Masatsugu Hori

Summary

Affiliation: Osaka Medical Center for Cancer and Cardiovascular Diseases
Country: Japan

Publications

  1. doi request reprint Oxidative stress and left ventricular remodelling after myocardial infarction
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Cardiovasc Res 81:457-64. 2009
  2. doi request reprint Efficacy and safety of bisoprolol fumarate compared with carvedilol in Japanese patients with chronic heart failure: results of the randomized, controlled, double-blind, Multistep Administration of bisoprolol IN Chronic Heart Failure II (MAIN-CHF II) stud
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka, 537 8511, Japan
    Heart Vessels 29:238-47. 2014
  3. doi request reprint Is tumor necrosis factor-α friend or foe for chronic heart failure?
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Circ Res 113:492-4. 2013
  4. doi request reprint Dabigatran versus warfarin: effects on ischemic and hemorrhagic strokes and bleeding in Asians and non-Asians with atrial fibrillation
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Stroke 44:1891-6. 2013
  5. ncbi request reprint Safety and efficacy of adjusted dose of rivaroxaban in Japanese patients with non-valvular atrial fibrillation: subanalysis of J-ROCKET AF for patients with moderate renal impairment
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Circ J 77:632-8. 2013
  6. doi request reprint Tolvaptan for the treatment of hyponatremia and hypervolemia in patients with congestive heart failure
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Future Cardiol 9:163-76. 2013
  7. ncbi request reprint Rivaroxaban vs. warfarin in Japanese patients with atrial fibrillation – the J-ROCKET AF study –
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Circ J 76:2104-11. 2012
  8. ncbi request reprint Efficacy and safety of dabigatran vs. warfarin in patients with atrial fibrillation--sub-analysis in Japanese population in RE-LY trial
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Osaka, 537 8511, Japan
    Circ J 75:800-5. 2011
  9. ncbi request reprint Celiprolol, a vasodilatory beta-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in mice
    Yulin Liao
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Circulation 110:692-9. 2004
  10. ncbi request reprint Bcl2 enhances survival of newborn neurons in the normal and ischemic hippocampus
    Tsutomu Sasaki
    Division of Stroke Research, Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Neurosci Res 84:1187-96. 2006

Detail Information

Publications90

  1. doi request reprint Oxidative stress and left ventricular remodelling after myocardial infarction
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Cardiovasc Res 81:457-64. 2009
    ..Since the extent of LV remodelling is a major predictor of prognosis of the patients with MI, the therapeutic approach to attenuating LV remodelling is critically important...
  2. doi request reprint Efficacy and safety of bisoprolol fumarate compared with carvedilol in Japanese patients with chronic heart failure: results of the randomized, controlled, double-blind, Multistep Administration of bisoprolol IN Chronic Heart Failure II (MAIN-CHF II) stud
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka, 537 8511, Japan
    Heart Vessels 29:238-47. 2014
    ..Bisoprolol, at half the dose used in other countries, is well tolerated and is as effective as carvedilol for treating Japanese patients with mild to moderate CHF. ..
  3. doi request reprint Is tumor necrosis factor-α friend or foe for chronic heart failure?
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Circ Res 113:492-4. 2013
    ..The double-edged effects of TNF-α/Toll-like receptors (TLRs)-related proinflammatory cytokines and downstream signal transduction, nuclear factor (NF)-κB activation on failing myocardium are discussed...
  4. doi request reprint Dabigatran versus warfarin: effects on ischemic and hemorrhagic strokes and bleeding in Asians and non-Asians with atrial fibrillation
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Stroke 44:1891-6. 2013
    ..This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from Asian and non-Asian countries...
  5. ncbi request reprint Safety and efficacy of adjusted dose of rivaroxaban in Japanese patients with non-valvular atrial fibrillation: subanalysis of J-ROCKET AF for patients with moderate renal impairment
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Circ J 77:632-8. 2013
    ..The aim of this subanalysis was to assess the safety and efficacy of the adjusted dose of rivaroxaban compared with warfarin in a cohort with moderate renal impairment...
  6. doi request reprint Tolvaptan for the treatment of hyponatremia and hypervolemia in patients with congestive heart failure
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Future Cardiol 9:163-76. 2013
    ....
  7. ncbi request reprint Rivaroxaban vs. warfarin in Japanese patients with atrial fibrillation – the J-ROCKET AF study –
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Circ J 76:2104-11. 2012
    ..A separate trial, J-ROCKET AF, compared the safety of a Japan-specific rivaroxaban dose with warfarin administered according to Japanese guidelines in Japanese patients with AF...
