estimation of bone metabolic status in HD patients, although serum intact OC accumulates in uremic serum...
  34. ncbi Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy
    Toshiki Nagasaki
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
    Eur J Endocrinol 150:125-31. 2004
    ....
  35. ncbi Diabetes mellitus, aortic stiffness, and cardiovascular mortality in end-stage renal disease
    T Shoji
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Am Soc Nephrol 12:2117-24. 2001
    ..These results demonstrate that the increased aortic stiffness of the ESRD patients with diabetes mellitus contributed to the higher all-cause and cardiovascular mortality rates...
  36. ncbi Influence of atherosclerosis on the relationship between anaemia and mortality risk in haemodialysis patients
    Kiyoshi Maekawa
    Kidney Center, Shirasagi Hospital, Osaka, Japan
    Nephrol Dial Transplant 23:2329-36. 2008
    ..Since CKD is a high-risk population for cardiovascular disease (CVD), we tested a hypothesis that the presence of atherosclerosis affects the relationship between anaemia and mortality risk...
  37. ncbi Elemental concentrations in scalp hair, nutritional status and health-related quality of life in hemodialysis patients
    Akinobu Ochi
    Metabolism, Endocrinology, Molecular Medicine and Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Ther Apher Dial 16:127-33. 2012
    ..Cadmium accumulation correlated with malnutrition. Iodine and selenium accumulation may adversely affect HRQOL. Further investigation is necessary to determine precisely how these elements affect these measures...
  38. ncbi Significance of Bio-intact PTH(1-84) assay in hemodialysis patients
    Masaaki Inaba
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, 545 8585 Osaka, Japan
    Osteoporos Int 16:517-25. 2005
    ....
  39. ncbi C-reactive protein is a significant predictor of decrease in fat mass in hemodialysis patients
    Yoko Fujino
    Shirasagi Hospital Kidney Center, Osaka City University Graduate School of Medicine, Osaka, Japan
    Biomed Pharmacother 59:264-8. 2005
    ..Chronic inflammation, represented by higher CRP levels, is a significant factor affecting decrease in fat mass, and is related to poorer nutritional status...
  40. ncbi Associations between physical activity, peripheral atherosclerosis and bone status in healthy Japanese women
    Shinsuke Yamada
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
    Atherosclerosis 188:196-202. 2006
    ....
  41. ncbi Annual fat mass change is a significant predictor of mortality in female hemodialysis patients
    Yoko Fujino
    Shirasagi Hospital Kidney Center, Osaka, Japan
    Biomed Pharmacother 60:253-7. 2006
    ..Fat mass change is also a useful parameter for measurement of nutritional status in hemodialysis patients...
  42. ncbi Decrease of brachial-ankle pulse wave velocity in female subclinical hypothyroid patients during normalization of thyroid function: a double-blind, placebo-controlled study
    Toshiki Nagasaki
    Department of Metabolism, Endocrinology and Molecular Medicine, Internal Medicine, Osaka City University Graduate School of Medicine, Osaka City, Japan
    Eur J Endocrinol 160:409-15. 2009
    ..The current study was performed to assess changes in baPWV in female subclinical hypothyroidism with autoimmune chronic thyroiditis (Hashimoto's disease) after restoration of normal thyroid function...
  43. ncbi Central pulse wave velocity is responsible for increased brachial-ankle pulse wave velocity in subclinical hypothyroidism
    Toshiki Nagasaki
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Osaka, Japan
    Clin Endocrinol (Oxf) 66:304-8. 2007
    ..The current study was performed to assess which arterial segment is responsible for enhanced baPWV in subclinical hypothyroidism...
  44. ncbi Glycated albumin is a better glycemic indicator than glycated hemoglobin values in hemodialysis patients with diabetes: effect of anemia and erythropoietin injection
    Masaaki Inaba
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Am Soc Nephrol 18:896-903. 2007
    ....
  45. ncbi Direct in vitro evidence of the suppressive effect of cinacalcet HCl on parathyroid hormone secretion in human parathyroid cells with pathologically reduced calcium-sensing receptor levels
    Takehisa Kawata
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan
    J Bone Miner Metab 24:300-6. 2006
    ..Data from this in vitro analysis support the clinical application of cinacalcet in PHPT and SHPT therapy...
