Hiroaki Inaba

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. doi request reprint Proliferation of smooth muscle cells stimulated by Porphyromonas gingivalis is inhibited by apple polyphenol
    Hiroaki Inaba
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Periodontol 82:1616-22. 2011
  2. pmc Identification of signaling pathways mediating cell cycle arrest and apoptosis induced by Porphyromonas gingivalis in human trophoblasts
    Hiroaki Inaba
    Department of Oral Frontier Biology, Center for Frontier Oral Science, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    Infect Immun 80:2847-57. 2012
  3. ncbi request reprint Painless mass of the cheek
    Hiroaki Inaba
    Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Disease, Osaka University, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:3-6. 2003
  4. ncbi request reprint Apple- and hop-polyphenols protect periodontal ligament cells stimulated with enamel matrix derivative from Porphyromonas gingivalis
    Hiroaki Inaba
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Periodontol 76:2223-9. 2005
  5. ncbi request reprint Identification of hop polyphenolic components which inhibit prostaglandin E2 production by gingival epithelial cells stimulated with periodontal pathogen
    Hiroaki Inaba
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biol Pharm Bull 31:527-30. 2008
  6. ncbi request reprint Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype
    Takahiro Kato
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    Cell Microbiol 9:753-65. 2007
  7. ncbi request reprint Proinflammatory gene expression in mouse ST2 cell line in response to infection by Porphyromonas gingivalis
    Takashi Ohno
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Microbes Infect 8:1025-34. 2006
  8. pmc Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae
    Ichiro Nakagawa
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Infect Immun 74:3773-82. 2006
  9. ncbi request reprint Inflammatory responses of gingival epithelial cells stimulated with Porphyromonas gingivalis vesicles are inhibited by hop-associated polyphenols
    Yurong Kou
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Periodontol 79:174-80. 2008
  10. doi request reprint Upregulation of S100 calcium-binding protein A9 is required for induction of smooth muscle cell proliferation by a periodontal pathogen
    Hiroaki Inaba
    Department of Oral Frontier Biology, Graduate School of Dentistry, Osaka University, Suita 565 0871, Japan
    FEBS Lett 583:128-34. 2009

