K Hotta

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 20:1595-9. 2000
  2. ncbi request reprint Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes 50:1126-33. 2001
  3. ncbi request reprint Mutation in bombesin receptor subtype-3 gene is not a major cause of obesity in the Japanese
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Horm Metab Res 32:33-4. 2000
  4. ncbi request reprint PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    N Maeda
    Department of Internal Medicine and Molecular Science (B5, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes 50:2094-9. 2001
  5. ncbi request reprint Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 102:1296-301. 2000
  6. ncbi request reprint Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 276:34089-97. 2001
  7. ncbi request reprint Thiazolidinedione derivative improves fat distribution and multiple risk factors in subjects with visceral fat accumulation--double-blind placebo-controlled trial
    T Nakamura
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine Osaka University, 2 2 Yamadaoka, Suita, 565 0871 Osaka, Japan
    Diabetes Res Clin Pract 54:181-90. 2001
  8. ncbi request reprint Enhancement of the aquaporin adipose gene expression by a peroxisome proliferator-activated receptor gamma
    K Kishida
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita 565 0871, Japan
    J Biol Chem 276:48572-9. 2001
  9. ncbi request reprint Genomic structure and mutations in adipose-specific gene, adiponectin
    M Takahashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int J Obes Relat Metab Disord 24:861-8. 2000
  10. ncbi request reprint The expression of SPARC in adipose tissue and its increased plasma concentration in patients with coronary artery disease
    M Takahashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Obes Res 9:388-93. 2001

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Arterioscler Thromb Vasc Biol 20:1595-9. 2000
    ..These results suggest that the decreased plasma adiponectin concentrations in diabetes may be an indicator of macroangiopathy...
  2. ncbi request reprint Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes 50:1126-33. 2001
    ..No clear association was found between the plasma levels of adiponectin and its mRNA levels in adipose tissue. These results suggest that reduction in circulating adiponectin may be related to the development of insulin resistance...
  3. ncbi request reprint Mutation in bombesin receptor subtype-3 gene is not a major cause of obesity in the Japanese
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Horm Metab Res 32:33-4. 2000
    ..No mutation, nor polymorphism was found in the coding region of BRS-3, suggesting that mutation of this gene is not a major cause of obesity in humans...
  4. ncbi request reprint PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    N Maeda
    Department of Internal Medicine and Molecular Science (B5, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes 50:2094-9. 2001
    ..TZDs might prevent atherosclerotic vascular disease in insulin-resistant patients by inducing the production of adiponectin through direct effect on its promoter and antagonizing the effect of TNF-alpha on the adiponectin promoter...
  5. ncbi request reprint Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 102:1296-301. 2000
    ..However, the intracellular signal by which adiponectin suppressed adhesion molecule expression was not elucidated. The present study investigated the mechanism of modulation for endothelial function by adiponectin...
  6. ncbi request reprint Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 276:34089-97. 2001
    ..These results suggest that galectin-12, an adipose-expressed galectin-like molecule, may participate in the apoptosis of adipocytes...
  7. ncbi request reprint Thiazolidinedione derivative improves fat distribution and multiple risk factors in subjects with visceral fat accumulation--double-blind placebo-controlled trial
    T Nakamura
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine Osaka University, 2 2 Yamadaoka, Suita, 565 0871 Osaka, Japan
    Diabetes Res Clin Pract 54:181-90. 2001
    ..However, it has not been reported yet that troglitazone affects fat distribution in subjects concomitant with visceral fat accumulation and multiple risk factors...
  8. ncbi request reprint Enhancement of the aquaporin adipose gene expression by a peroxisome proliferator-activated receptor gamma
    K Kishida
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita 565 0871, Japan
    J Biol Chem 276:48572-9. 2001
    ..We conclude that AQPap is a novel adipose-specific target gene of PPARgamma through the binding of PPARgamma-retinoid X receptor complex to the PPRE region in its promoter...
  9. ncbi request reprint Genomic structure and mutations in adipose-specific gene, adiponectin
    M Takahashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int J Obes Relat Metab Disord 24:861-8. 2000
    ..Adiponectin is a collagen-like plasma protein specifically synthesized in adipose tissue. Plasma adiponectin concentrations are decreased in obesity whereas it is adipose-specific...
  10. ncbi request reprint The expression of SPARC in adipose tissue and its increased plasma concentration in patients with coronary artery disease
    M Takahashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Obes Res 9:388-93. 2001
    ..In the current study, we have examined the expression of secreted protein, acidic and rich in cysteine (SPARC) in adipose tissue and its significance in obesity and coronary artery disease (CAD)...
  11. ncbi request reprint Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 103:1057-63. 2001
    ..The present study investigated the effects of adiponectin on lipid accumulation in human monocyte-derived macrophages...
  12. ncbi request reprint Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin
    N Ouchi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Circulation 100:2473-6. 1999
    ..The present study investigated whether adiponectin could modulate endothelial function and relate to coronary disease...
  13. ncbi request reprint Visceral fat is a major contributor for multiple risk factor clustering in Japanese men with impaired glucose tolerance
    H Nagaretani
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes Care 24:2127-33. 2001
    ..CONCLUSIONS: Visceral fat accumulation is a major contributor for multiple risk factor clustering in Japanese men with IGT and NGT...
  14. ncbi request reprint Aquaporin adipose, a putative glycerol channel in adipocytes
    K Kishida
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, 565 0871, Japan
    J Biol Chem 275:20896-902. 2000
    ..Exposure of epinephrine translocated AQPap protein from perinuclear cytoplasm to the plasma membrane in 3T3-L1 adipocytes. These results strongly suggest that AQPap plays an important role in glycerol release from adipocytes...
