Yasushi Ikuno

..To investigate the results of small gauge vitrectomy for myopic macular complications...

..25 %) of povidone-iodine (PI) eye drops, combined with 0.5 % topical levofloxacin (LVFX), with that of the standard of care (5 % PI) on conjunctival flora before intravitreal injections (IVT)...

..In all 6 eyes the fovea was reattached and vision improved by more than two lines. This pilot study indicates that vitrectomy is an effective and safe treatment for MF...

..We reviewed the surgical results of vitrectomy for macular holes (MHs) associated with myopic foveoschisis (MF)...

..Myopic foveoschisis (MF), a major cause of visual loss in highly myopic patients, shows varied foveal anatomic characteristics. We determined how the foveal status is related to surgical results in MF...

..We studied macular holes with retinal detachment after vitrectomy using optical coherence tomography and evaluated the anatomic status of the hole and factors associated with anatomic success...

..The purpose of this study was to compare and investigate the agreement among the retinal/choroidal thickness parameters...

..To assess the potential effect of intravitreal bevacizumab (IVB) (Avastin) on retinal function and anatomic recovery in eyes with choroidal neovascularization attributable to pathological myopia (mCNV)...

..To clarify the characteristics of choroidal neovascularization (CNV) due to myopic CNV (mCNV) and the relation to lacquer crack (LC) formation...

..Morphologic changes in the retina and choroid are closely related with high myopia-related diseases. This study was conducted to evaluate the morphologic characteristics of normal highly myopic eyes...

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..47; P = 0.22) by stepwise analysis. Conclusions. The profile of choroidal thickness depends on its location. RE, axial length, and especially age are critical for evaluation of choroidal thickness...

..To report a new sutureless ring system to fix corneal contact lens in place during vitrectomy...

..05), and the affected eyes had a significantly (P < 0.05) longer RPE curvature. CONCLUSIONS. Choroidal thinning resulting from increased RPE/choroid curvature is a risk factor for unilateral mCNV...

..To report retinal microfold formation after vitrectomy for myopic foveoschisis (MF)...

..To determine the safety and efficacy of transsclerally placed intrapapillary wire microelectrodes implanted chronically into the optic nerve head of rabbit eyes...

..Myopic foveoschisis is common in high myopia. We report results of a pilot study of vitrectomy for patients with myopic foveoschisis...

..To assess the efficacy, duration of effect and safety of one intravitreal injection of bevacizumab in diabetic macular oedema (DMO)...

..To evaluate the biologic efficacy of intravitreal bevacizumab (IVB) for iris neovascularization (INV) or neovascular glaucoma (NVG) in patients with ischemic retinal disorders...

..To investigate the feasibility of implanting a newly developed suprachoroidal-transretinal stimulation (STS) prosthesis in dogs and to determine its biocompatibility and stability over a 3-month period...

..To investigate fundus autofluorescence (FAF) characteristics in relation to morphological and functional features of idiopathic macular hole (IMH)...

..To compare the visual outcomes of intravitreal bevacizumab (Avastin; Genentech Inc, South San Franciso, California, USA) and sub-Tenon triamcinolone acetonide (TA) for choroidal neovascularization attributable to pathologic myopia (mCNV)...

..The authors observed residual ICG after vitrectomy for high myopia-related macular diseases and found a unique pattern specific to its pathologic features...

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..To investigate whether electrical stimulation of the optic nerve can elicit an electrical evoked potential (EEP) in rabbits and to determine whether such stimulation is a useful approach for the placement of a visual prosthesis...

..Internal limiting membrane (ILM) peeling with indocyanine green (ICG) staining is a commonly used procedure to treat idiopathic macular holes (MH)...

..To assess the efficacy of radial optic neurotomy (RON) for hemicentral retinal vein occlusion (hemi-CRVO) in patients with follow-up of >12 months...

..Inward vascular tractional force appearing as a retinal microfold can be a critical trigger of recurrent retinal detachment in patients with myopic macular hole...

..To report complications in patients after intravitreal injection of bevacizumab to treat ocular diseases associated with vascular endothelial growth factor...

..These results suggest that STS via intrascleral multichannel electrodes is a feasible method for stimulating the retina...

..To evaluate the possible long-term alterations of choroidal perfusion parameters in the new central macular area after macular translocation surgery...

..To study the choroidal thickness profile using high-penetration optical coherence tomography in central serous chorioretinopathy (CSC)...

..To report new indocyanine green angiographic (ICGA) findings after intravitreal bevacizumab (IVB) for myopic choroidal neovascularization (mCNV)...

..To reveal the pathogenesis of myopic foveoschisis (MF)...

..CONCLUSIONS: Surgical treatment can improve the visual function of eyes with a Nd:YAG laser-induced macular hole. Optical coherence tomography is valuable in providing precise information about the condition of the macula...

..To develop new micro vertical scissors for the ablation of retinal angiomatous proliferation (RAP) to minimize possible retinal damage...

..To determine whether wire microelectrodes implanted in the optic disc can be used to elicit cortical potentials...

