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Genomes and Genes | Seiichi HirotaSummaryAffiliation: Osaka University Country: Japan Publications
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Publications
Clinicopathological significance of poorly differentiated thyroid carcinomaT Nishida
First Department of Surgery, Osaka University Medical School, Japan
Am J Surg Pathol 23:205-11. 1999..15 versus 19.03 and 20.87 years; p < 0.0001) compared with the well and focal-poorly differentiated carcinomas. These data suggest that diffuse-poorly differentiated carcinoma is an important clinicopathological entity...
Clinical practice guidelines for gastrointestinal stromal tumor (GIST) in Japan: English versionToshirou Nishida
Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
Int J Clin Oncol 13:416-30. 2008..Here we present the English version of the Japanese Clinical Practice Guideline for GIST prepared by the GIST Guideline Subcommittee...- Efficacy and safety profile of imatinib mesylate (ST1571) in Japanese patients with advanced gastrointestinal stromal tumors: a phase II study (STI571B1202)Toshirou Nishida
Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
Int J Clin Oncol 13:244-51. 2008..The aim of this study was to assess the efficacy and safety of imatinib mesylate in Japanese patients with advanced GIST... - Secondary mutations in the kinase domain of the KIT gene are predominant in imatinib-resistant gastrointestinal stromal tumorToshirou Nishida
Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Osaka, Japan
Cancer Sci 99:799-804. 2008..Resistant lesions showed monoclonal development of tumor cells. Taken together, additional cis-positioned mutations in the kinase domains are a major cause of secondary resistance to imatinib in Japanese GIST patients... - Sunitinib-resistant gastrointestinal stromal tumors harbor cis-mutations in the activation loop of the KIT geneToshirou Nishida
Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
Int J Clin Oncol 14:143-9. 2009.... - The clinicopathological significance of histologic vascular invasion in differentiated thyroid carcinomaToshirou Nishida
Department of Surgery, E1, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, 565 0871 Osaka, Japan
Am J Surg 183:80-6. 2002..Clinicopathological correlation and clinical importance of histologic vascular invasion in differentiated thyroid carcinoma have not been fully examined... - Clinicopathological features of gastric stromal tumorsT Nishida
Dept of Surgery, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
J Exp Clin Cancer Res 19:417-25. 2000..Thus, this classification is considered to be clinically and pathologically important in the diagnosis of gastric stromal tumors... - Biological and clinical review of stromal tumors in the gastrointestinal tractT Nishida
Department of Surgery, E1, Osaka University Graduate School of Medicine, Suita, Japan
Histol Histopathol 15:1293-301. 2000..However, phenotypical resemblance to the interstitial cells of Cajal (ICCs) and gain-of-function mutations in the c-kit gene may suggest origin from ICCs and/or multipotential mesenchymal cells that differentiate into ICCs... - Vagus nerve is involved in lack of blood reflow into sinusoids after rat hepatic ischemiaT Nishida
Department of Surgery, Osaka University Medical School, Suita, Osaka 565 0871, Japan
Am J Physiol Heart Circ Physiol 278:H1565-70. 2000..These results suggest that the cholinergic vagus nerve is involved in causing the lag time of sinusoidal blood flow in hepatic ischemia-reperfusion... - Different inhibitory effect of imatinib on phosphorylation of mitogen-activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet-derived growth factor receptor-alphaAkiko Ohashi
Department of Pathology, Osaka University Medical School, Suita, Osaka, Japan
Int J Cancer 111:317-21. 2004..Ba/F3 cells expressing mutant PDGFRA are a good model to investigate the mechanism of cell proliferation or growth inhibition by imatinib in mutant PDGFRA-driven cells... - c-kit gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumorsKazuo Kinoshita