  46. ncbi Arterial stiffness in predialysis patients with uremia
    Kayo Shinohara
    Department of Metabolism, Osaka City University Graduate School of Medicine, Osaka, Japan
    Kidney Int 65:936-43. 2004
    ....
  47. ncbi Atherogenic lipoprotein changes in diabetic nephropathy
    T Shoji
    Second Department of Internal Medicine, Osaka City University Medical School, 1 4 3 Asahi machi, Osaka 545 8585, Abeno Ku, Japan
    Atherosclerosis 156:425-33. 2001
    ..These lipoprotein alterations may contribute to an increased cardiovascular risk in diabetic nephropathy, especially in diabetic renal failure...
  48. ncbi Impaired endothelium-dependent vascular responses of retinal and intrarenal arteries in patients with type 2 diabetes
    T Kawagishi
    Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Arterioscler Thromb Vasc Biol 19:2509-16. 1999
    ....
  49. ncbi Poor muscle quality as a predictor of high mortality independent of diabetes in hemodialysis patients
    Maki Yoda
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Biomed Pharmacother 66:266-70. 2012
    ....
  50. ncbi Arterial stiffness predicts cardiovascular death independent of arterial thickness in a cohort of hemodialysis patients
    Tetsuo Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Ashahi machi, Abeno Ku, Osaka 545 8585, Japan
    Atherosclerosis 210:145-9. 2010
    ..Although these arterial changes develop in parallel, no study has ever tested a hypothesis that arterial stiffness can predict mortality from CVD independent of arterial thickness. This study tested this possibility...
  51. ncbi Lower risk for cardiovascular mortality in oral 1alpha-hydroxy vitamin D3 users in a haemodialysis population
    Tetsuo Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Nephrol Dial Transplant 19:179-84. 2004
    ..We hypothesized that treatment with vitamin D(3) may be beneficial for survival in patients with end-stage renal disease (ESRD)...
  52. ncbi Significant correlation of glycated albumin, but not glycated haemoglobin, with arterial stiffening in haemodialysis patients with type 2 diabetes
    Yasuro Kumeda
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Clin Endocrinol (Oxf) 69:556-61. 2008
    ..As poor glycaemic control is considered an independent risk factor for atherosclerosis in diabetes, the relationship between GA, HbA1c and arterial stiffening was examined in HD patients with type 2 diabetes...
  53. ncbi Aortic calcification in haemodialysis patients with diabetes mellitus
    Hiromichi Taniwaki
    Inoue Hospital, Department of Nephrology, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
    Nephrol Dial Transplant 20:2472-8. 2005
    ....
  54. ncbi Association of glycated albumin, but not glycated hemoglobin, with peripheral vascular calcification in hemodialysis patients with type 2 diabetes
    Shinsuke Yamada
    Department of Metabolism, Endocrinology and Molecular Medicine, Internal Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Life Sci 83:516-9. 2008
    ..This study was to establish the significance of glycated albumin (GA) as a useful marker of peripheral vascular calcification in diabetic HD patients, in comparison with HbA(1C)...
  55. ncbi Diabetes mellitus increases the severity of anemia in non-dialyzed patients with renal failure
    E Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School, Japan
    J Nephrol 11:83-6. 1998
    ..494, p < 0.001). DM appeared to be a risk factor for the severity of anemia in patients with renal failure who were not receiving dialysis...
  56. ncbi Arterial wall stiffness is associated with peripheral circulation in patients with type 2 diabetes
    Akane Kizu
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
    Atherosclerosis 170:87-91. 2003
    ..Thus, arterial wall stiffness of femoral artery appears to be a major determinant of peripheral circulation in patients with type 2 diabetes...
  57. ncbi Impact of atherosclerosis on the relationship of glycemic control and mortality in diabetic patients on hemodialysis
    Masaaki Inaba
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Kyoto, Japan
    Clin Nephrol 78:273-80. 2012
    ..The impact of preexisting cardiovascular disease (CVD) on glycemic control-improved survival in hemodialysis patients with diabetes mellitus (DM) was investigated. Glycoalbumin (GA) was used as a glycemic marker...