  8. ncbi request reprint Efficacy and safety of dabigatran vs. warfarin in patients with atrial fibrillation--sub-analysis in Japanese population in RE-LY trial
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Osaka, 537 8511, Japan
    Circ J 75:800-5. 2011
    ..From Japan, 326 patients were randomized in RE-LY...
  9. ncbi request reprint Celiprolol, a vasodilatory beta-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in mice
    Yulin Liao
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Circulation 110:692-9. 2004
    ..Thus, we aimed to clarify whether celiprolol attenuates both myocardial hypertrophy and heart failure via the NO-signal pathway...
  10. ncbi request reprint Bcl2 enhances survival of newborn neurons in the normal and ischemic hippocampus
    Tsutomu Sasaki
    Division of Stroke Research, Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Neurosci Res 84:1187-96. 2006
    ..These findings suggest that Bcl-2 plays a crucial role in adult hippocampal neurogenesis under normal and ischemic conditions...
  11. ncbi request reprint Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling
    Toshihiro Takeda
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    FASEB J 19:2069-71. 2005
    ..Taken together, our results suggest that PS2 plays an important role in cardiac excitation-contraction coupling by interacting with RyR2...
  12. ncbi request reprint The antagonism of aldosterone receptor prevents the development of hypertensive heart failure induced by chronic inhibition of nitric oxide synthesis in rats
    Osamu Tsukamoto
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, 565 0871, Japan
    Cardiovasc Drugs Ther 20:93-102. 2006
    ..2 +/- 0.1), and LVEDP (6.2 +/- 0.7 mmHg). These results suggest that chronic inhibition of NO synthesis induces cardiac inflammation and dysfunction via an aldosterone receptor-dependent mechanism...
  13. ncbi request reprint Aldosterone nongenomically worsens ischemia via protein kinase C-dependent pathways in hypoperfused canine hearts
    Masashi Fujita
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, 565 0871, Japan
    Hypertension 46:113-7. 2005
    ..Elevation of plasma or cardiac aldosterone levels may be deleterious to ischemic heart disease through its nongenomic effects...
  14. ncbi request reprint Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs
    Akio Hirata
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Am Coll Cardiol 48:176-84. 2006
    ..We investigated the effects of erythropoietin (EPO) on neovascularization and cardiac function after myocardial infarction (MI)...
  15. ncbi request reprint Therapeutic effect of all-trans retinoic acid on rats with anti-GBM antibody glomerulonephritis
    Susumu Oseto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Kidney Int 64:1241-52. 2003
    ..We tested the therapeutic potential of ATRA on anti-glomerular basement membrane (GBM) glomerulonephritis rats...
  16. ncbi request reprint Pressure overload induces cardiac dysfunction and dilation in signal transducer and activator of transcription 6-deficient mice
    Shungo Hikoso
    Department of Internal Medicine and Therapeutics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Circulation 110:2631-7. 2004
    ..This suggests that STAT6 may be involved in the pathogenesis of cardiac hypertrophy and heart failure. For this study we used STAT6-deficient (STAT6-/-) mice to examine the in vivo role of STAT6...
  17. doi request reprint Cardiac iodine-123 metaiodobenzylguanidine imaging predicts sudden cardiac death independently of left ventricular ejection fraction in patients with chronic heart failure and left ventricular systolic dysfunction: results from a comparative study with si
    Shunsuke Tamaki
    Division of Cardiology, Osaka General Medical Center, Osaka, Japan
    J Am Coll Cardiol 53:426-35. 2009
    ....
  18. ncbi request reprint Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the phosphatidylinositol-3 kinase-dependent pathway in canine hearts
    Akio Hirata
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Cardiovasc Drugs Ther 19:33-40. 2005
    ..EPO administration can be a realistic strategy for the treatment of acute myocardial infarction...
  19. ncbi request reprint Chronic mild reduction of cerebral perfusion pressure induces ischemic tolerance in focal cerebral ischemia
    Kazuo Kitagawa
    Division of Strokology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Stroke 36:2270-4. 2005
    ..We focused on collateral development after mild reduction of perfusion pressure to find an endogenous response of the vascular system that contributes to development of ischemic tolerance...
  20. ncbi request reprint The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy
    Ikuko Tsujimoto
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertension 45:921-6. 2005
    ..These findings indicate that edaravone significantly attenuates pressure overload-induced cardiac hypertrophy mediated through its antioxidative function and subsequent inhibition of ASK1 signaling pathway...
