E Imai

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Smooth muscle alpha-actin deficiency in myofibroblasts leads to enhanced renal tissue fibrosis
    Masanobu Takeji
    Genome Information Research Center, Research Institute for Microbial Diseases, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:40193-200. 2006
  2. ncbi request reprint Olmesartan reducing incidence of endstage renal disease in diabetic nephropathy trial (ORIENT): rationale and study design
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 29:703-9. 2006
  3. ncbi request reprint Glowing podocytes in living mouse: transgenic mouse carrying a podocyte-specific promoter
    E Imai
    First Department of Medicine, University School of Medicine, Osaka University, Osaka, Japan
    Exp Nephrol 7:63-6. 1999
  4. ncbi request reprint Cardiovascular effect of normalizing the hematocrit level during erythropoietin therapy in predialysis patients with chronic renal failure
    T Hayashi
    Department of Nephrology, Osaka Prefectural Hospital, Osaka University School of Medicine, Japan terry
    Am J Kidney Dis 35:250-6. 2000
  5. ncbi request reprint Gene therapy approach in renal disease in the 21st century
    E Imai
    Division of Nephrology, Department of Internal Medicine and Therapeutics, Graduate School of Medicine, Osaka University, Japan
    Nephrol Dial Transplant 16:26-34. 2001
  6. ncbi request reprint Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 11:41-50. 2007
  7. ncbi request reprint Adenosine A1 receptor antagonist improves intradialytic hypotension
    E Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita 565 0871, Osaka, Japan
    Kidney Int 69:877-83. 2006
  8. ncbi request reprint Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 11:156-63. 2007
  9. ncbi request reprint Targeting growth factors to the kidney: myth or reality?
    Enyu Imai
    Division of Nephrology, Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Osaka, Japan
    Curr Opin Nephrol Hypertens 11:49-57. 2002
  10. ncbi request reprint Can bone marrow differentiate into renal cells?
    Enyu Imai
    Department of Internal Medicine and Therapeutics, Division of Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, 565 0871 Osaka, Japan
    Pediatr Nephrol 17:790-4. 2002

Collaborators

Detail Information

Publications117 found, 100 shown here

  1. ncbi request reprint Smooth muscle alpha-actin deficiency in myofibroblasts leads to enhanced renal tissue fibrosis
    Masanobu Takeji
    Genome Information Research Center, Research Institute for Microbial Diseases, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:40193-200. 2006
    ..These results indicate that SMalphaA suppresses the pro-fibrotic properties of myofibroblasts, highlighting the significance of smooth muscle-related proteins in moderating chronic organ fibrosis under pathological conditions...
  2. ncbi request reprint Olmesartan reducing incidence of endstage renal disease in diabetic nephropathy trial (ORIENT): rationale and study design
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 29:703-9. 2006
    ..0 mg/dl, the need for chronic dialysis, or renal transplantation) or death. The average follow-up period is 4 years and the study ends in 2009...
  3. ncbi request reprint Glowing podocytes in living mouse: transgenic mouse carrying a podocyte-specific promoter
    E Imai
    First Department of Medicine, University School of Medicine, Osaka University, Osaka, Japan
    Exp Nephrol 7:63-6. 1999
    ....
  4. ncbi request reprint Cardiovascular effect of normalizing the hematocrit level during erythropoietin therapy in predialysis patients with chronic renal failure
    T Hayashi
    Department of Nephrology, Osaka Prefectural Hospital, Osaka University School of Medicine, Japan terry
    Am J Kidney Dis 35:250-6. 2000
    ..In conclusion, from the perspective of LVH regression, the normalization of Ht was found to be more effective than that associated with a partial correction of anemia during rHuEPO therapy...
  5. ncbi request reprint Gene therapy approach in renal disease in the 21st century
    E Imai
    Division of Nephrology, Department of Internal Medicine and Therapeutics, Graduate School of Medicine, Osaka University, Japan
    Nephrol Dial Transplant 16:26-34. 2001
    ..The emerging strategies of gene transfer in kidneys are reviewed and the potential application of gene therapy in renal diseases are discussed...
  6. ncbi request reprint Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 11:41-50. 2007
    ..In the present study, the equations originally developed for a Caucasian population were tested in Japanese CKD patients, and modified with the Japanese coefficient determined by the data...
  7. ncbi request reprint Adenosine A1 receptor antagonist improves intradialytic hypotension
    E Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita 565 0871, Osaka, Japan
    Kidney Int 69:877-83. 2006
    ..No apparent side effects were observed from treatment with FK352. In conclusion, the A1 antagonist FK352 may offer a novel therapeutic option for chronic dialysis patients associated with intradialytic hypotension...
  8. ncbi request reprint Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 11:156-63. 2007
    ..However, to date, a nationwide epidemiological study has not been conducted yet to survey the CKD population...
  9. ncbi request reprint Targeting growth factors to the kidney: myth or reality?
