Seiichi Hirota

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Clinicopathological significance of poorly differentiated thyroid carcinoma
    T Nishida
    First Department of Surgery, Osaka University Medical School, Japan
    Am J Surg Pathol 23:205-11. 1999
  2. doi request reprint Clinical practice guidelines for gastrointestinal stromal tumor (GIST) in Japan: English version
    Toshirou Nishida
    Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Int J Clin Oncol 13:416-30. 2008
  3. ncbi request reprint Efficacy and safety profile of imatinib mesylate (ST1571) in Japanese patients with advanced gastrointestinal stromal tumors: a phase II study (STI571B1202)
    Toshirou Nishida
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Int J Clin Oncol 13:244-51. 2008
  4. doi request reprint Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor
    Toshirou Nishida
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Osaka, Japan
    Cancer Sci 99:799-804. 2008
  5. ncbi request reprint The clinicopathological significance of histologic vascular invasion in differentiated thyroid carcinoma
    Toshirou Nishida
    Department of Surgery, E1, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, 565 0871 Osaka, Japan
    Am J Surg 183:80-6. 2002
  6. ncbi request reprint Clinicopathological features of gastric stromal tumors
    T Nishida
    Dept of Surgery, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
    J Exp Clin Cancer Res 19:417-25. 2000
  7. ncbi request reprint Biological and clinical review of stromal tumors in the gastrointestinal tract
    T Nishida
    Department of Surgery, E1, Osaka University Graduate School of Medicine, Suita, Japan
    Histol Histopathol 15:1293-301. 2000
  8. ncbi request reprint Vagus nerve is involved in lack of blood reflow into sinusoids after rat hepatic ischemia
    T Nishida
    Department of Surgery, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    Am J Physiol Heart Circ Physiol 278:H1565-70. 2000
  9. doi request reprint Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene
    Toshirou Nishida
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Int J Clin Oncol 14:143-9. 2009
  10. ncbi request reprint Different inhibitory effect of imatinib on phosphorylation of mitogen-activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet-derived growth factor receptor-alpha
    Akiko Ohashi
    Department of Pathology, Osaka University Medical School, Suita, Osaka, Japan
    Int J Cancer 111:317-21. 2004

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Clinicopathological significance of poorly differentiated thyroid carcinoma
    T Nishida
    First Department of Surgery, Osaka University Medical School, Japan
    Am J Surg Pathol 23:205-11. 1999
    ..15 versus 19.03 and 20.87 years; p < 0.0001) compared with the well and focal-poorly differentiated carcinomas. These data suggest that diffuse-poorly differentiated carcinoma is an important clinicopathological entity...
  2. doi request reprint Clinical practice guidelines for gastrointestinal stromal tumor (GIST) in Japan: English version
    Toshirou Nishida
    Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Int J Clin Oncol 13:416-30. 2008
    ..Here we present the English version of the Japanese Clinical Practice Guideline for GIST prepared by the GIST Guideline Subcommittee...
  3. ncbi request reprint Efficacy and safety profile of imatinib mesylate (ST1571) in Japanese patients with advanced gastrointestinal stromal tumors: a phase II study (STI571B1202)
    Toshirou Nishida
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Int J Clin Oncol 13:244-51. 2008
    ..The aim of this study was to assess the efficacy and safety of imatinib mesylate in Japanese patients with advanced GIST...
  4. doi request reprint Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumor
    Toshirou Nishida
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Osaka, Japan
    Cancer Sci 99:799-804. 2008
    ..Resistant lesions showed monoclonal development of tumor cells. Taken together, additional cis-positioned mutations in the kinase domains are a major cause of secondary resistance to imatinib in Japanese GIST patients...
  5. ncbi request reprint The clinicopathological significance of histologic vascular invasion in differentiated thyroid carcinoma
    Toshirou Nishida
    Department of Surgery, E1, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, 565 0871 Osaka, Japan
    Am J Surg 183:80-6. 2002
    ..Clinicopathological correlation and clinical importance of histologic vascular invasion in differentiated thyroid carcinoma have not been fully examined...