  15. ncbi request reprint [Molecular mechanism in the development of the complications associated with obesity--the physiological and pathological role of adipocytokines]
    K Hotta
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
    Nippon Rinsho 59:481-6. 2001
    ..The finding of genes specifically expressed in visceral fat and new adipocytokines should facilitate clarification of the mechanism for the development and complications of visceral fat accumulation...
  16. ncbi request reprint Regulation of obese (ob) mRNA and plasma leptin levels in rhesus monkeys. Effects of insulin, body weight, and non-insulin-dependent diabetes mellitus
    K Hotta
    Obesity and Diabetes Research Center, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 271:25327-31. 1996
    ..Circulating levels of the ob gene product leptin were also significantly correlated with body weight. These results show that ob gene expression is related to body weight and is not acutely regulated by insulin...
  17. ncbi request reprint Monkey leptin receptor mRNA: sequence, tissue distribution, and mRNA expression in the adipose tissue of normal, hyperinsulinemic, and type 2 diabetic rhesus monkeys
    K Hotta
    Obesity and Diabetes Research Center and Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Obes Res 6:353-60. 1998
    ..We have cloned the rhesus monkey leptin receptor and examined its mRNA expression levels in the adipose tissue of monkeys to investigate the regulation of gene expression of the leptin receptor...
  18. pmc Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling
    L Rui
    Department of Physiology, University of Michigan Medical School, Ann Arbor 48109 0622, USA
    Mol Cell Biol 17:6633-44. 1997
    ..These pathways are likely to be shared by other cytokines that activate JAK2...
  19. ncbi request reprint Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling
    T J O'Neill
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 271:22506-13. 1996
    ..Our findings suggest that GRB10/IR-SV1 may serve to positively link the insulin and IGF-I receptors to an uncharacterized mitogenic signaling pathway...
  20. ncbi request reprint Relationships of PPARgamma and PPARgamma2 mRNA levels to obesity, diabetes and hyperinsulinaemia in rhesus monkeys
    K Hotta
    Obesity and Diabetes Research Center and Department of Physiology, University of Maryland, School of Medicine, Baltimore 21201, USA
    Int J Obes Relat Metab Disord 22:1000-10. 1998
    ....
  21. ncbi request reprint The loss of susceptibility to apoptosis in exudated tissue neutrophils is associated with their nuclear factor-kappa B activation
    K Hotta
    Department of Pharmacology, Gifu University School of Medicine, 40-Tsukasamachi, Gifu 500-8705, Japan
    Eur J Pharmacol 433:17-27. 2001
    ....
  22. ncbi request reprint Rat-liver-type phosphofructokinase mRNA. Structure, tissue distribution and regulation
    K Hotta
    Second Department of Internal Medicine, Osaka University Medical School, Japan
    Eur J Biochem 202:293-8. 1991
    ..These results suggested that rat liver-type phosphofructokinase mRNA in the liver was not under control of diet or insulin, in contrast to glucokinase and L-type pyruvate kinase...
  23. ncbi request reprint Disordered expression of glycolytic and gluconeogenic liver enzymes of juvenile visceral steatosis mice with systemic carnitine deficiency
    K Hotta
    Second Department of Internal Medicine, Osaka University Medical School, Japan
    Diabetes Res Clin Pract 32:117-23. 1996
    ..Carnitine administration restored the mRNA of these enzymes to normal levels. These results suggest that carnitine deficiency affects the expression of these liver enzymes...
  24. ncbi request reprint Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor
    K Hotta
    Department of Molecular Biology and Biochemistry, Osaka University Medical School, Suita, Japan
    Biochem Biophys Res Commun 225:69-74. 1996
    ..This protein is kinectin, known to be a vesicle membrane anchoring protein of kinesin, which is an ATPase motor transporting vesicles along microtubules...
  25. pmc ROM7/BEM4 encodes a novel protein that interacts with the Rho1p small GTP-binding protein in Saccharomyces cerevisiae
    H Hirano
    Department of Molecular Biology and Biochemistry, Osaka University Medical School, Japan
    Mol Cell Biol 16:4396-403. 1996
    ..These results indicate that Bem4p is a novel protein directly interacting with Rho1p and is involved in the RHO1-mediated signaling pathway...
  26. ncbi request reprint Cloning of a canine gene homologous to the human interleukin-8-encoding gene
    J Ishikawa
    Department of Bioactive Molecules, National Institute of Health, Shinjuku, Tokyo, Japan
    Gene 131:305-6. 1993
    ..Thus, it seems very likely that the cloned gene is a canine homologue of hIL8...
  27. ncbi request reprint Isolation and bacterial expression of a murine alpha leukocyte interferon gene
    B Daugherty
    J Interferon Res 4:635-43. 1984
    ..It was expressed in Escherichia coli under the control of the trp promoter/operator which resulted in antiviral activity on mouse L-cells. MuIFN-alpha A exhibits 60% homology to HuIFN-alpha A at the amino acid level...
  28. ncbi request reprint Continued gefitinib treatment after disease stabilisation prolongs survival of Japanese patients with non-small-cell lung cancer: Okayama Lung Cancer Study Group experience
    K Hotta
    Department of Medicine II, Okayama University Medical School, Okayama
    Ann Oncol 16:1817-23. 2005
    ....