  58. ncbi Increased pulse wave velocity in subclinical hypothyroidism
    Toshiki Nagasaki
    Department of Metabolism, Endocrinology, and Molecular Medicine, Internal Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
    J Clin Endocrinol Metab 91:154-8. 2006
    ..Furthermore, the results suggest that increased DBP might be one of the main factors responsible for increased arterial stiffening in subclinical hypothyroid patients...
  59. ncbi Serum C-reactive protein and thioredoxin levels in subjects with mildly reduced glomerular filtration rate
    Shoko Tsuchikura
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    BMC Nephrol 11:7. 2010
    ..We compared the levels of serum biomarkers for inflammation and oxidative stress between subjects with normal and mildly reduced glomerular filtration rate (GFR)...
  60. ncbi Altered relationship between body fat and plasma adiponectin in end-stage renal disease
    Tetsuo Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Metabolism 54:330-4. 2005
    ..Thus, plasma adipocytokine profile was altered in ESRD, and the effects of body fat and sex on adiponectin were less significant in the patients with ESRD...
  61. ncbi Direct in vitro evidence of extracellular Ca2+-induced amino-terminal truncation of human parathyroid hormone (1-84) by human parathyroid cells
    Takehisa Kawata
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
    J Clin Endocrinol Metab 90:5774-8. 2005
    ..CONCLUSIONS: These findings suggest that the N-terminal truncation is regulated by extracellular Ca2+ concentration and works to suppress the generation of (1-84)hPTH in parathyroid cells...
  62. ncbi Annual change in bone mineral density in predialysis patients with chronic renal failure: significance of a decrease in serum 1,25-dihydroxy-vitamin D
    Naoko Obatake
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Bone Miner Metab 25:74-9. 2007
    ..The serum 1,25(OH)(2)D level is the principal factor affecting BMD of the radius, suggesting that supplementation with an active form of vitamin D is of importance for predialysis CRF patients...
  63. ncbi Antibody to oxidized low-density lipoprotein and cardiovascular mortality in end-stage renal disease
    Tetsuo Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Kidney Int 62:2230-7. 2002
    ..Immune response to oxidized low-density lipoprotein (oxLDL) may modulate the process of atherogenesis and cardiovascular disease...
  64. ncbi Glycemic control is a predictor of survival for diabetic patients on hemodialysis
    T Morioka
    Department of Internal Medicine, Osaka City University Graduate Medical School, Osaka, Japan
    Diabetes Care 24:909-13. 2001
    ..133 per 1.0% increment of HbA1c, 95% CI 1.028-1.249, P = 0.012), as were Cre and CTR. CONCLUSIONS: Good glycemic control (HbA1c <7.5%) predicts better survival of diabetic ESRD patients starting hemodialysis treatment...
  65. ncbi Low circulating endogenous secretory receptor for AGEs predicts cardiovascular mortality in patients with end-stage renal disease
    Hidenori Koyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Arterioscler Thromb Vasc Biol 27:147-53. 2007
    ..Here, we evaluated if plasma esRAGE is a predictor of cardiovascular mortality in a cohort of 206 (171 nondiabetic) patients with end-stage renal diseases (ESRD)...
  66. ncbi Targeted proteomics of isolated glomeruli from the kidneys of diabetic rats: sorbin and SH3 domain containing 2 is a novel protein associated with diabetic nephropathy
    Shinya Nakatani
    Department of Pathology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Exp Diabetes Res 2011:979354. 2011
    ..Our findings suggested that SORBS2 may be associated with the development of diabetic nephropathy possibility by reorganization of actin filaments...
  67. ncbi Significant association of fracture of the lumbar spine with mortality in female hemodialysis patients: a prospective observational study
    Yoshifumi Maeno
    Kidney Center, Shirasagi Hospital, Osaka, Japan
    Calcif Tissue Int 85:310-6. 2009
    ..033-4.478, P < 0.05) and noncardiovascular (HR = 2.637, 95% CI 1.014-6.858, P < 0.05) mortality rates only in females. In conclusion, lumbar fracture is significantly associated with all-cause mortality in female patients...
