S Hirota

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi request reprint Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors
    Seiichi Hirota
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Gastroenterology 125:660-7. 2003
  2. ncbi request reprint Gastrointestinal stromal tumors: their origin and cause
    S Hirota
    Department of Pathology, Osaka University Medical School, 2 2 Yamada oka, Suita 565 0871, Japan
    Int J Clin Oncol 6:1-5. 2001
  3. ncbi request reprint Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours
    S Hirota
    Department of Pathology, Osaka University Medical School, Yamadaoka 2 2, Suita, Osaka 565 0871, Japan
    J Pathol 193:505-10. 2001
  4. ncbi request reprint Expression of bone matrix proteins mRNA during distraction osteogenesis
    M Sato
    Department of Orthopaedic Surgery, Osaka University Medical School, Suita, Japan
    J Bone Miner Res 13:1221-31. 1998
  5. ncbi request reprint Stem cell factor induces outgrowth of c-kit-positive neurites and supports the survival of c-kit-positive neurons in dorsal root ganglia of mouse embryos
    T Hirata
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Development 119:49-56. 1993
  6. ncbi request reprint Possible involvement of c-kit receptor and its ligand in increase of mast cells in neurofibroma tissues
    S Hirota
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Arch Pathol Lab Med 117:996-9. 1993
  7. ncbi request reprint Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis
    M Sato
    Department of Orthopaedic Surgery, Osaka University Medical School, Suita, Japan
    J Bone Miner Res 14:1084-95. 1999
  8. ncbi request reprint Clinicopathological features of gastric stromal tumors
    T Nishida
    Dept of Surgery, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
    J Exp Clin Cancer Res 19:417-25. 2000
  9. ncbi request reprint Infection with Nippostrongylus brasiliensis induces invasion of mast cell precursors from peripheral blood to small intestine
    T Kasugai
    Department of Pathology, Osaka University Medical School, Japan
    Blood 85:1334-40. 1995
  10. ncbi request reprint Characterization of c-kit-positive neurons in the dorsal root ganglion of mouse
    T Hirata
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Brain Res Dev Brain Res 85:201-11. 1995

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors
    Seiichi Hirota
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Gastroenterology 125:660-7. 2003
    ..We investigated the cause of GISTs without KIT mutations. Because GISTs apparently expressed platelet-derived growth factor receptor (PDGFR) alpha, we examined whether GISTs without KIT mutations had a mutation of PDGFR alpha...
  2. ncbi request reprint Gastrointestinal stromal tumors: their origin and cause
    S Hirota
    Department of Pathology, Osaka University Medical School, 2 2 Yamada oka, Suita 565 0871, Japan
    Int J Clin Oncol 6:1-5. 2001
    ....
  3. ncbi request reprint Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours
    S Hirota
    Department of Pathology, Osaka University Medical School, Yamadaoka 2 2, Suita, Osaka 565 0871, Japan
    J Pathol 193:505-10. 2001
    ..The mutant KIT exhibited constitutive autophosphorylation without SCF stimulation. The prognosis of the patients with the extracellular domain mutation was comparable to that of the patients with the juxtamembrane domain mutation...
  4. ncbi request reprint Expression of bone matrix proteins mRNA during distraction osteogenesis
    M Sato
    Department of Orthopaedic Surgery, Osaka University Medical School, Suita, Japan
    J Bone Miner Res 13:1221-31. 1998
    ..These results suggested that mechanical tension-stress modulates cell shape and phenotype, and stimulates the expression of the mRNA for bone matrix proteins...
  5. ncbi request reprint Stem cell factor induces outgrowth of c-kit-positive neurites and supports the survival of c-kit-positive neurons in dorsal root ganglia of mouse embryos
    T Hirata
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Development 119:49-56. 1993
    ..These results suggest that the stimulus through the c-kit receptor tyrosine kinase has an important role in development of the peripheral nervous system...
  6. ncbi request reprint Possible involvement of c-kit receptor and its ligand in increase of mast cells in neurofibroma tissues
    S Hirota
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Arch Pathol Lab Med 117:996-9. 1993
    ..The results suggest that SCF and the c-kit receptor are associated with the increase of mast cells in neurofibroma tissues...