    Enyu Imai
    Division of Nephrology, Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Osaka, Japan
    Curr Opin Nephrol Hypertens 11:49-57. 2002
    ..Thus, targeting growth factors and cytokines in renal diseases could be a promising therapeutic approach...
  10. ncbi request reprint Can bone marrow differentiate into renal cells?
    Enyu Imai
    Department of Internal Medicine and Therapeutics, Division of Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, 565 0871 Osaka, Japan
    Pediatr Nephrol 17:790-4. 2002
    ..Identification of factors that support stem cells or promote their differentiation should provide a relevant step towards cell therapy...
  11. ncbi request reprint Kidney disease screening program in Japan: history, outcome, and perspectives
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin J Am Soc Nephrol 2:1360-6. 2007
    ....
  12. doi request reprint Chronic Kidney Disease Japan Cohort (CKD-JAC) study: design and methods
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 31:1101-7. 2008
    ..Insights from the CKD-JAC study will provide a basis for future interventional trials focused on reducing the burden of ESRD and CVD in patients with CKD in Japan...
  13. ncbi request reprint Gene therapy in renal diseases
    Enyu Imai
    Division of Nephrology, Department of Internal Medicine, Osaka University Graduate School of Medicine, Japan
    Kidney Int 65:1551-5. 2004
    ..The importation of the novel technology, for example hybrid stem cell-gene therapy could promote the gene therapy of renal diseases toward clinical application...
  14. ncbi request reprint Towards gene therapy for renal diseases
    E Imai
    Division of Nephrology, Osaka University School of Medicine
    Nephrologie 19:397-402. 1998
    ..We believe that the gene transfer technique will become common strategy to study the molecular aspect of the renal diseases and will be possibly applicable to molecular intervention in nephrology...
  15. ncbi request reprint Carbonic adsorbent AST-120 retards progression of renal failure by additive effect with ACEI and protein restriction diet
    Enyu Imai
    Division of Nephrology, Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 7:113-9. 2003
    ....
  16. ncbi request reprint Strategies of gene transfer to the kidney
    E Imai
    The First Department of Medicine, Osaka University School of Medicine, Suita, Japan
    Kidney Int 53:264-72. 1998
    ..We believe that gene transfer techniques will become common tools for the dissection of molecular aspects of diseases and possibly for gene therapy in the field of nephrology...
  17. ncbi request reprint Modification of the Modification of Diet in Renal Disease (MDRD) Study equation for Japan
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Japan
    Am J Kidney Dis 50:927-37. 2007
    ..The Modification of Diet in Renal Disease (MDRD) Study equation was developed in whites and African Americans, but performance was not evaluated in Japanese...
  18. doi request reprint Slower decline of glomerular filtration rate in the Japanese general population: a longitudinal 10-year follow-up study
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 31:433-41. 2008
    ..Hypertension, proteinuria and lower GFR were found to be significant risk factors for a faster decline of GFR...
  19. ncbi request reprint Up-regulation of HSP47 in the mouse kidneys with unilateral ureteral obstruction
    T Moriyama
    First Department of Medicine, Osaka University School of Medicine, Faculty of Health and Sport Sciences, Japan
    Kidney Int 54:110-9. 1998
    ..It is well recognized that renin-angiotensin system (RAS) is enhanced in the setting of UUO and that enhanced RAS has been implicated in the pathogenesis of interstitial fibrosis in the obstructed kidneys...
  20. ncbi request reprint Bone marrow is a reservoir of repopulating mesangial cells during glomerular remodeling
    T Ito
    Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Osaka University, Suita, Osaka, Japan
    J Am Soc Nephrol 12:2625-35. 2001
    ..The results indicate that the bone marrow can give rise to mesangial cells in vivo...
  21. ncbi request reprint Electroporation-mediated PDGF receptor-IgG chimera gene transfer ameliorates experimental glomerulonephritis
    H Nakamura
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Kidney Int 59:2134-45. 2001
    ..CONCLUSION: These results suggest that gene therapy by the manipulation of PDGF action using electroporation-mediated PDGFR/Fc gene transfer to the skeletal muscle might be a useful treatment for mesangioproliferative glomerulonephritis...
  22. ncbi request reprint A case of tacrolimus nephrotoxicity appearing in a second renal transplantation patient
    K Oka
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Clin Transplant 15:30-4. 2001
    ..The case is interesting in considering the functional toxicity of tacrolimus and the difference between tacrolimus and cyclosporin in terms of immunosuppressive and nephrotoxic actions...
  23. ncbi request reprint Transforming growth factor-beta 1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction
    Y Isaka
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Kidney Int 58:1885-92. 2000
    ....
  24. ncbi request reprint TCV-116 inhibits interstitial fibrosis and HSP47 mRNA in rat obstructive nephropathy
    T Moriyama
    First Department of Medicine, Osaka University School of Medicine, Faculty of Health, Japan
    Kidney Int Suppl 63:S232-5. 1997
    ..A possible involvement of HSP47 in the pathogenesis of interstitial fibrosis in UUO is suggested; however, further investigation is required to identify the signals involved in the induction of HSP47 in UUO...