  68. ncbi Utility of serum tartrate-resistant acid phosphatase (TRACP5b) as a bone resorption marker in patients with chronic kidney disease: independence from renal dysfunction
    Shinsuke Yamada
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Clin Endocrinol (Oxf) 69:189-96. 2008
    ..The aim of the study was to establish the usefulness of a new assay for TRACP5b in assessing bone turnover in these patients...
  69. ncbi Advanced atherosclerosis in predialysis patients with chronic renal failure
    Tetsuo Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
    Kidney Int 61:2187-92. 2002
    ..The purpose of this study was to evaluate the effects of hemodialysis and renal failure on CA-IMT in patients with chronic renal failure...
  70. ncbi Intrarenal hemodynamic changes after captopril test in patients with type 2 diabetes: a duplex Doppler sonography study
    Hiromichi Taniwaki
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Diabetes Care 26:132-7. 2003
    ..The results emphasize the beneficial effects of ACE inhibition in improving intrarenal hemodynamics in diabetic patients...
  71. ncbi Regulation of plasma fibroblast growth factor 23 by calcium in primary hyperparathyroidism
    Keisuke Kobayashi
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Eur J Endocrinol 154:93-9. 2006
    ..To investigate the role of parathyroid hormone (PTH) and calcium in FGF-23 metabolism, we examined plasma FGF-23 levels in patients with primary hyperparathyroidism (PHPT)...
  72. ncbi Decreases in parathyroid gland volume after cinacalcet treatment in hemodialysis patients with secondary hyperparathyroidism
    Mitsuru Ichii
    Department of Endocrinology, Metabolism, and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Nephron Clin Pract 115:c195-202. 2010
    ..It was examined whether a regression of parathyroid glands in hemodialysis patients with secondary hyperparathyroidism was induced by cinacalcet treatment...
  73. ncbi Decrease of arterial stiffness at common carotid artery in hypothyroid patients by normalization of thyroid function
    Toshiki Nagasaki
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
    Biomed Pharmacother 59:8-14. 2005
    ..Furthermore, it was demonstrated that sustained euthyroidism might have the potential to reverse arterial stiffening in addition to thickening in hypothyroid patients...
  74. ncbi Increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function
    Toshiki Nagasaki
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Eur J Endocrinol 152:347-53. 2005
    ....
  75. ncbi Positive correlation of serum bio-intact PTH(1-84) but not intact PTH with parathyroid gland size in hemodialysis patients
    Masaaki Inaba
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Biomed Pharmacother 60:62-5. 2006
    ..In conclusion, serum Bio-PTH assay could provide a better assay than I-PTH assay to estimate parathyroid function in HD patients, due mainly to its exclusive correlation with parathyroid gland size...
  76. ncbi Preferential reductions of paraarticular trabecular bone component in ultradistal radius and of calcaneus ultrasonography in early-stage rheumatoid arthritis
    Masaaki Inaba
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, 545 8585 Osaka, Japan
    Osteoporos Int 14:683-7. 2003
    ....
  77. ncbi Femoral artery wall thickness and stiffness in evaluation of peripheral vascular disease in type 2 diabetes mellitus
    H Taniwaki
    Second Department of Internal Medicine, Osaka City University Medical School, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
    Atherosclerosis 158:207-14. 2001
    ..These data suggest that stiffening of arterial wall has a significant impact on PVD manifestations, particularly on the leg symptoms, in patients with type 2 diabetes...
  78. ncbi Relations between ACE gene and ecNOS gene polymorphisms and resistive index in type 2 diabetic patients with nephropathy
    H Taniwaki
    Second Department of Internal Medicine, Osaka City University Medical School, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Diabetes Care 24:1653-60. 2001
    ..In order to assess the effect of the gene polymorphism of both ACE and ecNOS on renal hemodynamic abnormality, we examined 155 Japanese patients with type 2 diabetes with various stages of nephropathy...