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University Medical School, Suita, Japan
J Gastroenterol Hepatol 18:147-51. 2003..In the present study, we examined the mutations at exon 17 and exon 13 by using direct sequencing... - Imatinib inhibits various types of activating mutant kit found in gastrointestinal stromal tumorsHui Chen
Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Int J Cancer 105:130-5. 2003.... - Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumorsSeiichi Hirota
Department of Pathology, Osaka University Medical School, Suita, Japan
Gastroenterology 125:660-7. 2003..We investigated the cause of GISTs without KIT mutations. Because GISTs apparently expressed platelet-derived growth factor receptor (PDGFR) alpha, we examined whether GISTs without KIT mutations had a mutation of PDGFR alpha... - Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumorKazufumi Sakurama
Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, and Okayama Citizens Hospital, 2 5 1 Shikatacho, Okayama 700 9558, Japan
Mol Cancer Ther 8:127-34. 2009..In summary, c-KIT mutation at exon 17 displayed a resistance to imatinib with maintained activations of FAK and subsequent survival signals. Targeting FAK could be a potential therapeutic strategy for imatinib-resistant GISTs... - The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid arthritis-like arthritisKatsuhiko Ishihara
Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
Int Immunol 16:455-65. 2004..gp130F759/F759/pX-Tg is a unique mouse model for RA... - Surgical interventions for focal progression of advanced gastrointestinal stromal tumors during imatinib therapyJunichi Hasegawa
Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
Int J Clin Oncol 12:212-7. 2007..The aim of this study was to retrospectively analyze the safety and prognostic effects of surgical interventions for focal progression during imatinib treatment... - Involvement of focal adhesion kinase in the progression and prognosis of gastrointestinal stromal tumorsNobuyuki Kamo
Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama 700 8558, Japan
Hum Pathol 40:1643-9. 2009.... - Endoscopic ultrasonography-guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumoursKazuo Kinoshita
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University Medical School, Japan
Eur J Gastroenterol Hepatol 15:1189-93. 2003..694). CONCLUSIONS: EUS-FNAB against SMTs was useful for the differential diagnosis of SMT and the analysis of c-kit mutation. The c-kit mutation might not be one of the predictable markers for rapid tumour growth... - Differential expression of connexin 43 in gastrointestinal stromal tumours of gastric and small intestinal originAkiko Nishitani
Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Japan
J Pathol 206:377-82. 2005..Furthermore, these data indicate that the gastric and the small intestinal subtypes of GIST may originate from different subtypes of ICC... - An enhanced risk-group stratification system for more practical prognostication of clinically malignant gastrointestinal stromal tumorsTsuyoshi Takahashi
Department of Surgery, Osaka University Graduate School of Medicine, 2 2, E1, Yamadaoka, Suita, Osaka 565 0871, Japan
Int J Clin Oncol 12:369-74. 2007..The aims of this study were to identify factors prognostic for an unfavorable postoperative outcome, and to enhance the current NIH-consensus risk-group stratification system (Fletcher's system)... - Gastrointestinal stromal tumors (GIST): a model for molecule-based diagnosis and treatment of solid tumorsYukihiko Kitamura
Department of Pathology, Medical School Graduate School of Frontier Biosicence, Osaka University, Suita, Osaka 565 0871, Japan
Cancer Sci 94:315-20. 2003..Imatinib mesylate also inhibits the mutated KIT observed in most GISTs, and this explains the effectiveness of Imatinib mesylate on GISTs. GISTs appear to serve as a model for molecule-based diagnosis and treatment of solid tumors... - Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient miceHironobu Nakane