  6. ncbi request reprint Clinicopathological features of gastric stromal tumors
    T Nishida
    Dept of Surgery, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
    J Exp Clin Cancer Res 19:417-25. 2000
    ..Thus, this classification is considered to be clinically and pathologically important in the diagnosis of gastric stromal tumors...
  7. ncbi request reprint Biological and clinical review of stromal tumors in the gastrointestinal tract
    T Nishida
    Department of Surgery, E1, Osaka University Graduate School of Medicine, Suita, Japan
    Histol Histopathol 15:1293-301. 2000
    ..However, phenotypical resemblance to the interstitial cells of Cajal (ICCs) and gain-of-function mutations in the c-kit gene may suggest origin from ICCs and/or multipotential mesenchymal cells that differentiate into ICCs...
  8. ncbi request reprint Vagus nerve is involved in lack of blood reflow into sinusoids after rat hepatic ischemia
    T Nishida
    Department of Surgery, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    Am J Physiol Heart Circ Physiol 278:H1565-70. 2000
    ..These results suggest that the cholinergic vagus nerve is involved in causing the lag time of sinusoidal blood flow in hepatic ischemia-reperfusion...
  9. doi request reprint Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT gene
    Toshirou Nishida
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Int J Clin Oncol 14:143-9. 2009
    ....
  10. ncbi request reprint Different inhibitory effect of imatinib on phosphorylation of mitogen-activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet-derived growth factor receptor-alpha
    Akiko Ohashi
    Department of Pathology, Osaka University Medical School, Suita, Osaka, Japan
    Int J Cancer 111:317-21. 2004
    ..Ba/F3 cells expressing mutant PDGFRA are a good model to investigate the mechanism of cell proliferation or growth inhibition by imatinib in mutant PDGFRA-driven cells...
  11. ncbi request reprint c-kit gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors
    Kazuo Kinoshita
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University Medical School, Suita, Japan
    J Gastroenterol Hepatol 18:147-51. 2003
    ..In the present study, we examined the mutations at exon 17 and exon 13 by using direct sequencing...
  12. ncbi request reprint Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors
    Seiichi Hirota
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Gastroenterology 125:660-7. 2003
    ..We investigated the cause of GISTs without KIT mutations. Because GISTs apparently expressed platelet-derived growth factor receptor (PDGFR) alpha, we examined whether GISTs without KIT mutations had a mutation of PDGFR alpha...
  13. doi request reprint Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor
    Kazufumi Sakurama
    Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, and Okayama Citizens Hospital, 2 5 1 Shikatacho, Okayama 700 9558, Japan
    Mol Cancer Ther 8:127-34. 2009
    ..In summary, c-KIT mutation at exon 17 displayed a resistance to imatinib with maintained activations of FAK and subsequent survival signals. Targeting FAK could be a potential therapeutic strategy for imatinib-resistant GISTs...
  14. ncbi request reprint Imatinib inhibits various types of activating mutant kit found in gastrointestinal stromal tumors
    Hui Chen
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Cancer 105:130-5. 2003
    ....
  15. ncbi request reprint Surgical interventions for focal progression of advanced gastrointestinal stromal tumors during imatinib therapy
    Junichi Hasegawa
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    Int J Clin Oncol 12:212-7. 2007
    ..The aim of this study was to retrospectively analyze the safety and prognostic effects of surgical interventions for focal progression during imatinib treatment...
  16. doi request reprint Involvement of focal adhesion kinase in the progression and prognosis of gastrointestinal stromal tumors
    Nobuyuki Kamo
    Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama 700 8558, Japan
    Hum Pathol 40:1643-9. 2009
    ....
  17. ncbi request reprint The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritis
    Katsuhiko Ishihara
    Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
    Int Immunol 16:455-65. 2004
    ..gp130F759/F759/pX-Tg is a unique mouse model for RA...