  79. ncbi Relationship between parathyroid gland size and responsiveness to maxacalcitol therapy in patients with secondary hyperparathyroidism
    Senji Okuno
    Shirasagi Hospital Kidney Center, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
    Nephrol Dial Transplant 18:2613-21. 2003
    ....
  80. ncbi Short-term aerobic exercise improves arterial stiffness in type 2 diabetes
    Hisayo Yokoyama
    Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Diabetes Res Clin Pract 65:85-93. 2004
    ..To investigate whether: (1) aerobic exercise decreases arterial stiffness and (2) reduction in arterial stiffness is associated with improvement in insulin resistance in type 2 diabetes...
  81. ncbi Plasma leptin level and its relationship with body composition in hemodialysis patients
    Y Nishizawa
    Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Am J Kidney Dis 31:655-61. 1998
    ....
  82. ncbi Association of muscle glycogen synthase polymorphism with insulin resistance in type 2 diabetic patients
    Koka Motoyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
    Metabolism 52:895-9. 2003
    ..In conclusion, the M416V polymorphism of GYS1 gene is not associated with insulin resistance in type 2 diabetes...
  83. ncbi Association between plasma angiopoietin-like protein 3 and arterial wall thickness in healthy subjects
    Sawako Hatsuda
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Vasc Res 44:61-6. 2007
    ..We evaluated the possible association between plasma ANGPTL3 level and carotid artery intima-media thickness (CA-IMT) and femoral artery intima-media thickness (FA-IMT) in healthy human subjects...
  84. ncbi Arterial wall thickness is associated with insulin resistance in type 2 diabetic patients
    Shigehiko Fujiwara
    Metabolism, Endocrinology and Molecular Medicine, Department of Internal Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 10:246-52. 2003
    ..0001, respectively). In conclusion, insulin resistance is associated with both CA-IMT and FA-IMT in type 2 diabetic patients, suggesting that it is an independent risk factor for the development of atherosclerosis in type 2 diabetes...
  85. ncbi The K469E polymorphism of the intercellular adhesion molecule-1 gene is associated with plasma fibrinogen level in type 2 diabetes
    Hisayo Yokoyama
    Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Metabolism 54:381-6. 2005
    ....
  86. ncbi Inverse relationship between circulating oxidized low density lipoprotein (oxLDL) and anti-oxLDL antibody levels in healthy subjects
    T Shoji
    Second Department of Internal Medicine, Osaka City University Medical School, 1 4 3, Asahi machi, Abeno Ku, Osaka, Japan
    Atherosclerosis 148:171-7. 2000
    ..Although these results suggest that oxLDL Ab may play a role in maintaining the low level of plasma oxLDL, its role in atherogenesis awaits further studies...
  87. ncbi Quantitative insulin sensitivity check index and the reciprocal index of homeostasis model assessment in normal range weight and moderately obese type 2 diabetic patients
    Hisayo Yokoyama
    Osaka City University Graduate School of Medicine, Metabolism, Endocrinology and Molecular Medicine, Osaka, Japan
    Diabetes Care 26:2426-32. 2003
    ..The latter can probably be applied clinically in view of its convenience...
  88. ncbi Significance of intima-media thickness in femoral artery in the determination of calcaneus osteo-sono index but not of lumbar spine bone mass in healthy Japanese people
    Shinsuke Yamada
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan
    Osteoporos Int 16:64-70. 2005
    ....
  89. ncbi Fetuin-A and atherosclerotic calcified plaque in patients with type 2 diabetes mellitus
    Masanori Emoto
    The Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Metabolism 59:873-8. 2010
    ..753; 95% confidence interval, 0.608-0.933; P = .010). These results suggest that fetuin-A may inhibit the calcification of atherosclerotic plaques independently of the dialyzed condition...
  90. ncbi Effect of insulin resistance on serum paraoxonase activity in a nondiabetic population
    A Yamada
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Metabolism 50:805-11. 2001
    ..These results suggest that insulin resistance or hyperinsulinemia is a factor contributing to the intragenotype variability of paraoxonase activity in a population without overt hyperglycemia...
