Affiliation: Osaka University
Honda T, Rahman M. Profiling of LINE-1-Related Genes in Hepatocellular Carcinoma. Int J Mol Sci. 2019;20: pubmed publisher
..Thus, L1 may be a novel prime therapeutic target for HBV-related HCC. Studies in this area will provide insights into HCC and other types of cancers. ..
Nakayama R, Ueno Y, Ueda K, Honda T. Latent infection with Kaposi's sarcoma-associated herpesvirus enhances retrotransposition of long interspersed element-1. Oncogene. 2019;: pubmed publisher
..Our results suggest that L1 retrotransposition may be a novel target for impeding tumor development in KSHV-infected patients. ..
Nishikawa Y, Nakayama R, Obika S, Ohsaki E, Ueda K, Honda T. Inhibition of LINE-1 Retrotransposition by Capsaicin. Int J Mol Sci. 2018;19: pubmed publisher
..Given that L1-mediated mutagenesis can cause tumorigenesis, our findings suggest the potential of capsaicin for suppressing cancer development. ..
Tokunaga T, Yamamoto Y, Sakai M, Tomonaga K, Honda T. Antiviral activity of favipiravir (T-705) against mammalian and avian bornaviruses. Antiviral Res. 2017;143:237-245 pubmed publisher
..Our findings provide a novel and effective option for treating persistent bornavirus infection. ..
Honda T, Sofuku K, Kojima S, Yamamoto Y, Ohtaki N, Tomonaga K. Linkage between the leader sequence and leader RNA production in Borna disease virus-infected cells. Virology. 2017;510:104-110 pubmed publisher
..On the other hand, mutation of the 3'-UTR affects leRNA production. Our findings add a novel viral transcript to the BDV life cycle and shed light on BDV replication and/or transcription. ..