  25. ncbi request reprint Increased expression of renin in chronic allograft nephropathy
    K Oka
    Department of Pathology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Transplant Proc 37:2131-4. 2005
    ..A possible role of renin-angiotensin system for CAN has been suggested through clinical observations that angiotensin-converting enzyme inhibition and angiotensin II receptor blockers prevent CAN...
  26. ncbi request reprint Electroporation-mediated gene transfer that targets glomeruli
    M Tsujie
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    J Am Soc Nephrol 12:949-54. 2001
    ..In conclusion, gene transfer into renal artery followed by electroporation was an effective and simple strategy for gene transfer that targets glomerular mesangial cells...
  27. ncbi request reprint A clinicopathologic study of p27(kip1) expression in renal allograft biopsy
    K Oka
    Department of Pathology, Osaka Kaisei Hospital, Osaka, Japan
    Transplant Proc 39:3068-71. 2007
    ..In IgA nephropathy, a decreased p27kip1 expression in podocytes has been reported to be related to lesion formation of focal segmental glomerulosclerosis and renal dysfunction. We reviewed the p27kip1 expression in transplanted kidneys...
  28. ncbi request reprint [Gene therapy and tissue engineering in nephrology and renal transplantation]
    E Imai
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
    Nippon Rinsho 59:65-71. 2001
    ..Completion of bioinformatics, can facilitate the above post-genome project...
  29. pmc Effects of olmesartan on renal and cardiovascular outcomes in type 2 diabetes with overt nephropathy: a multicentre, randomised, placebo-controlled study
    E Imai
    Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Diabetologia 54:2978-86. 2011
    ..The renal and cardiovascular protective effects of angiotensin receptor blocker (ARB) remain controversial in type 2 diabetic patients treated with a contemporary regimen including an angiotensin converting enzyme inhibitor (ACEI)...
  30. ncbi request reprint Electroporation-mediated HGF gene transfection protected the kidney against graft injury
    Y Isaka
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Gene Ther 12:815-20. 2005
    ..We conclude that electroporation-mediated ex vivo HGF gene transfection protects the kidney against graft injury in a porcine model...
  31. ncbi request reprint Fluvastatin suppresses oxidative stress and fibrosis in the interstitium of mouse kidneys with unilateral ureteral obstruction
    T Moriyama
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, School of Health and Sport Sciences, Osaka University, Osaka, Japan
    Kidney Int 59:2095-103. 2001
    ..Fluvastatin is an HMG-CoA reductase inhibitor and has been demonstrated to have an antioxidant activity in vitro...
  32. ncbi request reprint Prolonged transgene expression in glomeruli using an EBV replicon vector system combined with HVJ liposomes
    M Tsujie
    Department of Internal Medicine and Therapeutics (A8, and Division of Gene Therapy Science, Osaka University Graduate School of Medicine, Osaka, Japan
    Kidney Int 59:1390-6. 2001
    ....
  33. ncbi request reprint Transcription factor Ets-1 is essential for mesangial matrix remodeling
    M Mizui
    Department of Nephrology, Osaka University Graduate School of Medicine A8, Suita, Japan
    Kidney Int 70:298-305. 2006
    ..In contrast, knockdown of Ets-1 in glomeruli resulted in severe ECM deposition in diseased glomeruli. In conclusion, Ets-1 promotes degradation of ECM proteins and is critical for integral glomerular reorganization...
  34. ncbi request reprint Rapid and diverse changes of gene expression in the kidneys of protein-overload proteinuria mice detected by microarray analysis
    Y Nagasawa
    Department of Internal Medicine and Therapeutics, Graduate School of Medicine (A8, Osaka University, 2-2 Yamadaoka, Suita, Osaka 560-0871, Japan
    Nephrol Dial Transplant 16:923-31. 2001
    ..CONCLUSION: The microarray analysis revealed that the renal gene expression pattern was changed dynamically in mice with experimentally induced proteinuria within a few weeks...
  35. ncbi request reprint Exploring RNA interference as a therapeutic strategy for renal disease
    Y Takabatake
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine A8, Suita, Japan
    Gene Ther 12:965-73. 2005
    ..In addition, vector-based RNAi also inhibited TGF-beta1 expression in vitro and in vivo. In conclusion, siRNA-directed TGF-beta1 silencing may be of therapeutic value in the prevention and treatment of fibrotic diseases...
  36. doi request reprint Prevalence of chronic kidney disease in the Japanese general population
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Exp Nephrol 13:621-30. 2009
    ..We re-estimated the prevalence of CKD by measuring proteinuria using a dipstick test and by calculating the GFR using a new equation that estimates GFR based on data from the Japanese annual health check program in 2005...