Collaborators

Detail Information

Publications26

  1. doi request reprint Proliferation of smooth muscle cells stimulated by Porphyromonas gingivalis is inhibited by apple polyphenol
    Hiroaki Inaba
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Periodontol 82:1616-22. 2011
    ..In the present study, we examine the involvement of Pg gingipains and fimbriae in induction of the SMC transformation and proliferation, and effective inhibitors...
  2. pmc Identification of signaling pathways mediating cell cycle arrest and apoptosis induced by Porphyromonas gingivalis in human trophoblasts
    Hiroaki Inaba
    Department of Oral Frontier Biology, Center for Frontier Oral Science, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    Infect Immun 80:2847-57. 2012
    ..These results suggest that P. gingivalis activates cellular DNA damage signaling pathways that lead to G(1) arrest and apoptosis in trophoblasts...
  3. ncbi request reprint Painless mass of the cheek
    Hiroaki Inaba
    Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Disease, Osaka University, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:3-6. 2003
  4. ncbi request reprint Apple- and hop-polyphenols protect periodontal ligament cells stimulated with enamel matrix derivative from Porphyromonas gingivalis
    Hiroaki Inaba
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Osaka, Japan
    J Periodontol 76:2223-9. 2005
    ..In the present study, we examined apple- (AP) and hop-polyphenols to determine their ability to protect EMD-stimulated PDL cells from P. gingivalis...
  5. ncbi request reprint Identification of hop polyphenolic components which inhibit prostaglandin E2 production by gingival epithelial cells stimulated with periodontal pathogen
    Hiroaki Inaba
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biol Pharm Bull 31:527-30. 2008
    ..These results suggest that HBP is a potent inhibitor of cellular PGE2 production induced by P. gingivalis, and HBP may be useful for the prevention and attenuation of periodontitis...
  6. ncbi request reprint Virulence of Porphyromonas gingivalis is altered by substitution of fimbria gene with different genotype
    Takahiro Kato
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    Cell Microbiol 9:753-65. 2007
    ..In a mouse abscess model, the type II clones significantly induced serum IL-1beta and IL-6, as well as other infectious symptoms. These results suggest that type II fimbriae are a critical determinant of P. gingivalis virulence...
  7. ncbi request reprint Proinflammatory gene expression in mouse ST2 cell line in response to infection by Porphyromonas gingivalis
    Takashi Ohno
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Microbes Infect 8:1025-34. 2006
    ..These results suggest that P. gingivalis infection induces gene expression of a wide variety of proinflammatory proteins in stromal cells/osteoblasts, and gingipains may be involved in inducing several of the proinflammatory factors...
  8. pmc Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae
    Ichiro Nakagawa
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Infect Immun 74:3773-82. 2006
    ..gingivalis efficiently invades epithelial cells and degrades focal adhesion components with Arg-gingipain, which results in cellular impairment during wound healing and periodontal tissue regeneration...
  9. ncbi request reprint Inflammatory responses of gingival epithelial cells stimulated with Porphyromonas gingivalis vesicles are inhibited by hop-associated polyphenols
    Yurong Kou
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Periodontol 79:174-80. 2008
    ..In the present study, we examined the inhibitory effects of hop bract polyphenol (HBP) on cellular inflammatory responses induced by P. gingivalis membrane vesicles...
  10. doi request reprint Upregulation of S100 calcium-binding protein A9 is required for induction of smooth muscle cell proliferation by a periodontal pathogen
    Hiroaki Inaba
    Department of Oral Frontier Biology, Graduate School of Dentistry, Osaka University, Suita 565 0871, Japan
    FEBS Lett 583:128-34. 2009
    ..gingivalis on transformation and proliferation of hAOSMCs. Our data suggested that upregulation of S100A9 mediated by P. gingivalis is an important event in the development of aortic intimal hyperplasia...
  11. pmc Distinct roles of long/short fimbriae and gingipains in homotypic biofilm development by Porphyromonas gingivalis
    Masae Kuboniwa
    Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    BMC Microbiol 9:105. 2009
    ..The aim of this study was to examine the roles of these components in homotypic biofilm development by P. gingivalis, as well as in accumulation of exopolysaccharide in biofilms...
  12. ncbi request reprint Functional analysis of alpha5beta1 integrin and lipid rafts in invasion of epithelial cells by Porphyromonas gingivalis using fluorescent beads coated with bacterial membrane vesicles
    Kayoko Tsuda
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    Cell Struct Funct 33:123-32. 2008
    ..gingivalis adhesion to epithelial cells, while the subsequent uptake process requires lipid raft components for actin organization, with Rho GTPase Rac1...
  13. pmc Association between epithelial cell death and invasion by microspheres conjugated to Porphyromonas gingivalis vesicles with different types of fimbriae
    Hiroaki Inaba
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Infect Immun 74:734-9. 2006
    ..Cell death was induced by MS, though becoming less frequent over time, with invasion efficiency partially related to cell death and gingipains likely the major cause...
