Kazuhide Higuchi

Summary

Affiliation: Osaka Medical College
Country: Japan

Publications

  1. doi request reprint In vivo trial of a driving system for a self-propelling capsule endoscope using a magnetic field (with video)
    Eijiro Morita
    2nd Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan
    Gastrointest Endosc 72:836-40. 2010
  2. doi request reprint Endoscopic and histopathological evaluation of collagenous colitis
    Ken Narabayashi
    Second Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki shi, Osaka, Japan
    Digestion 85:136-40. 2012
  3. ncbi request reprint Is proton pump inhibitor therapy for reflux esophagitis sufficient?: a large real-world survey of Japanese patients
    Kazuhide Higuchi
    Second Department of Internal Medicine, Osaka Medical College, Japan
    Intern Med 52:1447-54. 2013
  4. pmc Adenocarcinoma arising in a heterotopic pancreas (Heinrich type III): a case report
    Yoshihiro Inoue
    Department of General and Gastroenterological Surgery, Osaka Medical College Hospital, 2 7 Daigaku machi, Takatsuki City, Osaka 569 8686, Japan
    J Med Case Reports 4:39. 2010
  5. doi request reprint Present status and strategy of NSAIDs-induced small bowel injury
    Kazuhide Higuchi
    2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, 569 8686, Japan
    J Gastroenterol 44:879-88. 2009
  6. doi request reprint Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori: a randomized controlled comparative trial with cimetidine, an H2-receptor antagonist
    Kazuhide Higuchi
    Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan
    J Gastroenterol Hepatol 25:S155-60. 2010
  7. doi request reprint Colonoscopic differences of erosive and/or small ulcerative lesions for diagnosis of colonic inflammatory diseases
    Takuya Inoue
    Second Department of Internal Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
    J Gastroenterol Hepatol 25:S149-54. 2010
  8. doi request reprint Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats
    Fumio Tanaka
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Life Sci 83:771-9. 2008
  9. pmc Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflammatory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study
    Takanori Kuramoto
    2nd Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka, Japan
    BMC Gastroenterol 13:85. 2013
  10. ncbi request reprint The efficacy of oral tacrolimus in patients with moderate/severe ulcerative colitis not receiving concomitant corticosteroid therapy
    Takuya Inoue
    Second Department of Internal Medicine, Osaka Medical College, Japan
    Intern Med 52:15-20. 2013

Detail Information

Publications76

  1. doi request reprint In vivo trial of a driving system for a self-propelling capsule endoscope using a magnetic field (with video)
    Eijiro Morita
    2nd Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan
    Gastrointest Endosc 72:836-40. 2010
    ..A capsule endoscope does not allow the examiner to observe a lesion from the desired direction in real time...
  2. doi request reprint Endoscopic and histopathological evaluation of collagenous colitis
    Ken Narabayashi
    Second Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki shi, Osaka, Japan
    Digestion 85:136-40. 2012
    ..The results suggest that endoscopic observation and biopsy of the proximal colon, where a coarse and nodular surface of the mucosa is often found, may be useful for confirmation of the diagnosis in patients with suspected CC...
  3. ncbi request reprint Is proton pump inhibitor therapy for reflux esophagitis sufficient?: a large real-world survey of Japanese patients
    Kazuhide Higuchi
    Second Department of Internal Medicine, Osaka Medical College, Japan
    Intern Med 52:1447-54. 2013
    ..We conducted a nationwide survey to evaluate the effectiveness of PPIs based on endoscopic findings in real-world clinical settings...
  4. pmc Adenocarcinoma arising in a heterotopic pancreas (Heinrich type III): a case report
    Yoshihiro Inoue
    Department of General and Gastroenterological Surgery, Osaka Medical College Hospital, 2 7 Daigaku machi, Takatsuki City, Osaka 569 8686, Japan
    J Med Case Reports 4:39. 2010
    ..We report a rare case of malignant transformation of heterotopic pancreas (Heinrich type III) in the duodenum with long-term survival of the patient, and review the 12 cases in the literature...
  5. doi request reprint Present status and strategy of NSAIDs-induced small bowel injury
    Kazuhide Higuchi
    2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, 569 8686, Japan
    J Gastroenterol 44:879-88. 2009
    ..Such drugs may be useful for preventing the adverse effects of NSAIDs not only in the stomach but also in the small intestine. We hope to examine these drugs in future clinical studies...