  21. ncbi request reprint Detection of TIMI-3 flow before mechanical reperfusion with ultrasonic tissue characterization in patients with anterior wall acute myocardial infarction
    Katsuomi Iwakura
    Division of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan
    Circulation 107:3159-64. 2003
    ..We investigated the ability of analyzing cardiac cycle-dependent variation of myocardial integrated backscatter (IBS) for predicting spontaneous reperfusion in anterior AMI...
  22. ncbi request reprint Concanavalin a injection activates intrahepatic innate immune cells to provoke an antitumor effect in murine liver
    Takuya Miyagi
    Department of Molecular Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Hepatology 40:1190-6. 2004
    ..In conclusion, a nonhepatotoxic low dose of ConA might serve as an immunomodulator that can preferentially activate the innate immune cells to induce an antitumor effect against metastatic liver tumor...
  23. pmc Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis
    Osamu Yamaguchi
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Clin Invest 114:937-43. 2004
    ..The ablation of ASK1 rescued heart dysfunction and dilatation as well as cardiac fibrosis. These results indicate that Raf-1 promotes cardiomyocyte survival through a MEK/ERK-independent mechanism...
  24. ncbi request reprint Clinical impact of metabolic syndrome and its additive effect with smoking on subsequent cardiac events after acute myocardial infarction
    Daisaku Nakatani
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, and Sakurabashi Watanabe Hospital, Osaka, Japan
    Am J Cardiol 99:885-9. 2007
    ..Smoking has an additive adverse effect on cardiac events after AMI, and cessation of smoking is beneficial and strongly recommended for AMI, especially in patients with MS...
  25. ncbi request reprint Carotid intima-media thickness and risk of cardiovascular events in high-risk patients. Results of the Osaka Follow-Up Study for Carotid Atherosclerosis 2 (OSACA2 Study)
    Kazuo Kitagawa
    Stroke Division, Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Cerebrovasc Dis 24:35-42. 2007
    ..The purpose of this study was to determine the usefulness of carotid IMT measurement in such patients...
  26. ncbi request reprint Amelioration of hippocampal neuronal damage after transient forebrain ischemia in cyclooxygenase-2-deficient mice
    Tsutomu Sasaki
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    J Cereb Blood Flow Metab 24:107-13. 2004
    ..These results of genetic disruption and chemical inhibition of cyclooxygenase-2 show that inhibition of COX-2 ameliorates selective neuronal death after transient forebrain ischemia in mice...
  27. ncbi request reprint Activation of adenosine A1 receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload model
    Yulin Liao
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Circ Res 93:759-66. 2003
    ..These results indicate that the stimulation of adenosine receptors attenuates both the cardiac hypertrophy and myocardial dysfunction via adenosine A1 receptor-mediated mechanisms...
  28. ncbi request reprint Postischemic exercise decreases neurogenesis in the adult rat dentate gyrus
    Yoshiki Yagita
    Stroke Division, Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Neurosci Lett 409:24-9. 2006
    ..These findings suggest that running exercise has a negative effect on neurogenesis in the ischemic hippocampus. This may be important with respect to assessment of therapeutic approaches for functional recovery after stroke...
  29. doi request reprint Cyclo-oxygenase-2 -765G > C promoter variants are associated with lower carotid plaque echogenicity in Japanese
    Shigetaka Furukado
    Department of Neurology, Stroke Division, Osaka University Graduate School of Medicine, Osaka, Japan
    Cerebrovasc Dis 27:91-8. 2009
    ..We examined the relation between a polymorphism in the COX-2 gene and carotid plaque echogenicity in patients with high risk of cerebrovascular disease to evaluate the involvement of COX-2 in plaque instability...
  30. ncbi request reprint Infiltrating macrophages as in vivo targets for intravenous gene delivery in cerebral infarction
    Shigeru Tanaka
    Division of Strokology, Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Stroke 35:1968-73. 2004
    ..The purpose of this study is to develop systemic gene therapy using macrophages infiltrating the infarct to deliver and express the gene...
  31. ncbi request reprint Ablation of MEK kinase 1 suppresses intimal hyperplasia by impairing smooth muscle cell migration and urokinase plasminogen activator expression in a mouse blood-flow cessation model
    Yan Li
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Circulation 111:1672-8. 2005
    ..Although MEK kinase 1 (MEKK1) has been shown to regulate cell migration and urokinase plasminogen activator (uPA) expression, the precise role of MEKK1 in this process remains unknown...