  7. ncbi request reprint Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis
    M Sato
    Department of Orthopaedic Surgery, Osaka University Medical School, Suita, Japan
    J Bone Miner Res 14:1084-95. 1999
    ..Abundant gene products of BMP-2 and BMP-4 could induce in situ bone formation by paracrine and autocrine mechanisms...
  8. ncbi request reprint Clinicopathological features of gastric stromal tumors
    T Nishida
    Dept of Surgery, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
    J Exp Clin Cancer Res 19:417-25. 2000
    ..Thus, this classification is considered to be clinically and pathologically important in the diagnosis of gastric stromal tumors...
  9. ncbi request reprint Infection with Nippostrongylus brasiliensis induces invasion of mast cell precursors from peripheral blood to small intestine
    T Kasugai
    Department of Pathology, Osaka University Medical School, Japan
    Blood 85:1334-40. 1995
    ..The present result suggests that NB infection induces the invasion of CFU-mast into the intestine from blood and their subsequent proliferation in the tissue site...
  10. ncbi request reprint Characterization of c-kit-positive neurons in the dorsal root ganglion of mouse
    T Hirata
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Brain Res Dev Brain Res 85:201-11. 1995
    ..c-kit-positive DRG neurons from neonatal mice survived without addition of any factor in culture, suggesting that the requirement for trophic support in c-kit-positive neurons changes during development...
  11. ncbi request reprint Developmental expression of flt3 mRNA in the mouse brain
    A Ito
    Department of Pathology, Osaka University Medical School, Suita, Japan
    J Mol Neurosci 4:235-43. 1993
    ..By in situ hybridization, some neurons that expressed flt3 formed synaptic connections with each other. The present findings suggest that the flt3 gene expression is related to the cell type and the developmental process...
  12. ncbi request reprint Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats
    K Isozaki
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Gastroenterology 109:456-64. 1995
    ..CONCLUSIONS: The abnormalities in the ileal movement and pyloric sphincter function in Ws/Ws rats were attributable to the deficiency of c-kit messenger RNA-expressing cells...
  13. ncbi request reprint Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    S Hirota
    Department of Pathology, Osaka University Medical School, Yamada oka 2 2, Suita 565, Japan
    Science 279:577-80. 1998
    ..GISTs may originate from the interstitial cells of Cajal (ICCs) because the development of ICCs is dependent on the SCF-KIT interaction and because, like GISTs, these cells express both KIT and CD34...
  14. ncbi request reprint PKC gamma gene expression is delayed in postnatal central nervous system of mi/mi mice
    H M Kim
    Department of Pathology, Osaka University Medical School, Japan
    J Mol Neurosci 4:245-53. 1993
    ..These results indicate that the deficiency of mi gene product causes the delayed expression of the cPKC gamma gene...
  15. ncbi request reprint Identification of the cells expressing cot proto-oncogene mRNA
    R Ohara
    Department of Oncogene Research, Osaka University, Suita, Japan
    J Cell Sci 108:97-103. 1995
    ..Two of the tissues overexpressed this gene markedly, suggesting that overproduction of Cot kinase may be one cause of their transformation...
  16. ncbi request reprint Enhanced expression of CD34 messenger RNA by developing endothelial cells of mice
    A Ito
    Department of Pathology, Osaka University Medical School, Japan
    Lab Invest 72:532-8. 1995
    ..Roles of CD34 for angiogenesis and its function as a homophilic adhesion molecule between endothelial and hematopoietic cells have been speculated...
  17. ncbi request reprint Poor response of cultured mast cells derived from mi/mi mutant mice to nerve growth factor
    T Jippo
    Department of Pathology, Osaka University Medical School, Japan
    Blood 84:2977-83. 1994
    ..Taken together, the poor response of mi/mi CMCs to NGF appeared to be attributable to the impaired transcription of the p75 gene...