  6. doi request reprint Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori: a randomized controlled comparative trial with cimetidine, an H2-receptor antagonist
    Kazuhide Higuchi
    Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan
    J Gastroenterol Hepatol 25:S155-60. 2010
    ..We compared a gastroprotective drug, sofalcone, and an H(2)-receptor antagonist, cimetidine, in terms of promoting ulcer healing after 7 weeks of administration following 1 week of eradication therapy...
  7. doi request reprint Colonoscopic differences of erosive and/or small ulcerative lesions for diagnosis of colonic inflammatory diseases
    Takuya Inoue
    Second Department of Internal Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
    J Gastroenterol Hepatol 25:S149-54. 2010
    ..However, few investigators report on differential diagnosis of colonic inflammatory diseases. Thus, we investigated the clinical significance of these lesions and the value of colonoscopy in the differential diagnosis of colitis...
  8. doi request reprint Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats
    Fumio Tanaka
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Life Sci 83:771-9. 2008
    ..We examined the therapeutic effects of exogenously administered MSCs in dextran sulfate sodium (DSS)-induced colitis in rats...
  9. pmc Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflammatory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study
    Takanori Kuramoto
    2nd Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka, Japan
    BMC Gastroenterol 13:85. 2013
    ..Here, we compare the efficacy of the gastromucoprotective drug irsogladine with omeprazole in preventing NSAID-induced esophagitis, peptic ulcers, and small-intestinal mucosal injury in healthy subjects...
  10. ncbi request reprint The efficacy of oral tacrolimus in patients with moderate/severe ulcerative colitis not receiving concomitant corticosteroid therapy
    Takuya Inoue
    Second Department of Internal Medicine, Osaka Medical College, Japan
    Intern Med 52:15-20. 2013
    ..However, the efficacy of tacrolimus in moderate to severe UC patients not receiving concomitant steroids remains unknown...
  11. doi request reprint Evaluation of small bowel injury in patients with rheumatoid arthritis by capsule endoscopy: effects of anti-rheumatoid arthritis drugs
    Satoshi Sugimori
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    Digestion 78:208-13. 2008
    ..We evaluated the incidence of small bowel injury in RA patients who were taking anti-RA drugs with or without concomitant NSAIDs by capsule endoscopy...
  12. doi request reprint Long-term use of nonsteroidal anti-inflammatory drugs normalizes the kinetics of gastric epithelial cells in patients with Helicobacter pylori infection via attenuation of gastric mucosal inflammation
    Tetsuya Tanigawa
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Gastroenterol 44:8-17. 2009
    ..pylori-induced gastritis remain unknown. We investigated the effects of NSAIDs on gastric inflammation and the kinetics of gastric epithelial cells in H. pylori-induced gastritis...
  13. ncbi request reprint R-etodolac induces E-cadherin and suppresses colitis-related mouse colon tumorigenesis
    Takuya Inoue
    Second Department of Internal Medicine, Osaka Medical College, Takatsuki City, Osaka 569 8686, Japan
    Oncol Rep 24:1487-92. 2010
    ..These results suggest that R-etodolac could be useful in the prevention of UC-associated neoplasia...
  14. ncbi request reprint What are the risk factors for aggravation of esophageal varices in patients with hepatocellular carcinoma?
    Kaori Kadouchi
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Gastroenterol Hepatol 22:240-6. 2007
    ..The aim of this study was to evaluate the effects of HCC on the appearance of the red color (RC) sign on EV and also investigate whether risk factors for the appearance of the RC sign differed between patients with and without HCC...
  15. ncbi request reprint Association between dinner-to-bed time and gastro-esophageal reflux disease
    Yasuhiro Fujiwara
    Department of Gastroenterology, Osaka City University, Graduate School of Medicine, Osaka, Japan
    Am J Gastroenterol 100:2633-6. 2005
    ..This study was designed to determine a possible association between dinner-to-bed time and GERD, compared with healthy adults...