  32. ncbi request reprint Usefulness of impairment of coronary microcirculation in predicting left ventricular dilation after acute myocardial infarction
    Yasunori Shintani
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Cardiol 93:974-8. 2004
    ..Time taken for normalization varied among patients. Persistence of microvascular dysfunction up to 7 days after reperfusion predicted LV remodeling...
  33. ncbi request reprint The phosphodiesterase inhibitor rolipram promotes survival of newborn hippocampal neurons after ischemia
    Tsutomu Sasaki
    Department of Cardiovascular Medicine, Division of Stroke Research, Osaka University Graduate School of Medicine, Yamadaoka, Suita City, Osaka, Japan
    Stroke 38:1597-605. 2007
    ..We examined whether treatment of mice with the phosphodiesterase-4 inhibitor rolipram enhances hippocampal neurogenesis after ischemia...
  34. ncbi request reprint Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia
    Yoshiki Yagita
    Stroke Division, Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Neurosci Res 85:2460-9. 2007
    ..The vascular protective effect of Rho-kinase inhibitors may be useful in the treatment of the acute phase of ischemic stroke...
  35. ncbi request reprint Hematopoietic and nonhematopoietic potentials of Hoechst(low)/side population cells isolated from adult rat kidney
    Hirotsugu Iwatani
    Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Suita, Osaka, Japan
    Kidney Int 65:1604-14. 2004
    ..Although the regenerative stem cell is expected to exist in many adult tissues, the cell contributing to the regeneration of the kidney remains unknown in its type and origin...
  36. doi request reprint Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes
    Shigemiki Omiya
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Mol Cell Cardiol 46:59-66. 2009
    ..The decrease in FHC expression in failing hearts may play an important role in the pathogenesis of heart failure...
  37. ncbi request reprint Raloxifene improves coronary perfusion, cardiac contractility, and myocardial metabolism in the ischemic heart: role of phosphatidylinositol 3-kinase/Akt pathway
    Hisakazu Ogita
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    J Cardiovasc Pharmacol 43:821-9. 2004
    ....
  38. ncbi request reprint Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis
    Ken ichiro Okada
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Circulation 110:705-12. 2004
    ..The ER responds to stress by upregulating ER chaperones, but prolonged and/or excess ER stress leads to apoptosis. However, the potential role of ER stress in pathophysiological hearts remains unclear...
  39. doi request reprint Quantitative evaluation of carotid plaque echogenicity by integrated backscatter analysis: correlation with symptomatic history and histologic findings
    Keiko Nagano
    Stroke Division, Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
    Cerebrovasc Dis 26:578-83. 2008
    ..This study examined the relation between echogenicity assessed by integrated backscatter (IBS) analysis and (1) symptomatic history and (2) histologic features of carotid plaques...
  40. ncbi request reprint Usefulness of plasma brain natriuretic peptide concentration for predicting subsequent left ventricular remodeling after coronary angioplasty in patients with acute myocardial infarction
    Atsushi Hirayama
    The Cardiovascular Division, Osaka Police Hospital, Osaka, Japan
    Am J Cardiol 98:453-7. 2006
    ..In conclusion, these results suggest that plasma BNP concentration predicts left ventricular dilation independently of IRA patency...
  41. ncbi request reprint Impaired glucose tolerance: a possible contributor to left ventricular hypertrophy and diastolic dysfunction
    Masashi Fujita
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, 565 0871, Japan
    Int J Cardiol 118:76-80. 2007
    ..This study was designed to investigate whether impaired glucose tolerance is related to left ventricular hypertrophy and abnormal diastolic function...
  42. pmc Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1
    Toshihiko Toyofuku
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    EMBO J 26:1373-84. 2007
    ..The effects of Sema4A on endothelial cells are dependent on its ability to suppress VEGF-mediated Rac activation and integrin-dependent cell adhesion. It thus appears that Sema4A-Plexin-D1 signaling negatively regulates angiogenesis...
  43. ncbi request reprint Hemodynamic influences of losartan on the brain in hypertensive patients
    Naohiko Oku
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan
    Hypertens Res 28:43-9. 2005
    ..The inclusion of losartan in anti-hypertensive regimens could be advantageous for cerebral circulation in patients with essential hypertension...
  44. ncbi request reprint Oral glucose tolerance test predicts prognosis of patients with liver cirrhosis
    Tsutomu Nishida
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Am J Gastroenterol 101:70-5. 2006
    ..The aim of this study was to evaluate whether oral glucose tolerance test (OGTT) was useful in evaluating the prognosis of patients with liver cirrhosis...