  18. doi request reprint Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patients
    Tatsuo Kanda
    Department of Surgery, Niigata University Medical and Dental Hospital, 1 754 Asahimachi dori, Chuo Ku, Niigata, 951 8520, Japan
    Int J Clin Oncol 18:38-45. 2013
    ..There are no data concerning the efficacy and safety of postoperative adjuvant therapy with imatinib for Japanese or East Asian patients with GIST...
  19. ncbi request reprint Differential expression of connexin 43 in gastrointestinal stromal tumours of gastric and small intestinal origin
    Akiko Nishitani
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Japan
    J Pathol 206:377-82. 2005
    ..Furthermore, these data indicate that the gastric and the small intestinal subtypes of GIST may originate from different subtypes of ICC...
  20. ncbi request reprint An enhanced risk-group stratification system for more practical prognostication of clinically malignant gastrointestinal stromal tumors
    Tsuyoshi Takahashi
    Department of Surgery, Osaka University Graduate School of Medicine, 2 2, E1, Yamadaoka, Suita, Osaka 565 0871, Japan
    Int J Clin Oncol 12:369-74. 2007
    ..The aims of this study were to identify factors prognostic for an unfavorable postoperative outcome, and to enhance the current NIH-consensus risk-group stratification system (Fletcher's system)...
  21. ncbi request reprint Endoscopic ultrasonography-guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumours
    Kazuo Kinoshita
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University Medical School, Japan
    Eur J Gastroenterol Hepatol 15:1189-93. 2003
    ..The relationship between tumour growth and c-kit mutation was also examined...
  22. ncbi request reprint Gastrointestinal stromal tumors (GIST): a model for molecule-based diagnosis and treatment of solid tumors
    Yukihiko Kitamura
    Department of Pathology, Medical School Graduate School of Frontier Biosicence, Osaka University, Suita, Osaka 565 0871, Japan
    Cancer Sci 94:315-20. 2003
    ..Imatinib mesylate also inhibits the mutated KIT observed in most GISTs, and this explains the effectiveness of Imatinib mesylate on GISTs. GISTs appear to serve as a model for molecule-based diagnosis and treatment of solid tumors...
  23. doi request reprint Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice
    Hironobu Nakane
    Human Cell Biology Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
    DNA Repair (Amst) 7:1938-50. 2008
    ..Xpa (-/-) mice provide a useful model for investigating the aging and internal tumor formation in XPA patients...
  24. doi request reprint Subgroups of patients with very large gastrointestinal stromal tumors with distinct prognoses: a multicenter study
    Noriko Wada
    Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
    J Surg Oncol 109:67-70. 2014
    ..We conducted a multicenter study to identify a subgroup with moderate prognosis even within the "high-risk" group...
  25. doi request reprint Clinical significance of surgery for gastric submucosal tumours with size enlargement during watchful waiting period
    Yasuhiro Miyazaki
    Division of Gastroenterological Surgery, Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan
    Eur J Cancer 49:2681-8. 2013
    ..The true impact of surgery for small, asymptomatic and biopsy-negative gastric submucosal tumours (SMTs) with size enlargement during 'watchful waiting' period has not been fully understood...
  26. ncbi request reprint Dose-dependent and time-limited proliferation of cultured murine interstitial cells of Cajal in response to stem cell factor
    Masanori Nakahara
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, Suita, Japan
    Life Sci 70:2367-76. 2002
    ..ICCs showed a dose-dependent and time-limited proliferation in response to SCF in the in vitro culture system used here in...
  27. ncbi request reprint T lymphocytes constitutively produce an interferonlike cytokine limitin characterized as a heat- and acid-stable and heparin-binding glycoprotein
    Kenji Oritani
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Japan
    Blood 101:178-85. 2003
    ..Although the longer limitin protein is structurally and characteristically related to type I interferons, its production is uniquely regulated by translation as well as transcription...