  37. ncbi request reprint Serum NTX is a practical marker for assessing antiresorptive therapy for glucocorticoid treated patients with chronic kidney disease
    Takayuki Hamano
    Department of Internal Medicine, Osaka University School of Medicine, Box A8, 2 2 Yamada oka, Suita 565 0871, Japan
    Bone 39:1067-72. 2006
    ..Glucocorticoid (GC), which is often used for the treatment of kidney disease, may enhance bone resorption. We studied the bone resorption state in GC-treated CKD patients and the effects of bisphosphonate on S-NTX...
  38. doi request reprint The impact of diabetes mellitus on vitamin D metabolism in predialysis patients
    Hirotaka Tanaka
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2 2 Yamadaoka, Suita, Osaka, Japan
    Bone 45:949-55. 2009
    ..Poorer vitamin D status and higher CaP product might be partly responsible for functional and structural changes of vasculature, respectively, in DM...
  39. ncbi request reprint Expression of the Na+/myo-inositol cotransporter in the juxtaglomerular region
    A Yamauchi
    First Department of Medicine, Osaka University School of Medicine, Japan
    Kidney Int Suppl 67:S183-5. 1998
    ..Because SMIT expression seemed to be proportional to the magnitude of NaCl reabsorption, it may be a good marker for examination of the tubuloglomerular feedback mechanism in vivo...
  40. ncbi request reprint Probucol suppresses ICAM-1 expression in rat mesangial cells: possible role of IL-1
    T Sugiura
    First Department of Medicine, Osaka University School of Medicine, Osaka National Hospital, Japan
    Kidney Int Suppl 71:S167-70. 1999
    ..In this brief report, we review the actions of probucol on IL-1 secretion and discuss the possible mechanism by which probucol may suppress the glomerular injury...
  41. ncbi request reprint Introduction of DNA enzyme for Egr-1 into tubulointerstitial fibroblasts by electroporation reduced interstitial alpha-smooth muscle actin expression and fibrosis in unilateral ureteral obstruction (UUO) rats
    H Nakamura
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Japan
    Gene Ther 9:495-502. 2002
    ....
  42. ncbi request reprint Risk factors for graft loss in patients with recurrent IGA nephropathy after renal transplantation
    Y Namba
    Department of Pathology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Transplant Proc 36:1314-6. 2004
    ..The recurrence rate of IgA nephropathy (IgAN) in transplanted kidneys has been reported to be >50%. Although recurrent IgAN has a benign clinical course, recent data suggest that it leads to graft loss in a substantial number of patients...
  43. ncbi request reprint Electroporation-mediated HGF gene transfer ameliorated cyclosporine nephrotoxicity
    Masayuki Mizui
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Kidney Int 65:2041-53. 2004
    ..Here, we investigated protective effects of HGF gene therapy on rat CsA-induced nephrotoxicity using electroporation-mediated gene transfer...
  44. ncbi request reprint Application of bone marrow-derived stem cells in experimental nephrology
    T Ito
    Osaka University School of Medicine, Department of Internal Medicine and Therapeutics, Osaka, Japan
    Exp Nephrol 9:444-50. 2001
    ..Using this system, we have reported that bone marrow provides mesangial cells during repair process. In this manuscript, we briefly summarize our experiences...
  45. ncbi request reprint Differential diagnosis of prerenal azotemia from acute tubular necrosis and prediction of recovery by Doppler ultrasound
    M Izumi
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Kidney Dis 35:713-9. 2000
    ..Furthermore, one can predict recovery from ATN by Doppler findings. Thus, we consider Doppler ultrasound an effective diagnostic tool in ARF...
  46. ncbi request reprint Early treatment with corticosteroids ameliorates proteinuria, proliferative lesions, and mesangial phenotypic modulation in adult diffuse proliferative IgA nephropathy
    T Shoji
    Department of Nephrology, Osaka Prefectural General Hospital, Japan
    Am J Kidney Dis 35:194-201. 2000
    ..EDA-FN did not change in either group. We conclude that early treatment with corticosteroids for adult diffuse proliferative IgA nephropathy is effective in reducing renal injury...
  47. doi request reprint Renal artery injection for delivery of biological materials to the glomerulus
    Yoshitsugu Takabatake
    Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Nephrology (Carlton) 13:23-6. 2008
    ..We investigated whether injection of synthetic small interfering siRNAs via renal artery followed by electroporation could be effective in silencing specific genes in glomerulus...
  48. ncbi request reprint Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction
    Katsuyuki Nagatoya
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, and School ofHealth and Sport Sciences, Osaka University, Osaka, Japan
    Kidney Int 61:1684-95. 2002
    ..These actions of Rho mediated by downstream Rho effectors such as Rho-associated coiled-coil forming protein kinase (ROCK) may be partly responsible for the progression of renal interstitial fibrosis...
  49. ncbi request reprint [Equation for estimating GFR from creatinine in Japan]
    Enyu Imai
    Department of Nephrology, Graduate School of Medicine, Osaka University
    Nihon Rinsho 66:1725-9. 2008
    ..The new Japanese equations provide more accurate estimation of GFR for Japanese population...