  45. ncbi request reprint The antioxidant N-2-mercaptopropionyl glycine attenuates left ventricular hypertrophy in in vivo murine pressure-overload model
    Moto o Date
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    J Am Coll Cardiol 39:907-12. 2002
    ..In order to identify the role of reactive oxygen species (ROS) in cardiac hypertrophy, we examined the effect of N-2-mercaptopropionyl glycine (MPG) on cardiac hypertrophy...
  46. ncbi request reprint Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia
    Tsutomu Sasaki
    Division of Strokology, Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    J Neurosci Res 72:461-71. 2003
    ..These results demonstrate that COX-2 is an important modulator in enhancement of proliferation of neural progenitor cells after ischemia...
  47. ncbi request reprint DNAzyme for TGF-beta suppressed extracellular matrix accumulation in experimental glomerulonephritis
    Yoshitaka Isaka
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Kidney Int 66:586-90. 2004
    ..Recently, a new generation of catalytic nucleic acid composed of DNA, named DNA enzyme (DNAzyme), has been developed...
  48. ncbi request reprint CCAAT/Enhancer-binding protein delta contributes to myofibroblast transdifferentiation and renal disease progression
    Masanobu Takeji
    Department of Internal Medicine and Therapeutics, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Am Soc Nephrol 15:2383-90. 2004
    ..These data suggest an important role for C/EBPdelta in myofibroblast transdifferentiation and glomerulonephritis exacerbation...
  49. ncbi request reprint Canine DNA array as a potential tool for combining physiology and molecular biology
    Masanori Asakura
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Circ J 67:788-92. 2003
    ..The canine DNA microarray is a useful tool for assessing the precise molecular events following changes in the pathophysiological conditions of the heart...
  50. ncbi request reprint Cross-talk between bone morphogenetic protein 2 and leukemia inhibitory factor through ERK 1/2 and Smad1 in protection against doxorubicin-induced injury of cardiomyocytes
    Masahiro Izumi
    Department of Cardiology, Osaka Medical Center for Cancer and Cardiovascular Disease, 1 3 3, Nakamichi, Higashinari ku, Osaka, Osaka 537 8511, Japan
    J Mol Cell Cardiol 40:224-33. 2006
    ....
  51. ncbi request reprint Activation of the signal transducer and activator of transcription signaling pathway in renal proximal tubular cells by albumin
    Hideaki Nakajima
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    J Am Soc Nephrol 15:276-85. 2004
    ....
  52. doi request reprint Effect of intracoronary thrombectomy on 30-day mortality in non-diabetic patients with acute hyperglycemia after acute myocardial infarction
    Masaya Usami
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Cardiol 53:429-36. 2009
    ..There is limited evidence about useful therapeutic interventions for patients with acute hyperglycemia (AH) after acute myocardial infarction (AMI)...
  53. doi request reprint Rivaroxaban versus warfarin in Japanese patients with nonvalvular atrial fibrillation in relation to the CHADS2 score: a subgroup analysis of the J-ROCKET AF trial
    Masatsugu Hori
    Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Stroke Cerebrovasc Dis 23:379-83. 2014
    ..In this subanalysis, we investigated the safety and efficacy of rivaroxaban and warfarin in relation to patients' CHADS2 scores...
  54. doi request reprint Oral treatment with nicorandil at discharge is associated with reduced mortality after acute myocardial infarction
    Yasuhiko Sakata
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Cardiol 59:14-21. 2012
    ..Previous studies showed that nicorandil can reduce coronary events in patients with coronary artery disease. However, it is unclear whether oral nicorandil treatment may reduce mortality following acute myocardial infarction (AMI)...
  55. ncbi request reprint Heterogeneity of cerebral blood flow in Alzheimer disease and vascular dementia
    Takuya Yoshikawa
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    AJNR Am J Neuroradiol 24:1341-7. 2003
    ..We examined the usefulness of 3D fractal analysis of CBF SPECT images to objectively quantify the heterogeneity of CBF in patients with AD and VaD...
  56. ncbi request reprint Glycated albumin is a better indicator for glucose excursion than glycated hemoglobin in type 1 and type 2 diabetes
    Kazutomi Yoshiuchi
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Endocr J 55:503-7. 2008
    ..28, P<0.001). In summary, GA could be a better marker for glycemic control than glycated hemoglobin in diabetic patients, especially for evaluating glycemic excursion, which is considered to be a major cause of diabetic angiopathy...
  57. ncbi request reprint Quantification of the heterogeneity of cerebral blood flow in vascular dementia
    Takuya Yoshikawa
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine A8, 2 2, Yamadaoka, Suita City, Osaka, 565 0871, Japan
    J Neurol 250:194-200. 2003
    ..In this study, we applied three-dimensional fractal analysis (3D-FA) to CBF SPECT images as a method for assessing the heterogeneity of the cerebral blood flow distribution in VaD. Subjects and..