  16. ncbi request reprint Differences in clinical characteristics between patients with endoscopy-negative reflux disease and erosive esophagitis in Japan
    Yasuhiro Fujiwara
    Department of Gastroenterology, Osaka City University, Graduate School of Medicine, Osaka, Japan
    Am J Gastroenterol 100:754-8. 2005
    ..Whether these factors affect the pathogenesis of endoscopy-negative reflux disease is not clear. We aimed to elucidate the differences in clinical characteristics between endoscopy-negative erosive disease and erosive esophagitis...
  17. doi request reprint Protective effect of roxatidine against indomethacin-induced small intestinal mucosal injury in rats
    Eiji Umegaki
    Second Department of Internal Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
    J Gastroenterol Hepatol 25:S35-40. 2010
    ....
  18. doi request reprint Utility and problems of endoscopic submucosal dissection for early gastric cancer in elderly patients
    Satoshi Tokioka
    Second Department of Internal Medicine, Osaka Medical College, Osaka, Japan
    J Gastroenterol Hepatol 27:63-9. 2012
    ..In the present study, we retrospectively elucidated the usefulness and problems of ESD for early gastric cancer in elderly patients (≥ 65 years) in comparison with non-elderly patients...
  19. pmc Management of gastric fundal varices without gastro-renal shunt in 15 patients
    Natsuhiko Kameda
    Second Department of Internal Medicine, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, Osaka, Japan
    World J Gastroenterol 14:448-53. 2008
    ..To examine the portal hemodynamics of gastric fundal varices (GV) without gastro-renal shunt (GRS), and to retrospectively investigate the effects of various kinds of treatment on eradication...
  20. doi request reprint Small bowel injury by low-dose enteric-coated aspirin and treatment with misoprostol: a pilot study
    Toshio Watanabe
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Clin Gastroenterol Hepatol 6:1279-82. 2008
    ..With capsule endoscopy, the ulcerogenic effect of low-dose enteric-coated aspirin on the small bowel and the therapeutic effect of misoprostol on intestinal injury were evaluated...
  21. doi request reprint Significance of chymase-dependent matrix metalloproteinase-9 activation on indomethacin-induced small intestinal damages in rats
    Kazuki Kakimoto
    Second Department of Internal Medicine, Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 569 8686, Japan
    J Pharmacol Exp Ther 332:684-9. 2010
    ..The area of small intestinal damage was also significantly ameliorated by TY-51469 treatment. These findings suggest that chymase-dependent MMP-9 activation has a significant role in indomethacin-induced small intestinal damage in rats...
  22. ncbi request reprint Anti-inflammatory effects of pravastatin on Helicobacter pylori-induced gastritis in mice
    Masanori Yamato
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka, 545 8585, Japan
    Dig Dis Sci 52:2833-9. 2007
    ..Pravastatin did not affect the viability of H. pylori. In conclusion, pravastatin exerts an anti-inflammatory effect on H. pylori-induced gastritis in mice without affecting eNOS expression...
  23. pmc Clinical effects of adalimumab treatment with concomitant azathioprine in Japanese Crohn's disease patients
    Kumi Ishida
    Second Department of Internal Medicine, Osaka Medical College, Takatsuki City, Osaka 569 8686, Japan
    World J Gastroenterol 19:2676-82. 2013
    ..To assess adalimumab's efficacy with concomitant azathioprine (AZA) for induction and maintenance of clinical remission in Japanese Crohn's disease (CD) patients...
  24. doi request reprint Simvastatin attenuates intestinal fibrosis independent of the anti-inflammatory effect by promoting fibroblast/myofibroblast apoptosis in the regeneration/healing process from TNBS-induced colitis
    Yosuke Abe
    2nd Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan
    Dig Dis Sci 57:335-44. 2012
    ..The current study established a model of the regeneration/healing process from TNBS-induced colitis and investigated the anti-inflammatory and anti-fibrotic effects of SIMV...
  25. ncbi request reprint Cross-reactivity of yeast antigens in human colon and peripheral leukocytes
    Nobuhide Oshitani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Pathol 199:361-7. 2003
    ..cerevisiae antigen and the presence of S. cerevisiae antigen in Crohn's disease granulomas suggest the possibility of involvement of S. cerevisiae in the pathogenesis of Crohn's disease...