Human Cell Biology Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
DNA Repair (Amst) 7:1938-50. 2008..Xpa (-/-) mice provide a useful model for investigating the aging and internal tumor formation in XPA patients... - Dose-dependent and time-limited proliferation of cultured murine interstitial cells of Cajal in response to stem cell factorMasanori Nakahara
Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, Suita, Japan
Life Sci 70:2367-76. 2002..ICCs showed a dose-dependent and time-limited proliferation in response to SCF in the in vitro culture system used here in... - Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patientsTatsuo Kanda
Department of Surgery, Niigata University Medical and Dental Hospital, 1 754 Asahimachi dori, Chuo Ku, Niigata, 951 8520, Japan
Int J Clin Oncol 18:38-45. 2013..There are no data concerning the efficacy and safety of postoperative adjuvant therapy with imatinib for Japanese or East Asian patients with GIST... - Deficiency of KIT-positive cells in the colon of patients with diabetes mellitusMasanori Nakahara
Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, 2-2 B-5 Yamada-oka, Suita, Osaka 565-0871, Japan
J Gastroenterol Hepatol 17:666-70. 2002..CONCLUSIONS: Deficiency of ICC might be related to the pathogenesis of diabetic gastroenteropathy in humans... - T lymphocytes constitutively produce an interferonlike cytokine limitin characterized as a heat- and acid-stable and heparin-binding glycoproteinKenji Oritani
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Japan
Blood 101:178-85. 2003..Although the longer limitin protein is structurally and characteristically related to type I interferons, its production is uniquely regulated by translation as well as transcription... - Transient expression of cellular retinol-binding protein-1 during cardiac repair after myocardial infarctionMengyue Yu
Department of Pathology, National Cerebral and Cardiovascular Center, Osaka, Japan
Pathol Int 62:246-53. 2012..We have demonstrated that CRBP-1 is transiently expressed by fibroblasts during cardiac remodeling. Our results suggest that CRBP-1 plays a role in ventricular remodeling after MI allegedly through its RA binding activity... - Establishment of a lymph node metastasis model from subcutaneous tumors of gastrointestinal stromal tumor model cellsKazufumi Sakurama
Department of Gastroenterological Surgery, Okayama University, Okayama 700 8558, Japan
Oncol Rep 21:407-11. 2009..The significance of this model is helpful to understand the molecular mechanisms of c-KIT-mediated metastasis and is useful for assessments of molecular therapeutics and in vivo imaging... - Additive roles of XPA and MSH2 genes in UVB-induced skin tumorigenesis in miceMasafumi Yoshino
Laboratories of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Japan
DNA Repair (Amst) 1:935-40. 2002..Our results indicate that the MSH2-deficiency caused a high incidence of spontaneous and UVB-induced skin tumorigenesis and the XPA and MSH2 genes have additive roles in the UV-induced skin tumorigenesis... - Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT geneSeiichi Hirota
Department of Pathology, Osaka University Medical School, Suita, Japan
Gastroenterology 122:1493-9. 2002..These findings indicate that the dysphagia of the present family is different from typical achalasia. This is the first report of familial dysphagia caused by germline gain-of-function mutation of the KIT gene at the TK II domain... - CD44 expression in plexiform lesions of idiopathic pulmonary arterial hypertensionKeiko Ohta-Ogo
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita ku, Okayama, Japan
Pathol Int 62:219-25. 2012..These findings suggest that CD44 and activated T cell infiltration play an important role in the development of plexiform lesions particularly in IPAH... 