  50. doi request reprint Pharmacokinetics of olmesartan medoxomil in hemodialysis patients: little effect of dialysis upon its pharmacokinetics
    Hirotaka Tanaka
    Department of Nephrology, Osaka University Graduate School of Medicine, B6 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Clin Exp Nephrol 13:61-5. 2009
    ..This result suggests that plasma concentration of olmesartan medoxomil does not decrease during hemodialysis, and that it is not necessary to change prescription on hemodialysis day or not...
  51. ncbi request reprint Integrated therapies including erythropoietin decrease the incidence of dialysis: lessons from mapping the incidence of end-stage renal disease in Japan
    Yoshiyuki Furumatsu
    Department of Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka A8, Suita City, Osaka 565 0871, Japan
    Nephrol Dial Transplant 23:984-90. 2008
    ..In order to test the hypothesis that the usage of EPO in predialysis CKD patients may ameliorate the progression of renal disease, we conducted a macro-level observational study dealing with all Japanese predialysis CKD patients...
  52. doi request reprint Revised equations for estimated GFR from serum creatinine in Japan
    Seiichi Matsuo
    Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Kidney Dis 53:982-92. 2009
    ..Our previously reported GFR-estimating equations for Japanese had limitations because all participants had a GFR less than 90 mL/min/1.73 m2 and serum creatinine was assayed in different laboratories...
  53. doi request reprint Effect of a carbonaceous oral adsorbent on the progression of CKD: a multicenter, randomized, controlled trial
    Tadao Akizawa
    Department of Nephrology, Showa University School of Medicine, Tokyo, Japan
    Am J Kidney Dis 54:459-67. 2009
    ..The carbonaceous oral adsorbent AST-120 slows the deterioration of kidney function in patients with advanced chronic kidney disease (CKD). However, information about AST-120 in patients with less severe stages of CKD is lacking...
  54. ncbi request reprint Perspectives for gene therapy in renal diseases
    Enyu Imai
    Division of Nephrology, Department of Internal Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871
    Intern Med 43:85-96. 2004
    ..We believe that the future of gene therapy research is exciting and promising and it holds an enormous potential for clinical application...
  55. ncbi request reprint Apoptosis induced by hypertonicity in Madin Darley canine kidney cells: protective effect of betaine
    M Horio
    School of Allied Health Sciences, Department of Internal Medicine and Therapeutics and. Faculty of Health and Sport Science, Osaka University School of Medicine, Suita, Osaka, Japan
    Nephrol Dial Transplant 16:483-90. 2001
    ....
  56. ncbi request reprint A case of Guillain-Barré syndrome developed minimal change nephrotic syndrome simultaneously
    H Kitamura
    First Department of Medicine, Osaka University School of Medicine, Japan
    Am J Nephrol 18:151-4. 1998
    ..To our knowledge, this is the first report of a case beneficially treated with glucocorticoids, suggesting that immune disorder may play an important role in the association between MCNS and GBS...
  57. ncbi request reprint Gene therapy for kidney disease
    E Imai
    Division of Nephrology, Department of Internal Medicine and Therapeutics, Graduate School of Medicine, Osaka University, Japan
    Expert Opin Investig Drugs 9:1029-39. 2000
    ..We review emerging strategies of gene transfer with reference to the kidney and discuss the potential application of gene therapy to renal diseases...
  58. doi request reprint Exercise-induced acute kidney injury with reversible posterior leukoencephalopathy syndrome
    Tomonori Kimura
    Department of Geriatric Medicine and Nephrology, Osaka University School of Medicine, Suita, Osaka 585 0871, Japan
    Clin Exp Nephrol 14:173-5. 2010
    ..This is the first reported case of exercise-induced AKI associated with RPLS. Vasoconstriction and endothelial dysfunction are considered as the common etiology of these diseases...
  59. ncbi request reprint Prospective randomized study evaluating the efficacy of the spherical adsorptive carbon AST-120 in chronic kidney disease patients with moderate decrease in renal function
    Tatsuya Shoji
    Department of Nephrology, Osaka General Medical Center, Osaka, Japan
    Nephron Clin Pract 105:c99-107. 2007
    ..We studied whether adding the spherical adsorptive carbon AST-120 to conventional treatments is effective in inhibiting progression of chronic kidney disease (CKD) at the stage of moderate decrease in renal function...
  60. ncbi request reprint Electroporation-mediated gene therapy
    Yoshitaka Isaka
    Osaka University Graduate School of Medicine, Divisions of Advanced Technology for Transplantation and Nephrology, Suita, Osaka 565 0871, Japan
    Expert Opin Drug Deliv 4:561-71. 2007
    ..Based on the accumulation of positive results, the first clinical study for the treatment of malignant melanoma is now underway, and preclinical studies have suggested that electroporation is useful as a gene therapy protocol...