  28. pmc A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis
    Toru Atsumi
    Department of Molecular Oncology C7, Graduate School of Medicine, Osaka University, Suita, Japan
    J Exp Med 196:979-90. 2002
    ..Finally, we showed that disease development was dependent on lymphocytes. These results provide evidence that a point mutation of a cytokine receptor has the potential to induce autoimmune disease...
  29. ncbi request reprint Deficiency of KIT-positive cells in the colon of patients with diabetes mellitus
    Masanori Nakahara
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, 2 2 B 5 Yamada oka, Suita, Osaka 565 0871, Japan
    J Gastroenterol Hepatol 17:666-70. 2002
    ..Therefore, we investigated a possible involvement of ICC in the pathogenesis of diabetic gastroenteropathy in humans...
  30. doi request reprint Transient expression of cellular retinol-binding protein-1 during cardiac repair after myocardial infarction
    Mengyue Yu
    Department of Pathology, National Cerebral and Cardiovascular Center, Osaka, Japan
    Pathol Int 62:246-53. 2012
    ..We have demonstrated that CRBP-1 is transiently expressed by fibroblasts during cardiac remodeling. Our results suggest that CRBP-1 plays a role in ventricular remodeling after MI allegedly through its RA binding activity...
  31. ncbi request reprint Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene
    Seiichi Hirota
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Gastroenterology 122:1493-9. 2002
    ..These findings indicate that the dysphagia of the present family is different from typical achalasia. This is the first report of familial dysphagia caused by germline gain-of-function mutation of the KIT gene at the TK II domain...
  32. ncbi request reprint Additive roles of XPA and MSH2 genes in UVB-induced skin tumorigenesis in mice
    Masafumi Yoshino
    Laboratories of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Japan
    DNA Repair (Amst) 1:935-40. 2002
    ..Our results indicate that the MSH2-deficiency caused a high incidence of spontaneous and UVB-induced skin tumorigenesis and the XPA and MSH2 genes have additive roles in the UV-induced skin tumorigenesis...
  33. ncbi request reprint Establishment of a lymph node metastasis model from subcutaneous tumors of gastrointestinal stromal tumor model cells
    Kazufumi Sakurama
    Department of Gastroenterological Surgery, Okayama University, Okayama 700 8558, Japan
    Oncol Rep 21:407-11. 2009
    ..The significance of this model is helpful to understand the molecular mechanisms of c-KIT-mediated metastasis and is useful for assessments of molecular therapeutics and in vivo imaging...
  34. doi request reprint CD44 expression in plexiform lesions of idiopathic pulmonary arterial hypertension
    Keiko Ohta-Ogo
    Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita ku, Okayama, Japan
    Pathol Int 62:219-25. 2012
    ..These findings suggest that CD44 and activated T cell infiltration play an important role in the development of plexiform lesions particularly in IPAH...
  35. doi request reprint Aberrant expression of glycosylation in juvenile gastrointestinal stromal tumors
    Tsuyoshi Takahashi
    Department of Surgery, Osaka University Graduate School of Medicine, Suita, Japan
    Proteomics Clin Appl 2:1246-54. 2008
    ..This suggests that the difference in KIT is generated by post-translational modification and may play a role in the progression of juvenile GIST...
  36. ncbi request reprint Complete response of highly advanced colon cancer with multiple lymph node metastases to irinotecan combined with UFT: report of a case
    Yujiro Fujie
    Department of Surgery, Graduate School of Medicine, Osaka University, Suita 565 0871, Japan
    Surg Today 36:1133-8. 2006
    ....
  37. ncbi request reprint Expression of matrix Gla protein and osteonectin mRNA by human aortic smooth muscle cells
    Hiroyuki Hao
    Department of Pathology, National Cardiovascular Center, Suita, Osaka, Japan
    Cardiovasc Pathol 13:195-202. 2004
    ..Recent data indicate that matrix proteins such as matrix Gla protein (MGP) and osteonectin (ON) influence not only mineralization of vasculature but smooth muscle cell (SMC) differentiation...