  18. ncbi request reprint Expression of the 150-kd oxygen-regulated protein in human breast cancer
    Y Tsukamoto
    Department of Pathology, National Cardiovascular Center, Suita City, Japan
    Lab Invest 78:699-706. 1998
    ..Furthermore, pancreatic and thyroid carcinomas also displayed greater ORP150 expression. These results suggest that ORP150 is up-regulated in tumors and, in breast tumors, may be associated with tumor invasiveness...
  19. ncbi request reprint A loss-of-function mutation of c-kit results in depletion of mast cells and interstitial cells of Cajal, while its gain-of-function mutation results in their oncogenesis
    Y Kitamura
    Department of Pathology, and Surgery, Osaka University Medical School, Room C2, Yamada oka 2 2, Suita, 565 0871, Osaka, Japan
    Mutat Res 477:165-71. 2001
    ..Mutations of the c-kit gene are a good model for understanding the relationship between mutations and diseases in both humans and mice...
  20. ncbi request reprint Gastric carcinoma with psammomatous calcification after Billroth II reconstruction: case report and literature review
    K Kawahara
    Department of Pathology, Osaka National Hospital, Osaka, Japan
    Pathol Int 51:718-22. 2001
    ..To our knowledge, this is the first case of gastric carcinoma with psammomatous calcification arising in the remnant stomach. We also review previously published reports regarding gastric carcinoma with psammomatous calcification...
  21. ncbi request reprint Localization and developmental expression of a novel protein kinase C delta gene
    H M Kim
    Department of Pathology, Osaka University Medical School, Japan
    Brain Res Dev Brain Res 70:239-44. 1992
    ..These results suggest that the gene expression of nPKC delta is strictly controlled by both the cell type and the developmental process...
  22. ncbi request reprint Impaired expression of noncollagenous bone matrix protein mRNAs during fracture healing in ascorbic acid-deficient rats
    M Sugimoto
    Department of Pathology, Osaka University Medical School, Suita, Japan
    J Bone Miner Res 13:271-8. 1998
    ....
  23. ncbi request reprint Characterization of Ws mutant allele of rats: a 12-base deletion in tyrosine kinase domain of c-kit gene
    T Tsujimura
    Department of Pathology, Osaka University Medical School, Japan
    Blood 78:1942-6. 1991
    ..Taken together, the Ws/Ws rat is the first characterized mutant of the c-kit gene in an animal species other than the mouse...
  24. ncbi request reprint Expression of mRNA of murine bone-related proteins in ectopic bone induced by murine bone morphogenetic protein-4
    S Hirota
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Cell Tissue Res 277:27-32. 1994
    ..Since the sequential gene expression pattern of bone-related proteins in the present system is comparable to that in embryonic osteogenesis, this system may be useful as a model for studying gene expression in osteogenesis...
  25. ncbi request reprint Biological and clinical review of stromal tumors in the gastrointestinal tract
    T Nishida
    Department of Surgery, E1, Osaka University Graduate School of Medicine, Suita, Japan
    Histol Histopathol 15:1293-301. 2000
    ..However, phenotypical resemblance to the interstitial cells of Cajal (ICCs) and gain-of-function mutations in the c-kit gene may suggest origin from ICCs and/or multipotential mesenchymal cells that differentiate into ICCs...
  26. ncbi request reprint Detection of SYT-SSX fusion gene in peripheral blood from a patient with synovial sarcoma
    N Hashimoto
    Department of Orthopedic Surgery, Osaka University Medical School, Suita, Japan
    Am J Surg Pathol 25:406-10. 2001
    ..These findings suggest that circulating tumor cells should be monitored because they may serve as a prognostic indicator for synovial sarcoma...
  27. pmc 150-kD oxygen-regulated protein is expressed in human atherosclerotic plaques and allows mononuclear phagocytes to withstand cellular stress on exposure to hypoxia and modified low density lipoprotein
    Y Tsukamoto
    Department of Pathology, Osaka University Medical School, Suita City, Japan
    J Clin Invest 98:1930-41. 1996
    ..The presence of antibody to ORP150 in sera of patients with severe atherosclerosis emphasizes the possibility that ORP150 may be a marker of vascular pathology...