  26. ncbi request reprint Concurrent assessment of reservoir and emptying of the stomach for dyspepsia patients
    Kazunari Tominaga
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Hepatogastroenterology 55:744-9. 2008
    ..Next, we examined the interaction between the association and abdominal symptoms...
  27. doi request reprint Usefulness of polyethylene glycol solution with dimethylpolysiloxanes for bowel preparation before capsule endoscopy
    Sadaharu Nouda
    Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan
    J Gastroenterol Hepatol 25:70-4. 2010
    ..In some cases, however, observation of target sites is very poor during CE because of residues etc. Herein we report the usefulness of a preparation comprised of polyethylene glycol solution (PEG) for CE...
  28. ncbi request reprint Increased expression of cytokines and adhesion molecules in rat chronic esophagitis
    Masaki Hamaguchi
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Digestion 68:189-97. 2003
    ....
  29. ncbi request reprint Close association between activated platelets and neutrophils in the active phase of ulcerative colitis in humans
    Soichiro Kayo
    Department of Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Inflamm Bowel Dis 12:727-35. 2006
    ..To test this hypothesis, we performed immunohistochemical and flow cytometric analyses on tissue and blood samples from patients with UC...
  30. ncbi request reprint Multiple metastatic leiomyosarcoma of the pancreas: a first case report and review of the literature
    Takeshi Ogura
    The 2nd Department of Internal Medicine, Osaka Medical College, Japan
    Intern Med 52:561-6. 2013
    ..On laparotomy, peritoneal washing cytology yielded negative results, and no dissemination was observed. Ultimately, metastatic pancreatic leiomyosarcoma was histologically diagnosed...
  31. doi request reprint Primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory ulcerative colitis
    Kazuki Kakimoto
    Second Department of Internal Medicine, Osaka Medical College, 2 7 Daigakumachi, Takatsuki 569 8686, Japan
    J Gastroenterol 43:576-80. 2008
    ..Based on these findings, the patient was diagnosed with primary CD56+ NK/T-cell lymphoma of the rectum (stage IIE). This is the first case report of primary rectal NK/T-cell lymphoma accompanied with UC...
  32. ncbi request reprint Primary duodenal lymphoma: successful rituximab treatment and evaluation by FDG-PET
    Fumio Tanaka
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Hepatogastroenterology 54:1658-61. 2007
    ..Rituximab may be useful for duodenal follicular lymphoma and PET with 18F-fluorodeoxyglucose has a potential value for the evaluation of mesenteric lymph nodes spread...
  33. ncbi request reprint Feasibility, safety, and efficacy of the Stretta procedure in Japanese patients with gastroesophageal reflux disease: first report from Asia
    Kazuhide Higuchi
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka, 545 8585, Japan
    J Gastroenterol 42:205-10. 2007
    ..In 2006, we imported a Stretta system from the United States and investigated important clinical aspects of the system in Japanese patients with GERD...
  34. doi request reprint Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma
    Hiroshi Tatsuwaki
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Cancer Sci 101:550-8. 2010
    ..These findings suggest that reduction of 15-PGDH is an independent predictor of poor survival associated with enhancement of cell proliferation in gastric adenocarcinoma...
  35. ncbi request reprint Geranylgeranylacetone, a Gastromucoprotective Drug, Protects Against NSAID-induced Esophageal, Gastroduodenal and Small Intestinal Mucosal Injury in Healthy Subjects: A Prospective Randomized Study Involving a Comparison with Famotidine
    Eiji Umegaki
    The Second Department of Internal Medicine, Osaka Medical College, Japan
    Intern Med 53:283-90. 2014
    ..In the upper digestive tract, the prophylactic effects were similar between the two drugs. However, in the small intestine, GGA more markedly inhibited the development of lesions compared to famotidine. ..
  36. ncbi request reprint Role of chymase-dependent matrix metalloproteinase-9 activation in mice with dextran sodium sulfate-induced colitis
    Kumi Ishida
    Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 569 8686, Japan
    J Pharmacol Exp Ther 324:422-6. 2008
    ..Furthermore, NK3201 significantly attenuated not only chymase activity but also MMP-9 activity in DSS-treated mice. These findings suggest that chymase plays an important role in the development of colitis via MMP-9 activation...
