Takashi Hishida

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. doi request reprint RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light
    Takashi Hishida
    Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nature 457:612-5. 2009
  2. pmc Srs2 plays a critical role in reversible G2 arrest upon chronic and low doses of UV irradiation via two distinct homologous recombination-dependent mechanisms in postreplication repair-deficient cells
    Takashi Hishida
    Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Mol Cell Biol 30:4840-50. 2010
  3. pmc Role of the Escherichia coli RecQ DNA helicase in SOS signaling and genome stabilization at stalled replication forks
    Takashi Hishida
    Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Genes Dev 18:1886-97. 2004
  4. pmc Functional and physical interaction of yeast Mgs1 with PCNA: impact on RAD6-dependent DNA damage tolerance
    Takashi Hishida
    Genome Dynamics Group, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    Mol Cell Biol 26:5509-17. 2006
  5. pmc Saccharomyces cerevisiae MGS1 is essential in strains deficient in the RAD6-dependent DNA damage tolerance pathway
    Takashi Hishida
    Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    EMBO J 21:2019-29. 2002
  6. pmc A SUMO-like domain protein, Esc2, is required for genome integrity and sister chromatid cohesion in Saccharomyces cerevisiae
    Tomoko Ohya
    Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Genetics 180:41-50. 2008
  7. ncbi request reprint Structure-function analysis of the three domains of RuvB DNA motor protein
    Takayuki Ohnishi
    Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 280:30504-10. 2005
  8. pmc Essential and distinct roles of the F-box and helicase domains of Fbh1 in DNA damage repair
    Chikako Sakaguchi
    Laboratory of Genome Dynamics, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    BMC Mol Biol 9:27. 2008
  9. ncbi request reprint Functional overlap between RecA and MgsA (RarA) in the rescue of stalled replication forks in Escherichia coli
    Tatsuya Shibata
    Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Genes Cells 10:181-91. 2005
  10. pmc Chronic low-dose ultraviolet-induced mutagenesis in nucleotide excision repair-deficient cells
    Nami Haruta
    Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Nucleic Acids Res 40:8406-15. 2012

