S Inui

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Dry dermoscopy in clinical treatment of alopecia areata
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Dermatol 34:635-9. 2007
  2. doi request reprint Coudability hairs: a revisited sign of alopecia areata assessed by trichoscopy
    S Inui
    Department of Regenerative Dermatology, Osaka University School of Medicine, Suita Shi, Osaka, Japan
    Clin Exp Dermatol 35:361-5. 2010
  3. doi request reprint Reduction of conspicuous facial pores by topical fullerene: possible role in the suppression of PGE2 production in the skin
    Shigeki Inui
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, 2 2, G2, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    J Nanobiotechnology 12:6. 2014
  4. doi request reprint Androgen actions on the human hair follicle: perspectives
    Shigeki Inui
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan
    Exp Dermatol 22:168-71. 2013
  5. doi request reprint Nalfurafine hydrochloride for the treatment of pruritus
    Shigeki Inui
    Osaka University School of Medicine, Department of Regenerative Dermatology, 2 2, G2, Yamadaoka, Suita Shi, Osaka 5650871, Japan
    Expert Opin Pharmacother 13:1507-13. 2012
  6. doi request reprint Glucocorticoid resistance in atopic dermatitis associated with decreased expression of glucocorticoid receptor-alpha in peripheral blood mononuclear cells
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University School of Medicine, Suita Shi, Osaka, Japan
    J Dermatol 37:496-9. 2010
  7. doi request reprint Clinical significance of dermoscopy in alopecia areata: analysis of 300 cases
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University School of Medicine, and Department of Dermatology, Saiseikai Tondabayashi Hospital, Osaka, Japan
    Int J Dermatol 47:688-93. 2008
  8. doi request reprint Fexofenadine hydrochloride enhances the efficacy of contact immunotherapy for extensive alopecia areata: Retrospective analysis of 121 cases
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University, Japan
    J Dermatol 36:323-7. 2009
  9. doi request reprint Dermoscopic findings in frontal fibrosing alopecia: report of four cases
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University School of Medicine, Osaka 5650871, Japan
    Int J Dermatol 47:796-9. 2008
  10. doi request reprint Scalp dermoscopy of androgenetic alopecia in Asian people
    Shigeki Inui
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Dermatol 36:82-5. 2009

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Dry dermoscopy in clinical treatment of alopecia areata
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Dermatol 34:635-9. 2007
    ..In addition, regrowing vellus hairs, which were difficult to clinically recognize, were detected by dry dermoscopy. Dry dermoscopy is therefore useful for both diagnosis and follow up of AA...
  2. doi request reprint Coudability hairs: a revisited sign of alopecia areata assessed by trichoscopy
    S Inui
    Department of Regenerative Dermatology, Osaka University School of Medicine, Suita Shi, Osaka, Japan
    Clin Exp Dermatol 35:361-5. 2010
    ..Coudability hairs', which are normal-looking hairs tapered at the proximal end, have been previously reported as another sign of AA...
  3. doi request reprint Reduction of conspicuous facial pores by topical fullerene: possible role in the suppression of PGE2 production in the skin
    Shigeki Inui
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, 2 2, G2, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    J Nanobiotechnology 12:6. 2014
    ..Ten healthy Japanese females participated in this study, and they received applications of 1% fullerene lotion to the face twice a day for 8 weeks...
  4. doi request reprint Androgen actions on the human hair follicle: perspectives
    Shigeki Inui
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan
    Exp Dermatol 22:168-71. 2013
    ..Moreover, AGA involves crosstalk between androgen and Wnt/β-catenin signalling. Finally, recent data on susceptibility genes have provided us with the impetus to investigate the molecular pathogenesis of AGA...
  5. doi request reprint Nalfurafine hydrochloride for the treatment of pruritus
    Shigeki Inui
    Osaka University School of Medicine, Department of Regenerative Dermatology, 2 2, G2, Yamadaoka, Suita Shi, Osaka 5650871, Japan
    Expert Opin Pharmacother 13:1507-13. 2012
    ..However, based on the findings of a recent randomized controlled trial, nalfurafine hydrochloride was officially approved in Japan for the treatment of resistant pruritus in hemodialysis patients...