  37. ncbi request reprint Roles of ZO-1 and epidermal growth factor in esophageal epithelial defense against acid
    Masatsugu Okuyama
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Abenoku, Osaka, Japan
    Digestion 75:135-41. 2007
    ..We examined the roles of ZO-1 and epidermal growth factor (EGF) in esophageal epithelial defense against acid using human esophageal epithelial cells...
  38. ncbi request reprint Safety and efficacy of S-1, a novel oral fluorouracil antitumor drug, for a chronic renal failure patient maintained on hemodialysis
    Kazunari Tominaga
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Oncology 66:358-64. 2004
    ..We examined the influence of HD on the pharmacokinetics (PK) of S-1 and its therapeutic efficacy in liver metastases from gastric cancer...
  39. ncbi request reprint Prevalence of gastroesophageal reflux disease and gastroesophageal reflux disease symptoms in Japan
    Yasuhiro Fujiwara
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Gastroenterol Hepatol 20:26-9. 2005
    ..The present study aimed to examine the prevalence of GERD symptoms and GERD in Japanese subjects...
  40. ncbi request reprint Successful treatment of giant rectal varices by modified percutaneous transhepatic obliteration with sclerosant: Report of a case
    Hirotoshi Okazaki
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3, Asahimachi, Abeno Ku, Osaka, Japan
    World J Gastroenterol 12:5408-11. 2006
    ..After the patient received this therapy, her condition of rectal varices was markedly improved...
  41. ncbi request reprint Regression of primary low-grade mucosa-associated lymphoid tissue lymphoma of duodenum after long-term treatment with clarithromycin
    Masahiro Ochi
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Scand J Gastroenterol 41:365-9. 2006
    ..It is suggested that the long-term use of clarithromycin may be effective for diseases of the gastrointestinal tract associated with the lymphocyte proliferation...
  42. doi request reprint Bile aspiration cytology in diagnosis of bile duct carcinoma: factors associated with positive yields
    Yasser A Abdelghani
    Second Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 568 8686, Japan
    J Hepatobiliary Pancreat Sci 19:370-8. 2012
    ..The aim of this study was to evaluate the actual sensitivity of BAC and to evaluate the factors that affect positive yields of BAC in patients with defined BDC...
  43. ncbi request reprint Adult intussusception caused by Yersinia enterocolitica enterocolitis
    Akira Imoto
    The 2nd Department of Internal Medicine, Osaka Medical College, Japan
    Intern Med 51:2545-9. 2012
    ..Serological testing revealed that the cause of the intussusception was a YE infection. The patient's postoperative course was good and no recurrence was seen during the follow-up...
  44. doi request reprint Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan
    Kazunari Tominaga
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1 4 3, Asahimachi, Abeno Ku, Osaka, Japan
    J Gastroenterol 47:284-92. 2012
    ....
  45. ncbi request reprint Esophagogastric varices due to arterioportal shunt in a serous cystadenoma of the pancreas in von Hippel-Lindau disease
    Masatsugu Okuyama
    Department of Gastroenterology, Osaka City University Medical School, Osaka, Japan
    Dig Dis Sci 48:1948-54. 2003
    ..Rupture of esophageal varices was successfully treated with endoscopic injection sclerotherapy...
  46. doi request reprint Comparative study of conventional colonoscopy and pan-colonic narrow-band imaging system in the detection of neoplastic colonic polyps: a randomized, controlled trial
    Takuya Inoue
    Second Department of Internal Medicine, Osaka Medical College, 2 7 Daigakumachi, Takatsuki, 569 8686, Japan
    J Gastroenterol 43:45-50. 2008
    ..We conducted a randomized, controlled trial to determine the efficacy of the pancolonic NBI system in adenoma detection...
  47. ncbi request reprint Analysis of intestinal HLA-DR bound peptides and dysregulated immune responses to enteric flora in the pathogenesis of inflammatory bowel disease
    Nobuhide Oshitani
    Department of Gastroenterology, Osaka City University Medical School, Osaka, Japan
    Int J Mol Med 11:99-104. 2003
    ..Increased immune responses against E. coli, S. cerevisiae and C. elegans found in patients with inflammatory bowel may participate as dysregulated immune responses to enteric flora in the pathogenesis of inflammatory bowel disease...