Collaborators

Detail Information

Publications16

  1. doi request reprint RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light
    Takashi Hishida
    Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nature 457:612-5. 2009
    ..Thus, the error-free PRR pathway is specifically important during chronic low-dose ultraviolet exposure to prevent counter-productive DNA checkpoint activation and allow cells to proliferate normally...
  2. pmc Srs2 plays a critical role in reversible G2 arrest upon chronic and low doses of UV irradiation via two distinct homologous recombination-dependent mechanisms in postreplication repair-deficient cells
    Takashi Hishida
    Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Mol Cell Biol 30:4840-50. 2010
    ..The first (required to suppress HR during PRR) is regulated by PCNA sumoylation, whereas the second (required for HR-dependent recovery following CLUV exposure) is regulated by CDK1-dependent phosphorylation...
  3. pmc Role of the Escherichia coli RecQ DNA helicase in SOS signaling and genome stabilization at stalled replication forks
    Takashi Hishida
    Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Genes Dev 18:1886-97. 2004
    ....
  4. pmc Functional and physical interaction of yeast Mgs1 with PCNA: impact on RAD6-dependent DNA damage tolerance
    Takashi Hishida
    Genome Dynamics Group, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    Mol Cell Biol 26:5509-17. 2006
    ..The proposed roles for Mgs1, Srs2, and modified PCNA during replication arrest highlight the importance of modulating the RAD6 and RAD52 pathways to avoid genome instability...
  5. pmc Saccharomyces cerevisiae MGS1 is essential in strains deficient in the RAD6-dependent DNA damage tolerance pathway
    Takashi Hishida
    Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    EMBO J 21:2019-29. 2002
    ..These findings suggest that Mgs1 is essential for preventing genome instability caused by replication fork arrest in cells deficient in the RAD6 pathway and may modulate replication fork movement catalyzed by yeast polymerase delta...
  6. pmc A SUMO-like domain protein, Esc2, is required for genome integrity and sister chromatid cohesion in Saccharomyces cerevisiae
    Tomoko Ohya
    Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Genetics 180:41-50. 2008
    ....
  7. ncbi request reprint Structure-function analysis of the three domains of RuvB DNA motor protein
    Takayuki Ohnishi
    Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 280:30504-10. 2005
    ..The data also provide evidence that coordinated ATP-dependent interactions between domains N, M, and C play an essential role during formation of the RuvAB Holliday junction ternary complex...
  8. pmc Essential and distinct roles of the F-box and helicase domains of Fbh1 in DNA damage repair
    Chikako Sakaguchi
    Laboratory of Genome Dynamics, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    BMC Mol Biol 9:27. 2008
    ..cerevisiae RAD51)-dependent recombinational repair of DSBs. Fbh1 fused to GFP localizes to discrete nuclear foci following DNA damage...
  9. ncbi request reprint Functional overlap between RecA and MgsA (RarA) in the rescue of stalled replication forks in Escherichia coli
    Tatsuya Shibata
    Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Genes Cells 10:181-91. 2005
    ....
  10. pmc Chronic low-dose ultraviolet-induced mutagenesis in nucleotide excision repair-deficient cells
    Nami Haruta
    Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Nucleic Acids Res 40:8406-15. 2012
    ..More generally, our data suggest that PolĪ· can act as both an error-free and a mutagenic DNA polymerase, depending on whether the NER pathway is available to efficiently repair damaged templates...
  11. ncbi request reprint Degradation of Escherichia coli RecN aggregates by ClpXP protease and its implications for DNA damage tolerance
    Kohji Nagashima
    Laboratory of Genome Dynamics, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    J Biol Chem 281:30941-6. 2006
    ..These data demonstrate that ClpXP is a critical factor in the cellular clearance of cytoplasmic RecN aggregates from the cell and therefore plays an important role in DNA damage tolerance...
  12. pmc Direct evidence that a conserved arginine in RuvB AAA+ ATPase acts as an allosteric effector for the ATPase activity of the adjacent subunit in a hexamer
    Takashi Hishida
    Department of Molecular Microbiology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 101:9573-7. 2004
    ..This study demonstrates that R174 plays an intermolecular catalytic role during ATP hydrolysis by RuvB. This role may be a general feature of the oligomeric AAA/AAA(+) ATPases...
  13. ncbi request reprint Uncoupling of the ATPase activity from the branch migration activity of RuvAB protein complexes containing both wild-type and ATPase-defective RuvB proteins
    Takashi Hishida
    Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    Genes Cells 8:721-30. 2003
    ..In this study, we examined RuvAB-dependent branch migration in the presence of a mutant RuvB, K68A...
  14. pmc Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest
    Izumi Miyabe
    Genome Dynamics Group, Research Institute for Microbial Disease, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Mol Cell Biol 26:343-53. 2006
    ..These results suggest that Rad60 is required for recombination repair at a step downstream of Rhp51. We propose that Rhp51-dependent DNA structures that cannot activate the mitotic checkpoints accumulate in rad60-1 cells...
  15. ncbi request reprint [Molecular mechanisms of RAD6 DNA damage tolerance pathway in Saccharomyces cerevisiae]
    Takashi Hishida
    Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    Seikagaku 80:124-8. 2008
  16. pmc Direct observation of DNA rotation during branch migration of Holliday junction DNA by Escherichia coli RuvA-RuvB protein complex
    Yong Woon Han
    Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    Proc Natl Acad Sci U S A 103:11544-8. 2006
    ..3 bp per second. This real-time observation of the DNA rotation not only allows us to measure the kinetics of the RuvA-RuvB-mediated branch migration, but also opens the possibility of elucidating the branch migration mechanism in detail...