  61. pmc Fetuin-mineral complex reflects extraosseous calcification stress in CKD
    Takayuki Hamano
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Am Soc Nephrol 21:1998-2007. 2010
    ..These data suggest that a quantitative measure of FMC, not supernatant or serum fetuin-A as measured in previous studies, reflects extraosseous calcification stress...
  62. doi request reprint Specialist care and improved long-term survival of dialysis patients
    Yoshiyuki Furumatsu
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Nephrol Dial Transplant 25:1930-5. 2010
    ..We sought to determine whether specialist care can actually be associated with better survival rates in a nationwide Japanese dialysis cohort...
  63. ncbi request reprint Kidney repair using stem cells: myth or reality as a therapeutic option?
    Hirotsugu Iwatani
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka Japan
    J Nephrol 23:143-6. 2010
    ..The origin, localization and role of kidney stem cells are under investigation. We also discuss potential applications of embryonic stem cells and induced pluripotent stem cells in kidney regeneration...
  64. doi request reprint Modification of the CKD epidemiology collaboration (CKD-EPI) equation for Japanese: accuracy and use for population estimates
    Masaru Horio
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Kidney Dis 56:32-8. 2010
    ..We modified the CKD-EPI equation for use in Japan, compared its accuracy with the Japanese modification of the MDRD Study equation, and compared the prevalence of CKD in Japan using both equations...
  65. doi request reprint A challenge to chronic kidney disease in Asia: The report of the second Asian Forum of Chronic Kidney Disease Initiative
    Yusuke Tsukamoto
    Department of Nephrology, Shuwa General Hospital, Saitama, Japan
    Nephrology (Carlton) 15:248-52. 2010
    ..Based on the outcome of the first meeting, the second meeting was organized as a consensus conference to frame the most relevant issues, and develop research recommendations and action plan...
  66. pmc The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature
    Yoshitsugu Takabatake
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine B6, Suita, Japan
    J Am Soc Nephrol 20:1714-23. 2009
    ..We conclude that CXCL12 secreted from stromal cells or podocytes acts on endothelial cells to regulate vascular development in the kidney. These findings suggest new potential therapeutic targets for remodeling the injured kidney...
  67. doi request reprint Usefulness of bone resorption markers in hemodialysis patients
    Takayuki Hamano
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Bone 45:S19-25. 2009
    ..Taken together, both markers give us additional information that cannot be obtained just by using PTH, provided that we know the characteristics of these markers...
  68. doi request reprint Simple sampling strategy for measuring inulin renal clearance
    Masaru Horio
    Department of Functional Diagnostic Science, Course of Health Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Exp Nephrol 13:50-4. 2009
    ..The aim of this study was to evaluate the validity of inulin renal clearance with assumed single urine collection with a period such as 30, 60 or 90 minutes...
  69. doi request reprint Current status of estimated glomerular filtration rate (eGFR) equations for Asians and an approach to create a common eGFR equation
    Seiichi Matsuo
    Department of Nephrology, Nagoya University Hospital, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nephrology (Carlton) 15:45-8. 2010
    ..These include ethnicity, reference method to measure GFR, method of creatinine measurement and calibration. Towards the future, Asian collaborative study is necessary to validate and standardize eGFR equations...
  70. doi request reprint Chronic kidney disease in Asia
    Enyu Imai
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, 565 0871 Osaka, Japan
    Lancet 371:2147-8. 2008
  71. doi request reprint Comparison of a simple and a standard method for inulin renal clearance
    Masaru Horio
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka, 565 0871, Japan
    Clin Exp Nephrol 14:427-30. 2010
    ..The standard method of renal inulin clearance consists of three sets of 30-min clearances. We previously proposed a simple method with a single urine collection for 1 h and two blood samples. In this study, we compared the two methods...
  72. doi request reprint Chronic deteriorating renal function and renal fibrosis
    Yoshitaka Isaka
    Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine, Suita, Japan
    Contrib Nephrol 159:109-21. 2008
    ..The sustained expression of these cytokines underlies the development of renal fibrosis. Understanding the molecular mechanisms of the cytokines and their signaling could lead to the application of clinically useful gene therapy...
  73. doi request reprint Hepatocyte growth factor gene therapy for hypertension
    Kazuo Komamura
    Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center, Suita, Japan
    Methods Mol Biol 423:393-404. 2008
    ..We outline the technique of intramuscular electroporation of HGF gene as a remedy for hypertension...
  74. doi request reprint Utility of the Japanese GFR estimation equation for evaluating potential donor kidney function
    Yoichi Kakuta
    Department of Specific Organ Regulation Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    Clin Exp Nephrol 14:63-7. 2010
    ..This study compared the accuracy of eGFR and creatinine clearance (Ccr) values with that of inulin clearance (Cin) for assessing renal function in kidney donors...
  75. ncbi request reprint CCAAT/Enhancer-binding protein delta contributes to myofibroblast transdifferentiation and renal disease progression
    Masanobu Takeji
    Department of Internal Medicine and Therapeutics, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Am Soc Nephrol 15:2383-90. 2004
    ..These data suggest an important role for C/EBPdelta in myofibroblast transdifferentiation and glomerulonephritis exacerbation...