  48. ncbi request reprint Evaluation of deep small bowel involvement by double-balloon enteroscopy in Crohn's disease
    Nobuhide Oshitani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Gastroenterol 101:1484-9. 2006
    ..The aim of this study was to evaluate ileal involvement, which cannot be achieved using conventional colonoscopy, by DBE in patients with Crohn's disease...
  49. doi request reprint Potential predictors of disease progression for main-duct intraductal papillary mucinous neoplasms of the pancreas
    Takeshi Ogura
    Second Department of Internal Medicine, Osaka Medical College, Osaka, Japan
    J Gastroenterol Hepatol 28:1782-6. 2013
    ..The aim of the present study is to investigate the natural history of MPD-IPMN and examine potential predictors of disease progression in MPD-IPMN patients who conformed to "high-risk stigmata" criteria...
  50. ncbi request reprint [A case of xanthogranulomatous cholecystitis diagnosed by EUS-FNA in which changes were observed on FDG-PET]
    Takeshi Ogura
    2nd Department of Internal Medicine, Osaka Medical College
    Nihon Shokakibyo Gakkai Zasshi 110:1640-8. 2013
    ..Cholecystectomy was performed on the basis of a histological and clinical diagnosis of XGC. Histological examination revealed inflammatory and foamy cells and exuberant granulation of the gall bladder wall, confirming XGC. ..
  51. doi request reprint Retrospective study as first-line chemotherapy combined anti-VEGF antibody with fluoropyrimidine for frail patients with unresectable or metastatic colorectal cancer
    Motoki Yoshida
    Division of Cancer Chemotherapy Center and Gastroenterology, Osaka Medical College Hospital, Osaka, Japan
    Digestion 87:59-64. 2013
    ..However, the incidence of adverse events is not so low. We investigated the efficacy and safety of chemotherapy combined bevacizumab with fluoropyrimidine as a first-line treatment for frail patients...
  52. pmc Strategies for peptic ulcer healing after 1 week proton pump inhibitor-based triple Helicobacter pylori eradication therapy in Japanese patients: differences of gastric ulcers and duodenal ulcers
    Toshihisa Takeuchi
    2nd Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki City, Osaka 569 8686, Japan
    J Clin Biochem Nutr 51:189-95. 2012
    ..In DU study, high healing rates were seen both the group C and D. In conclusion, a PPI could significantly heal GU than a GP after eradication therapy in GU. Meanwhile, the eradication alone is sufficient for DU...
  53. pmc Development of Fibrosis in Nonalcoholic Steatosis through Combination of a Synthetic Diet Rich in Disaccharide and Low-Dose Lipopolysaccharides in the Livers of Zucker (fa/fa) Rats
    Shinya Fukunishi
    Department of Legal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    J Clin Biochem Nutr 45:322-8. 2009
    ..Synthetic diet-fed Zucker (fa/fa) rats treated with LPS could be useful for understanding the development of hepatic fibrosis in the two-hit theory...
  54. ncbi request reprint [The role of prostaglandin derivatives in a treatment and prevention for gastric ulcers in the aged patients]
    Kazuhide Higuchi
    2nd Department of Internal Medicine, Osaka Medical College
    Nihon Rinsho 68:2071-5. 2010
    ..Prostaglandin derivatives are also useful for these small intestinal damages...
  55. pmc p59fyn is associated with the development of hepatic steatosis due to chronic ethanol consumption
    Shinya Fukunishi
    Department of Gastroenteroloy and Hepatology, Osaka Medical College, 2 7 Daigaku machi, Takatsuki, Osaka 569 8686, Japan
    J Clin Biochem Nutr 49:20-4. 2011
    ..The results suggest that Fyn is involved in the enhancement of fatty acid oxidation and the development of hepatic steatosis caused by chronic ethanol consumption...
  56. pmc The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection
    Toshihisa Takeuchi
    2nd Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki 569 8686, Osaka, Japan
    BMC Gastroenterol 13:136. 2013
    ..We examined postoperative bleeding rates and risk factors for postoperative hemorrhage from post-ESD gastric ulcers in patients on antithrombotic therapy...