  6. doi request reprint Glucocorticoid resistance in atopic dermatitis associated with decreased expression of glucocorticoid receptor-alpha in peripheral blood mononuclear cells
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University School of Medicine, Suita Shi, Osaka, Japan
    J Dermatol 37:496-9. 2010
    ..As a result, the expression of GRalpha was remarkably decreased compared to normal controls and the other AD patients. Therefore, his poor response to corticosteroid was at least partially caused by this GRalpha decrease in the PBMC...
  7. doi request reprint Clinical significance of dermoscopy in alopecia areata: analysis of 300 cases
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University School of Medicine, and Department of Dermatology, Saiseikai Tondabayashi Hospital, Osaka, Japan
    Int J Dermatol 47:688-93. 2008
    ..To determine dermoscopic findings of alopecia areata (AA) from a large-scale study that can be used as clinical indicators of disease...
  8. doi request reprint Fexofenadine hydrochloride enhances the efficacy of contact immunotherapy for extensive alopecia areata: Retrospective analysis of 121 cases
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University, Japan
    J Dermatol 36:323-7. 2009
    ..303 (n = 33) and that of the control 1.048 (n = 21). There was no significant difference by Mann-Whitney's U-test (P = 0.872). Together, fexofenadine is a helpful reagent in the treatment extensive atopic AA with contact immunotherapy...
  9. doi request reprint Dermoscopic findings in frontal fibrosing alopecia: report of four cases
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University School of Medicine, Osaka 5650871, Japan
    Int J Dermatol 47:796-9. 2008
    ..Differential diagnosis from other types of alopecia, including alopecia areata (AA), is necessary in some cases...
  10. doi request reprint Scalp dermoscopy of androgenetic alopecia in Asian people
    Shigeki Inui
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Dermatol 36:82-5. 2009
    ..In conclusion, dermoscopy is useful to diagnose AGA and FAGA and provides insights into the pathogenesis of AGA...
  11. ncbi request reprint Two cases of pressure ulcer healing after liver transplantation in cirrhosis patients
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Dermatol 34:400-2. 2007
    ..From these findings, the condition of the pressure ulcer in liver cirrhosis patients synchronized with serum bilirubin as well as systemic condition, suggesting a possible influence of bilirubin for wound healing...
  12. doi request reprint Significance of dermoscopy in acute diffuse and total alopecia of the female scalp: review of twenty cases
    Shigeki Inui
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Suita, Japan
    Dermatology 217:333-6. 2008
    ..Differential diagnosis of other types of diffuse alopecia such as female pattern hair loss (FPHL) is necessary in some cases...
  13. doi request reprint Pigmented contact dermatitis due to therapeutic sensitizer as complication of contact immunotherapy in alopecia areata
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University School of Medicine, Suita, Osaka, Japan
    J Dermatol 37:888-93. 2010
    ..Together, pigmentary complication by CI corresponds to PCD from therapeutic sensitizer, representing clinical indicator of poor responsiveness...
  14. doi request reprint Improvement of acne vulgaris by topical fullerene application: unique impact on skin care
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University School of Medicine, Osaka, Japan
    Nanomedicine 7:238-41. 2011
    ..05) increased from 51.7 ± 7.9 to 60.4 ± 10.3 instrumental units. Therefore, the fullerene gel may help in controlling acne vulgaris with skin care benefit...
  15. doi request reprint Trichoscopy for common hair loss diseases: algorithmic method for diagnosis
    Shigeki Inui
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Dermatol 38:71-5. 2011
    ..Finally, an algorithmic method for trichoscopic diagnosing is proposed...
  16. doi request reprint Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University School of Medicine, 2 2, G2, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    J Dermatol Sci 61:1-6. 2011
    ..We expect that more pathogenic mediators will be identified in the future, enabling easier understanding of AGA pathogenesis and providing new therapeutic targets from aspect of andrology...
  17. doi request reprint Dermoscopic evaluation of erythema associated with pressure ulcers
    Shigeki Inui
    Department of Regenerative Dermatology and Department of Traumatology and Acute Critical Medicine, Osaka University School of Medicine 2 2, G2, Yamadaoka, Suita Shi, Osaka 5650871, Japan
    Int J Dermatol 50:945-7. 2011
    ..To assess dermoscopic findings of "non-blanchable erythema" in stage I pressure ulcers and to determine their characteristics...