  58. ncbi request reprint Distal protection improved reperfusion and reduced left ventricular dysfunction in patients with acute myocardial infarction who had angioscopically defined ruptured plaque
    Isamu Mizote
    Cardiovascular Division, Osaka Police Hospital, Osaka, 543 0035, Japan
    Circulation 112:1001-7. 2005
    ..Therefore, we classified the type of culprit lesion by angioscopy and examined its influence on the effectiveness of distal protection, comparing patients with AMI treated with and without distal protection...
  59. doi request reprint Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure
    Tetsuya Watanabe
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Am Coll Cardiol 52:779-86. 2008
    ..This study examined whether a reduction in hemoglobin-oxygen affinity improves exercise capacity in mice with heart failure...
  60. ncbi request reprint Cardiac-specific overexpression of a high Ca2+ affinity mutant of SERCA2a attenuates in vivo pressure overload cardiac hypertrophy
    Hiroyuki Nakayama
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    FASEB J 17:61-3. 2003
    ..Our findings indicate an association of SERCA2a activity with cardiac hypertrophy and thus a new therapeutic target for the prevention and treatment of cardiac hypertrophy...
  61. ncbi request reprint Alteration in gene expression profile by full-length hepatitis B virus genome
    Fumihiko Nakanishi
    Department of Internal Medicine and Therapeutic, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Intervirology 48:77-83. 2005
    ..Thus, expression of the virus genome caused carcinogenesis-related changes in host cell gene expression. HBV expression may change the host cell to a malignant phenotype through alterations in the expression levels of a set of genes...
  62. pmc Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling
    Yasunori Shintani
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    EMBO J 25:3045-55. 2006
    ..These findings indicate that GAG modification of NRP1 plays a critical role in modulating VEGF signaling, and may provide new insights into physiological and pathological angiogenesis...
  63. ncbi request reprint C-reactive protein predicts carotid atherosclerosis progression in mild to moderate risk and middle-aged patients
    Hiroyuki Hashimoto
    Department of Internal Medicine, Osaka National Hospital 2 1 14, Hoenzaka, Chuo Ku, Osaka, Japan
    Clin Invest Med 29:77-82. 2006
    ..This study investigated the utility of C-reactive protein to predict the progression of atherosclerosis in relation to the Framingham risk score and age...
  64. ncbi request reprint Usefulness of high-resolution real-time three-dimensional echocardiography to visualize the left ventricular endocardial surface in myocardial infarction
    Koichi Inoue
    Division of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan
    Am J Cardiol 97:1578-81. 2006
    ..We can make rough estimation of the size of the MI and its healing stage from endocardial observation with RT3DE...
  65. ncbi request reprint Fetal cells in mother rats contribute to the remodeling of liver and kidney after injury
    Yu Wang
    Department of Internal Medicine and Therapeutics, Osaka University School of Medicine, Suita, Osaka, Japan
    Biochem Biophys Res Commun 325:961-7. 2004
    ..These results indicate that fetal cells are engrafted to maternal hematopoietic system without apparent injury and they also contribute to the repairing process of maternal liver and kidney...
  66. ncbi request reprint Oestrogen increases myocardial blood flow in men: assessment by 13N-ammonia positron emission tomography
    Jun Yoshioka
    Division of Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan
    Nucl Med Commun 25:557-62. 2004
    ..Oestrogen has been shown to increase nitric oxide-mediated vasodilatation and modulate sympathetic tone in postmenopausal women. We investigated the acute effects of oestrogen on the coronary microcirculation in men...
  67. ncbi request reprint Evaluation of the use of a standard input function for compartment analysis of [123I]iomazenil data: factors influencing the quantitative results
    Yujiro Seike
    Strokology Medical Department, Bobath Memorial Hospital, Osaka, Japan
    Ann Nucl Med 18:563-72. 2004
    ..These results suggested that the simplified method with one-point arterial sampling and SIF can not be applied clinically. One additional arterial sampling in the late period may be useful...
  68. ncbi request reprint Quantitative analyses of osteopontin mRNA expression in human proximal tubules isolated from renal biopsy tissue sections of minimal change nephrotic syndrome and IgA glomerulonephropathy patients
    Jun Ya Kaimori
    Department of Internal Medicine and Therapeutics, Graduate School of Medicine, Osaka University, Osaka, Japan
    Am J Kidney Dis 39:948-57. 2002
    ..In patients with mild IgA glomerulonephritis, OPN mRNA expression in proximal tubules increased exponentially in response to a small amount of urinary protein (<1.2 g/d)...