  14. ncbi request reprint Inhibitory effects of tumor necrosis factor-alpha on migration of human periodontal ligament cells
    Akane Takemura
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Periodontol 77:883-90. 2006
    ..In the present study, we examined the effects of TNF-alpha on migration and proliferation of human periodontal ligament (PDL) cells...
  15. ncbi request reprint Effect of enamel matrix derivative on periodontal ligament cells in vitro is diminished by Porphyromonas gingivalis
    Hiroaki Inaba
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Periodontol 75:858-65. 2004
    ..The present study examined the influence of Porphyromonas gingivalis on EMD-stimulated periodontal ligament (PDL) cells...
  16. doi request reprint Distribution and molecular characterization of Porphyromonas gulae carrying a new fimA genotype
    Yoshie Yamasaki
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
    Vet Microbiol 161:196-205. 2012
    ..gulae is diverse with the virulence of genotype C strains the highest and that molecular identification of genotype C P. gulae could be a possible useful marker for identifying dogs at high risk of developing periodontitis...
  17. doi request reprint [Cardiovascular diseases and periodontal diseases]
    Atsuo Amano
    Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, Japan
    Clin Calcium 22:43-8. 2012
    ..These findings likely indicate the tight relationship between periodontitis/periodontal pathogens and cardiovascular diseases...
  18. pmc Porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation
    Hiroaki Inaba
    Department of Oral Frontier Biology, Center for Frontier Oral Science, Osaka University Graduate School of Dentistry, Suita, Osaka, 565 0871, Japan
    Cell Microbiol 16:131-45. 2014
    ..These findings suggest a novel mechanism of progression and metastasis of OSCC associated with periodontitis. ..
  19. pmc Detection of cariogenic Streptococcus mutans in extirpated heart valve and atheromatous plaque specimens
    Kazuhiko Nakano
    Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, 1 8 Yamada oka, Suita, Osaka 565 0871, Japan
    J Clin Microbiol 44:3313-7. 2006
    ..These results indicate that S. mutans is a possible causative agent of cardiovascular disease...
  20. ncbi request reprint Impaired degradation of matrix collagen in human gingival fibroblasts by the antiepileptic drug phenytoin
    Takahiro Kato
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Periodontol 76:941-50. 2005
    ..However, the etiology of such collagen accumulation is still largely unknown. We examined the effects of PHT on the collagen degradation process leading to collagen accumulation in human gingival fibroblasts (HGF)...
  21. ncbi request reprint Roles of oral bacteria in cardiovascular diseases--from molecular mechanisms to clinical cases: Implication of periodontal diseases in development of systemic diseases
    Hiroaki Inaba
    Department of Oral Frontier Biology, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan
    J Pharmacol Sci 113:103-9. 2010
    ....
  22. ncbi request reprint Inhibitory effects of Porphyromonas gingivalis fimbriae on interactions between extracellular matrix proteins and cellular integrins
    Ichiro Nakagawa
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    Microbes Infect 7:157-63. 2005
    ..gingivalis cells. These results suggest that P. gingivalis fimbriae compete with ECM proteins for alphavbeta3- and alpha5beta1-integrins, and inhibit integrin/ECM protein-related cellular functions...
  23. ncbi request reprint Odd-skipped related 2 splicing variants show opposite transcriptional activity
    Shinji Kawai
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
    Biochem Biophys Res Commun 328:306-11. 2005
    ..Further, Flag-tagged variants also showed opposite transcriptional activities, though they were in contrast to the findings for the Gal4-fused variants. Our results indicate that Osr2 bifurcates its function by alternative splicing...
  24. pmc Porphyromonas gingivalis induces receptor activator of NF-kappaB ligand expression in osteoblasts through the activator protein 1 pathway
    Nobuo Okahashi
    Department of Oral Frontier Biology, Osaka University Graduate School of Dentistry, Osaka Suita 565 0871, Japan
    Infect Immun 72:1706-14. 2004
    ..These results suggest that P. gingivalis infection induces RANKL expression in osteoblasts through AP-1 signaling pathways and cysteine proteases of the organism are involved in RANKL production...
  25. ncbi request reprint Relationship of serum advanced glycation end products with deterioration of periodontitis in type 2 diabetes patients
    Munehiro Takeda
    Department of Oral Frontier Biology, Graduate School of Dentistry, Osaka University, Suita Osaka, Japan
    J Periodontol 77:15-20. 2006
    ..In the present study, we examined whether other biomarkers are related to the development and deterioration of periodontitis often seen in type 2 diabetic individuals...
  26. pmc Porphyromonas gingivalis SerB-mediated dephosphorylation of host cell cofilin modulates invasion efficiency
    Catherine E Moffatt
    Center for Oral Health and Systemic Disease, School of Dentistry, University of Louisville, Louisville, KY 40202, USA
    Cell Microbiol 14:577-88. 2012
    ..These results show that P. gingivalis SerB activity induces dephosphorylation of cofilin, and that active cofilin is required for optimal invasion into gingival epithelial cells...