  18. pmc Identification and characterization of cartilage oligomeric matrix protein as a novel pathogenic factor in keloids
    Shigeki Inui
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan
    Am J Pathol 179:1951-60. 2011
    ..Further, COMP knockdown decreased amount collagens type I to V in the medium and on the cell surfaces. Our data suggest that COMP facilitates keloid formation by accelerating collagen deposition, thus providing a new therapeutic target...
  19. ncbi request reprint Androgen-inducible TGF-beta1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understand paradoxical effects of androgen on human hair growth
    Shigeki Inui
    Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    FASEB J 16:1967-9. 2002
    ....
  20. ncbi request reprint Potential anti-androgenic activity of roxithromycin in skin
    S Inui
    Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University, Osaka, 2 2, C5, Yamada oka, Suita Shi, Osaka 565 0871, Japan
    J Dermatol Sci 27:147-51. 2001
    ....
  21. ncbi request reprint Identification of androgen-inducible TGF-beta1 derived from dermal papilla cells as a key mediator in androgenetic alopecia
    Shigeki Inui
    Department of Dermatology, Osaka University School of Medicine, Osaka, Japan
    J Investig Dermatol Symp Proc 8:69-71. 2003
    ..Moreover, neutralizing anti-TGF-beta1 antibody reversed the inhibition of KC proliferation. Thus, we suggest that androgen-inducible TGF-beta1 derived from DPCs mediates hair growth suppression in AGA...
  22. ncbi request reprint Contact dermatitis due to pirfenoxone
    S Inui
    Department of Dermatology, Unit of Molecular Medicine, Graduate School of Medicine, Osaka University, 2 2, C 5, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Contact Dermatitis 50:375-6. 2004
  23. ncbi request reprint Frictional dermatitis due to paper tissues
    S Inui
    Department of Dermatology, Unit of Molecular Medicine, Graduate School of Medicine, Osaka University, 2 2, C 5, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Contact Dermatitis 50:374-5. 2004
  24. ncbi request reprint Androgen receptor co-activator Hic-5/ARA55 as a molecular regulator of androgen sensitivity in dermal papilla cells of human hair follicles
    Shigeki Inui
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Invest Dermatol 127:2302-6. 2007
    ..Our findings suggest that Hic-5/ARA55 is a molecular regulator for androgen sensitivity in human hair follicles...
  25. ncbi request reprint Churg-Strauss syndrome involving medium-sized arteries
    S Inui
    Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University, 2-2-C5, Yamadaoka, Suita-shi, Osaka, 565-0871, Japan
    J Dermatol 28:161-4. 2001
    ..The neuron conduction rate of his lower leg was slower than that of the normal control, demonstrating mononeuritis. From these findings, we diagnosed this patient as Churg-Strauss syndrome...
  26. ncbi request reprint Contact dermatitis due to alkyl diaminoethylglycine hydrochloride
    H Ito
    Department of Dermatology, Graduate School of Medicine, Osaka University, 2 2 C 5, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Contact Dermatitis 48:233-4. 2003
  27. ncbi request reprint A case of lichenoid purpura possibly caused by diltiazem hydrochloride
    S Inui
    Department of Dermatology, Graduate School of Medicine, Osaka University, Yamadaoka, Suita-shi, Osaka, 565-0871, Japan
    J Dermatol 28:100-2. 2001
    ..Based on the clinical and pathological findings, we diagnosed this case as lichenoid purpura of Gougerot-Blum. The lesions disappeared when the diltiazem hydrochloride that he had been taking was discontinued...
  28. ncbi request reprint Modulation of androgen receptor transcriptional activity by anti-acne reagents
    Shigeki Inui
    Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University, Osaka, 2 2, C5, Yamada oka, Suita Shi, Osaka 565 0871, Japan
    J Dermatol Sci 36:97-101. 2004
    ....