  76. ncbi request reprint Direct transfer of hepatocyte growth factor gene into kidney suppresses cyclosporin A nephrotoxicity in rats
    Koji Yazawa
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Nephrol Dial Transplant 19:812-6. 2004
    ..Here, we investigated protective effects of HGF gene therapy on CsA-induced nephrotoxicity by using an electroporation-mediated gene transfer method...
  77. ncbi request reprint DNAzyme for TGF-beta suppressed extracellular matrix accumulation in experimental glomerulonephritis
    Yoshitaka Isaka
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Kidney Int 66:586-90. 2004
    ..Recently, a new generation of catalytic nucleic acid composed of DNA, named DNA enzyme (DNAzyme), has been developed...
  78. ncbi request reprint Therapeutic effect of all-trans retinoic acid on rats with anti-GBM antibody glomerulonephritis
    Susumu Oseto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Kidney Int 64:1241-52. 2003
    ..We tested the therapeutic potential of ATRA on anti-glomerular basement membrane (GBM) glomerulonephritis rats...
  79. ncbi request reprint Role of myofibroblasts in progressive renal diseases
    Toshiki Moriyama
    Department of Health Science II, School of Health and Sport Sciences, Osaka University, Toyonaka, Osaka, Japan
    Contrib Nephrol 139:120-40. 2003
  80. ncbi request reprint Induction of glia maturation factor-beta in proximal tubular cells leads to vulnerability to oxidative injury through the p38 pathway and changes in antioxidant enzyme activities
    Jun Ya Kaimori
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    J Biol Chem 278:33519-27. 2003
    ..In conclusion, we suggest that the proteinuria induction of GMF-beta in renal PT cells may play a critical role in the progression of renal diseases by enhancing oxidative injuries...
  81. ncbi request reprint Gene electrotransfer: potential for gene therapy of renal diseases
    Enyu Imai
    Department of Internal Medicine and Therapeutics, Division of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Kidney Int 61:S37-41. 2002
    ..We review on an emerging strategy of gene electrotransfer and discuss the potential application of gene therapy to renal diseases...
  82. ncbi request reprint Effects of the oral adsorbent AST-120 on tryptophan metabolism in uremic patients
    Yoshiharu Tsubakihara
    Department of Nephrology, Osaka Prefectural General Hospital, 3 1 56 Bandaihigashi, Sumiyoshi ku, Osaka 558 8558, Japan
    Am J Kidney Dis 41:S38-41. 2003
    ..We therefore investigated whether AST-120 recovers TRP binding to plasma proteins and improves the nutritional state of uremic patients...
  83. ncbi request reprint Tornado extraction: a method to enrich and purify RNA from the nephrogenic zone of the neonatal rat kidney
    Takahito Ito
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Box A8, Suita, Osaka 565 0871, Japan
    Kidney Int 62:763-9. 2002
    ..Therefore, expanding our knowledge of molecules that are associated with nephrogenesis will be helpful to understand the whole process...
  84. ncbi request reprint Nilvadipine attenuates mesangial expansion and glomerular hypertrophy in diabetic db/db mice, a model for type 2 diabetes
    Toshiki Moriyama
    Second Department of Medical Science, School of Health and Sport Sciences, Osaka University, 1 17 Machikaneyama cho, Toyonaka, Osaka 560 0043, Japan
    Clin Exp Nephrol 8:230-6. 2004
    ..In contrast, the therapeutic efficacy of calcium channel blockers (CCBs) in the treatment of diabetic nephropathy still remains controversial...
  85. ncbi request reprint Different routes bridging calcium in Japanese hemodialysis patients
    Takayuki Hamano
    Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Suita, Osaka 565 0871, Japan
    Ther Apher Dial 9:32-8. 2005
    ..5 mEq/L dialysate. As the new K/DOQI guidelines are released, it is time to discuss the appropriate D-Ca as well as doses and kinds of phosphate binders and vitamin D for the comprehensive management of Japanese hemodialysis patients...
  86. ncbi request reprint Pharmacokinetics and lipid-lowering effect of fluvastatin in hypercholesterolaemic patients on maintenance haemodialysis
    N Ichimaru
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Int Med Res 32:45-52. 2004
    ..The therapeutic efficacy and safety of fluvastatin were demonstrated in this patient group. Furthermore, fluvastatin is not influenced by the dialysis membrane and does not accumulate in haemodialysis patients with hyperlipidaemia...
  87. ncbi request reprint Hemodialysis-associated hypotension as an independent risk factor for two-year mortality in hemodialysis patients
    Tatsuya Shoji
    Department of Nephrology, Osaka General Medical Center, Osaka, Japan
    Kidney Int 66:1212-20. 2004
    ..We conducted a multicenter prospective cohort study to evaluate the impact of hemodialysis-associated hypotension on mortality...