A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritisToru Atsumi
Department of Molecular Oncology C7, Graduate School of Medicine, Osaka University, Suita, Japan
J Exp Med 196:979-90. 2002..Finally, we showed that disease development was dependent on lymphocytes. These results provide evidence that a point mutation of a cytokine receptor has the potential to induce autoimmune disease...- Complete response of highly advanced colon cancer with multiple lymph node metastases to irinotecan combined with UFT: report of a caseYujiro Fujie
Department of Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan
Surg Today 36:1133-8. 2006.... - Aberrant expression of glycosylation in juvenile gastrointestinal stromal tumorsTsuyoshi Takahashi
Department of Surgery, Osaka University Graduate School of Medicine, Suita, Japan
Proteomics Clin Appl 2:1246-54. 2008..This suggests that the difference in KIT is generated by post-translational modification and may play a role in the progression of juvenile GIST... - Expression of matrix Gla protein and osteonectin mRNA by human aortic smooth muscle cellsHiroyuki Hao
Department of Pathology, National Cardiovascular Center, Suita, Osaka, Japan
Cardiovasc Pathol 13:195-202. 2004..Recent data indicate that matrix proteins such as matrix Gla protein (MGP) and osteonectin (ON) influence not only mineralization of vasculature but smooth muscle cell (SMC) differentiation... - Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces imatinib-resistant constitutive KIT activationNami Nakagomi
Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
Lab Invest 87:365-71. 2007.... - [Gain-of-function mutation of c-kit gene and molecular target therapy in GISTs]Seiichi Hirota
Division of Surgical Pathology, Osaka University Medical Hospital
Nippon Shokakibyo Gakkai Zasshi 100:13-20. 2003 - Pathology of gastrointestinal stromal tumorsSeiichi Hirota
Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
Pathol Int 56:1-9. 2006..Mutational analyses of c-kit and PDGFRA genes are also significant for prediction of effectiveness of drugs including newly developed agents... - Two cases of gastrointestinal stromal tumor of the stomach with lymph node metastasisTomoi Sato
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Hepatogastroenterology 54:1057-60. 2007..In the former case, there was a deletion mutation in CD117 exon 11, the most common genotype in GIST. In the latter, there were no detectable mutations in CD117 or platelet-derived growth factor receptor alpha... - Familial adenomatous polyposis complicated by chronic myelogenous leukemia: response to imatinib mesylateTakeyoshi Itsukuma
Division of Hematology Oncology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
J Gastroenterol 42:402-5. 2007..Eighteen months later, however, the polyps were enlarged. In this patient, imatinib administration led to the remission of CML and might also have been responsible for the temporary regression of adenomatous polyps of FAP... - [A case of metastatic gastrointestinal stromal tumor developing a resistance to STI571 (imatinib mesylate)]Masakazu Miyake
Dept. of Surgery, Osaka National Hospital
Gan To Kagaku Ryoho 31:1791-4. 2004..Currently STI571 is the first-line therapy for non-resectable GISTs, but a single-agent therapy often leads to tumor resistance. It is our hope that we will be able to design an alternative treatment to overcome such resistance... - [A case of gastrointestinal stromal tumor of the small intestine, preoperatively diagnosed by the enteroscopy]Miyako Kishimoto
Department of Internal Medicine, Rokko Island Hospital
Nippon Shokakibyo Gakkai Zasshi 100:572-7. 2003 - [GIST (gastrointestinal stromal tumor)]Seiichi Hirota
Nippon Naika Gakkai Zasshi 93:1451-8. 2004 - Pathophysiology, diagnosis, and treatment of gastrointestinal stromal tumorsYasuhisa Shinomura
First Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan
J Gastroenterol 40:775-80. 2005..The continued development of target-specific therapies should increase the probability of cure in most patients with GISTs... - Diagnostic efficacy of free to total ratio of prostate-specific antigen and prostate-specific antigen velocity, singly and in combination, in detecting prostate cancer in patients with total serum prostate-specific antigen between 4 and 10 ng/mlShingo Yamamoto
Department of Urology, Hyogo College of Medicine, 1 1 Mukogawacho, Nishinomiya, Hyogo 663 8501, Japan
Int Urol Nephrol 40:85-9. 2008..40 ng/ml per year. Our results showed that unnecessary prostate biopsies could be more effectively avoided among patients with "gray zone PSA" by combination of f/t PSA and PSAV than single usage of these indexes... - Characterization of tyrosine kinase I domain c-kit gene mutation Asn655Lys newly found in primary jejunal gastrointestinal stromal tumorKazuo Kinoshita
Am J Gastroenterol 102:1134-6. 2007 - Absence of c-kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patientsKazuo Kinoshita
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Japan
J Pathol 202:80-5. 2004..These results suggest that the pathogenesis of GISTs in NF1 patients is different from that in non-NF1 patients...