..To compare the surgical outcomes and evaluate the effectiveness of two treatments for central retinal vein occlusion: radial optic neurotomy (RON) and cannulation of tissue plasminogen activator (tPA) into the retinal vein (tPA)...

..To examine the safety and effectiveness of a retinal prosthesis that is implanted semichronically in two patients with advanced retinitis pigmentosa (RP)...

..To investigate whether indocyanine green (ICG) migrates into the optic nerve after intravitreal application in the rabbit eye...

..We present two cases with early macular holes (MH) complicated by retinoschisis and foveal detachment (RSFD)...

..To report difference in fundus autofluorescence (FAF) results between macular hole retinal detachment (MHRD) and myopic foveoschisis (MF) in highly myopic eyes...

..We performed vitrectomy on two eyes for persistent myopic foveoschisis (MF) after primary surgery that did not include internal limiting membrane (ILM) peeling...

..We studied the efficient parameters in normal subjects and investigated if suprachoroidal-transretinal stimulation (STS) is effective in patients with advanced retinitis pigmentosa (RP) using these efficient parameters...

..Because the threshold for the safe charge was lower with shorter pulse durations, care should be taken using pulses of short durations...

..To evaluate the efficacy of sub-Tenon's injection of triamcinolone acetonide for age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV)...

..The aim of this work was to investigate the choroidal morphologic changes of Vogt-Koyanagi-Harada (VKH) disease in vivo using high-penetration optical coherence tomography (HP-OCT) with a long-wavelength light source (1,060 nm)...

..To investigate circadian changes in subfoveal choroidal thickness (SFCT) and the relation to systemic factors in healthy subjects...

..To explore the factors affecting surgical outcomes of highly myopic macular holes (HMMHs)...

..We measured postoperative macular hole (MH) size after vitrectomy for MH and retinal detachment (MHRD) in high myopia and investigated potentially associated factors...

..PI3K may regulate collagen gel contraction by another mechanism other than the up-regulation of integrin expression...

..The drug may affect the biological event by inhibiting alpha-SMA expression, and Y27632 could be useful for preventing PVR...

..To quantify and compare the retinal circulation times before and after macular translocation surgery...

..CONCLUSIONS: PDGF receptor specific inhibitor AG1295 attenuated PVR without significant side effects in rabbits. This reagent could be a useful treatment to prevent PVR...

..To assess time-course changes in best-corrected visual acuity (BCVA) up to 5 years after vitrectomy to treat idiopathic full-thickness macular holes (MHs) and identify the relationship of the changes to postoperative complications...

..To evaluate the choroidal thickness by high-penetration optical coherence tomography (OCT) using long wavelength in highly myopic normal-tension glaucoma (NTG)...

..The presence of these microfolds indicates that inward retinal vascular traction could be common in highly myopic eyes...

..The MP-1 fixation test is useful for measuring PRL and fixation stability in a short time. MP-1 might be helpful to evaluate the foveal function in patients with macular disorders without severely damaged macular function...

..To report reading ability using a standardized reading chart after macular translocation with 360-degree retinotomy in eyes with age-related macular degeneration (AMD) or with myopic choroidal neovascularization (mCNV)...

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..To examine three layers of membranes detected by triamcinolone acetonide (TA) and indocyanine green (ICG) during surgery for macular hole and retinal detachment (MHRD) as a result of high myopia...

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..To report two cases of macular hole (MH) associated with myopic foveoschisis (MF)...

..To investigate whether the type of posterior staphyloma (PS) affects the development of macular hole and retinal detachment (MHRD) in high myopia...

..To report a new wide-angle viewing contact lens for vitrectomy...

..0 diopters. The best-corrected visual acuity levels ranged from 20/400 to 20/13. CONCLUSIONS: Rigidity of the ILM seems to cause tangential traction and results in a major cause of a disease specific to high myopia; that is, MF...

..To evaluate pathologic features of the photoreceptors in myopic foveoschisis with the Fourier-domain optical coherence tomography (FD-OCT)...

..22, p<0.001). CONCLUSIONS Significant choroidal changes were observed in eyes with mCNV. Ischaemia-induced growth factor expression caused by decreased choroidal perfusion may be related to the development of mCNV...

..In this study, we investigated if transretinal stimulation from the suprachoroidal space can elicit an electrical evoked potential (EEP) in albino rabbits...

..CONCLUSIONS: Pericyte growth is stimulated in vitro by RGC-CM through aFGF, bFGF, PDGF-BB, at least in part. This finding suggests that RGCs may modulate in vivo pericyte cell growth through these three growth factors...

..Therefore, the alphaPDGFR is responsible for mediating cellular contraction of multiple growth factors: TGFbeta and members of the PDGF family...

..Consequently, these two signaling enzymes are required for one or more of the cellular responses (chemotaxis, proliferation, extracellular matrix production, contraction) that contribute to PVR...

..To report the occurrence of sub-retinal hemorrhage during peeling of the internal limiting membrane (ILM)...

..CONCLUSIONS: Gene therapy with a retrovirus used to express a dominant negative alphaPDGFR attenuates PVR in a rabbit model of the disease. This strategy may be a new approach to preventing PVR in humans...