  91. ncbi Increased stiffness in common carotid artery in hyperthyroid Graves' disease patients
    M Inaba
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    Biomed Pharmacother 56:241-6. 2002
    ..In summary, the significant increase in stiffness beta in the hyperthyroid state may reflect the harmful effect of hyperthyroidism on the arterial wall, which may in turn result from increased stroke volume...
  92. ncbi Regional arterial stiffness in patients with type 2 diabetes and chronic kidney disease
    Eiji Kimoto
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Am Soc Nephrol 17:2245-52. 2006
    ..The cross-sectional result may explain the increased risk for cardiovascular disease in CKD, although longitudinal studies are needed to confirm it...
  93. ncbi A novel index of insulin resistance determined from the homeostasis model assessment index and adiponectin levels in Japanese subjects
    Munehide Matsuhisa
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, 2 2 Yamadaoka, Suita City, Japan
    Diabetes Res Clin Pract 77:151-4. 2007
    ..535, P=0.005 versus r=-0.461, P=0.010). We would therefore like to propose a novel index, HOMA-AD, as a simple and adequate index for determining insulin resistance even in diabetic patients with overt hyperglycemia...
  94. ncbi Pulse wave velocity in lower-limb arteries among diabetic patients with peripheral arterial disease
    Hisayo Yokoyama
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 10:253-8. 2003
    ..CONCLUSIONS: These results suggest that baPWV is increased in diabetic patients, whereas it is decreased in the affected legs in diabetic patients with PAD. Widening of the right-left difference in baPWV may be a novel marker of PAD...
  95. ncbi Effects of pravastatin on serum osteoprotegerin levels in patients with hypercholesterolemia and type 2 diabetes
    Katsuhito Mori
    Departments of Metabolism, Endocrinology, and Molecular Medicinev Osaka City University Graduate School of Medicine, Osaka, Japan
    Angiology 61:86-91. 2010
    ..05 +/- 2.22 pmol/L, P = .026). These findings suggest that pravastatin may exert its pleiotropic effects in part through alteration of osteoprotegerin levels...
  96. ncbi Glimepiride increases high-density lipoprotein cholesterol via increasing adiponectin levels in type 2 diabetes mellitus
    Takahiro Araki
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Metabolism 58:143-8. 2009
    ..524, P = .036). In conclusion, glimepiride improved plasma adiponectin level, especially in the subjects with type 2 diabetes mellitus with low adiponectin level before treatment, and may directly contribute to improving HDL-c level...
  97. ncbi Plasma angiopoietin-like protein 3 (ANGPTL3) concentration is associated with uremic dyslipidemia
    Tetsuo Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Atherosclerosis 207:579-84. 2009
    ..Since the role of angiopoietin-like protein 3 (ANGPTL3) in uremic dyslipidemia is unknown, we examined its possible association with the lipoprotein abnormalities in patients with chronic renal failure (CRF)...
  98. ncbi The association of plasma adiponectin level with carotid arterial stiffness
    Takahiro Araki
    Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
    Metabolism 55:587-92. 2006
    ....
  99. ncbi Neuropsychological status of elderly patients with diabetes mellitus
    Hiroyuki Shimada
    Department of Geriatrics and Neurology, Osaka City University Medical School, Japan
    Diabetes Res Clin Pract 87:224-7. 2010
    ..We studied the prevalence of MCI in DM patients...
  100. ncbi Association of serum TRAIL level with coronary artery disease
    Katsuhito Mori
    The Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Thromb Res 125:322-5. 2010
    ..68; 95% confidence interval 0.51-0.90; p=0.006). Serum TRAIL levels were inversely associated with the advanced CAD, suggesting that TRAIL may be useful as a biomarker of CAD severity...
  101. ncbi Insulin resistance index as a predictor for pioglitazone treatment in type 2 diabetes
    Takahiro Araki
    Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan
    Osaka City Med J 51:19-25. 2005
    ..2%, 22.2%, and 79.4%, respectively, and those for BMI at the cut-off value, 29.1, were 87.5%, 53.3%, and 67.7%, respectively. CONCLUSION: HOMA-IR is a useful predictor of pioglitazone treatment in type 2 diabetic patients...