  57. pmc Risk management for gastrointestinal endoscopy in elderly patients: questionnaire for patients undergoing gastrointestinal endoscopy
    Eiji Umegaki
    Second Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki shi, Osaka 569 8686, Japan
    J Clin Biochem Nutr 46:73-80. 2010
    ..Taking a detailed history before UGITE with the aid of a questionnaire at the same time as informed consent is obtained, is extremely useful in terms of risk management and selection of the appropriate premedication...
  58. ncbi request reprint A rare case of propofol-induced liver injury during modified electroconvulsive therapy in an elderly woman
    Akira Asai
    The 2nd Department of Internal Medicine, Osaka Medical College, Japan
    Intern Med 52:761-5. 2013
    ..We herein report the first case of propofol-induced liver injury definitively diagnosed based on positive drug lympocyte stimulation testing (DLST)...
  59. pmc An immunosuppressive subtype of neutrophils identified in patients with hepatocellular carcinoma
    Yasuhiro Tsuda
    Department of Gastroenteroloy and Hepatology, Osaka Medical College, Osaka 569 8686, Japan
    J Clin Biochem Nutr 51:204-12. 2012
    ..Moreover, distinct PMN subsets may exist in the peripheral blood of HCC patients. These PMN subsets, especially CCL2-producing PMN, may be involved in tumor extension and the survival outcomes for HCC patients...
  60. pmc Evaluation of portal hypertensive enteropathy by scoring with capsule endoscopy: is transient elastography of clinical impact?
    Usama M Abdelaal
    Second Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki shi, Osaka 569 8686, Japan
    J Clin Biochem Nutr 47:37-44. 2010
    ..We concluded that using our scoring system might be helpful in grading PHE severity, and TE might be a new non-invasive method for detecting the presence and severity of PHE in cirrhotic patients...
  61. pmc Prevention of NSAID-Induced Small Intestinal Mucosal Injury: Prophylactic Potential of Lansoprazole
    Kazuhide Higuchi
    2 Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka 569 8686, Japan
    J Clin Biochem Nutr 45:125-30. 2009
    ..Therefore, lansoprazole may be useful for preventing the adverse effects of NSAIDs not only in the stomach but also in the small intestine...
  62. ncbi request reprint Plummer-Vinson syndrome successfully treated by endoscopic dilatation
    Masaru Enomoto
    Third Department of Internal Medicine, Osaka City University Medical School, Abeno Ku, Osaka, Japan
    J Gastroenterol Hepatol 22:2348-51. 2007
    ..The patient's dysphagia resolved shortly after the treatment and did not recur. This experience indicates that endoscopic bougienage is safe, effective, and relatively easy to perform in patients with severe esophageal stenosis...
  63. ncbi request reprint Comprehensive analysis of intestinal cytokine messenger RNA profile by real-time quantitative polymerase chain reaction in patients with inflammatory bowel disease
    Yoshinori Sawa
    Department of Gastroenterology, Osaka City University, Graduate School of Medicine, Osaka, Japan
    Int J Mol Med 11:175-9. 2003
    ..In patients with Crohn's disease, Th1 cytokine mRNA levels were increased in colonic mucosa, suggesting predominance of cellular immunity in the pathogenesis of this disease...
  64. ncbi request reprint Increased proliferation of middle to distal colonic cells during colorectal carcinogenesis in experimental murine ulcerative colitis
    Takuya Inoue
    Second Department of Internal Medicine, Osaka Medical College, Osaka 569 8686, Japan
    Oncol Rep 18:1457-62. 2007
    ..These findings may provide insight into the development of colorectal cancer in humans with long-standing UC...
  65. doi request reprint Differential diagnosis of pancreatobiliary carcinoma from autoimmune pancreatitis-related diseases: a report of three cases
    Michihiro Hayashi
    Department of General and Gastroenterological Surgery, Osaka Medical College Hospital, 2 7 Daigaku machi, 569 8686, Takatsuki City, Osaka, Japan
    J Gastrointest Cancer 42:241-51. 2011
    ..Japanese clinical guidelines for autoimmune pancreatitis" advised to carefully differentiate between two conditions: autoimmune pancreatitis (AIP) and associated sclerosing cholangitis (SC), and pancreatobiliary malignancy...