  88. doi request reprint Serum osteoprotegerin as a screening tool for coronary artery calcification score in diabetic pre-dialysis patients
    Satoshi Mikami
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 31:1163-70. 2008
    ..Serum OPG was positively associated with high CACS and can be a useful screening tool for severe coronary calcification, whereas no association between fetuin-A and CACS was found...
  89. ncbi request reprint Gene expression profile of renal proximal tubules regulated by proteinuria
    Hideaki Nakajima
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, School of Allied Health Sciences, and Institute for Molecular and Cellular Biology, Osaka University, Osaka, Japan
    Kidney Int 61:1577-87. 2002
    ..Thus, identification of genes related to proteinuria should provide insights into the pathological process of tubulointerstitial fibrosis...
  90. ncbi request reprint Hematopoietic and nonhematopoietic potentials of Hoechst(low)/side population cells isolated from adult rat kidney
    Hirotsugu Iwatani
    Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Suita, Osaka, Japan
    Kidney Int 65:1604-14. 2004
    ..Although the regenerative stem cell is expected to exist in many adult tissues, the cell contributing to the regeneration of the kidney remains unknown in its type and origin...
  91. ncbi request reprint Risedronate, an effective treatment for glucocorticoid-induced bone loss in CKD patients with or without concomitant active vitamin D (PRIUS-CKD)
    Naohiko Fujii
    FASN Department of Internal Medicine, Osaka University School of Medicine, Box A8, 2 2 Yamada oka, Suita 565 0871, Japan
    Nephrol Dial Transplant 22:1601-7. 2007
    ....
  92. ncbi request reprint Targeting of interstitial cells using a simple gene-transfer strategy
    Naohiko Fujii
    Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine, Suita 565 0871, Japan
    Nephrol Dial Transplant 21:2745-53. 2006
    ..We examined the efficiency of a new gene transfer method that targets interstitial cells by using parenchymal injection of DNA followed by electroporation...
  93. ncbi request reprint cDNA cloning of a cytosolic protein tyrosine phosphatase (RKPTP) from rat kidney
    T Moriyama
    First Department of Medicine, Osaka University School of Medicine, Japan
    FEBS Lett 353:305-8. 1994
    ..The recombinant protein of the cloned cDNA expressed in Escherichia coli was shown to possess PTPase activity using myelin basic protein, tyrosine phosphorylated by p43v-abl tyrosine kinase, as a substrate...
  94. doi request reprint Serum 25-hydroxyvitamin D as an independent determinant of 1-84 PTH and bone mineral density in non-diabetic predialysis CKD patients
    Kodo Tomida
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Box B6, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Bone 44:678-83. 2009
    ..Since the significant associations for 25(OH)D with 1-84 PTH and BMD were independent of serum calcitriol and bone ALP, this might imply that 25(OH)D has a direct effect on the parathyroid gland and bone...
  95. ncbi request reprint Intravenous immunoglobulin (IVIg) therapy in MPO-ANCA related polyangiitis with rapidly progressive glomerulonephritis in Japan
    Eri Muso
    Division of Nephrology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Osaka, Japan
    Jpn J Infect Dis 57:S17-8. 2004
    ..No fatal infection was noted. IVIg might be the potent inducible therapy which can be promoted before the beginning of conventional immunosuppressant treatment for relatively aged and lower immunopotent MPO-ANCA patients in Japan...
  96. doi request reprint Participation of autophagy in renal ischemia/reperfusion injury
    Chigure Suzuki
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
    Biochem Biophys Res Commun 368:100-6. 2008
    ..Furthermore, inhibition of autophagy significantly inhibited H(2)O(2)-induced cell death. In conclusion, high turnover of autophagy may lead to autophagic cell death during I/R injury...
  97. ncbi request reprint Fetal cells in mother rats contribute to the remodeling of liver and kidney after injury
    Yu Wang
    Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Suita, Osaka, Japan
    Biochem Biophys Res Commun 325:961-7. 2004
    ..These results indicate that fetal cells are engrafted to maternal hematopoietic system without apparent injury and they also contribute to the repairing process of maternal liver and kidney...
  98. pmc Antisense oligonucleotides against thrombospondin-1 inhibit activation of tgf-beta in fibrotic renal disease in the rat in vivo
    Christoph Daniel
    Division of Nephrology, Universitat Erlangen Nurnberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Am J Pathol 163:1185-92. 2003
    ..These results demonstrate that TSP1 is the major endogenous activator of TGF-beta in experimental inflammatory kidney disease...
  99. ncbi request reprint [RNAi gene therapy for kidney disease]
    Yoshitaka Isaka
    Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine
    Nihon Rinsho 64:659-61. 2006
  100. ncbi request reprint [New kidney function tests]
    Enyu Imai
    Nihon Naika Gakkai Zasshi 96:881-6. 2007
  101. ncbi request reprint Gene therapy for renal diseases: its potential and limitation
    Enyu Imai
    J Am Soc Nephrol 14:1102-4. 2003