  29. ncbi request reprint Role of androgen in mesenchymal epithelial interactions in human hair follicle
    Satoshi Itami
    Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University, Japan
    J Investig Dermatol Symp Proc 10:209-11. 2005
    ..This growth suppression of KC was mediated by transforming growth factor-beta1 (TGF-beta1) derived from DPC of AGA, suggesting that TGF-beta1 is a paracrine mediator for AGA...
  30. doi request reprint Venous insufficiency in patients with necrobiosis lipoidica
    Takeshi Nakajima
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan
    J Dermatol 36:166-9. 2009
    ..However, these results indicate that both hyperlipidemia and venous reflux, in addition to other pathogenic factors, can trigger tissue damage in the lower legs and lead to the onset of NL...
  31. ncbi request reprint Pulse corticosteroid therapy for alopecia areata: study of 139 patients
    Takeshi Nakajima
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan
    Dermatology 215:320-4. 2007
    ..The purpose of this study was to evaluate the efficacy and safety of pulse corticosteroid therapy for recent-onset AA patients...
  32. ncbi request reprint Baseball pitcher's friction dermatitis
    S Inui
    Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University, 2 2 C 5 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Contact Dermatitis 47:176-7. 2002
  33. ncbi request reprint Aneurysmal fibrous histiocytoma showing transition from factor XIIIa-positive to -negative
    Shigeki Inui
    Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University, Japan
    J Dermatol 29:744-7. 2002
    ....
  34. ncbi request reprint A case of dermatomyositis complicated with pneumomediastinum
    Mika Terao
    Department of Dermatology, Osaka University, 2 2 Yamadaoka, Suita 565 0871, Japan
    Mod Rheumatol 17:156-9. 2007
    ..Pneumomediastinum is a rare complication of DM and its pathogenesis remains unclear. We review the literature and discuss the possible mechanism of this disease...
  35. ncbi request reprint Allergic contact dermatitis induced by rosemary leaf extract in a cleansing gel
    Shigeki Inui
    Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University, Yamadaoka, Suita Shi, Japan
    J Dermatol 32:667-9. 2005
    ..From the patch test results, she reacted positively to the cleansing gel (1% in distilled water) and the rosemary leaf extract (0.1% in distilled water), one of its ingredients...
  36. ncbi request reprint [Vitamin D nuclear receptor and its signal transduction]
    Shigeki Inui
    Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University
    Clin Calcium 14:120-3. 2004
    ..Vitamin D receptor (VDR) recruits mainly DRIP (vitamin D receptor interacting protein) during keratinocyte proliferation, but SRC (steroid receptor coactivator) during differentiation...
  37. ncbi request reprint Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia
    Yutaka Suzuki
    Read Generation Laboratory, Tanabe Seiyaku Co Ltd, 3 16 89 Kashima, Yodogawa ku, Osaka, Japan
    FEBS Lett 521:67-71. 2002
    ..Interestingly, the LIG-1 expression was apparently down-regulated in the psoriatic lesions, suggesting that LIG-1 inversely correlates with proliferative ability of epidermal keratinocytes...
  38. ncbi request reprint Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes
    Shigeki Inui
    Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Dermatol Sci 31:65-71. 2003
    ..We have reported that human TR2 orphan nuclear receptor (TR2) can modulate the transcriptional activity of the reporter gene containing an AGGTCA direct repeat-hormone response element...
  39. ncbi request reprint A case of pruritic urticarial papules and plaques of pregnancy associated with external cephalic version
    Aiko Imanaka
    J Dermatol 31:767-8. 2004
  40. ncbi request reprint Reversal of androgenetic alopecia by topical ketoconzole: relevance of anti-androgenic activity
    Shigeki Inui
    J Dermatol Sci 45:66-8. 2007
  41. pmc TR4 orphan nuclear receptor functions as an apoptosis modulator via regulation of Bcl-2 gene expression
    Eungseok Kim
    George Whipple Lab for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 361:323-8. 2007
    ..Together, our results demonstrate that TR4 might function as an apoptosis modulator through induction of Bcl-2 gene expression...
  42. doi request reprint Granulomatous cheilitis successfully treated with roxithromycin
    Shigeki Inui
    J Dermatol 35:244-5. 2008
  43. ncbi request reprint Two cases of alopecia areata responsive to fexofenadine
    Shigeki Inui
    J Dermatol 34:852-4. 2007