  66. ncbi request reprint [Prevention and treatment of NSAIDs-induced small intestinal lesions]
    Yukiko Yoda
    Second Department of Internal Medicine, Osaka Medical College
    Nihon Rinsho 69:1093-7. 2011
    ..Considering the cost benefit and the load of patients, we hope that one drug can prevent NSAIDs-induced lesions from esophagus to small intestines. We should use mucoprotective drugs well for these diseases...
  67. ncbi request reprint Oxidized low-density lipoprotein levels circulating in plasma and deposited in the tissues: comparison between Helicobacter pylori-associated gastritis and acute myocardial infarction
    Soichiro Kayo
    Department of Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am Heart J 148:818-25. 2004
    ..Thus the question arises whether an increase in the plasma levels of ox-LDL occurs in patients with H pylori gastritis...
  68. pmc Gastric ulcer healing after treatment of endoscopic submucosal dissection in Japanese: comparison of H(2) receptor antagonist and proton pump inhibitor administration
    Nozomi Takeuchi
    Second Department of Internal Medicine, Osaka Medical College, 2 7 Daigaku machi, Takatsuki shi, Osaka 569 8686, Japan
    J Clin Biochem Nutr 49:216-21. 2011
    ..The efficacy of H(2) Receptor Antagonists in curing this type of ulcer can thus be expected to be comparable to that of Proton Pump Inhibitors...
  69. ncbi request reprint Efficacy and safety of Helicobacter pylori eradication therapy with omeprazole, amoxicillin and high- and low-dose clarithromycin in Japanese patients: a randomised, double-blind, multicentre study
    Kazuhide Higuchi
    Department of Gastroenterology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Clin Drug Investig 26:403-14. 2006
    ..We investigated the efficacy and safety of an omeprazole-based triple therapy regimen in combination with amoxicillin and low-dose clarithromycin in Japanese patients...
  70. ncbi request reprint Long-term feeding of a synthetic diet rich in disaccharides induces hepatic fibrosis in nonalcoholic fatty liver disease in Zucker rats
    Shinya Fukunishi
    Department of Legal Medicine, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
    Int J Mol Med 25:187-93. 2010
    ..However, they also suggest that long-term feeding of this synthetic diet to Zucker (fa/fa) rats is useful for studying the hepatic fibrogenesis during the pathogenesis of NAFLD...
  71. ncbi request reprint Altered expression of both β-carotene 15,15' monooxygenase and lecithin:retinol acyltransferase in obese Zucker rats
    Kimitaka Takitani
    Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan
    J Nutr Sci Vitaminol (Tokyo) 57:108-13. 2011
    ..There was no difference in hepatic CRBP-I and CYP26A1 gene expression between fa/fa rats and lean rats. Altered expression of BCM and LRAT genes may affect plasma retinol status in obesity and dyslipidemia...
  72. doi request reprint Neural invasion induces cachexia via astrocytic activation of neural route in pancreatic cancer
    Akira Imoto
    Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Int J Cancer 131:2795-807. 2012
    ..These data provide the first evidence that N-inv induces cachexia via astrocytic activation of neural route in pancreatic cancer...
  73. ncbi request reprint Slow-wave photic stimulation relieves patient discomfort during esophagogastroduodenoscopy
    Tsutomu Nomura
    Endoscopy Center, Wakakusa First Hospital and Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Gastroenterol Hepatol 21:54-8. 2006
    ..The aim of this study was to examine the effect of slow-wave photic stimulation on discomfort and/or pain felt during EGD...
  74. ncbi request reprint Expression of 4C8 antigen, a novel transendothelial migration-associated molecule on activated T lymphocytes, in inflammatory bowel disease
    Nobuhide Oshitani
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Pathol 197:589-94. 2002
    ..Inhibition of the 4C8-ligand system could have potentially uses in the treatment of inflammatory bowel disease...
  75. doi request reprint The role of linear array EUS for diagnosis of pancreatic malignancies in the current situation
    Reiko Ashida
    The Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan
    Dig Endosc 23:12-6. 2011
    ..This review will focus on the features of linear array EUS and discuss the current role of linear array EUS in the diagnosis of pancreatic malignancies...
  76. ncbi request reprint A case of gastric duplication evaluated by gastric emptying scintigraphy
    Susumu Shiomi
    Department of Nuclear Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Ann Nucl Med 16:227-30. 2002
    ..Gastric emptying of the primary stomach was not affected by formation of the duplication cyst...