  69. ncbi request reprint Cerebral and cerebellar activation in power and precision grip movements: an H2 15O positron emission tomography study
    Masashi Takasawa
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan
    J Cereb Blood Flow Metab 23:1378-82. 2003
    ..Our findings indicate no difference in brain activation between the acts of power grip and precision grip without a target object...
  70. pmc Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathway
    Tatsuya Koyama
    Department of Structural Analysis, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka, Japan
    J Biol Chem 283:24234-44. 2008
    ..Collectively, these data suggest that the Gab1-SHP2-ERK1/2 signaling pathway comprises an inhibitory axis for IGF-I-dependent myogenic differentiation...
  71. ncbi request reprint Repeated physiologic stresses provide persistent cardioprotection against ischemia-reperfusion injury in rats
    Shiro Hoshida
    Division of Cardiology, Osaka Rosai Hospital, Sakai, Japan
    J Am Coll Cardiol 40:826-31. 2002
    ..We investigated the time course of myocardial tolerance to ischemia-reperfusion injury after repeated physiologic or pharmacologic stresses...
  72. ncbi request reprint A persistent increase in C-reactive protein is a risk factor for restenosis in patients with stable angina who are not receiving statins
    Shiro Hoshida
    Division of Cardiology, Osaka Rosai Hospital, Sakai, Osaka, Japan
    Atherosclerosis 173:285-90. 2004
    ..In conclusions, the persistent increase in CRP is a risk factor for restenosis in patients with stable angina who have not been treated with statins...
  73. ncbi request reprint Comparison of the prognostic value of cardiac iodine-123 metaiodobenzylguanidine imaging and heart rate variability in patients with chronic heart failure: a prospective study
    Takahisa Yamada
    Division of Cardiology, Osaka Prefectural General Hospital, Japan
    J Am Coll Cardiol 41:231-8. 2003
    ..We sought to prospectively compare the prognostic value of cardiac iodine-123 (I-123) metaiodobenzylguanidine (MIBG) imaging with that of heart rate variability (HRV) in patients with mild-to-moderate chronic heart failure (HF)...
  74. ncbi request reprint Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy
    Shinichi Hirotani
    Department of Pathophysiology, Osaka University Graduate School of Medicine, Osaka, Japan
    Circulation 105:509-15. 2002
    ....
  75. pmc Prediction of sudden death in patients with mild-to-moderate chronic heart failure by using cardiac iodine-123 metaiodobenzylguanidine imaging
    Hidetaka Kioka
    Division of Cardiology, Osaka General Medical Centre, Osaka, Japan
    Heart 93:1213-8. 2007
    ..To evaluate the usefulness of cardiac iodine-123 (123I) metaiodobenzylguanidine (MIBG) imaging as a predictor of sudden death in patients with chronic heart failure (CHF)...
  76. ncbi request reprint Association between hyperglycemia and the no-reflow phenomenon in patients with acute myocardial infarction
    Katsuomi Iwakura
    Division of Cardiology, Sakurabashi Watanabe Hospital, Osaka University, Osaka, Japan
    J Am Coll Cardiol 41:1-7. 2003
    ..We investigated the association between hyperglycemia and the no-reflow phenomenon in patients with acute myocardial infarction (AMI)...
  77. ncbi request reprint Detection of misery perfusion with split-dose 123I-iodoamphetamine single-photon emission computed tomography in patients with carotid occlusive diseases
    Masao Imaizumi
    Division of Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Stroke 33:2217-23. 2002
    ..In clinical practice, the detection of patients with misery perfusion through the use of widely available, noninvasive, and cost-effective modalities such as single-photon emission computed tomography (SPECT) is extremely important...
  78. ncbi request reprint Gastroesophageal reflux disease related to diabetes: Analysis of 241 cases with type 2 diabetes mellitus
    Tsutomu Nishida
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    J Gastroenterol Hepatol 19:258-65. 2004
    ..We examined the incidence of symptomatic gastroesophageal reflux disease (GERD) in patients with type 2 diabetes mellitus (DM)...
  79. ncbi request reprint Carotid artery intima-media thickness and plaque score for the risk assessment of stroke subtypes
    Yoji Nagai
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Ultrasound Med Biol 28:1239-43. 2002
    ..80) was greater than that defined by IMT (0.68) (p < 0.05). Thus, although both CCA IMT and PS appear to help for risk assessment of AI and LI, risk of AI may be more effectively assessed by PS...