  28. ncbi request reprint Strand specificity and absence of hot spots for p53 mutations in ultraviolet B-induced skin tumors of XPA-deficient mice
    S Takeuchi
    Division of Cellular Genetics, Institute for Molecular and Cellular Biology, Osaka University, Suita, Japan
    Cancer Res 58:641-6. 1998
    ....
  29. ncbi request reprint Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis
    T Miyatsuka
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Biochem Biophys Res Commun 310:1017-25. 2003
    ..The conditional PDX-1 transgenic mouse system developed in this study appeared to be useful for efficient screening of PDX-1 responsive somatic tissues and cells...
  30. ncbi request reprint Clonal nature of seborrheic keratosis demonstrated by using the polymorphism of the human androgen receptor locus as a marker
    H Nakamura
    Department of Pathology, Osaka University Medical School, Osaka, Japan
    J Invest Dermatol 116:506-10. 2001
    ..In total, 25 of 38 seborrheic keratoses were considered to be monoclonal. The histologic type of seborrheic keratoses did not affect clonality...
  31. ncbi request reprint Early stage small cell carcinoma of the urinary bladder
    K Fujita
    Department of Urology, Osaka University Medical School, Osaka, Japan
    Int J Urol 8:643-4. 2001
    ..The pathological findings revealed the tumor confined to the submucosal layer (pT1) without metastasis. No adjuvant chemotherapy was carried out. He is alive with no evidence of the disease 24 months after the operation...
  32. pmc The "pulvinar sign" in a case of paraneoplastic limbic encephalitis associated with non-Hodgkin's lymphoma
    M Mihara
    Department of Neurology, Osaka University Graduate School of Medicine, D 4, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Neurol Neurosurg Psychiatry 76:882-4. 2005
    ..Her symptoms included progressive psychiatric disturbance and resembled the initial symptoms of variant Creutzfeldt-Jakob disease (vCJD). Clinicians should consider this treatable disorder in the differential diagnosis of vCJD...
  33. ncbi request reprint Spatial expression of genes encoding c-kit receptors and their ligands in mouse cerebellum as revealed by in situ hybridization
    E Morii
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Brain Res Dev Brain Res 65:123-6. 1992
    ..Since neurons in the molecular layer construct suppressive neurojunctions with Purkinje cells, the present result suggests that c-kit receptors and their ligands may play an important role for the construction of their junctions...
  34. ncbi request reprint Improvement of psoriasis during imatinib therapy in a patient with a metastatic gastrointestinal stromal tumour
    S Miyagawa
    Br J Dermatol 147:406-7. 2002
  35. pmc Late resistance to imatinib therapy in a metastatic gastrointestinal stromal tumour is associated with a second KIT mutation
    T Wakai
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata City 951 8510, Japan
    Br J Cancer 90:2059-61. 2004
    ..Here, we report a case of metastatic gastrointestinal stromal tumour that relapsed during imatinib therapy. Mutation analysis showed that the imatinib-resistant liver tumour contained two c-kit mutations...
  36. pmc Polyclonal nature of diffuse proliferation of interstitial cells of Cajal in patients with familial and multiple gastrointestinal stromal tumours
    H Chen
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine Osaka University, Osaka, Japan
    Gut 51:793-6. 2002
    ..However, it is not fully understood whether proliferation is polyclonal or monoclonal...
  37. pmc Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats
    T Katafuchi
    Department of Integrative Physiology, Graduate School of Medical Sciences Kyushu University, Fukuoka 812 8582 Japan
    Learn Mem 7:383-92. 2000
    ..These findings suggest an involvement of SCF/c-kit signaling in hippocampal synaptic potentiation and spatial learning and memory...
  38. ncbi request reprint Familial gastrointestinal stromal tumours with germline mutation of the KIT gene
    T Nishida
    Nat Genet 19:323-4. 1998
  39. ncbi request reprint A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy
    N Nakai
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    J Pathol 214:302-11. 2008
    ..These mutant mice are considered to be useful for further investigation of the mechanism of GIST development as a result of ICC hyperplasia and for assessment of the in vivo effects of drugs against molecular targets...