  38. ncbi request reprint Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces imatinib-resistant constitutive KIT activation
    Nami Nakagomi
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Lab Invest 87:365-71. 2007
    ....
  39. ncbi request reprint Pathology of gastrointestinal stromal tumors
    Seiichi Hirota
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Pathol Int 56:1-9. 2006
    ..Mutational analyses of c-kit and PDGFRA genes are also significant for prediction of effectiveness of drugs including newly developed agents...
  40. ncbi request reprint Familial adenomatous polyposis complicated by chronic myelogenous leukemia: response to imatinib mesylate
    Takeyoshi Itsukuma
    Division of Hematology Oncology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    J Gastroenterol 42:402-5. 2007
    ..Eighteen months later, however, the polyps were enlarged. In this patient, imatinib administration led to the remission of CML and might also have been responsible for the temporary regression of adenomatous polyps of FAP...
  41. ncbi request reprint [Gain-of-function mutation of c-kit gene and molecular target therapy in GISTs]
    Seiichi Hirota
    Division of Surgical Pathology, Osaka University Medical Hospital
    Nihon Shokakibyo Gakkai Zasshi 100:13-20. 2003
  42. ncbi request reprint Two cases of gastrointestinal stromal tumor of the stomach with lymph node metastasis
    Tomoi Sato
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Hepatogastroenterology 54:1057-60. 2007
    ..In the former case, there was a deletion mutation in CD117 exon 11, the most common genotype in GIST. In the latter, there were no detectable mutations in CD117 or platelet-derived growth factor receptor alpha...
  43. ncbi request reprint [A case of metastatic gastrointestinal stromal tumor developing a resistance to STI571 (imatinib mesylate)]
    Masakazu Miyake
    Dept of Surgery, Osaka National Hospital
    Gan To Kagaku Ryoho 31:1791-4. 2004
    ..Currently STI571 is the first-line therapy for non-resectable GISTs, but a single-agent therapy often leads to tumor resistance. It is our hope that we will be able to design an alternative treatment to overcome such resistance...
  44. ncbi request reprint [A case of gastrointestinal stromal tumor of the small intestine, preoperatively diagnosed by the enteroscopy]
    Miyako Kishimoto
    Department of Internal Medicine, Rokko Island Hospital
    Nihon Shokakibyo Gakkai Zasshi 100:572-7. 2003
  45. ncbi request reprint Diagnostic efficacy of free to total ratio of prostate-specific antigen and prostate-specific antigen velocity, singly and in combination, in detecting prostate cancer in patients with total serum prostate-specific antigen between 4 and 10 ng/ml
    Shingo Yamamoto
    Department of Urology, Hyogo College of Medicine, 1 1 Mukogawacho, Nishinomiya, Hyogo 663 8501, Japan
    Int Urol Nephrol 40:85-9. 2008
    ..40 ng/ml per year. Our results showed that unnecessary prostate biopsies could be more effectively avoided among patients with "gray zone PSA" by combination of f/t PSA and PSAV than single usage of these indexes...
  46. ncbi request reprint Pathophysiology, diagnosis, and treatment of gastrointestinal stromal tumors
    Yasuhisa Shinomura
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo, 060 8543, Japan
    J Gastroenterol 40:775-80. 2005
    ..The continued development of target-specific therapies should increase the probability of cure in most patients with GISTs...
  47. ncbi request reprint Absence of c-kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patients
    Kazuo Kinoshita
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Japan
    J Pathol 202:80-5. 2004
    ..These results suggest that the pathogenesis of GISTs in NF1 patients is different from that in non-NF1 patients...
  48. ncbi request reprint Characterization of tyrosine kinase I domain c-kit gene mutation Asn655Lys newly found in primary jejunal gastrointestinal stromal tumor
    Kazuo Kinoshita
    Am J Gastroenterol 102:1134-6. 2007
  49. ncbi request reprint [GIST (gastrointestinal stromal tumor)]
    Seiichi Hirota
    Nihon Naika Gakkai Zasshi 93:1451-8. 2004