  80. ncbi request reprint Long-acting Ca2+ blockers prevent myocardial remodeling induced by chronic NO inhibition in rats
    Shoji Sanada
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertension 41:963-7. 2003
    ..Thus, long-acting dihydropyridine calcium channel blockers inhibited cardiac hypertrophy induced by chronic inhibition of NO synthesis by inhibiting both p70S6K and ERK in vivo...
  81. ncbi request reprint Association between cardiac troponin T elevation and angioscopic morphology of culprit lesion in patients with non-ST-segment elevation acute coronary syndrome
    Tomohito Ohtani
    Cardiovascular Division, Osaka Police Hospital, Osaka, Japan
    Am Heart J 150:227-33. 2005
    ..The aim of this study is to clarify the association between the serum TnT elevation and the angioscopically evaluated morphology of culprit lesion in the patients with NSEACS...
  82. ncbi request reprint New attempt of ultrasonic tissue characterization: decreased chaos in myocardial echo in patients with dilated cardiomyopathy
    Tohru Masuyama
    The Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan
    Ultrasound Med Biol 28:93-9. 2002
    ..6 in DCM patients. In conclusion, chaotic behavior is prevalent in the RF signals for the healthy myocardium, and a decrease in such chaos may be indicative of the damaged myocardium in DCM patients...
  83. ncbi request reprint Relations of serum high-sensitivity C-reactive protein and interleukin-6 levels with silent brain infarction
    Taku Hoshi
    Division of Stroke Medicine, Department of Internal Medicine and Therapeutics A8, Osaka University Graduate School of Medicine, Osaka, Japan
    Stroke 36:768-72. 2005
    ..This study examines the associations between serum inflammatory markers and SBI as a manifestation of cerebral small vessel disease...
  84. ncbi request reprint Enhanced method for predicting left ventricular reverse remodeling after surgical repair of aortic regurgitation: application of ultrasonic tissue characterization
    Keiji Hirooka
    Cardiology Division of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Am Soc Echocardiogr 15:695-701. 2002
    ..These data indicate that preoperative CVIB from the left ventricle provides pivotal information for predicting reverse remodeling after operation for aortic regurgitation in addition to the conventional echocardiographic parameters...
  85. ncbi request reprint Elevated C-reactive protein associates with early-stage carotid atherosclerosis in young subjects with type 1 diabetes
    Rieko Hayaishi-Okano
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan Osaka Police Hospital, Osaka, Japan
    Diabetes Care 25:1432-8. 2002
    ..To evaluate whether low-grade inflammation contributes to early-stage advanced carotid atherosclerosis in young subjects with type 1 diabetes...
  86. ncbi request reprint Ultrasonic integrated backscatter discloses intramyocardial hemorrhage in patients with acute myocardial infarction
    Masami Nishino
    Division of Cardiology, Osaka Rosai Hospital, Sakai, Osaka, Japan
    Echocardiography 24:52-60. 2007
    ..We examined whether integrated backscatter (IBS) can disclose IH in patients with AMI. We recorded IBS images in 34 patients with AMI who underwent coronary angioplasty within 12 hours of symptom onset...
  87. ncbi request reprint Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia
    Yoshiki Yagita
    Division of Strokology, Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    J Neurosci Res 69:750-6. 2002
    ..In contrast, very few nestin-positive cells were labeled by BrdU. Our results suggest that neuronal progenitor cells in the SGZ expressed Msi1 but not nestin...
  88. ncbi request reprint GATA-4 regulates cardiac morphogenesis through transactivation of the N-cadherin gene
    Hong Zhang
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, 565 0871, Osaka, Japan
    Biochem Biophys Res Commun 312:1033-8. 2003
    ..We therefore concluded that the cardia bifida observed in the GATA-4-deleted model is caused by the transcriptional down-regulation of N-cadherin expression...
  89. ncbi request reprint Analysis of transmural trends in myocardial integrated backscatter in patients with progressive systemic sclerosis
    Keiji Hirooka
    Cardiovascular Divisions of Osaka National Hospital, Hoenzaka, Chuo Ku, Osaka, Japan
    J Am Soc Echocardiogr 16:340-6. 2003
    ..2 +/- 1.1 vs 5.0 +/- 1.0 dB, P =.0165). Early changes in the myocardium of patients with PSS, possibly related to increased interstitial collagen deposition, can be detected by quantitative analysis of THIB...
  90. ncbi request reprint Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase
    Dan Kawamori
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    Diabetes 52:2896-904. 2003
    ....